Virological – Page 15 – Communicable Diseases Research

ECMO in COVID-19—prolonged therapy needed? A retrospective analysis of outcome and prognostic factors

Original Papers

Published on 2021-02-202022-10-28
Journal: Perfusion [Category] COVID-19, MERS, SARS,

Influenza and Respiratory Virus Surveillance, Vaccine Uptake, and Effectiveness at a Time of Cocirculating COVID-19: Protocol for the English Primary Care Sentinel System for 2020-2021

Protocol

Published on 2021-02-192022-10-31
Journal: JMIR Public Health and Surveillance [Category] COVID-19, MERS,

[키워드] addition adverse event Analysis approval approved Care clinical Clinical data coded coding collected collecting data college computerized medical record systems condition Control Coronavirus infections COVID-19 COVID-19 cases COVID-19 pandemic Digital distribution Effectiveness England English General practice general practitioner IMPROVE include infections Influenza informatics Intervention Long-term follow-up Lower respiratory tract medical record Medicine National nomenclature objective outcome Patient PHE point-of-care primary care public health Public Health England RCGP records as topic recruit Research respiratory Result RSC SARS-COV-2 infection SARS-CoV-2 infections second second wave secure sentinel sentinel surveillance serology service specimen study outcomes Surveillance surveillance data Swab System term time Trial trials unique University of Oxford uptake Vaccine Virological Virology
[DOI] 10.2196/24341 PMC 바로가기 [Article Type] Protocol

Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

기능적 SARS-CoV-2-특이적 T 세포의 조기 유도는 COVID-19 환자의 빠른 바이러스 제거 및 경증 질병과 관련이 있습니다.

Case Reports

Published on 2021-02-092022-09-12
Journal: Cell Reports [Category] MERS, 진단,

Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial

COVID-19 환자에서 Baloxavir Marboxil 및 Favipiravir의 임상 결과 및 혈장 농도: 탐색적 무작위 대조 시험

Randomized Controlled Trial

Published on 2021-02-012022-09-11
Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 임상, 치료제,

[키워드] addition antiviral activities antiviral activity antiviral drug antiviral drugs Arbidol Arm assigned baloxavir baloxavir acid baloxavir marboxil benefit Blood Chinese Chinese Clinical Trial Registry clinical clinical benefit clinical benefits Clinical improvement Clinical outcome clinical outcomes comparable Concentration conducted control group control groups Controlled COVID-19 COVID-19 patients Day dosage drug enrolled evaluate evaluated exploratory Favipiravir half-maximal effective concentration Hospitalized in vitro lack limitation Lopinavir medians Patient patients with COVID-19 pharmacokinetics plasma concentration plasma concentrations Primary outcome randomization Randomized reason for reduction Registered registry SARS-CoV-2 standard treatment subject symptom onset the half-maximal effective concentration (EC(50)). the median Treatment Trial Viral Virological
[DOI] 10.1016/j.ejps.2020.105631 PMC 바로가기 [Article Type] Randomized Controlled Trial

CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

중요한 COVID-19 환자의 CCR5 억제는 염증성 사이토카인을 감소시키고 CD8 T 세포를 증가시키며 14일째까지 혈장에서 SARS-CoV2 RNA를 감소시킵니다

Article

Published on 2021-02-012022-09-11
Journal: International Journal of Infectious Diseases [Category] SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed antibody baseline blockade CCR5 CD4/CD8 CD8 changes in Clinical efficacy Complete coronavirus correlated COVID-19 critical COVID-19 patient decrease discharged Donor dose dysregulated immune response Emergency use global pandemic IL-6 Immune cell immune cell populations immunological Immunotherapy increase increase in Inference Inflammation Inflammatory cytokines investigated Leronlimab Migration over parameter Patient plasma Plasma viral load. randomized clinical trials Receptor occupancy reduction in respiratory restoration RNA SARS-CoV-2 SARS-CoV2 severe acute respiratory syndrome Coronavirus severe COVID-19 patients statistically significant reduction Study design study period survived T-cells therapeutic target Treatment Viral Viral load Viremia Virological
[DOI] 10.1016/j.ijid.2020.10.101 PMC 바로가기 [Article Type] Article

Insight into the practical performance of RT-PCR testing for SARS-CoV-2 using serological data: a cohort study

혈청학적 데이터를 사용한 SARS-CoV-2에 대한 RT-PCR 테스트의 실제 성능에 대한 통찰력: 코호트 연구

Articles

Published on 2021-02-012022-09-10
Journal: The Lancet. Microbe [Category] Fulltext, MERS, 치료기술,

