IL-2 – Page 15 – Communicable Diseases Research

Case Report: A Patient With COVID-19 Who Benefited From Hemoadsorption

Medicine

Published on 2020-12-012022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Continuous tracking of COVID-19 patients’ immune status

COVID-19 환자의 면역 상태를 지속적으로 추적

Article

Published on 2020-12-012022-09-11
Journal: International immunopharmacology [Category] SARS, 치료기술,

[키워드] Admission AUC basophils Blood blood cell CD3 CD4 CD8 Cell change clinical evolution Continuous contrary correlated COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokine storms Cytokines Depletion diagnostic Efficacy enrolled eosinophil eosinophils flow cytometer HCs Health healthy control help hospital IFN-γ IL-10 IL-2 IL-6 Immune monitoring Immune status increase in Infection Laboratory leucocytes lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Mild mild case Monocytes neutrophil Neutrophils predict Secondary infection severe cases severe group significantly sustained T cells the disease
[DOI] 10.1016/j.intimp.2020.107034 PMC 바로가기 [Article Type] Article

Circulating Cytokines and Lymphocyte Subsets in Patients Who Have Recovered from COVID-19

Research Article

Published on 2020-11-262022-10-27
Journal: BioMed Research International [Category] COVID-19,

[키워드] Alpha Analysis analyzed B cell B cells CD19 CD3 CD4 CD56 CD8 circulating Cohort Concentration consequence correlation COVID-19 COVID-19 infections cytokine decrease discharge Efficacy flow cytometry growth factor healthy controls hospital Hyperinflammatory IFN IL-10 IL-17 IL-2 IL-4 IL-6 IL-8 Immune status immune system increases in independent predictor Infection interferon gamma longitudinal study lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Necrosis NK cell NK cells observation Patient patients positively correlated recovered recovered patient recruited rehabilitation remained ROC Curve serum significantly higher significantly lower sustained T cell T cells TGF TNF- α
[DOI] 10.1155/2020/7570981 PMC 바로가기 [Article Type] Research Article

Circulating Cytokines and Lymphocyte Subsets in Patients Who Have Recovered from COVID-19

Research Article

Published on 2020-11-262022-10-27
Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS,

[키워드] Alpha Analysis analyzed B cell B cells CD19 CD3 CD4 CD56 CD8 circulating Cohort Concentration consequence correlation COVID-19 COVID-19 infections cytokine decrease discharge Efficacy flow cytometry growth factor healthy controls hospital Hyperinflammatory IFN IL-10 IL-17 IL-2 IL-4 IL-6 IL-8 Immune status immune system increases in independent predictor Infection interferon gamma longitudinal study lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Necrosis NK cell NK cells observation Patient patients positively correlated recovered recovered patient recruited rehabilitation remained ROC Curve serum significantly higher significantly lower sustained T cell T cells TGF TNF- α
[DOI] 10.1155/2020/7570981 PMC 바로가기 [Article Type] Research Article

Application value of artificial liver support system in the treatment of cytokine storm in patients with COVID-19

Article

Published on 2020-10-312022-10-04
Journal: International immunopharmacology [Category] SARS, 치료법,

[키워드] abnormality addition alanine aminotransferase ALT Analysis analyzed application Artificial liver support system Aspartate aminotransferase AST B lymphocyte C-reactive protein carried CD3 CD4 CD8 T cell Cell Clinical effect Clinical treatment college Computed tomography contributed coronavirus disease COVID-19 COVID-19 patients cytokine cytokine level Cytokine storm decrease IFN-γ IL-10 IL-2 IL-4 IL-6 Inflammation lesions liver lymphocyte Medicine natural killer neutrophil no significant difference objective observé Patient patients with COVID-19 plasma exchange procalcitonin promote proportion pulmonary lesion pulmonary lesions recruited reduce reduced Result severe COVID-19 patient significantly Support the patient TNF-α treated Treatment university was used White blood cell Zhejiang
[DOI] 10.1016/j.intimp.2020.107120 PMC 바로가기 [Article Type] Article

Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacology

Research

Published on 2020-10-162022-10-28
Journal: BioData Mining [Category] COVID-19,

[키워드] activated Activation Active ingredient ALB albumin Analysis Anti-inflammatory AutoDock B cell binding activity biological process BPS cascade CASP3 cellular response Chinese component Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Cytoscape Cytoscape software database demonstrated disease docking score Effect effective Effector mechanism Effects EGFR endothelial enrichment analysis epidermal ESR1 estrogen receptor Examining explain Extracellular GAPDH GeneCard Genes growth factor IL-2 Inflammation ingredient injection International JUN KEGG Kyoto less MAPK MAPK1 MAPK14 MAPK8 mechanism Mild molecular docking Necrosis network pharmacology NF-κB nuclear Ontology participated Pathways pharmacological mechanism PI3K potential mechanism potential therapeutic target PPI predict produced Protein protein-protein interaction provided PTGS2 RAS receptor regulated Regulation renin-angiotensin system Result searched Sepsis severe pneumonia signaling pathway STAT3 SwissTargetPrediction database synergistic T-cell receptor target targets therapeutic effect TLR TNF Toll-like receptor Topology Transcription Treatment TRP VEGF was used Xuebijing
[DOI] 10.1186/s13040-020-00227-6 PMC 바로가기 [Article Type] Research

