Longitudinal clinical and radiographic evaluation reveals interleukin-6 as an indicator of persistent pulmonary injury in COVID-19종단 임상 및 방사선 사진 평가에서 코로나19의 지속적인 폐 손상의 지표로 인터루킨-6이 밝혀졌습니다.Research Paper Published on 2021-01-012022-09-10 Journal: International Journal of Medical Sciences [Category] MERS, 바이오마커, [키워드] Admission Analysis analyzed association B cell B cells CD19 CD4 CD8 change Chest computed tomography Chest CT Clinical management collected Computed tomography coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patients cross-sectional analysis disease course elevated evaluate expression favor feature Features follow-up period IL-6 immunological increase in independent interleukin interleukin-6 Intervention laboratory-confirmed lesion lesions longitudinal Lung injury lymphocyte Lymphocytes Mild moderate Multivariate analysis neutrophil Neutrophils outcome Patient patients Peripheral blood Peripheral blood sample peripheral blood samples Previous studies previous study Prolonged pulmonary injury pulmonary lesion pulmonary lesions Radiographic rationale reveal scored semi-quantification sequential monitoring Severe patient severe patients significantly sustained T cells the disease [DOI] 10.7150/ijms.49728 PMC 바로가기 [Article Type] Research Paper
Corticosteroid therapy in critically ill patients with COVID-19: a multicenter, retrospective studyCOVID-19 중증 환자의 코르티코스테로이드 요법: 다기관, 후향적 연구Multicenter Study Published on 2020-12-182022-09-11 Journal: Critical Care [Category] MERS, 변종, [키워드] 95% CI adjusted Administered affected Analysis applied association baseline clearance confounding factor confounding factors correlation Corticosteroid corticosteroid treatment Corticosteroids COVID-19 Cox proportional-hazards model Critically ill Critically ill patient critically ill patients Efficacy evaluate ICU ICU admission investigated Logistic regression Marginal structural modeling Methylprednisolone Mortality multicenter not performed outcome Patient performed recruited Result Retrospective study SARS-CoV-2 RNA severe COVID-19 Severe patient severe patients Stratification stratified subgroup analysis therapy treated Treatment variables was performed with COVID-19 [DOI] 10.1186/s13054-020-03429-w PMC 바로가기 [Article Type] Multicenter Study
Clinical features and risk factors for severe inpatients with COVID-19: A retrospective study in ChinaCOVID-19 중증 입원환자의 임상적 특징 및 위험인자: 중국에서의 후향적 연구Multicenter Study Published on 2020-12-172022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, [키워드] accompanied addition advanced age age age factor age factors albumin Asthma baseline Blood blood cell carried Cell Characteristics China clinical clinical information clinical symptom coronavirus coronavirus disease count COVID-19 COVID-19 patient COVID-19 patients Critical case critical cases cystatin C D-dimer decrease disaster distribution during treatment Efficacy Elderly patient elderly patients electronic medical record electronic medical records Epidemiological study ESR Factor faster feature female female patient Female patients Fever Gender Glucose group guideline hemoglobin hospital IMPROVE increase in inflammatory markers Inpatient Intervention IQR Kidney function Laboratory laboratory-confirmed Laboratory-confirmed COVID-19 liver liver and kidney function Logistic regression low-density Low-density lipoprotein lymphocyte male marker median age medical records neutrophil neutrophil count non-severe cases non-severe group Older outbreak oxygen oxygen saturation Patient patients with COVID-19 potential risk Prevent red blood cell researcher Result Retrospective study risk factor Risk factors Severe patient severe patients severity severity of COVID-19 shown Therapies treat Treatment White blood cell [DOI] 10.1371/journal.pone.0244125 PMC 바로가기 [Article Type] Multicenter Study
