Computational Analysis of MolnupiravirArticle Published on 2022-01-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Acidic applied Computational study COVID-19 DFT docking exhibited forms Migration molecular docking molnupiravir optical performed protein 3 Proteins proton SARS-CoV-2 Structure the SARS-CoV-2 treat virus [DOI] 10.3390/ijms23031508 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combinationSARS-CoV-2 Omicron 변이체는 molnupiravir, nirmatrelvir 및 조합에 매우 민감합니다.Letter to the Editor Published on 2022-01-202022-09-11 Journal: Cell Research [Category] MERS, SARS, 변종, 치료제, [키워드] Combination immunology Molecular biology molnupiravir omicron SARS-CoV-2 variant [DOI] 10.1038/s41422-022-00618-w PMC 바로가기 [Article Type] Letter to the Editor
Potential COVID-19 Drug Candidates Based on Diazinyl-Thiazol-Imine Moieties: Synthesis and Greener Pastures Biological StudyDiazinyl-Thiazol-Imine 모이어티에 기반한 잠재적인 COVID-19 약물 후보: 합성 및 더 친환경적인 목초지 생물학 연구Article Published on 2022-01-132022-09-10 Journal: Molecules [Category] 치료제, [키워드] Amino acid amino acid residues approved drugs aryl binding affinity binding score binding scores Biological biological activity calculated candidate characterized Compound condensation conditions COVID-19 cytotoxicity determine docking study drug Elemental free energy greener pastures hydrophobic hydrophobic interaction hydrophobic interactions imines-tethered thiazoles in silico molecular docking indicated Ligand ligands M pro molecular molecular docking molecules molnupiravir Pass Pasture PDB phenyl Potential potential therapeutic agent potential therapeutic agents receptor Remdesivir Research statistical analysis suggested synthesis therapeutic agents were used [DOI] 10.3390/molecules27020488 PMC 바로가기 [Article Type] Article
Progress, pitfalls, and path forward of drug repurposing for COVID-19 treatmentArticle Published on 2022-01-012022-11-15 Journal: Therapeutic Advances in Respiratory Disease [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome antivirals approach approved Baricitinib clinical trials Compound conditions coronavirus coronavirus disease COVID-19 death Dexamethasone drug drug combination Drug repurposing effective effective drug Epidemic Evidence food growth indication International mechanism of action molnupiravir multiorgan disease patients Progress progression public health emergency Remdesivir Repurposed drug SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient selected suppress tested Tocilizumab Treatment turn viral outbreak WHO World Health Organization [DOI] 10.1177/17534666221132736 PMC 바로가기
Model-based cost-effectiveness analysis of oral antivirals against SARS-CoV-2 in Korea국내 SARS-CoV-2에 대한 경구용 항바이러스제의 모델 기반 비용 효율성 분석Article Published on 2022-01-012022-09-11 Journal: Epidemiology and Health [Category] SARS, 치료제, [키워드] Admission Adult patients Adults Analysis Antiviral antiviral agent Antiviral agents calculated Care coronavirus disease Coronavirus disease 2019 Cost-effectiveness analysis country COVID-19 COVID-19 patient Efficacy Elderly patient elderly patients Emergency use group health system Hospital admission Hospitalization ICU less medical system Mild-to-moderate molnupiravir Nirmatrelvir Patient patients predicted reduce reducing Ritonavir SARS-CoV-2 Severe case severe COVID-19 Severe patient standard care symptomatic Treatment underlying disease underlying diseases [DOI] 10.4178/epih.e2022034 PMC 바로가기 [Article Type] Article
