intranasal – Page 15 – Communicable Diseases Research

Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2

Article

Published on 2021-08-042022-10-04
Journal: iScience [Category] 비임상,

The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19

Research Article

Published on 2021-08-032022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] ACE2 acute respiratory syndrome Ad5-hACE2 airway epithelia angiotensin-converting enzyme 2 bind Calu-3 camostat Camostat mesylate caused Cell cell line cleaved coronavirus coronavirus disease COVID-19 disease pathogenesis entry of SARS-CoV-2 epithelia exhibiting greater hACE2 host cell human ACE2 in vivo Infection inhibit inhibitors initiate intranasal K18 K18-hACE2 limit lung tissue membrane fusion MERS-CoV mice Middle East Model morbidity and mortality Mortality mouse Mouse models nafamostat pandemic pathogenic coronavirus preclinical drug studies primary human airway Prophylactic protease Protease inhibitor protease TMPRSS2 Protective pulmonary receptor reduced respiratory syndrome coronavirus respiratory tract SARS-CoV-2 SARS-COV-2 infection serine protease serine protease inhibitors significantly Spike protein tested the spike protein TMPRSS2 transgenic mice Treatment viral burden weight loss
[DOI] 10.1128/mBio.00970-21 PMC 바로가기 [Article Type] Research Article

Intranasal Administration of a Monoclonal Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection

단일 클론 중화 항체의 비강 내 투여는 SARS-COV-2 감염으로부터 마우스를 보호한다.

Article

Published on 2021-07-292022-09-01
Journal: Viruses [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Administered animal experiments anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies antiviral potency B.1.1.7 B.1.351 bind Bioavailability clinical trial clinical trials coronavirus drugs Effectiveness highlight human SARS-CoV-2 in vitro in vivo injected intravenously intranasal intranasal administration lead lung Lung pathology Lungs mice monoclonal monoclonal antibody neutralize Neutralizing Neutralizing antibodies neutralizing antibody pandemic Particle pharmacokinetic Prophylactic prophylactically Receptor-binding domain reduced respiratory respiratory virus respiratory viruses SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 spike protein Spike protein the receptor-binding domain the SARS-CoV-2 therapeutic topical administration transduction Vaccine variant virus viruses VoC
[DOI] 10.3390/v13081498 PMC 바로가기 [Article Type] Article

A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19

Article

Published on 2021-07-222022-10-30
Journal: NPJ Vaccines [Category] COVID-19,

Intranasal plus subcutaneous prime vaccination with a dual antigen COVID-19 vaccine elicits T-cell and antibody responses in mice

이중 항원 코비드 -19 백신을 사용한 비강 + 피하 주요 예방 접종은 마우스에서 T- 세포 및 항체 반응을 유도한다.

Article

Published on 2021-07-212022-09-01
Journal: Scientific Reports [Category] SARS, 진단, 치료기술, 치료법,

Scalable live-attenuated SARS-CoV-2 vaccine candidate demonstrates preclinical safety and efficacy

확장 가능한 약독화 생 SARS-CoV-2 백신 후보, 전임상 안전성 및 효능 입증

423

Published on 2021-07-202022-09-12
Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, SARS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus added addition administration Amino acid amino acid sequence antibody antigenic antigenic drift approach Brain clinical development clinical testing codon deoptimization combating component condition conditions coronavirus COVID-19 COVID-19 pandemic deleted dose Effect Efficacy emerging disease engage feasibility furin furin cleavage site furin cleavage site deletion hamster hamsters herd immunity host immune system IgG antibody Immunity immunization in vitro in vivo model inoculated intranasal intranasally live attenuated Live virus lung Lung pathology mass immunization mass vaccination Mesocricetus mutations parental plaque reduction neutralization potency Protective recipients reduced reversion SARS-CoV-2 SARS-CoV-2 vaccine segment sequence Significance silent spike IgG Spike protein Support synonymous Syrian golden hamster Syrian Golden hamsters temperature temperature sensitive the spike protein the vaccine undetectable vaccination Vaccine vaccine candidate vaccine candidates vaccine strain viral genome Viral load Viral protein Viral proteins viral spike protein viral titers virus virus growth weight loss wild-type WT virus
[DOI] 10.1073/pnas.2102775118 PMC 바로가기 [Article Type] 423

