A single-centre observational cohort study to evaluate volume and severity of emergency general surgery admissions during the COVID-19 pandemic: Is there a “lockdown” effect?Observational Study Published on 2020-11-012022-10-05 Journal: International journal of surgery (London, England) [Category] 임상, [키워드] 30-Day mortality Acute kidney injury Admission Admissions appear Cancer changes in Characteristics clinical outcomes Cohort collected Complication COVID-19 COVID-19 pandemic disease Emergency Emergency surgery evaluate gastrointestinal symptoms GRADE groups impacted increase in Inflammatory inpatient admission lockdown Lockdown effect median NHS no significant difference Observational cohort study Older operative outcomes pandemic Patient patients per day reduced reduction in severity Severity of disease significantly significantly higher significantly more surgical UK Government Volume [DOI] 10.1016/j.ijsu.2020.09.011 PMC 바로가기 [Article Type] Observational Study
Prevalence of underlying diseases in died cases of COVID-19: A systematic review and meta-analysisResearch Article Published on 2020-10-232022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Analysis article Asthma cardiovascular disease Cerebrovascular disease conducted COPD COVID-19 COVID-19 cases Critical database diabete diabetes died disease greater Health high mortality rate highest hypertension Liver disease lowest Lung disease malignancy Meta-analysis morbidity and mortality most prevalent comorbidity outcomes people with COVID-19 Population Prevalence protocols reported Result searched Severity of disease systematic review underlying disease was related Web of Science [DOI] 10.1371/journal.pone.0241265 PMC 바로가기 [Article Type] Research Article
Home Management of Children With COVID-19 in the Emilia-Romagna Region, ItalyPediatrics Published on 2020-10-232022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] acute respiratory syndrome Asymptomatic Care children children with COVID-19 Clinical finding Community community health service coronavirus coronavirus disease COVID-19 Emilia-Romagna evaluate exposure to Frequency Health healthy children home home management hospital Hospital admission Hospitalized hospitals Infection Italy laboratory-confirmed SARS-CoV-2 infection majority management median age Mild moderate moderate disease Patient Pediatric infectious diseases positive problems reduce Region required Research SARS-CoV-2 SARS-COV-2 infection Severity of disease significantly lower significantly more swab sample tested the epidemic [DOI] 10.3389/fped.2020.575290 PMC 바로가기 [Article Type] Pediatrics
High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19Clinical Medicine Published on 2020-10-152022-10-30 Journal: JCI Insight [Category] COVID-19, MERS, SARS, [키워드] Activation acute respiratory syndrome affecting alteration analyzed Anergy antibody CD4 CD8 Cellular immune response Characteristics characterized controls convalescent individuals Convalescent patients coronavirus coronavirus disease correlated Course COVID-19 COVID-19 patient cytokine disease severity ELISA expression functional IFN-γ IgA IgA antibody IgG IgG levels IL-2 Immunity immunoglobulins immunopathology lung lymphocyte lymphocyte subpopulation lymphopenia marker mounted Patient patient group peptide pool phenotypical plasmablast proliferation quantified Rolf SARS-CoV-2 SARS-CoV-2 specific T-cell severe disease Severity of disease significantly higher state subpopulations supported T cell T cells TNF-α uninfected uninfected control university viral replication [DOI] 10.1172/jci.insight.142167 PMC 바로가기 [Article Type] Clinical Medicine
Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age childrenAnalysis Published on 2020-10-152022-10-29 Journal: Scientific Data [Category] Coronavirus, MERS, SARS, [키워드] Adults age Analysis assumed Bacterial Bacterial infection children Course COVID-19 pandemic dataset Diseases extreme groups Health immune function immune senescence implication Infection infections Infectious disease information lowest manifestation Older age outcome reached relative Resilience Risk factors severe disease severity Severity of disease systematic analysis Vaccine vaccine response viral infection [DOI] 10.1038/s41597-020-00668-y PMC 바로가기 [Article Type] Analysis
Antibody responses to SARS-CoV-2 in patients with differing severities of coronavirus disease 20192019년 코로나바이러스 질병의 중증도가 다른 환자의 SARS-CoV-2에 대한 항체 반응Research Article Published on 2020-10-092022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 95% CI analyzed Antibody Response Antigen association clinical manifestations collected coronavirus disease COVID-19 Cutoff ELISA enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Euroimmun female greater healthy control IgA IgG IgG antibodies IgG antibody infections male Mild moderate onset of symptom onset of symptoms optical optical density other respiratory infections participant Patient patient group patients positive result respiratory respiratory infections Result SARS-CoV-2 SARS-CoV-2 infections sensitivity serological response serological test severe group severity Severity of disease Severity of infection Sex significantly higher Symptom the antibody response the patient the SARS-CoV-2 vaccination was performed [DOI] 10.1371/journal.pone.0240502 PMC 바로가기 [Article Type] Research Article
