Should Autism Spectrum Conditions Be Characterised in a More Positive Way in Our Modern World?Editorial Published on 2020-05-132022-10-30 Journal: Medicina [Category] Coronavirus, MERS, SARS, [키워드] adjusted American Psychiatric Association approach ASC autism autism spectrum condition (ASC) cognitive comparison complex condition COVID-19 COVID-19 pandemic description Diagnostic Criteria diagnostic system disorder Guidance help individual media outcomes positive public opinion question reflected Research Spectrum strengths World Health Organisation [DOI] 10.3390/medicina56050233 PMC 바로가기 [Article Type] Editorial
The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica포스포릴레이 BarA/SirA는 Salmonella enterica에서 비동족 조절기 RcsB를 활성화합니다.Research Article Published on 2020-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated activating addition Alter Bacteria bacterium binding site Cell cell envelope cell wall changes in condition Control detect domain environmental stress expressed Gene Expression Genes growth help Infection life logarithmic growth Luria-Bertani medium modify organism Organisms outer membrane perturbations promote Protein Proteins RcsB regulator Regulatory respond RNA Salmonella Signal transduction specificity Spectrum Stress Transcription [DOI] 10.1371/journal.pgen.1008722 PMC 바로가기 [Article Type] Research Article
Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies새로운 효모 단백병증 모델 및 유전자 변형 파리에서 PBP1/ATXN2 기능의 손실에 의해 칼슘 반응성 트랜스활성제(CREST) 독성이 구출됩니다Research Article Published on 2019-08-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Affect aggregate aggregation ALS Amyotrophic lateral sclerosis ATXN2 calcium caused chaperone CREST cytoplasmic degenerative Deletion disease Disease model Diseases downregulation Drosophila effective enhancer expressed facilitate foci form ganglion cell ganglion cells Genes inhibit Lateral Sclerosis Like Localization mammalian cells mechanism modify Mutation neurodegenerative neurons nuclear ortholog overexpressing overexpression phenotype Propagation Protein Proteins reduce reduced regulated required rescued risk factor shown Spectrum SS18L1 targets therapeutic target therapy Thioflavin toxic Toxicity transgenic yeast yeast form yeast forms [DOI] 10.1371/journal.pgen.1008308 PMC 바로가기 [Article Type] Research Article
Spectrum of opportunistic infections and associated factors among people living with HIV/AIDS in the era of highly active anti-retroviral treatment in Dawro Zone hospital: a retrospective studyResearch Note Published on 2018-08-202024-09-02 Journal: BMC Research Notes [Category] 대상포진, [키워드] Associated factors magnitude OI PLHIV Spectrum [DOI] 10.1186/s13104-018-3707-9 PMC 바로가기 [Article Type] Research Note
Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia급성 폐렴의 마우스 모델에서 병원체 및 모델 특이적 조직병리학의 스펙트럼Research Article Published on 2017-11-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, 폐렴구균 감염증, [키워드] Acinetobacter Affect caused cell types Characteristics comparison contribute coronavirus criteria Critical death distribution Escherichia coli Factor genetic background histological histopathological feature Histopathology humans IAV infectious dose Inflammatory influenza A virus Klebsiella pneumoniae Legionella pneumophila lesion lesions Lung infection MERS mice Middle East mouse model Other outcomes pathogen pathology Pneumonia pneumoniae quantification scoring system Spectrum Staphylococcus aureus Streptococcus syndrome the disease therapeutic interventions tissue tissues Treatment strategies treatment strategy [DOI] 10.1371/journal.pone.0188251 PMC 바로가기 [Article Type] Research Article
Distinct Prion Domain Sequences Ensure Efficient Amyloid Propagation by Promoting Chaperone Binding or Processing In Vivo고유한 프리온 도메인 서열은 생체 내 샤페론 결합 또는 처리를 촉진하여 효율적인 아밀로이드 증식을 보장합니다Research Article Published on 2016-11-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting aggregate Alter Amino acid amyloid assembly binding change chaperone chaperones complementary composed conformation conformational conformational flexibility contribute creating efficient element elements Ensure functional in vitro in vivo inheritance Interaction maintain mechanism molecular observation occur open persistence physical physical properties predict prion processing promote Promoting Propagation Protein Protein misfolding Proteins proximal PSI question Regulation required resulting sequence Spectrum stability Transmission yeast [DOI] 10.1371/journal.pgen.1006417 PMC 바로가기 [Article Type] Research Article
Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug DesignArticle Published on 2016-03-072022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Analysis anti-CoV drug antiviral therapeutics antiviral therapy biochemical caused children complex coronavirus CoV genome CoVs Critical drug effective enzyme HCoV-NL63 human coronavirus human CoV human CoVs Infection infections inhibitor insight isolate Lower respiratory tract M pro MERS-CoV Michael molecular mechanism molecular target Netherland NL63 Pneumonia presenting protease Proteolytic processing provide reveal RNA SARS-CoV sequence Spectrum Strains Structure Symptom treat viral replication zoonotic CoVs [DOI] 10.1038/srep22677 PMC 바로가기 [Article Type] Article
Potential Broad Spectrum Inhibitors of the Coronavirus 3CL pro : A Virtual Screening and Structure-Based Drug Design StudyArticle Published on 2015-12-152022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] 3CL pro 3CLpro acute respiratory syndrome Antiviral approach can be used Cluster Compound Consensus coronavirus cross defined disease drug drug design drug target experiments Features Glide highlight Human human coronaviruses Infection inhibitor less likelihood MERS Middle East molecular molecular docking molecular dynamics outbreak Potential provide screened Screening sequence homology significantly Spectrum Structure-based drug design subset syndrome these compound Virtual screening [DOI] 10.3390/v7122963 PMC 바로가기 [Article Type] Article
Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence AttenuationCryptococcus neoformans var.의 게놈 및 전사체 분석 grubii, 복잡한 RNA 발현 및 독성 약화로 이어지는 소진화를 밝혀냄Research Article Published on 2014-04-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major addition alternative polyadenylation Analysis analyzed annotation attenuation automated C. neoforman CDS chromosomal coding coding DNA sequence coding DNA sequences Comparative analysis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans death Efficiency examination expressed gene expressed genes feature fungi Gene Expression Genes Genetic genetics Genome genome sequence genomic studies genomic study human pathogen identify Immunocompromised Immunocompromised patients in vitro culturing indicate intron introns involved isolate isolates Laboratory leading manual curation meningoencephalitis microevolution microevolutionary miscRNA miscRNAs molecular motif Mutation Non-coding RNAs occur opportunistic pathogen pathogen pathogenic performed phenotypic phenotypic and genome re-sequencing analysis polyadenylation site polyadenylation sites provide Region Regulation Replication representing responses responsible resulting RNA RNA-Seq-based analysis sequence sequenced sequences Sequencing serotype Spectrum strain Stress stress responses Transcription Transcriptome untranslated regions UTRs VAR variant variety virulence yeast [DOI] 10.1371/journal.pgen.1004261 PMC 바로가기 [Article Type] Research Article
A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness관련성 전체 스펙트럼에 걸친 일배체형 단계에 대한 일반적인 접근 방식Research Article Published on 2014-04-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy allele alleles approach association can be used chance chromosome Cohort cohorts correction detect disease downstream analyses error rate explicit Genetic Genetic studies genetics Genotype genotyped individuals genotypes genotyping Haplotype haplotypes IBD individual individuals information investigated isolates Merlin much lower parents Phenotypes Population populations provide Recombination recombination event researcher sequence Spectrum [DOI] 10.1371/journal.pgen.1004234 PMC 바로가기 [Article Type] Research Article