Shotgun proteomics analysis of SARS-CoV-2-infected cells and how it can optimize whole viral particle antigen production for vaccinesResearch Article Published on 2020-07-272022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] amplification analysed Analysis Antigen biological processe can be used change characterized condition coronavirus COVID-19 drug target effective effort globe host cell host response inactivated include infection kinetics information mass spectrometry modulated new virus overcome pandemic platform Prevent produced proteome proteomics resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell shotgun Spread Tandem mass spectrometry Vaccine Vaccine development viral amplification viral particle Viral particles viral protein detection virus [DOI] 10.1080/22221751.2020.1791737 PMC 바로가기 [Article Type] Research Article
Global Psychological Implications of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease-2019 (COVID-19). What Can Be Learned From Italy. Reflections, Perspectives, OpportunitiesPsychology Published on 2020-07-242022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] Black Swan Can cause China Chinese Cluster coronavirus coronavirus 2 coronavirus disease-2019 COVID-19 death disease etiology Implications individual Italy New coronavirus new virus observé opportunity pandemic Pneumonia pneumonia case positive problem Psychological Psychosocial factors quarantine respiratory SARS-CoV-2 Spread Stress Wuhan [DOI] 10.3389/fpsyg.2020.01836 PMC 바로가기 [Article Type] Psychology
Human Immunodeficiency Virus: A Dark Cloud With Silver Lining During the COVID-19 PandemicHIV/AIDS Published on 2020-07-202022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome Asymptomatic China cloud Cluster coronavirus coronavirus disease COVID-19 dark HIV Human immune deficiency Infection lining Mild multiorgan failure new virus pandemic Patient patients who survived Pneumonia progression remdesavir reported SARS-CoV-2 severe disease silver Spread virus WHO World Health Organization [DOI] 10.7759/cureus.9302 PMC 바로가기 [Article Type] HIV/AIDS
Demographic and Comorbidities Data Description of Population in Mexico with SARS-CoV-2 Infected Patients(COVID19): An Online Tool AnalysisArticle Published on 2020-07-172022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] acute respiratory syndrome addition Analysis approach automatically benefit caused Community Comorbidity comorbidity analysis coronavirus coronavirus disease COVID-19 dataset death demographic demographic analysis demographic data description facilitate Gender Government group Health information Interpretation new virus organization outcome pandemic platform Population positive Public released reported SARS-CoV-2 Secretary Source SSA statistical supported user web interface development WHO [DOI] 10.3390/ijerph17145173 PMC 바로가기 [Article Type] Article
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin stormShort Report Published on 2020-07-072022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] ACE ACE2 activate addition addressed Affect affected affecting Analysis analyzed Atypical BALF blood pressure blood vessel bradykinin Brain Bronchoalveolar lavage fluid cause caused Cell changes in China clinical trial clinician collected Combination contribute Control cough COVID-19 COVID-19 patient COVID-19 patients Critical decrease decreased expression degrade develop disease drug effective enzyme expand experiment explain Gene Expression help high temperature Host Human Hyaluronic acid identify increases in individual induce Inflammation life-threatening Lower lung lung cell maintain mechanism Mild molecular mechanism multiple tissue new virus no symptom opposite outcome oxygen uptake Pain Pathogenesis Patient patients with COVID-19 predicted previous study produced provide RAS receptors regulate renin-angiotensin system researcher responsible risk SARS-CoV-2 sequence severe symptom shown Spread storm Symptom Symptoms symptoms of COVID-19 the disease the SARS-CoV-2 virus therapeutic intervention tissue treat treatments for COVID-19 turn vascular dilation vascular permeability virus was increased were used [DOI] 10.7554/eLife.59177 PMC 바로가기 [Article Type] Short Report
