Knockdown of FLT4, Nup98, and Nup205 Cellular Genes Effectively Suppresses the Reproduction of Influenza Virus Strain A/WSN/1933 (H1N1) In vitroArticle Published on 2022-01-012023-06-23 Journal: Infectious disorders drug targets [Category] 신종인플루엔자, [키워드] Genes influenza A virus Messenger RNA RNA interference small interfering RNAs transfection [DOI] 10.2174/1871526522666220325121403
Immunogenicity and safety of SARS-CoV-2 vaccine with immunosuppressive agentsArticle Published on 2022-01-012022-11-15 Journal: Pediatrics international : official journal of the [Category] SARS, 진단, [키워드] acute respiratory syndrome Administered adolescents Adverse adverse event antibody Antibody titer Antibody titers Breakthrough infection children clinical effectiveness conducted coronavirus defined diagnosed disease domain dose enrolled evaluated event Factor FIVE immunogenic immunogenicity immunosuppressants immunosuppressive immunosuppressive agent Immunosuppressive agents Infection interquartile range median median age Messenger RNA mRNA mRNA vaccine non-recipient non-specific occurred Patient patients postvaccination Prospective Study recipient recipients rejection SARS-CoV-2 SARS-CoV-2 mRNA vaccine SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 vaccine significantly lower solid organ transplant Solid organ transplant recipients SOT titer vaccination Vaccine Vaccine failure was measured were measured [DOI] 10.1111/ped.15331 PMC 바로가기
Maternal-neonatal transfer of SARS-CoV-2 immunoglobulin G antibodies among parturient women treated with BNT162b2 messenger RNA vaccine during pregnancy임신 중 BNT162b2 메신저 RNA 백신으로 치료받은 분만 여성에서 SARS-CoV-2 면역글로불린 G 항체의 산모-신생아 전이Article Published on 2022-01-012022-09-12 Journal: American journal of obstetrics & gynecology MFM [Category] SARS, 진단, [키워드] addition antibodies transfer antibody Antibody concentrations benefit Blood BNT162b2 breast milk Concentration conducted control group COVID-19 COVID-19 vaccine defined demonstrated determine Efficacy evaluate exclusion Humoral immunity Immunoglobulin initial interquartile range median Messenger RNA Neonatal neonatal immunity Neonates parturient Patient Placenta placental positive positive correlation Pregnancy pregnant women prospective cohort study raised recovered COVID-19 patient recovered patients SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody sera serum Serum level significantly higher the vaccine transfer treated vaccination Vaccine vaccine trial were measured women [DOI] 10.1016/j.ajogmf.2021.100492 PMC 바로가기 [Article Type] Article
Efficacy of the BNT162b2 mRNA COVID-19 Vaccine in Patients with Chronic Lymphocytic Leukemia: A Serologic and Cellular Study만성 림프구성 백혈병 환자에서 BNT162b2 mRNA COVID-19 백신의 효능: 혈청 및 세포 연구Article Published on 2022-01-012022-09-12 Journal: Chemotherapy [Category] SARS, 진단, [키워드] acute respiratory syndrome age Analysis anti-CD20 antibody antibody response rate association BNT162b2 BNT162b2 mRNA BNT162b2 vaccine cellular immunity cellular response chronic chronic lymphocytic leukemia CLL CLL patient coronavirus correlation COVID-19 COVID-19 vaccination dosage healthy control highest humoral immune increase in independent predictor inhibitor leukemia median time Messenger RNA monotherapy mRNA NK cell pathway Patient patients positive cells respond SARS-CoV-2 SARS-CoV-2 vaccination second dose serologic Serologic response serological response Severe acute respiratory syndrome coronavirus 2 mRNA vaccination Sex sustained T-cell T-cell assessment. the SARS-CoV-2 therapy treated unlikely vaccination Vaccine vaccine dose [DOI] 10.1159/000521229 PMC 바로가기 [Article Type] Article
Criteria for judging the immune markers of COVID‐19 disease vaccinesOriginal Article Published on 2021-12-312022-10-30 Journal: MedComm [Category] COVID-19, [키워드] acute respiratory syndrome adjusted analyzed antibody assessment boost coronavirus coronavirus disease COVID‐19 disease effective Efficacy evaluated explained IgG immune marker Immunoglobulin inactivated logistic regression model Messenger RNA mRNA Neutralizing Neutralizing antibodies peaked reached receptor‐binding domain reduce Research SARS‐CoV‐2 SARS‐CoV‐2 the mean the vaccine Vaccine Vaccines Viral vector vaccines virus [DOI] 10.1002/mco2.109 PMC 바로가기 [Article Type] Original Article
