Sequence analysis and pathogenicity of Avian Orthoavulavirus 1 strains isolated from poultry flocks during 2015–2019Research Article Published on 2020-07-222022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Amino acid residue substitution Analysis Avian Orthoavulavirus 1 cause Co-infection decrease Delta disease examined F protein fusion protein gene sequence genetic analysis Genotype glycosylation high mortality highly pathogenic IBV indicated Infectious Bronchitis Virus Influenza Intensive Intracerebral isolate isolates Isolation molecular motif neutralizing epitopes newcastle disease virus pathogenic pathogenicity positive Prevalence primer qRT-PCR ranged RBCs reduce residue respiratory viral disease Result selected sequenced Sequencing Seven Spread strain submitted suffered tested vaccination Vaccines [DOI] 10.1186/s12917-020-02470-9 PMC 바로가기 [Article Type] Research Article
Understanding genomic diversity, pan-genome, and evolution of SARS-CoV-2Bioinformatics Published on 2020-07-172022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] Analysis analyzed ancestor bat bioinformatics contributed coronavirus CoV COVID-19 Diagnosis disease Epidemiology Evolution Evolution of SARS-CoV-2 Genome genome organization genomic Genomics genus Betacoronavirus help homology hosts indicate Infection isolate isolates majority medium mutational hotspot mutations novel virus pandemic pangolin pathogenicity Phylogeny predicted Probability respiratory SARS SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains sequenced the SARS-CoV-2 genome Treatment understanding unique viral disease Wuhan, China [DOI] 10.7717/peerj.9576 PMC 바로가기 [Article Type] Bioinformatics
COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/ProfileOrginal Article Published on 2020-06-282022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] aging Antiviral effect approach cellular miRNA coding region contagiousness coronavirus Coronavirus disease 2019 correlated COVID-19 Diseases effective Factor Genome global pandemic Health Organization Host human miRNA identify in silico analysis in vitro in vivo individual induce involved isolate isolates KEGG KEGG pathway analysis lack measure microRNA MicroRNAs miRNA miRNA targets Mortality mortality rates patient population potential therapeutic targets public health crisis recent regions severity Signaling signaling pathway suggested target targets treatment strategy underlying conditions unique UTR viral genome WHO Wuhan [DOI] 10.14336/AD.2020.0428 PMC 바로가기 [Article Type] Orginal Article
Phylogenetic background and habitat drive the genetic diversification of Escherichia coli계통발생적 배경과 서식지가 대장균의 유전적 다양화를 주도Research Article Published on 2020-06-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition adaptation adaptive Analysis analyzed Antibiotic resistance association Author Bacteria Bacterial birds clinical isolates clone commensal contribute determine Divergence driven by E . coli early stage element elements epidemiological epidemiologically Escherichia coli Evolution explain facilitate Factor fecal fecal contaminations Frequency gene flow gene transfer Genes Genetic genetic background genetic diversity genetic information Genome group gut bacteria habitat heterogeneous highest horizontal gene Horizontal gene transfer Human humans information investigated isolate isolates Isolation lead lineages linear mammals marker mechanism opportunistic pathogen paradigm pathogen pathogenic Phylogenetic Phylogeny poultry previous study sequence species strain Strains These data traits transfer Variation variations virulence virulence factors water while whole genome widespread wild animal wild animals [DOI] 10.1371/journal.pgen.1008866 PMC 바로가기 [Article Type] Research Article