Buying time: Drug repurposing to treat the host in COVID‐19H구매 시간: COVID-19H에서 숙주를 치료하기 위한 약물 용도 변경Commentary Published on 2020-06-232022-08-31 Journal: Pharmacology Research & Perspectives [Category] MERS, 신약개발, [키워드] approach clinical experience COVID19 drug Drug repurposing Ebola Ebola virus focus global collaboration global health global pandemic H5N1 Health health system Host host response Infectious disease mechanism new virus offer outbreak pandemic patients Reflection renin‐angiotensin treat Treatment Vaccine virus viruses [DOI] 10.1002/prp2.620 PMC 바로가기 [Article Type] Commentary
SARS-CoV-2 neutralizing antibody development strategiesArticle Published on 2020-06-212022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] ACE2 animal models approved cell entry city coronavirus epidemic COVID-19 COVID-19 disease current described display technologies element enzyme global pandemic Health host cells Human monoclonal antibody human scFv Implications in vitro in vivo neutralization assays Neutralizing antibodies neutralizing antibody neutralizing assays new virus Novel coronavirus patients receptor SARS-CoV-2 SARS-CoV-2 neutralizing antibody Spread the S protein Transmission Treatment triggered virus virus spread WHO World Health Organization Wuhan [DOI] 10.3906/biy-2005-91 PMC 바로가기 [Article Type] Article
Neutrophils, Crucial, or Harmful Immune Cells Involved in Coronavirus Infection: A Bioinformatics Study코로나바이러스 감염과 관련된 호중구, 결정적 또는 유해한 면역 세포: 생물정보학 연구Genetics Published on 2020-06-092022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] activated biological processe analyzed ARG1 arginase Arginase inhibitor Arginase inhibitors basophilia bioinformatics BPI CAMP cause caused Cell co-expression network analysis Coronaviridae Coronaviridae family coronavirus disease Coronavirus disease 2019 CoV infection COVID-19 COVID-19 patients CXCL1 death deconvolution analysis DEFA4 demonstrated disease ELANE evaluated followed by GEO2R GEO2R analysis global health GO analysis GSE1739 GSE1739 microarray dataset Health infect inhibitor inhibitors involved Lower respiratory tract lymphopenia molecular mechanism most activated biological processes network analysis neutrophil neutrophil activation neutrophil degranulation neutrophilia new virus ORM2 pandemic PBMC Pneumonia predicted preserved respiratory respiratory tract respiratory tract cells RETN SARS infection SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-positive patients SARS-positive PBMC serpin serpins severe acute respiratory tract syndrome significantly similarity suggested survival syndrome the Coronaviridae the disease turquoise module WGCNA [DOI] 10.3389/fgene.2020.00641 PMC 바로가기 [Article Type] Genetics
Propagation, Inactivation, and Safety Testing of SARS-CoV-2Article Published on 2020-06-062022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Biosafety Level 3 causes Cellulose Chinese coronavirus COVID-19 deaths described DNA effective facilitated focus forming assay inactivation infected cell Infection Infectious virus multiple cell line neutral buffered formalin new virus Novel coronavirus pandemic performed Plaque assay Propagation Protein quantification Research responsible resulting RNA Safe Safety SARS-CoV-2 Testing the disease Trizol Virology virus virus infectivity widespread worldwide pandemic Wuhan [DOI] 10.3390/v12060622 PMC 바로가기 [Article Type] Article
Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARSImmunology Published on 2020-06-052022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] absence ADE antibody antibody dependent enhancement (ADE) Antigen antigenic antigenic sin arise cause children Clinical course Clinical sign contrary convalescent sera coronavirus Coronavirus infection coronavirus strain Course COVID-19 cross-reactive cross-reactive antibody cross-reactivity Dependent described development ENhance enhancement expected Human IgG immune response immune system Infection infection with SARS-CoV-2 infections memory new virus original pandemic Patient patients progression protecting IgG Protective question Receptor binding protein related virus respiratory tract infection respond SARS-CoV-2 Sin Spike protein the SARS-CoV-2 treating COVID-19 patient viral clearance viral infections virus [DOI] 10.3389/fimmu.2020.01120 PMC 바로가기 [Article Type] Immunology