Short‐term safety of an anti‐severe acute respiratory syndrome coronavirus 2 messenger RNA vaccine for patients with advanced lung cancer treated with anticancer drugs: A multicenter, prospective, observational studyObservational Study Published on 2021-12-282022-10-04 Journal: Thoracic cancer [Category] COVID19(2023년), Fulltext, MERS, SARS, 임상, [키워드] acute respiratory syndrome adverse event age Analysis anticancer anticancer drug anticancer drugs BNT162b2 Chemotherapy comparable coronavirus COVID‐19 dose enrolled evaluated Fatality rate Fever frequencies healthy healthy individuals in healthy individuals increase in lung cancer lung cancer patient Male sex Messenger RNA mRNA mRNA vaccination mRNA vaccine multicenter multivariate analyses multivariate logistic regression participant Patient patients prevalent receive receiving Result RNA Safe SARS‐CoV‐2 SARS‐CoV‐2 severe cases the mean the patient Therapies therapy treated Treatment Trial tyrosine kinase inhibitors vaccination Vaccine vaccine injection were used [DOI] 10.1111/1759-7714.14281 PMC 바로가기 [Article Type] Observational Study
Safety and antibody response to two-dose SARS-CoV-2 messenger RNA vaccination in patients with multiple myeloma다발성 골수종 환자에서 2 용량 SARS-COV-2 메신저 RNA 백신 접종에 대한 안전성 및 항체 반응Research Published on 2021-12-272022-09-01 Journal: BMC Cancer [Category] 진단, [키워드] Adverse reaction Adverse reactions antibody Antibody Response binding domain characterized COVID-19 detectable dose immunogenicity leads Messenger RNA mRNA vaccination mRNA vaccine mRNA vaccines Multiple myeloma Patient Rate RBD reactogenic reassurance receive Result Safety SARS-CoV-2 Seroconversion seroconverted supplementary material therapy trials vaccination Vaccine Vaccine hesitancy were excluded [DOI] 10.1186/s12885-021-09097-5 PMC 바로가기 [Article Type] Research
Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates비인간 영장류에서 RBD 표적 COVID-19 mRNA 백신의 장기 안정성 및 보호 효능Article Published on 2021-12-242022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 비임상, 임상, 진단, 치료기술, [키워드] animals Antibody-dependent enhancement breath caused cellular response characterized clinical trial Complete COVID-19 COVID-19 pandemic cynomolgus macaques decrease dose Efficacy elicited Emergency use evidence of full-length S protein High dose immunization immunized immunogenicity Infection lung lung lesion lung lesions Lungs macaque macaques messenger Messenger RNA mouse model mRNA mRNA vaccine nasal swab nasal swabs Neutralizing antibodies neutralizing antibody no evidence of RBD Receptor-binding domain RNA robust SARS-CoV-2 secretion shown significantly stability Support temperature the receptor-binding domain vaccination Vaccine Vaccines Viral viral replication [DOI] 10.1038/s41392-021-00861-4 PMC 바로가기 [Article Type] Article
Understanding COVID-19 Pathogenesis: A Drug-Repurposing Effort to Disrupt Nsp-1 Binding to Export Machinery Receptor ComplexArticle Published on 2021-12-172022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Antiviral beta coronavirus binding complex conformation COVID-19 COVID-19 infection crystal structure docking docking score drug drug antagonists drugs targeting export FDA-approved drug form Ganirelix Gene Expression GNRHR gonadotrophs hormone receptor Host include induce interact interfere knowledge Messenger RNA mRNA mRNA export adaptor nonstructural protein 1 nsp1 nuclear nuclear export NXF1 NXT1 offer Pituitary Protein recent receptor complex Repurposed drug RNA SARS-CoV-2 virus secretion shown Structural analysis structural docking structural modeling Transport understanding unlikely virulence [DOI] 10.3390/pathogens10121634 PMC 바로가기 [Article Type] Article
Estimated Effectiveness of COVID-19 Messenger RNA Vaccination Against SARS-CoV-2 Infection Among Older Male Veterans Health Administration Enrollees, January to September 20212021년 1월부터 9월까지 노인 남성 제대군인 보건국 등록자 중 SARS-CoV-2 감염에 대한 COVID-19 메신저 RNA 예방 접종의 예상 효과Research Published on 2021-12-152022-09-10 Journal: JAMA Network Open [Category] SARS, 변종, [키워드] Against case-control study COVID-19 Effectiveness Estimated male messenger Messenger RNA Older RNA SARS-CoV-2 SARS-COV-2 infection vaccination veteran [DOI] 10.1001/jamanetworkopen.2021.38975 PMC 바로가기 [Article Type] Research