SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanismsSARS-COV-2 바이러스 단백질 NSP1 및 NSP13은 별개의 메커니즘을 통해 인터페론 활성화를 억제합니다.Research Article Published on 2021-06-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus bind bypasse caused coronavirus Disease progression downregulate global pandemic host mRNA identify IFIT1 immune evasion infecting inhibit innate immune activation interferon interferon signaling IRF3 Last mechanism mechanisms molecular mechanism molecular mechanisms multiple innate immune activation pathways NF-κB NF-κB activation NF-κB phosphorylation NF-κB promoter signaling nsp1 nsp13 nuclear translocation pathway phospho-IRF3 phospho-TBK1 Protein protein expression protein level reduce reduced respiratory SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 TBK1 the SARS-CoV-2 These data translation Viral protein Viral proteins virus infection [DOI] 10.1371/journal.pone.0253089 PMC 바로가기 [Article Type] Research Article
A Novel SARS-CoV-2 Viral Sequence Bioinformatic Pipeline Has Found Genetic Evidence That the Viral 3′ Untranslated Region (UTR) Is Evolving and Generating Increased Viral DiversityMicrobiology Published on 2021-06-212022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 3cpsdummy′UTR accumulating Analysis analyzed annotation arising assist B.1.1.7 Bioinformatic conserved dataset Diversity downstream format Frequency Genetic testing Genome genomes greater Host immune response inactivation Increased interfere K68 less novel nucleotide diversity (π) orf3a gene ORF8 ORF8 gene performed Polymorphisms processed Region regions researcher SARS-CoV-2 SARS-CoV-2 genome sequencing SARS-CoV-2 lineage SARS-CoV-2 sequencing SARS-CoV-2 variants SARS-CoV-2 viral sequence sequencing errors Spread stop codon Tajima’s D-statistic United Kingdom UTR variant Variation VCF viral evolution virulence [DOI] 10.3389/fmicb.2021.665041 PMC 바로가기 [Article Type] Microbiology
Genome-Wide Analysis of Codon Usage Patterns of SARS-CoV-2 Virus Reveals Global Heterogeneity of COVID-19SARS-COV-2 바이러스의 코돈 사용 패턴의 게놈 전체 분석은 COVID-19의 글로벌 이질성을 보여줍니다.Article Published on 2021-06-182022-09-10 Journal: Biomolecules [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 can not causative agents characterized codon codon usage Codon usage bias comprehensive analysis coronavirus coronavirus disease coronavirus disease COVID-19 COVID-19 error genome organization geographic location global genome global genomes globe heterogeneity heterogeneity of COVID-19 Host host adaptation implicated lack margin margin of error Mutation Mutational bias natural selection outbreak pattern performed reduce Research respiratory Sample size SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 viral selection pressure severe acute respiratory syndrome Coronavirus significantly Standard deviation strain Strains Support Taking the SARS-CoV-2 the SARS-CoV-2 genome Usage Viral viral genome viral lineage viral strains virus virus genome whole genome [DOI] 10.3390/biom11060912 PMC 바로가기 [Article Type] Article
The First Molecular Characterization of Serbian SARS-CoV-2 Isolates From a Unique Early Second Wave in EuropeMicrobiology Published on 2021-06-182022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] amino acid substitution Analysis characterization circulating clade confirmed case COVID-19 COVID-19 epidemic COVID-19 pandemic Epidemic Europe European First wave functional Future genetic diversity Genome genome variant genomic information identified variant identify isolate Local Mutation NGS pandemic preventive measure recorded Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral second second wave Serbia Seven specificity the epidemic Transmission unique variations Wave [DOI] 10.3389/fmicb.2021.691154 PMC 바로가기 [Article Type] Microbiology
Expression of Human ACE2 N-terminal Domain, Part of the Receptor for SARS-CoV-2, in Fusion With Maltose-Binding Protein, E. coli Ribonuclease I and Human RNase AMicrobiology Published on 2021-06-112022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] E. coli ribonuclease I (RNase I) ACE2 ACE2 protein Antiviral antiviral agent bacterial cell Cartoon cleaving degrade dsRNA E. coli enzyme evaluated expressed expression fusion fusion protein Genome Human human ACE2 receptor human RNase A-ACE2NTD fusion in vitro Inclusion Infection Membrane proteins N-terminal N-terminal domain Nucleocapsid proteins Part Protein Proteins provide purified receptor ribonuclease RNA RNA degradation RNase RNase I-ACE2NTD fusion RNase III RNases SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral SARS-CoV-2 virus single-stranded soluble fraction Strains viral genome viral nucleic acids virions [DOI] 10.3389/fmicb.2021.660149 PMC 바로가기 [Article Type] Microbiology
