translational – Page 15 – Communicable Diseases Research

Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19

아미노산 감지 경로: 비만과 코로나19 발병의 주요 체크포인트

Review

Published on 2021-04-012022-09-11
Journal: Obesity Reviews [Category] SARS, 유전자 메커니즘,

A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway

Psychology

Published on 2021-03-312022-10-31
Journal: Frontiers in Psychology [Category] COVID-19,

[키워드] Affect Anti-inflammatory caused childhood cholinergic Cholinergic anti-inflammatory pathway coronavirus 2 COVID-19 cross-talk cytokine disorder epidemiological Evidence exacerbate fetal gestation heart rate variability highlight Human Development immune activation immunological impair increase increased risk Infection Inflammatory response International Maternal Maternal Immune Activation mental illness MIA Modification multicenter Neurodevelopmental disorders Newborn offspring origin pathway Perspective physiological Post-infection Potential preclinical study pregnant women produced Quality of life respiratory risk role SARS-CoV-2 severity of COVID-19 subsequent the SARS-CoV-2 translational triggered
[DOI] 10.3389/fpsyg.2021.614451 PMC 바로가기 [Article Type] Psychology

Vaccinomic approach for novel multi epitopes vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Research Article

Published on 2021-03-252022-10-27
Journal: BMC Immunology [Category] COVID-19,

[키워드] acute respiratory syndrome Amino acid antigenic approach assist average B-lymphocytes binding energy Cell China cloned Combination composed conserved Coronavirus-2 country demonstrated Disulfide DNA sequence effective ENhance epitope expression greater hydrophilic immunogenic immunoglobulins immunoinformatics INF-γ Infection linkers microbial multi Multiepitopes vaccine Novel coronavirus ORF1ab polyprotein pandemic physiochemical property polyprotein predicted ProSA-web Protein protocol provided Ramachandran plot reduce Region Result reverse transcribed S protein SARS CoV-2 SARS-CoV-2 SARSCoV-2 shown significantly Spike S protein Spread stability T lymphocyte T-helper cells T-lymphocytes the vaccine TLR4 translational unique Vaccine vaccine construct was performed
[DOI] 10.1186/s12865-021-00412-0 PMC 바로가기 [Article Type] Research Article

Vaccinomic approach for novel multi epitopes vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Research Article

Published on 2021-03-252022-10-27
Journal: BMC Immunology [Category] Coronavirus, COVID-19, Fulltext, SARS,

[키워드] acute respiratory syndrome Amino acid antigenic approach assist average B-lymphocytes binding energy Cell China cloned Combination composed conserved Coronavirus-2 country demonstrated Disulfide DNA sequence effective ENhance epitope expression greater hydrophilic immunogenic immunoglobulins immunoinformatics INF-γ Infection linkers microbial multi Multiepitopes vaccine Novel coronavirus ORF1ab polyprotein pandemic physiochemical property polyprotein predicted ProSA-web Protein protocol provided Ramachandran plot reduce Region Result reverse transcribed S protein SARS CoV-2 SARS-CoV-2 SARSCoV-2 shown significantly Spike S protein Spread stability T lymphocyte T-helper cells T-lymphocytes the vaccine TLR4 translational unique Vaccine vaccine construct was performed
[DOI] 10.1186/s12865-021-00412-0 PMC 바로가기 [Article Type] Research Article

Immuno-informatics design of a multimeric epitope peptide based vaccine targeting SARS-CoV-2 spike glycoprotein

SARS-CoV-2 스파이크 당단백질을 표적으로 하는 다중 에피토프 펩티드 기반 백신의 면역 정보학 설계

Research Article

Published on 2021-03-172022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, SARS,

[키워드] alleles antibody Antigen antigenic antigenicity approach array B cell epitope B cell epitopes CD4+ T cell CD8+ T cell Cell-mediated immunity characterized chimeric cloned Community COVID-19 Critical Cytokines decrease Developing eight elicit epitope epitope peptide Epitopes expressed fatality homologous IgM and IgG immune immune protection Immuno-informatics in silico increase in information linker mapped MERS MHC I MHC I and II alleles peptide peptide-based vaccine predicted SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein Spike protein T cell Th1 Th2 cytokines the spike protein the vaccine Toll-like receptor translational triggering Vaccine vaccine construct Vaccine design virus
[DOI] 10.1371/journal.pone.0248061 PMC 바로가기 [Article Type] Research Article

Research informatics and the COVID-19 pandemic: Challenges, innovations, lessons learned, and recommendations

