In silico immune infiltration profiling combined with functional enrichment analysis reveals a potential role for naïve B cells as a trigger for severe immune responses in the lungs of COVID-19 patients기능 강화 분석과 결합된 인실리코(in silico) 면역 침투 프로파일링은 COVID-19 환자의 폐에서 심각한 면역 반응을 유발하는 촉발제로서 순진한 B 세포의 잠재적 역할을 보여줍니다Research Article Published on 2020-12-022022-09-10 Journal: PLoS ONE [Category] MERS, 유전자 메커니즘, [키워드] Activation acute respiratory distress acute respiratory distress syndrome alleviate Analysis antibody antibody-secreting cells antiviral drugs applied ARDS B cell B cells B-cell B-cells cause caused Clinical outcome Clinical treatment collected country COVID-19 COVID-19 case COVID-19 group COVID-19 patient COVID-19 patients DN2 effective effort evaluate excessive immune response fibrosis functional functional enrichment Gene Expression genetic difference genetic differences humoral immune response Idiopathic pulmonary fibrosis Immune cell Immune cell infiltration immune infiltration immune response immune responses impairment infiltration IPF leads lung lung damage Lung function lung tissue lung tissues mechanism memory Mild mitigate modulating naïve naïve B cell naïve B cells Patient Pneumonia populations pulmonary fibrosis reducing resource respiratory distress resulting reveal SARS-CoV-2 SARS-COV-2 infection Severe patient severe patients severe pneumonia severe symptom severe symptoms significantly Single-cell RNA sequencing spread to subset subtype syndrome targets therapy transcriptional transcriptomic treated Trigger variety [DOI] 10.1371/journal.pone.0242900 PMC 바로가기 [Article Type] Research Article
Tocilizumab for treatment patients with COVID-19: Recommended medication for novel diseaseCOVID-19 치료 환자를 위한 Tocilizumab: 새로운 질병에 권장되는 약물Review Published on 2020-12-012022-09-12 Journal: International immunopharmacology [Category] MERS, SARS, 진단, 치료법, [키워드] actemra China Commission coronavirus disease COVID-19 CT scan disease drug Effect effective Efficacy Evidence fatal COVID-19 IMPROVE in some infected patients infiltration Inflammation introduced Iran lung tissue medication Patient patients patients with COVID-19 peripheral positive predicted provide reduced researcher respiratory inflammation saturation scientist Spread Tocilizumab treat Treatment virus with COVID-19 [DOI] 10.1016/j.intimp.2020.107018 PMC 바로가기 [Article Type] Review
Could flank pain be an indicator of COVID-19 infection?옆구리 통증이 COVID-19 감염의 지표가 될 수 있습니까?Article Published on 2020-12-012022-09-11 Journal: Malawi medical journal : the journal of Medical As [Category] SARS, 치료기술, [키워드] abdomen abdomen CT Admission analysed complaint Computed tomography control group cough COVID-19 COVID-19 disease COVID-19 pandemic cross-sectional CT scans defined Diagnosis Evidence evidence of Fever flank pain hydronephrosis infiltration kidney lung Lungs no evidence of Outpatient outpatient clinic pandemic pathology Patient patients with COVID-19 pneumonic Region Shortness of breath significantly higher study group subject the study group training Urology with COVID-19 [DOI] 10.4314/mmj.v32i4.3 PMC 바로가기 [Article Type] Article
Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infectionResearch Article Published on 2020-11-302022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accompanied Activation Antiviral effect Brain caused CD4 T cell cellular chemokine Chemokine receptor Clinical sign CNS contributing to coronavirus Coronavirus infection Critical CX3CL1 CX3CR1 cytokine deficiency develop dissemination expression functions IFN IFNs immune protection Infection infiltration interferon-induced protein ISG ISGs lack leukocyte mechanism mice microglial Migration morbidity and mortality murine Neurological deficit neurotropic NK1.1 Pathogenesis PROTECT protective mechanism Protein receptor recruitment reduced regulate restrict significantly Spread stimulated Symptom T cell tissue homeostasis viral clearance Viral load viral replication virus virus load virus replication viruses wild-type [DOI] 10.1371/journal.ppat.1009034 PMC 바로가기 [Article Type] Research Article
CT chest findings in patients infected with COVID-19: review of literatureReview Published on 2020-11-272022-10-31 Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19, [키워드] can be used Chest CT co-morbidities consolidation coronavirus Coronavirus disease 2019 Course COVID-19 COVID-19 pneumonia CT chest CT finding Diagnosis disease severity ground glass Infectious disease infiltration lobes management pandemic patchy Patient Pneumonia Prognosis reported Severe respiratory distress symptomatic patient syndrome the disease variety Viral pneumonia Wuhan, China [DOI] 10.1186/s43055-020-00355-3 PMC 바로가기 [Article Type] Review
Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primatesSARS-CoV-2에 감염된 비인간 영장류에서 급성, 해결 또는 진행성 COVID-19의 세포 사건Article Published on 2020-11-272022-09-10 Journal: Nature Communications [Category] SARS, 진단, 치료기술, [키워드] accumulation acute phase animals anti-inflammatory response anti-inflammatory responses association CCL17 CD11b CD11c CD16 Cell cell population Cellular immune response cellular mechanism cellular mechanisms COVID-19 detectable develop disease event expressing heterogeneous HLA-DR identify IL-10 IL-6 IL-6 level IL-6 levels immune Infection infiltration Innate immunity interstitial Kynurenine less long-lasting lung Lungs Macrophage macrophages Migration Mild monocyte Monocytes Neutrophils NHP non-human primate non-human primates outcome pathology plasma progressive COVID-19 Pulmonary pathology robust SARS-CoV-2 SARS-COV-2 infection subset subtype Therapies Tryptophan understanding Vaccine Viral Viral load viral replication [DOI] 10.1038/s41467-020-19967-4 PMC 바로가기 [Article Type] Article
An integrative analysis identifying transcriptional features and key genes involved in COVID-19COVID-19와 관련된 전사적 특징과 핵심 유전자를 식별하는 통합 분석Research Article Published on 2020-11-262022-09-11 Journal: Epigenomics [Category] SARS, 유전자 메커니즘, 진단, [키워드] Analysis approach Bronchoalveolar lavage Bronchoalveolar lavage fluid Cell Characteristics core gene core genes COVID-19 COVID-19 patient COVID-19 patients downregulated gene expressed feature Immune cell immune cells immune response infiltration Integrative analysis involved Lcn2 lung material molecular feature molecular features neutrophil neutrophil activation SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection Stat1 suggested transcriptional transcriptional features UBE2L6 upregulated gene upregulated genes [DOI] 10.2217/epi-2020-0168 PMC 바로가기 [Article Type] Research Article
Deep-learning algorithms for the interpretation of chest radiographs to aid in the triage of COVID-19 patients: A multicenter retrospective studyCOVID-19 환자 분류에 도움이 되는 흉부 방사선 사진 해석을 위한 딥 러닝 알고리즘: 다기관 후향적 연구Multicenter Study Published on 2020-11-242022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, [키워드] Accuracy Adult patients Algorithm all the patients Chain Reaction Chest Chest computed tomography chest CT scan Chest CT scans Chest radiography Clinical efficacy clinician Community comparable Computed tomography consolidation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 pneumonia demonstrated diagnose diagnosed Diagnosis diagnostic Efficacy Emergency Departments evaluate evaluated Evidence evidence of facilitate FIVE Formal ground-glass opacity infiltration Interpretation Isolation medical staff multicenter offer outcomes Patient physician Pneumonia polymerase chain polymerase chain reaction positive positive COVID-19 radiologist Radiologists reduce Retrospective study reverse transcription reverse transcription polymerase chain reaction Sensitivity and specificity significantly speed the patient Treatment were used [DOI] 10.1371/journal.pone.0242759 PMC 바로가기 [Article Type] Multicenter Study
Recent Advances in Pathophysiology, Drug Development and Future Perspectives of SARS-CoV-2Cell and Developmental Biology Published on 2020-11-062022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 acute respiratory distress addition advance Affect angiotensin-converting enzyme-2 bind Clinical data clinical trial complications Computed tomography conducted convalescent coronavirus develop development Diagnosis disease Disseminated intravascular coagulation drug Drug discovery effective Epidemic Epidemiology evaluated Future health worker highly pathogenic identify IgG antibody IgM immune response include infiltration intestinal epithelial cells lymphocytic myocarditis management pandemic Pathogenesis pathophysiology Patient care patients Perspective Pneumonia public health quantitative reverse-transcription PCR recent receptor recognize researcher SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 pneumonia shown Spike protein the disease the SARS-CoV-2 Transmission Treatment upper respiratory tract Vaccine Vaccine development [DOI] 10.3389/fcell.2020.580202 PMC 바로가기 [Article Type] Cell and Developmental Biology
The Landscape of Coronavirus Disease 2019 (COVID-19) and Integrated Analysis SARS-CoV-2 Receptors and Potential Inhibitors in Lung Adenocarcinoma PatientsCell and Developmental Biology Published on 2020-10-232022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] AAK1 ACE2 addition adenocarcinoma anti-inflammatory effect B cell bioinformatic analysis Cancer patients CD4 T cells Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient death differentially expressed gene Effect endocytic explain expression Factor Health immune Immune cell immune infiltration infiltration Inflammation involved landscape lung adenocarcinoma lung adenocarcinoma (LUAD) malignant tumors novel coronavirus disease outbreak Patient positive Potential Prognosis Regulation SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signaling pathways significantly significantly increased susceptibility susceptible the patient TMPRSS2 Treatment [DOI] 10.3389/fcell.2020.577032 PMC 바로가기 [Article Type] Cell and Developmental Biology