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Patients사설: 입원하지 않은 환자의 SARS-CoV-2 감염에 대한 경구용 항바이러스제 치료 현황Editorial Published on 2022-01-012022-09-11 Journal: Medical science monitor : international medical jo [Category] SARS, 변종, 신약개발, 진단, 치료제, [키워드] administration antiviral drug antiviral drug treatment antiviral drugs approval approved bamlanivimab can be used Casirivimab children Community community setting costly COVID-19 current drug drug treatments early stage early stages editorial effective Emergency use authorization etesevimab EUA FDA healthcare facility Healthcare Products Regulatory Agency Hospitalization Imdevimab increased risk intravenous Intravenous administration Medicine Medicines MHRA Mild Moderate COVID-19 molnupiravir neutralizing monoclonal antibodies Nirmatrelvir oral Paxlovid positive priority product progression Regulatory Remdesivir Ritonavir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test SARS-CoV-2 virus severe COVID-19 status the SARS-CoV-2 virus therapeutic Treatment variants of concern [DOI] 10.12659/MSM.935952 PMC 바로가기 [Article Type] Editorial
Molnupiravir: A new candidate for COVID‐19 treatmentReview Published on 2021-12-302023-06-15 Journal: Pharmacology Research & Perspectives [Category] COVID19(2023년), MERS, SARS, [키워드] antiviral drugs COVID‐19 treatment EIDD‐2801 MK‐4482 molnupiravir Novel coronavirus disease 2019 [DOI] 10.1002/prp2.909 PMC 바로가기 [Article Type] Review
Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study초기 SARS-COV-2 환자에서 Molnupiravir의 최적 용량 및 안전성 : A 상 I, 오픈 라벨, 용량-에스calating, 무작위 대조 연구Randomized Controlled Trial Published on 2021-12-272022-08-13 Journal: Journal of Antimicrobial Chemotherapy [Category] MERS, SARS, 임상, [키워드] adaptive adult outpatients adverse event Bayesian Clinical research Control controls COVID-19 treatments dose enrolled evaluated facility greater group Mild molnupiravir objective Open-label optimal dose outcome Outpatient participant Patient PCR-confirmed pharmacokinetics phase platform Primary outcome Probability progression Randomized randomized controlled study randomized-controlled receiving responses Result Safe SARS-COV-2 infection screened secondary Secondary outcomes severe adverse events Standard-of-care symptom onset symptomatic infection Toxicity Trial Virological [DOI] 10.1093/jac/dkab318 PMC 바로가기 [Article Type] Randomized Controlled Trial
An update of anti-viral treatment of COVID-19COVID-19의 항바이러스 치료 업데이트Review Published on 2021-12-172022-09-10 Journal: Turkish Journal of Medical Sciences [Category] SARS, 치료제, [키워드] ACE-2 Administered Anti-viral treatment Antiviral AT-527 biological processe biological processes bromhexine camostat clinical trial clinical trials convalescent plasma COVID-19 drug dutasteride early phase effective effective antiviral treatment evaluated Favipiravir fluvoxamine group Host host protein host proteins human cell Hydroxychloroquine include inhibitor inhibitors interfere interferons Ivermectin knowledge Laboratory lactoferrin Lopinavir Lopinavir/ritonavir merimepodib molnupiravir moment monoclonal antibodies monoclonal antibody nanobodies natural immunity niclosamide nitazoxanide pandemic PF-07304814 PF-07321332 Plitidepsin protease Protein Proteins proxalutamide PTC299 RCTs Remdesivir Result Ritonavir RNA SARS-CoV-2 subject Support target protein target proteins the disease to define Treatment treatment for COVID-19 treatment of COVID-19 Trial umifenovir Viral viral entry Viral RNA virus [DOI] 10.3906/sag-2106-250 PMC 바로가기 [Article Type] Review
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19Review article Published on 2021-12-102022-10-05 Journal: Organic Process Research & Development [Category] 치료법, [키워드] Antiviral baseline COVID-19 crystallization demonstrated described development dosed dramatic increase Efficiency FIVE molnupiravir patients with COVID-19 route Treatment [DOI] 10.1021/acs.oprd.1c00400 [Article Type] Review article