Socioeconomic inequalities and COVID-19 – A review of the current international literatureFocus Published on 2020-10-092022-10-30 Journal: Journal of Health Monitoring [Category] COVID-19, [키워드] Analysis conducted correlation Course COVID-19 ecological epidemiological European Evidence Germany Health Health inequality help indicate individual level infection risk International less literature review MOST pathway Population provide reported Research risk SARS-CoV-2 severity Severity of disease the disease [DOI] 10.25646/7059 PMC 바로가기 [Article Type] Focus
A multi-center, randomized controlled trial by the Integrative Management in Japan for Epidemic Disease (IMJEDI study-RCT) on the use of Kampo medicine, kakkonto with shosaikotokakikyosekko, in mild-to-moderate COVID-19 patients for symptomatic relief and prevention of severe stage: a structured summary of a study protocol for a randomized controlled trialLetter Published on 2020-10-022022-10-29 Journal: Trials [Category] COVID-19, MERS, SARS, [키워드] 1:1 Ability to communicate acute respiratory syndrome addition administration age Analysis antipyretics Arm Blinding calculated clinical clinical trial Combination common cold-like symptom control group coronavirus cough COVID-19 COVID-19 patient criteria decrease defined Dementia difficulty dissemination effective Efficacy element exclusion criteria fatigue female Fever Follow-up group H1N1 influenza hospitals Hypothesis IMPROVE in both group include Inclusion Infection Inpatient Japan Japanese Kampo Kampo medicines lactating less malaise Medicine Mild-to-moderate number objective occurred outcome Outpatient parallel-group participant Patient patients positive Prevention for severe stage previous study protocol Psychiatric random Randomized Randomized controlled trial receive recruited registry required Research Sample size SARS-CoV-2 Severe infection Severity of disease Shortness of breath significance level significantly sputum Stage steroid Study protocol survival survival curve Symptom Symptom relief symptomatic temperature the Kaplan-Meier method the log-rank test the median the primary endpoint the SARS-CoV-2 to define treated Treatment Two-arm website [DOI] 10.1186/s13063-020-04746-9 PMC 바로가기 [Article Type] Letter
Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of OutcomeACE2 변이의 스펙트럼 분석은 COVID-19에 대한 감수성과 결과의 심각성에 대한 희귀 및 공통 변이의 가능한 영향을 시사합니다Genetics Published on 2020-09-292022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect allele frequency alternative allele analyzed angiotensin angiotensin-converting enzyme-2 caused Cohort common coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dataset disease severity eQTL European population European populations explain frequencies Frequency Genetic variant genetic variants Genome Aggregation Database gnomAD gnomAD database Health Organization influence Missense missense variant mutations objective outcome pandemic Patient patients with COVID-19 Regulatory respiratory Respiratory disease Result rs146598386 rs73195521 rs755766792 Russia Russian population severity Severity of disease Southern European population Spectrum statistical Support susceptibility variant variants whole-exome sequencing World Health Organization [DOI] 10.3389/fgene.2020.551220 PMC 바로가기 [Article Type] Genetics
Clinical, laboratory and radiological characteristics and outcomes of novel coronavirus (SARS-CoV-2) infection in humans: A systematic review and series of meta-analysesResearch Article Published on 2020-09-172022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] alanine aminotransferase Analysis Aspartate aminotransferase association associations build C-reactive protein Characteristics clinical Clinical practice Computed tomography consolidation contributed cough COVID-19 COVID-19 pandemic D-dimer disease disease severity Dyspnea Effect elevated eligible erythrocyte sedimentation rate Evidence explained fatigue Fever gastrointestinal symptoms Ground glass opacity heterogeneity heterogeneous hospitalized patients identify Infection interleukin-6 investigator Laboratory LILACS Lymphocytes lymphocytopenia Male sex meta-analyses Meta-analysis meta-regression New non-specific Novel coronavirus Older age other variable outcome Patient Platelets Pneumonia Prevalence radiological Risk of bias SARS-CoV-2 searched septal thickening severe disease Severity of disease sore throat Study design systematic review variable was used White blood cell [DOI] 10.1371/journal.pone.0239235 PMC 바로가기 [Article Type] Research Article