Special Communications

Published on 2021-03-162022-10-30
Journal: Journal of Clinical and Translational Science [Category] COVID-19,

[키워드] Award build clinical Clinical data clinical decision consortia contributed COVID-19 COVID-19 pandemic CTSA demonstrated EHR feature Health Healthcare provider informatics initial Local N3C National pandemic Patient care Perspective practitioners public health recipient recommendation Repository Research researcher response Science Seven Support Surveillance translational
[DOI] 10.1017/cts.2021.26 PMC 바로가기 [Article Type] Special Communications

Phenotypes and Subphenotypes of Patients With COVID-19: A Latent Class Modeling Analysis

Research article

Published on 2021-02-262022-10-05
Journal: Chest [Category] 바이오마커,

[키워드] Analysis analyzed assist association Basic science Biomarker Blood class Cleveland clinic Clinical outcome clinical trial clinical trials Cluster Comorbidities Concordance COVID-19 COVID-19 phenotype COVID-19 symptom database death demographics elevated evaluated help heterogeneity hospital Hospital admission Hospitalization hospitalized patient hospitalized patients Hyperinflammatory ICU identifying independent investigated investigator kidney dysfunction laboratory-confirmed SARS-CoV-2 infection Latent latent class latent class analysis lymphopenic modeling Mortality Patient patients patients with COVID-19 phenotype Phenotypes phenotypic Platelet positive predict presenting presenting symptoms profile Research researcher Result significantly stratified subphenotypes Symptoms System transfer translational WBC
[DOI] 10.1016/j.chest.2021.01.057 [Article Type] Research article

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

플리티뎁신은 숙주 단백질 eEF1A를 표적으로 삼아 SARS-CoV-2에 대한 강력한 전임상 효능을 갖고 있다.

Research Article

Published on 2021-02-262022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 변종, 신약개발, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity antiviral effects aplidin approach approval Cell Cell culture cells cellular complementary coronavirus COVID-19 depsipeptide drug drug-resistant Efficacy effort elongation factor eukaryotic translation Factor Host host protein host proteins in vitro in vivo inhibitor inhibitors inhibitory concentration life cycle lung Lungs magnitude mice mouse model Mouse models mutant Perspective Plitidepsin prophylactic treatment reduction Remdesivir required respiratory SARS-CoV-2 SARS-COV-2 infection Science severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 target therapeutic Toxicity translation translational Treatment Viral Viral protein Viral proteins viral replication virus white
[DOI] 10.1126/science.abf4058 PMC 바로가기 [Article Type] Research Article

Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents

주요 변이체 표면 항원 암호화 유전자의 진화적 분석은 대륙 내 및 대륙 간 열원충의 개체군 구조를 나타냅니다.

Research Article

Published on 2021-02-252022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

[키워드] absence Analysis Antigen approach asked biological significance complexity conserved country dataset deep sequencing demonstrated detect diagnostic Disease surveillance Diversity DNA DNA sequence DNA sequences domain East effort ENCODE Epidemics Evolution Gabon genomes Globalization health problem hidden hidden markov model HIV Host identify identity immunodominant implication infect Influenza isolate Local malaria malaria parasite malaria parasites Markov methodology Microbiologist MOST outcome parasite parasites pathogen Pathogens Plasmodium Plasmodium falciparum population immunity precluded presence or absence public health recent Recombination sensitivity sequence South America Spread subsequent surface antigen Surface Antigens Surveillance tested to define translational Transmission dynamics Uganda unique VAR var gene var genes variant variants West
[DOI] 10.1371/journal.pgen.1009269 PMC 바로가기 [Article Type] Research Article

Furin Expression in Patients With Psoriasis—A Patient Cohort Endangered to SARS-COV2?

Medicine

Published on 2021-02-102022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] ACE2 ACE2 expression analyzed Angiotensin converting enzyme-2 Arthritis baseline biologic blood cell Blood cells blood sample clinical clinical trial Control controls Course COVID-19 decreased expression Endangered enzyme evaluate Express expression expression level expression levels Follow-up furin host cell in viral induce Infection mRNA expression not differ overexpressed Patient patients patients treated psoriasis psoriatic arthritis raised reduce registry retrieved risk SARS-CoV-2 Secukinumab severe COVID-19 significantly significantly increased therapeutic intervention translational Treatment treatment initiation untreated patients ustekinumab
[DOI] 10.3389/fmed.2021.624462 PMC 바로가기 [Article Type] Medicine