High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19

Clinical Medicine

Published on 2020-10-152022-10-30
Journal: JCI Insight [Category] COVID-19, MERS, SARS,

[키워드] Activation acute respiratory syndrome affecting alteration analyzed Anergy antibody CD4 CD8 Cellular immune response Characteristics characterized controls convalescent individuals Convalescent patients coronavirus coronavirus disease correlated Course COVID-19 COVID-19 patient cytokine disease severity ELISA expression functional IFN-γ IgA IgA antibody IgG IgG levels IL-2 Immunity immunoglobulins immunopathology lung lymphocyte lymphocyte subpopulation lymphopenia marker mounted Patient patient group peptide pool phenotypical plasmablast proliferation quantified Rolf SARS-CoV-2 SARS-CoV-2 specific T-cell severe disease Severity of disease significantly higher state subpopulations supported T cell T cells TNF-α uninfected uninfected control university viral replication
[DOI] 10.1172/jci.insight.142167 PMC 바로가기 [Article Type] Clinical Medicine

A whole blood test to measure SARS-CoV-2-specific response in COVID-19 patients

Original Article

Published on 2020-10-102022-10-04
Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단,

[키워드] Abstract Activation Antigen approach characterized CMV COVID-19 COVID-19 patient diagnostic diagnostic test disease endothelial Enterotoxin evaluated expressed FGF fibroblast G-CSF GM-CSF granulocyte-colony stimulating factor growth factor IFN-γ IFN-γ IL-10 IL-12p70 IL-13 IL-15 IL-17A IL-1ra IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 Image immune response individual inflammatory protein interferon IP-10 Macrophage MCP-1 median MIP-1β monocyte chemoattractant protein-1 Multiplex analysis Necrosis objective parameters Patient PDGF peptide platelet-derived growth factor Protein RANTES regulated Result SARS-CoV-2 SARS-CoV-2 peptide SEB secreted Serology response significantly increased Specific response T cell T-cell T-cell based tests Th1 Th2 TNF-α Vaccine Vascular VEGF Whole blood with COVID-19
[DOI] 10.1016/j.cmi.2020.09.051 PMC 바로가기 [Article Type] Original Article

Descriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 Patients

Research Article

Published on 2020-10-072022-10-30
Journal: mSphere [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Alpha antibody Asymptomatic Asymptomatic COVID-19 Asymptomatic disease asymptomatic individual asymptomatic patient asymptomatic patients B cell B cells Biochemistry Blood Cellular immune response clinical Clinical characteristics clinical symptom collected complete blood count coronavirus coronavirus disease COVID-19 COVID-19 patients Diagnosis disease elevated epidemicity evaluated examined Face mask faster flow cytometry greater IFN-γ IgG and IgM IL-10 IL-2 IL-4 IL-6 immune response indicated infection control interferon interleukin 2 liver Liver damage liver enzyme Liver function Lymphocytes Necrosis NK cell NK cells outbreak outcome pandemic Patient performed Person phenotype Prevent proceed Protein public health Public health intervention Public health interventions qRT-PCR Quantitative resulting reverse transcription-PCR risk risk factor SARS-CoV-2 serum significantly significantly lower social distancing Spread symptomatic Symptomatic patients T cell T cells throat swab TNF-α Transmission Treatment viral clearance Viral load viral shedding viral titer virus virus transmission were measured while Wuhan, China
[DOI] 10.1128/mSphere.00922-20 PMC 바로가기 [Article Type] Research Article

Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic Individuals

Research Article

Published on 2020-09-292022-10-31
Journal: Mediators of Inflammation [Category] COVID-19, MERS, SARS,

[키워드] abnormal increase acute respiratory syndrome Affect bead C reactive protein caused CD16 CD19 CD3 CD4 CD56 CD8 Clinical severity Comorbidity complement conducted confirmed case coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical CRP cytokine Data analysis decrease demonstrated disease severity effort eligible flow cytometric Frequency global pandemic IFN IgA IgE IgG IgM IL-10 IL-2 IL-4 IL-6 immune system Immunity immunoassay Immunoglobulin Immunologic immunological characteristics immunological parameters Immunological response in both group individual Level lymphocyte subpopulation NDM neutrophil count NK cell no significant difference participant Peripheral blood pilot study proportion Result retrospective risk factor SARS-CoV-2 Sex significantly higher surface marker T2D Th1 cytokine TNF- α two groups Type type 2 diabete virus
[DOI] 10.1155/2020/6914878 PMC 바로가기 [Article Type] Research Article