Proteomic insights into SARS-CoV-2 infection mechanisms, diagnosis, therapies and prognostic monitoring methodsArticle Published on 2022-09-202022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome body fluid caused Cell changes in coronavirus COVID-19 COVID-19 pandemic COVID-19 patients damaged Diagnosis Factor Host host infection Infection information Invasion marker mechanism mechanisms organism pathological change Perspective prognostic Protein protein biomarker proteomic study proteomics public health Quantitative SARS-CoV-2 SARS-COV-2 infection therapy tissues viral particle virus infection [DOI] 10.3389/fimmu.2022.923387 PMC 바로가기
Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine CandidatesArticle Published on 2022-09-132022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Affect Amino acid association candidate cellular immunity change changed composed coronavirus COVID-19 creating Delta Epidemic immune immune responses immunized mice Inactivated vaccine Inactivated Vaccines induce induced metabolic metabolism metabolomic metabolomics mice neutralizing antibody positive profile Protein proteomic proteomics response resulting SARS-CoV-2 Vaccine vaccine candidates Vaccine design Vaccines variant variants Variation virus [DOI] 10.3390/ijms231810644 PMC 바로가기
Correlates with Vaccine Protective Capacity and COVID-19 Disease Symptoms Identified by Serum Proteomics in Vaccinated IndividualsArticle Published on 2022-09-132022-11-15 Journal: Molecules [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Algorithm allergy Analysis Asymptomatic autoantibodies autoantibody biological processes Biomarker Capacity caused characterized circulating Cohort coronavirus coronavirus disease correlated COVID-19 disease disease severity disease-associated effective intervention Efficacy epitope Evidence Genetic HBV Identified Immunoglobulin immunology implementation individual individuals mechanism non-severe cases pandemic PCR-negative PCR-positive PCR-positive individual profile Protective Protein Proteins proteomic proteomics purpura Quantitative RBD reducing response to vaccination risk SARS-CoV-2 severe disease severe symptom spike receptor-binding domain Symptom thrombosis understanding uninfected vaccinated individual Vaccine Vaccine development virus transmission virus variant viruses with COVID-19 [DOI] 10.3390/molecules27185933 PMC 바로가기
Noninvasive nasopharyngeal proteomics of COVID-19 patient identify abnormalities related to complement and coagulation cascade and mucosal immune systemArticle Published on 2022-09-122022-11-15 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] abnormal immune response abnormality Analysis approach Biomarker can be used cells Coagulation coagulation cascade collected combating complement COVID-19 COVID-19 patient Critical demonstrated disease down-regulated down-regulation evaluate group host response identify identity IgG4 indicate KEGG lipids marker mucosal mucosal immune nasal nasopharyngeal Nasopharyngeal swab noninvasive Pathway analysis Patient patients plasma positive Protein proteome proteomics Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral infection significantly targets thrombotic up-regulated [DOI] 10.1371/journal.pone.0274228 PMC 바로가기
Proteomic Analysis Identifies Molecular Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial CellsArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory disease acute respiratory syndrome addition Analysis analyzed assays Biological Blood coagulation caused cell receptor cells cellular receptors changes in clinical manifestation coronavirus coronavirus disease correlated COVID-19 cytopathic effects damage different time points disease endothelial Endothelial cell endothelial cells Endothelial dysfunction Endothelium exposure expression help HUVECs identify immune response increase in Infection lack mass spectrometry Mild symptom molecular molecular mechanism oxidative stress pandemic pathway Protein proteome proteomic proteomics responsible SARS-CoV-2 SARS-CoV-2 entry severe cases severe respiratory failure Specific SUMO2 thrombosis triggered umbilical Vascular [DOI] 10.3390/ijms231810452 PMC 바로가기
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactionsArticle Published on 2022-09-082022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] accompanied Activation animal model bioinformatics cells characterized chemokine COVID-19 COVID-19 patients E protein expression Extracellular matrix immune immune response immunological immunomodulatory property Inflammation Interaction intrinsic kinases lipid metabolism Loss of Smell machine metabolic molecular multifunctional olfactory Protein proteome proteomic proteomics receptor reveal SARS-CoV-2 secretion Signaling Smell structural protein survival Symptom TGF-beta signaling the SARS-CoV-2 These data trajectory transcriptomics tyrosine virion widespread [DOI] 10.3389/fimmu.2022.866564 PMC 바로가기
Serum Proteome Signatures of Anti-SARS-CoV-2 Vaccinated Healthcare Workers in Greece Associated with Their Prior Infection StatusArticle Published on 2022-09-052022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected All participant analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 vaccination approach bioinformatics blood sample BNT162b2 mRNA Characteristics collected contribute contributed controls Course COVID-19 COVID-19 vaccination COVID-19 vaccine database differentially expressed down-regulated Gene ontology Greece humoral immune response identify IgG immune response Immune status individuals infected patient KEGG knowledge Kyoto LC-MS/MS majority mechanism molecular over pandemic pathogenic pathway Pfizer/BioNTech processed profiling analysis Protein proteome proteomics provided Quantitative RBD-specific IgG recipients Research SARS-CoV-2 SARS-COV-2 infection sera serum signature significantly status the SARS-CoV-2 Thessaloniki titer vaccinated individual vaccination Vaccine virus worker [DOI] 10.3390/ijms231710153 PMC 바로가기
Protein Expression Profile of ACE2 in the Normal and COVID-19-Affected Human BrainArticle Published on 2022-09-022022-11-16 Journal: Journal of Proteome Research [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 antibodies antibody Brain caused cell types coronavirus disease COVID-19 COVID-19 disease differential expression Endothelial cell enzyme ependymal cell expression expression pattern highest highlight host cell Human immunohistochemistry mechanism Neurological symptom Neurological symptoms NEUROLOGY normal pandemic Patient patients previous study profile protein expression proteomics receptor Region risk SARS-coronavirus SARS-CoV-2 shown suggested Symptom the patient tissue transcriptomics upregulation [DOI] 10.1021/acs.jproteome.2c00184 PMC 바로가기
A review of mass spectrometry-based analyses to understand COVID-19 convalescent plasma mechanisms of actionReview Published on 2022-09-012023-07-09 Journal: Proteomics [Category] COVID19(2023년), [키워드] antibodies convalescent plasma COVID-19 mass spectrometry metabolomics proteomics SARS-CoV-2 [DOI] 10.1002/pmic.202200118 PMC 바로가기 [Article Type] Review
Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort studyResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] absence adverse outcomes analysed approach assigned Biomarker Biomarkers Classifier CLEC6A Clinical improvement Clinical outcome Clinical use Cohort cohorts collected complex complications Course COVID-19 COVID-19 pandemic Critical cytokine Cytokines dataset defined development disease disease severity disorder domain Eric ether example finding funding high variability hospital Hospital admission independent Lipid lipids machine Machine learning algorithms marker Mayo Clinic metabolite metabolites molecular MOST multidimensional outcome participant Patient patients with COVID-19 plasma plasma sample positive predict predicted Predictive producing Protein Proteins proteomics proximity extension assay quantified reported representing retrospective cohort study SARS-CoV-2 RT-PCR severity subgroup subset Tandem mass spectrometry the WHO USA was done with COVID-19 [DOI] 10.1016/S2589-7500(22)00112-1 [Article Type] Research article