COVID-19: Spatial analysis of hospital case-fatality rate in FranceResearch Article Published on 2020-12-152022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Accuracy Admission age Analysis analyzed appear average Care CFR country COVID-19 COVID-19 epidemic Critical death deaths Efficiency Endotracheal intubation Epidemic France French greater health system healthcare Healthcare system hospital Hospitalization hospitalizations intensive care unit less Local lockdown magnitude management morbidity Mortality pathogen reported risk factor Severe patient severity significant difference the epidemic the SARS-CoV-2 virus time Variability Variation virulence [DOI] 10.1371/journal.pone.0243606 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 and Viral Sepsis: Immune Dysfunction and Implications in Kidney FailureReview Published on 2020-12-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] abdominal pain ACE-2 Acute cardiac injury Acute kidney injury acute respiratory distress acute respiratory syndrome addition affected AKI antiviral medicine ARDS binding cardiovascular complication Cell clinical manifestation Clinical outcome co-morbidity coronavirus coronavirus disease cough COVID-19 COVID-19 patient dysfunction Dyspnea effective Endothelial dysfunction Evidence exacerbate explained failure Fever Host human Angiotensin-converting enzyme Hyperinflammatory ICU include infected with COVID-19 Inflammatory response inhibit intensive care unit Intervention kidney dysfunction lung mechanism modulate Mounting multi-organ failure Occurrence organ outcome overexpression pathogenic mechanism Patient pro-inflammatory cytokine Probability receptor renal renal dysfunction renal impairment reported Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike Sepsis severe COVID-19 Severe patient severity shown Support syndrome systemic inflammatory response the cytokine storm the disease treating COVID-19 Vaccine viral cytopathic effect viral entry viral replication Wuhan, China [DOI] 10.3390/jcm9124057 PMC 바로가기 [Article Type] Review
The efficacy and safety of Xuebijing injection for corona virus disease 2019 A protocol for a systematic review and meta-analysis코로나 바이러스 질병 2019에 대한 Xuebijing 주사의 효능 및 안전성 체계적인 검토 및 메타 분석을 위한 프로토콜Meta-Analysis Published on 2020-12-042022-08-31 Journal: Medicine [Category] MERS, SARS, 임상, 치료제, [키워드] Abstract acute respiratory syndrome affected Analysis Atypical carried caused Characteristics China Chinese clinical evidence Clinical symptoms Clinical treatment conducted Corona virus corona virus disease 2019 coronavirus coronavirus 2 COVID-19 cytokine data extraction Deterioration Diagnosis disease Efficacy and safety Eger Epidemic evidence of exclusion criteria Health heterogeneity Inclusion inclusion and exclusion criteria Infection injection lead leads Meta-analysis Misdiagnosis patients present protocol publication bias Research researcher respiratory respiratory infectious disease risks of bia Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus severe acute respiratory syndrome Coronavirus severe COVID-19 patients Severe patient severe patients systematic review systemic cytokine title Traditional Chinese medicine Transmission virus Virus Disease xuebijing injection [DOI] 10.1097/MD.0000000000023401 PMC 바로가기 [Article Type] Meta-Analysis
Early prediction and identification for severe patients during the pandemic of COVID-19: A severe COVID-19 risk model constructed by multivariate logistic regression analysisResearch Theme 1: COVID-19 Pandemic Published on 2020-12-042022-10-31 Journal: Journal of Global Health [Category] COVID-19, MERS, SARS, [키워드] age albumin Analysis caused Clinical characteristics Clinical data clinician Comorbidities Corona COVID-19 demonstrated duration of fever early stage elevated enrolled evaluate Factor force help hypertension identify illness onset independent Infectious disease Lymphocyte count lymphopenia mechanical ventilation Mild Mortality Most patient multivariate logistic regression Negative predictive value neutrophil lymphocyte ratio NLR oxygen pandemic Patient patients with COVID-19 Positive predictive value Predictive predictor proportion receiver operating characteristic reducing required respiratory symptoms Result retrospective risk ROC ROC Curve second Sensitivity and specificity severe COVID-19 severe group Severe patient severe patients therapeutic Treatment two groups university viral clearance was used were used worldwide pandemic [DOI] 10.7189/jogh.10.020510 PMC 바로가기 [Article Type] Research Theme 1: COVID-19 Pandemic