Differing susceptibility of C57BL/6J and DBA/2J mice—parents of the murine BXD family, to severe acute respiratory syndrome coronavirus infection

Letter to the Editor

Published on 2021-07-192022-11-01
Journal: Cell & Bioscience [Category] COVID-19,

[키워드] accompanied acute respiratory syndrome Asymptomatic BXD family C57BL/6J caused Cohort complex conditions coronavirus coronavirus disease-2019 Coronavirus infection Coronavirus-2 COVID-19 DBA/2J develop disease manifestation Disease progression dissect evidenced Factors feasibility fraction Genetic genetic difference genetics Health Host infected individuals Infection intranasal life-threatening MA15 majority mice microbial infections Mild symptom modulate mouse-adapted SARS-CoV murine Novel coronavirus outcome pandemic parent phenotypic pulmonary viral Replication SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease strain Support susceptibility sustained System systemically systems genetics Variation viral challenge viral clearance viral replication Virus-host interaction weight loss
[DOI] 10.1186/s13578-021-00656-8 PMC 바로가기 [Article Type] Letter to the Editor

Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

SARS-CoV-2 변이체에 의한 감염을 예방하기 위한 비강내 유전자 요법

Research Article

Published on 2021-07-152022-09-10
Journal: PLoS Pathogens [Category] SARS, 변종,

[키워드] ACE2 administration affinity airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animals Antiviral approach bind binding caused Cell combating coronavirus Coronaviruses countermeasure CoV COVID-19 COVID-19 pandemic CoVs demonstrated effective Efficacy evade expression Gene therapy human ACE2 humans immune response improvement infecting Infection Intervention intranasal intranasally less long-lasting monoclonal antibodies monoclonal antibody mouse model nasal Nasal spray neutralize Pandemics pathogenicity pathologic consequence Patient Population pre-existing immunity Prevent Prophylaxis Protein proximal receptor reduce respond SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral secrete significantly Spread tested the patient therapeutic Transmissibility unlikely vaccination Vaccinations Vaccine Vaccines variant variants variants of SARS-CoV-2 Viral viral mutation Viral mutations viral particle Viral particles Viral vector virus Vulnerable populations zoonosis
[DOI] 10.1371/journal.ppat.1009544 PMC 바로가기 [Article Type] Research Article

Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters

중증 급성 호흡기 증후군 코로나바이러스 2는 햄스터의 성숙하고 미성숙한 후각 감각 뉴런을 감염시키고 손상시킵니다

Article

Published on 2021-07-152022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술,

[키워드] Acute inflammation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affecting Antigen Apoptosis Cell cells chemokine ciliated contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient Cytokines damage destruction develop epithelial cells hamster hamsters highest immature Infection Inflammatory inflammatory cell inflammatory cell infiltration Inflammatory cytokine Inflammatory cytokines intranasal Invasion investigated less location Loss of Smell marker nasal nasal turbinate Neuron neuronal function olfactory olfactory bulb olfactory bulbs olfactory dysfunction Olfactory epithelium olfactory neuron olfactory neuron. Pathogenesis patients peaked Postinfection proinflammatory Proinflammatory cytokine proportion Protein reported respiratory respiratory epithelial cells respiratory tract infection response resulting SARS-CoV-2 SARS-CoV-2 viral Sensory sensory neuron severe acute respiratory syndrome Coronavirus Symptom tissues unique Viral load β-tubulin
[DOI] 10.1093/cid/ciaa995 PMC 바로가기 [Article Type] Article

Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease

SARS-CoV-2 수용체 결합 도메인을 표적으로 하는 초강력 미니단백질은 감염과 질병으로부터 보호합니다

Article

Published on 2021-07-142022-09-11
Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단,

[키워드] administration approach B.1.1.7 COVID-19 COVID-19 pandemic death develop disease domain dose E484K Immune cell infiltration in vivo Infection Inflammation intranasal investigated lead lung Lung disease mice miniprotein mitigate N501Y Pathogenesis pathology prevented Prophylaxis PROTECT Protein-based vaccines public health measure public health measures Receptor-binding domain reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike receptor-binding domain Spike protein spike protein-based vaccine spike protein-based vaccines spike receptor-binding domain strain substitutions Support systemic the SARS-CoV-2 therapy Treatment variants Viral viral burden virus WA1/2020
[DOI] 10.1016/j.chom.2021.06.008 PMC 바로가기 [Article Type] Article