Evolution of Salmonella enterica serotype Typhimurium driven by anthropogenic selection and niche adaptation살모넬라 엔테리카 혈청형 Typhimurium의 인위적 선택과 틈새 적응에 의한 진화Research Article Published on 2020-06-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 살모넬라증, [키워드] a minor accumulation acquisition acting adaptation Affect affecting anthropogenic antimicrobial resistance Biology Characteristics characterized circulation clade clone coding sequence coding sequences composed convergent evolution disease disease potential distribution Diversity driven by drug resistance elements elevated Epidemics Epidemiology Evolution exhibit exhibited food safety framework function functional functions Gain gastroenteritis Genes Genetic genomes genotypic genotypic variation group Health Host host adaptation host range host-pathogen interactions human infection IMPROVE Infection information invasive isolate isolates Laboratory less Lineage livestock minor monophasic observation organism outcome pandemic pathogen pathogenicity Population predicted predisposition prophage provide Recombination reflected risk Salmonella Salmonella Typhimurium sequence Sequencing serotype serotypes strain Strains subclade subclades subgroup subgroups survival undergo Variation whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1008850 PMC 바로가기 [Article Type] Research Article
Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?Research Article Published on 2020-05-302022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] Analysis applied bat caused comparison coronavirus Coronaviruses correlated COVID-19 Cross-species transmission described difference envelope homologous isolate isolates pangolin predicted Protein Proteins related virus reported Respiratory Coronavirus SARS-CoV-2 similarity three-dimensional structure variant viral infection virus [DOI] 10.1155/2020/4389089 PMC 바로가기 [Article Type] Research Article
Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?Research Article Published on 2020-05-302022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] Analysis applied bat caused comparison coronavirus Coronaviruses correlated COVID-19 Cross-species transmission described difference envelope homologous isolate isolates pangolin predicted Protein Proteins related virus reported Respiratory Coronavirus SARS-CoV-2 similarity three-dimensional structure variant viral infection virus [DOI] 10.1155/2020/4389089 PMC 바로가기 [Article Type] Research Article
A virus that has gone viral: amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding, and thus, infectivityVirology Published on 2020-05-292022-10-28 Journal: Bioscience Reports [Category] COVID-19, MERS, SARS, [키워드] ACE2 Alter Amino acid Analysis arginine binding caused coronavirus Course COVID-19 CoVs domain GenBank Genome genome sequence hydrophobic amino acid India information isolate isolates MERS-CoV in 2012 Mutation Novel coronavirus outbreak Outbreaks performed Point mutation Protein RBD receptor Receptor binding replaced reported S protein SARS-CoV SARS-CoV- SARS-CoV-2 secondary structure sequence sequenced Sequencing spike structural protein the Spike therapeutic targeting Vaccine Virology virus virus entry while Wuhan isolate Wuhan, China zoonotic [DOI] 10.1042/BSR20201312 PMC 바로가기 [Article Type] Virology
Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, IndiaBrief Report Published on 2020-05-182022-10-31 Journal: F1000Research [Category] Coronavirus, MERS, SARS, [키워드] analysed Analysis changes in Complete decrease downstream FIVE flu GISAID Gujarat host cells India isolate isolates molecular Mutation mutations Receptor binding Receptor binding domain reported S1 and S2 S1 domain S2 domain SARS-CoV2 SARS-CoV2 genome secondary structure sequence Sequencing similarity spike Spike protein the spike protein unique West West Bengal Wuhan [DOI] 10.12688/f1000research.23805.1 PMC 바로가기 [Article Type] Brief Report
Genetic determinants of genus-level glycan diversity in a bacterial protein glycosylation system박테리아 단백질 글리코실화 시스템에서 속 수준 글리칸 다양성의 유전적 결정인자Research Article Published on 2019-12-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Bacteria Bacterial bacterial pathogen bacterial species bacterial specy biosynthetic biosynthetic pathway biosynthetic pathways Comparative genomics component components conjunction conservation core genome determine driven by effort event Evolution Express expressed functional gene networks Genes Genetic genetic determinant genetic difference genetic interactions genus glycosylation Host Human human disease human pathogen identify independent influence instance instances Interaction involved isolate isolates loss-of-function Neisseria gonorrhoeae Neisseria meningitidis oligosaccharide oligosaccharides Pathogens pathway Pathways Perspective phylogenetically polymorphism post-translational modification Protein Recombination required robust selective status subset sugar sugars unique [DOI] 10.1371/journal.pgen.1008532 PMC 바로가기 [Article Type] Research Article