Increased risk of acute kidney injury in coronavirus disease patients with renin–angiotensin–aldosterone-system blockade use: a systematic review and meta-analysisArticle Published on 2021-06-302022-10-04 Journal: Scientific Reports [Category] MERS, 임상, [키워드] 95% confidence interval Acute kidney injury Affect AKI Analysis association blockade Complication concern coronavirus disease COVID-19 COVID-19 patient COVID-19 patients database estimate hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient Increased increased risk investigated Kidney diseases Kidney injury Meta-analysis Odds ratio outcome Patient patients potential risk RAAS raised random-effects model renal risk searched severity significantly Stratification systematic review viral infection [DOI] 10.1038/s41598-021-92323-8 PMC 바로가기 [Article Type] Article
Development and Validation of a Multivariable Predictive Model for Mortality of COVID-19 Patients Demanding High Oxygen Flow at Admission to ICU: AIDA ScoreClinical Trial Published on 2021-06-302022-10-04 Journal: Oxidative Medicine and Cellular Longevity [Category] MERS, SARS, 임상, [키워드] 95% CI addition Admission admitted to ICU age AIDA Analysis coefficient Cohort Comorbidity Coronary artery disease COVID-19 COVID-19 disease COVID-19 patient Critical care D dimer development diabete external validation Final Flow Health high risk hypertension ICU IL-6 management material mechanical ventilation men Model moderate Mortality mortality risk Most patient multivariable multivariate model Negative predictive value outcome Patient patients Positive predictive value Predictive resources Result risk Risk category risk factor score sensitivity serum albumin severe ARDS significant variable specificity Stratification study population treated utility validation validation cohort validation cohorts were used women [DOI] 10.1155/2021/6654388 PMC 바로가기 [Article Type] Clinical Trial
Prognostic Factors in COVID-19 Patients With New Neurological Manifestations: A Retrospective Cohort Study in a Romanian Neurology DepartmentNeuroscience Published on 2021-06-172022-10-31 Journal: Frontiers in Aging Neuroscience [Category] COVID-19, [키워드] activated acute respiratory syndrome Admission advanced age age Aspartate transaminase average biological parameter biological parameters Blood urea nitrogen C-reactive protein caused Characteristics Clinical course clinical feature Comorbidities Confusion confusional consecutive patient coronavirus COVID-19 COVID-19 patient COVID-19 severity creatinine criteria D-dimer Dementia demographic data Department determine Diagnosis elderly enrolled event Factor Fatality rate ferritin fibrinogen Final future therapeutic headache hemoglobin high mortality rate Hospitalization in-hospital mortality independent predictor lack lung involvement Lymphocyte count majority median value Mortality mortality rate neurological Neurological symptoms NEUROLOGY neutrophil count New outcome pandemic Patient patients with COVID-19 Prognostic factor Prothrombin time public health required responsible retrospective cohort study risk Risk factors SARS-CoV-2 SARS-COV-2 infection Secondary outcomes severity of COVID-19 significantly specific treatment statistically significant Stratification stroke supplemental oxygen Symptom two groups were recorded White blood cell with COVID-19 women [DOI] 10.3389/fnagi.2021.645611 PMC 바로가기 [Article Type] Neuroscience
Characterising the background incidence rates of adverse events of special interest for covid-19 vaccines in eight countries: multinational network cohort studyResearch Published on 2021-06-142022-10-28 Journal: The BMJ [Category] COVID-19, Fulltext, MERS, [키워드] 95% confidence interval Acute myocardial infarction adverse event AESI AESIs age age and sex anaphylaxis Appendicitis Bell’s palsy category cohort study Council database Deep vein thrombosis Disseminated intravascular coagulation eight Electronic health record estimate example France Frequency Germany Health heterogeneity IBM Immune thrombocytopenia incidence rate Japan mapped Medicaid Medical Sciences men Meta-analysis Myocardial infarction myocarditis Narcolepsy Netherlands objective Older organization Other outcome measure participant person year population level random effect ranged Rate Result setting Sex Spain Stratification stratified stroke Surveillance syndrome The United States thrombosis United Kingdom Vaccine Vaccines Variation women [DOI] 10.1136/bmj.n1435 PMC 바로가기 [Article Type] Research
Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical IndustryReview Published on 2021-06-082022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] addressed Analysis approach association bioinformatics COVID-19 database Diagnosis dimension disorders Drug discovery drug side effects genetics Genome sequencing genomic sequencing healthcare information Interpretation Major management manuscript Microbiology microRNA miRNA pandemic pharmaceutical pharmacovigilance promoted proteomics public health Research researcher Stratification Systems biology translational Treatment [DOI] 10.3390/ijms22126184 PMC 바로가기 [Article Type] Review
Excess mortality associated with the COVID-19 pandemic among Californians 18–65 years of age, by occupational sector and occupation: March through November 2020직업 부문 및 직업에 의한 18 ~ 65 세의 캘리포니아 주민들의 Covid-19 Pandemic과 관련된 초과 사망률 : 2020 년 3 월부터 11 월까지Clinical Trial Published on 2021-06-042022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] addressed affected age Analysis Asian average black capita Coronavirus infection COVID-19 COVID-19 pandemic death Department died ethnic group Ethnic groups examined excess mortality expected food Health highest individuals information Intervention Latino Mortality moving average notable outbreak pandemic Public Racial Regulation representing risk factor SARS-CoV-2 sector Stratification Transmission vaccination Vaccine white work environments [DOI] 10.1371/journal.pone.0252454 PMC 바로가기 [Article Type] Clinical Trial