[키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adjusted age Analysis anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody approach asymptomatic individual Asymptomatic individuals both group both groups Characteristics China close contact cohort study collected Commission Community complementary Contact Contact tracing coronavirus Course defined detect determine diagnosed distribution ELISA ELISAs enrolled exposure to false false-negative rate false-negative rates finding foundation Frequency funding Guangdong IgG IgM include index case individual Infection initial Innovation insight limitation mandatory meal Melinda Gate Melinda Gates miss a mode optimal sensitivity positive proportion protocol quarantine rates of infection recruit reported respiratory RT-PCR RT-PCR testing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Science sensitivity serological serological sample serological samples serological test Serological tests seropositive Seropositivity Serosurvey serum sample serum samples severe acute respiratory syndrome Coronavirus Sex Shenzhen significantly higher Spread Stage Strategy Surveillance Symptom symptom onset technology telephone the timing Virological Volunteer volunteers
[DOI] 10.1016/S2666-5247(20)30200-7 PMC 바로가기 [Article Type] Articles

Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge

Research

Published on 2021-01-272022-10-29
Journal: JAMA Network Open [Category] COVID-19, MERS,

[키워드] 113 patient age age and sex anomalies battery clinical manifestations cohort study Comorbidities Complete Computed tomography conducted coronavirus disease Course COVID-19 defined Diagnosis died diffusing discharge evaluate expected exposure Factor Fatality rate finding Follow-up functional hospital Hospital admission hospital discharge Hospitalization Hospitalized Impact impairment Importance Infection Italy less lung capacity Lung function measure median Month Mortality objective Older outcome participant Patient patients hospitalized patients with COVID-19 performance physical Point Posttraumatic Stress Prevalence Primary outcome proportion prospective cohort study Psychological Pulmonary function test reduction reference range Relevance reported respiratory Respiratory Coronavirus Result risk factor SARS-CoV-2 SARS-COV-2 infection secondary Serological testing setting severe coronavirus disease severe COVID-19 stress symptom suggested survivor Swab Symptom Virological was reduced
[DOI] 10.1001/jamanetworkopen.2020.36142 PMC 바로가기 [Article Type] Research

Clinical features and natural history of the first 2073 suspected COVID-19 cases in the Corona São Caetano primary care programme: a prospective cohort study

Infectious Diseases

Published on 2021-01-122022-10-28
Journal: BMJ Open [Category] COVID-19, Fulltext, MERS,

[키워드] Ageusia Anosmia arthralgia assist Brazil Care clinical Clinical data Community consecutive patient Corona cough COVID-19 COVID-19 case COVID-19 cases cycle threshold death Diagnosis Epidemiology Fatality rate fatigue feature Fever finding hospital hospitalisation hospitalised Infection Infectious diseases men Mild Most patient myalgia obesity offered Older age older patients Patient platform population-based cohort positive COVID-19 positive patient presenting primary care prospective cohort study public health respiratory diseases RT-PCR SARS-CoV-2 serology serology testing seropositive severe cases Symptom symptom onset tested transcriptase Virological with COVID-19
[DOI] 10.1136/bmjopen-2020-042745 PMC 바로가기 [Article Type] Infectious Diseases

SARS-CoV-2 diagnosis: a single-centre experience

SARS-CoV-2 진단: 단일 센터 경험

Original Article

Published on 2021-01-012022-09-10
Journal: Journal of Medicine and Life [Category] SARS, 진단, 치료기술, 치료법,

[키워드] acute respiratory syndrome Adults age analyzed anti nucleocapside anti-protein S antibody Care Chain Reaction chemiluminescence clinical collected confirmed case confirmed cases coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deaths diagnosed Diagnosis effort extraction gastroenterology Gender Health Health care Health Organization Ig – immunoglobulin IgG infected patients Infection majority Most patient Most patients New coronavirus nucleocapsid number of infected Other pandemic Patient patients and healthcare workers patients with SARS-CoV-2 polymerase chain reaction presence of antibody Protein qualitative detection Registered respiratory RNA RNA – ribonucleic acid Romania RT-PCR RT-PCR – reverse transcription-polymerase chain reaction SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 RNA SARS-CoV-2 spike protein screened second dose Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein sustained swab samples tested the SARS-CoV-2 Virological WHO WHO – World Health Organization World Health Organization
[DOI] 10.25122/jml-2021-0064 PMC 바로가기 [Article Type] Original Article

Chloroquine nasal drops in asymptomatic & mild COVID-19: An exploratory randomized clinical trial

Randomized Controlled Trial

Published on 2021-01-012022-10-05
Journal: The Indian journal of medical research [Category] 임상,

[키워드] 1:1 Administered administration adverse event Analysis analyzed ARMS Asymptomatic asymptomatic patient Chloroquine - COVID-19 clinical Control COVID-19 COVID-19 infection cycle threshold demonstrated Efficacy and safety enrolment exploratory eye drop False-positive greater indicated Infection intervention arm Local measure Mild mild COVID-19 illness modified intention-to-treat nasal nasal drop nasal drops National Early Warning Score outcome Patient patients prevention of COVID-19 progression Prophylaxis proportion randomization Randomized randomized clinical trial receiving reducing RT-PCR Sample size SARS CoV-2 score Seven significant difference standard treatment Supportive treatment tissue Treatment Trial uninfected Viral load Virological was done were excluded were measured
[DOI] 10.4103/ijmr.IJMR_3665_20 PMC 바로가기 [Article Type] Randomized Controlled Trial