Viral infiltration of pancreatic islets in patients with COVID-19COVID-19 환자에서 췌도의 바이러스 침투Article Published on 2021-06-102022-09-10 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] absence ACE2 Autopsy Cell Complication comprehensive analysis contribute COVID-19 patient COVID-19 patients detectable diabete diabetes disease DPP4 dysregulation electron microscopy Endocrine examined expressed expression facilitate Factors hyperglycemia Immune cell infiltration immunofluorescence immunohistochemistry increased risk Infection infiltration islet cell islet cells mechanism metabolic Metabolic diseases Microscopy necroptotic cell death NRP1 pancreatic pancreatic beta-cell pancreatic beta-cells pancreatic islet patients patients with COVID-19 performed pseudoviruses receptor RNA SARS-CoV-2 SARS-CoV-2 pseudoviruses SARS-CoV-2 viral SARS-CoV-2 viral infection severe COVID-19 tissue TMPRSS vasculature Viral viral infection virus entry [DOI] 10.1038/s41467-021-23886-3 PMC 바로가기 [Article Type] Article
Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1Article Published on 2021-06-082022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] addition C-terminal caused Cell complex COVID-19 pandemic Cryo-electron microscopy cryo-EM Cryoelectron microscopy determine domain E protein envelope protein facilitate Health human cell human protein human proteins hydrophobic residue inhibitor Interaction junctions lung epithelial motif observation occur PALS1 peptide promote Protein provide recognize recruit reduce Replication reported SARS-CoV-2 SARS-CoV-2 envelope SARS-CoV-2 viral SARS-CoV-2 virus Spread Structural analysis target targets the SARS-CoV-2 virus Viral protein viral-host protein virulence Virus structures Virus-host interactions [DOI] 10.1038/s41467-021-23533-x PMC 바로가기 [Article Type] Article
Improved diagnosis of SARS-CoV-2 by using nucleoprotein and spike protein fragment 2 in quantitative dual ELISA tests정량적 이중 ELISA 검사에서 핵단백질 및 스파이크 단백질 단편 2를 사용하여 SARS-CoV-2 진단 개선Original Paper Published on 2021-06-082022-09-11 Journal: Epidemiology and Infection [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] (Abbott) Abbott antibody antibody levels Antibody test Antibody testing antibody tests causative agent Combination Community complement coronavirus coronavirus disease COVID-19 COVID-19 diagnosis detect determine develop diagnosing Diagnosis diagnosis of SARS-CoV-2 diagnostic diagnostic test disease ELISA ELISA test ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epidemiological greater herd immunity Immunity immunogenic Improved individual Infection Novel coronavirus nucleocapsid nucleocapsid protein pandemic Patient positive produced Protein Quantitative respiratory response SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral serum Severe acute respiratory syndrome severe disease specific antibodies specific antibody Spike protein Spread subunit Surveillance Viral proteins virus virus spread were used [DOI] 10.1017/S0950268821001308 PMC 바로가기 [Article Type] Original Paper
Identification of COVID-19 B-cell epitopes with phage-displayed peptide library파지 디스플레이 펩타이드 라이브러리로 코로나19 B 세포 에피토프 확인Research Published on 2021-06-072022-09-10 Journal: Journal of Biomedical Science [Category] MERS, SARS, 치료기술, 치료제, [키워드] antibody Antibody binding applied B-cell epitope B-cell epitopes BepiPred Care China city Consensus coronavirus coronavirus disease coronavirus disease 19 country COVID-19 COVID-19 pathogenesis COVID-19 patients Critical deaths determine diagnostic Diagnostic tool diagnostics enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epitope Epitopes facilitate globe identification immunological Medical care motif peptide peptides Phage-displayed peptides Protein Proteins PyMol residue Result SARS-CoV-2 SARS-CoV-2 viral sera serological Serological detection specific antibodies specific antibody spread of COVID-19 Structural analysis target targets transmitted two COVID-19 patients Vaccine Vaccines Viral Viral proteins virus was used Wuhan [DOI] 10.1186/s12929-021-00740-8 PMC 바로가기 [Article Type] Research
Inefficient Placental Virus Replication and Absence of Neonatal Cell-Specific Immunity Upon Sars-CoV-2 Infection During Pregnancy임신 중 Sars-CoV-2 감염 시 비효율적인 태반 바이러스 복제 및 신생아 세포 특이적 면역 부재Observational Study Published on 2021-06-032022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 임상, 치료기술, [키워드] acute infection Analysis Asymptomatic Birth Blood children’s health complications consequence convalescent Cord blood Course COVID-19 COVID-19 pandemic described detectable disease during pregnancy Evidence Ex vivo expression higher risk human trial immune immune activation in vitro indicate inefficient infected with SARS-CoV-2 Infection infections inoculation Mild mother Neonatal neonatal infections non-infected observational study Placenta placental Placentas Pregnancy pregnancy complications pregnant pregnant women prenatal infection progression provide rationale recent required risk SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 viral SARS-CoV2 infection severity of COVID-19 T cell T cell response tissues Transmission transmission of SARS-CoV-2 undetectable variants of concern vertical transfer vertical transmission Viral virus virus replication women [DOI] 10.3389/fimmu.2021.698578 PMC 바로가기 [Article Type] Observational Study