Machine Learning to Predict In-Hospital Mortality in COVID-19 Patients Using Computed Tomography-Derived Pulmonary and Vascular FeaturesArticle Published on 2021-06-032022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] Admission age build Chest computed tomography Chest CT Clinical data computer contributing to COVID-19 COVID-19 patient dataset death died discharge Features highlighting Hospitalization in-hospital mortality lung machine learning machine learning model Mann–Whitney U test median Metrics neural networks outcome parenchymal Patient patients patients who survived performed Precision Predictive Prognosis pulmonary pulmonary artery radiological recall reported SARS-COV-2 infection Stratification Support support vector machine SVM tomography Univariate analysis Vascular Vascular damage vector X-ray computed yielding [DOI] 10.3390/jpm11060501 PMC 바로가기 [Article Type] Article
Early prediction of COVID‐19 severity using extracellular vesicle COPB2세포외소포 COPB2를 이용한 코로나19 중증도 조기예측Research Article Published on 2021-06-022022-09-10 Journal: Journal of Extracellular Vesicles [Category] MERS, SARS, 바이오마커, [키워드] 95% CI Acute respiratory failure Admission analyzed Antiviral antiviral response asymptomatic infection AUC best Biomarker clinical decision clinical manifestation clinical manifestations Cohort collected complex component COPB2 correlation correlations Corticosteroids COVID‐19 COVID‐19 patient COVID‐19 symptom COVID‐19 symptoms COVID‐19 death determinant Evidence EVs exhibited expression exRNAs Extracellular extracellular RNA extracellular RNAs extracellular vesicle Extracellular vesicles Golgi group healthy control healthy controls highlight Hypothesis indicate involved liver Liver damage marker Mild Patient Predictive Predictive value predictor profile profiles Protein Proteins remained Respiratory failure SARS‐CoV‐2 serum sample serum samples severity significantly higher Stratification subunit Symptomatic treatment therapy three group three groups Variability Vesicle [DOI] 10.1002/jev2.12092 PMC 바로가기 [Article Type] Research Article
A multi-center study of COVID-19 patient prognosis using deep learning-based CT image analysis and electronic health recordsResearch article Published on 2021-06-012022-10-05 Journal: European Journal of Radiology [Category] SARS, 바이오마커, [키워드] 95 % CI age Analysis applied area under the curve AUC AUCarea under the curve Biomarker Biomarkers caused CIconfidence interval Cohort cohorts Computed tomography conducted confidence interval confirmed case consolidation Consolidation ratio coronavirus disease coronavirus disease of 2019 correlation coefficient COVID-19 COVID-19 patient COVID-19Coronavirus disease of 2019 CRConsolidation ratio CTComputed Tomography dataset death deep learning Deep Learning Method EHR EHRElectronic health records Electronic health record Electronic health records erythrocyte sedimentation rate ESRerythrocyte sedimentation rate Final Generalized linear model GGOground-glass opacity GLM GLMGeneralized linear model GPUGraphics processing unit Graphics processing unit ground-glass opacity hemoglobin HgbHemoglobin High-sensitivity C-reactive protein Hounsfield unit hs-CRPHigh-sensitivity C-reactive protein HUHounsfield unit ICUIntensive Care Unit indicated institutional review board intensive care unit IRBinstitutional review board laboratory data lactate dehydrogenase LDHlactate dehydrogenase Lung infection mechanical ventilation Medical resources MODSMultiple Organ Dysfunction Score Multiple Organ Dysfunction Score MVMechanical ventilation outcomes oxygen saturation Patient Platelet PLTPlatelet predict predictor Prognosis prognostic regions Result reverse-transcription polymerase chain reaction risk RT-PCRReverse-transcription polymerase chain reaction Sequential Organ Failure Assessment severity SOFASequential Organ Failure Assessment SpO2 SpO2Oxygen saturation Stratification TORTotal opacity ratio Total opacity ratio vital sign WBC WBCWhite blood cell White blood cell [DOI] 10.1016/j.ejrad.2021.109583 [Article Type] Research article
Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trialResearch article Published on 2021-06-012022-10-05 Journal: The Lancet Rheumatology [Category] 임상, [키워드] 1:1 adverse event analysed assigned benefit C-reactive protein concentration colony stimulating factor Confidence intervals COVID-19 death deaths double-blind enrolled enrolment evaluate finding funding GM-CSF groups hospital hospitalisation hypoxaemia IMPROVE Inflammatory response initiated intention-to-treat population investigator investigator-initiated mechanical ventilation monoclonal antibody multicentre nine no significant difference Odds ratio outcome Oxygen therapy participant Patient patient population patients with COVID-19 Placebo placebo-controlled trial Pneumonia Potential treatment primary endpoint Primary outcome proportion randomised Randomised trial Randomly receive receptor Registered required Research Respiratory failure Seven Severe COVID-19 pneumonia single intravenous infusion Stratification Supplemental oxygen therapy systemic hyperinflammation the placebo group therapy Treatment Trial USA was done were excluded [DOI] 10.1016/S2665-9913(21)00070-9 [Article Type] Research article