In silico immune infiltration profiling combined with functional enrichment analysis reveals a potential role for naïve B cells as a trigger for severe immune responses in the lungs of COVID-19 patients기능 강화 분석과 결합된 인실리코(in silico) 면역 침투 프로파일링은 COVID-19 환자의 폐에서 심각한 면역 반응을 유발하는 촉발제로서 순진한 B 세포의 잠재적 역할을 보여줍니다Research Article Published on 2020-12-022022-09-10 Journal: PLoS ONE [Category] MERS, 유전자 메커니즘, [키워드] Activation acute respiratory distress acute respiratory distress syndrome alleviate Analysis antibody antibody-secreting cells antiviral drugs applied ARDS B cell B cells B-cell B-cells cause caused Clinical outcome Clinical treatment collected country COVID-19 COVID-19 case COVID-19 group COVID-19 patient COVID-19 patients DN2 effective effort evaluate excessive immune response fibrosis functional functional enrichment Gene Expression genetic difference genetic differences humoral immune response Idiopathic pulmonary fibrosis Immune cell Immune cell infiltration immune infiltration immune response immune responses impairment infiltration IPF leads lung lung damage Lung function lung tissue lung tissues mechanism memory Mild mitigate modulating naïve naïve B cell naïve B cells Patient Pneumonia populations pulmonary fibrosis reducing resource respiratory distress resulting reveal SARS-CoV-2 SARS-COV-2 infection Severe patient severe patients severe pneumonia severe symptom severe symptoms significantly Single-cell RNA sequencing spread to subset subtype syndrome targets therapy transcriptional transcriptomic treated Trigger variety [DOI] 10.1371/journal.pone.0242900 PMC 바로가기 [Article Type] Research Article
Subcutaneous tocilizumab in adults with severe and critical COVID-19: A prospective open-label uncontrolled multicenter trial심각하고 치명적인 COVID-19가 있는 성인의 피하 토실리주맙: 전향적 공개 표지 비통제 다기관 시험Clinical Trial Published on 2020-12-012022-09-12 Journal: International immunopharmacology [Category] MERS, SARS, 임상, 진단, [키워드] added all-cause mortality rate Antiviral approved body temperature changes in clinical parameter concerning coronavirus coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patients Critical Critical disease dose early stage Endpoint enrolled immunomodulator immunomodulatory IMPROVE in both group interleukin interleukin 6 Laboratory male Most patient multicenter Multicenter trial occurred Open-label oral temperature oxygen saturation oxygen-support Oxygenation Patient patients died Potential reduce reported required Respiratory failure respiratory rate risk of death Serious Adverse Event Seven Severe patient severe patients Significant significantly standard care Subcutaneous subjects Therapeutic approach therapy Tocilizumab tocilizumab administration variable [DOI] 10.1016/j.intimp.2020.107102 PMC 바로가기 [Article Type] Clinical Trial
Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, ChinaResearch Published on 2020-11-262022-10-28 Journal: Respiratory Research [Category] COVID-19, [키워드] 2019 coronavirus disease age alanine aminotransferase analyzed Characteristics Chest CT children China clinical Clinical characteristics Clinical features Cohort Comorbidities convalescent patient Convalescent patients Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patients develop diabetes discharged discharged patient disease disease severity elevated evaluate fibrosis Follow-up ground-glass opacity had more hospitalized patient hypertension IgG IgM antibody IQR laboratory data Limited Liver injury lymphocytopenia lymphopenia median men non-severe cases non-severe patients Older patchy Patient patients physician Pneumonia positive rate previous study radiological features rehabilitation Result Retrospective study severe cases severe COVID-19 patients Severe patient severe patients significant difference staff Thyroid Treatment with COVID-19 women [DOI] 10.1186/s12931-020-01580-0 PMC 바로가기 [Article Type] Research