Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoproteinSARS-CoV-2의 전사체 및 프로테옴의 특성화는 스파이크 당단백질에서 푸린 유사 절단 부위의 세포 통과 유도된 프레임 내 결실을 보여줍니다Research Published on 2020-07-282022-08-13 Journal: Genome Medicine [Category] SARS, 유전자 메커니즘, [키워드] 24 nt in-frame deletion analysed Analysis animal challenge model animal challenge models Cell cleavage clinical samples contribute Coronaviruses deleted detection determine Direct RNA sequencing exit expected Frame functional furin furin cleavage site furin site furin-like cleavage site genomic glycoprotein growth Health impacted in-frame deletion infected cells mass spectrometry morbidity morbidity and mortality mutate Novel coronavirus ORF-centric pipeline Pathogenesis peptide peptides phosphopeptide phosphoproteome predicted Protein proteome proteomic Region Research respiratory respiratory pathogen Result reveal S glycoprotein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 protein SARS-CoV-2 proteins significantly spike glycoprotein subgenomic mRNA subgenomic mRNAs subunit tandem Tandem mass spectrometry the SARS-CoV-2 genome Transcription Transcriptome transcriptomic unique Vaccine variant Variation Vero E6 Vero E6 cell VERO E6 cells viable deletion Viral viral genome sequence viral peptide viral peptides viral stock viral stocks viral transcript viral transcriptome viral transcripts virulence virus virus entry virus-infected cells zoonosis [DOI] 10.1186/s13073-020-00763-0 PMC 바로가기 [Article Type] Research
Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2Cellular and Infection Microbiology Published on 2020-07-272022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] Activation acute respiratory distress analyses Analysis ARDS (Acute Respiratory Distress Syndrome) binding Cluster Complication core gene COVID-19 death E protein E protein Inhibitors envelope protein envelope protein (E) Evidence feature Features functional Health host cells impacts Inflammasome inhibit SARS-CoV-2 motif Mutation neutralizing antibody Novel coronavirus pathogenicity Prevent RBD receptor ACE2 Receptor binding domain reduce reveal S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sequenced show Spike protein Spread syndrome therapeutic target therapeutic targets therapy triggered Vaccine variant viral entry virus viruses [DOI] 10.3389/fcimb.2020.00405 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Identification of key interactions between SARS-CoV-2 main protease and inhibitor drug candidatesArticle Published on 2020-07-272022-10-04 Journal: Scientific Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome against SARS-CoV caused Computational biology and bioinformatics coronavirus COVID-19 drug drug candidate drug candidates targeting Drug screening effective Features functional Glu166 Gly143 group His41 identification Infection Infectious diseases inhibitor Interaction M pro MD simulations mechanism of action molecular pandemic peptide-like inhibitor Phylogenetic relationship protease reached reported SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease target Virtual drug screening Wuhan, China [DOI] 10.1038/s41598-020-69337-9 PMC 바로가기 [Article Type] Article
Pt-, Rh-, Ru-, and Cu-Single-Wall Carbon Nanotubes Are Exceptional Candidates for Design of Anti-Viral Surfaces: A Theoretical StudyArticle Published on 2020-07-232022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Adsorption antiviral surfaces candidate carbon copper Coronaviruses COVID-19 detrimental equipment evaluated exceptional functional globe hydrogen peroxide inactivation nickel oxygen palladium peroxide Platinum Rh- rhodium ROS ruthenium SARS-CoV-2 single wall carbon nanotubes viral inactivation virus viruses [DOI] 10.3390/ijms21155211 PMC 바로가기 [Article Type] Article
Quinolines-Based SARS-CoV-2 3CLpro and RdRp Inhibitors and Spike-RBD-ACE2 Inhibitor for Drug-Repurposing Against COVID-19: An in silico AnalysisMicrobiology Published on 2020-07-232022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 3CLpro Against anti-SARS-CoV-2 therapeutics catalytic dyad China complex coronavirus COVID-19 disease docking study drug Drug repurposing functional in silico in silico analysis Infection interfere macromolecule main-protease (3CLpro) novel coronavirus SARS-CoV-2 NTP outcome oxolinic acid polymerase positive predicted quinoline based-drugs RdRP RNA-dependent RNA-polymerase SARS-CoV-2 SARS-CoV-2 RdRp seeking specific treatment spike-ACE2 complex Spread spread to suggested the WHO treat Treatment viral entry [DOI] 10.3389/fmicb.2020.01796 PMC 바로가기 [Article Type] Microbiology
Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73 – Phenotype Identifies Polyfunctional Cytotoxic LymphocytesArticle Published on 2020-07-222022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] analyzed axis CD39 CD73 CD8 cells cellular Cohort correlated COVID-19 COVID-19 patient COVID-19 patients Cytokines cytotoxic cytotoxic lymphocytes decrease disease stage expression extracellular ATP functional Future granzyme B IFN-γ immune response Immunomodulatory therapies in healthy individuals Inflammation involved lymphocyte majority natural killer Necrosis NKT NKT cell pathophysiology Patient perforin Population populations Prognostic marker purinergic signaling regulate SARS-CoV-2 secreting secretion Serum ferritin significantly higher significantly lower subset T cell target TNF-α [DOI] 10.3390/cells9081750 PMC 바로가기 [Article Type] Article
COVID-19 and the Gut Microbiome: More than a Gut FeelingPerspective Published on 2020-07-212022-10-29 Journal: mSystems [Category] COVID-19, [키워드] Alter caused clinical trial complications conditions coronavirus disease COVID-19 Critical develop Disease progression feeling functional Gut gut microbiome gut microbiome composition help immune system include influence Intervention lung Microbiome other disease proinflammatory respiratory viruses risk susceptibility understanding viral infection [DOI] 10.1128/mSystems.00453-20 PMC 바로가기 [Article Type] Perspective
COVID-19: A Review on Diagnosis, Treatment, and ProphylaxisReview Published on 2020-07-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 addition Affect angiotensin Anti-inflammatory drugs antibody attenuate binding CD4+ T cell CD8+ clinical trial common cold contribute coronavirus 2 correlated country CoV COVID-19 infection develop diffusion drug Efficacy enzymatic activity Frequency functional healthcare identify immune immune system immunization in viral infect Infection involved measure Neutralizing antibodies outbreak outcome pandemic Patient Perspective Pneumonia positive prevention receptor Replication resources respiratory review SARS-CoV2 SARS-CoV2 infection severe respiratory syndrome severity single-stranded RNA virus Symptom the disease Tocilizumab Transcription Treatment turn Vaccine virus [DOI] 10.3390/ijms21145145 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45 − Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 InflammasomeArticle Published on 2020-07-202022-10-28 Journal: Stem cell reviews and reports [Category] COVID-19, MERS, [키워드] ACE2 ACE2 receptor activate Ang II CD133 CD34 CD45 Cell cell death cell lysis cells COVID19 Cytokine storm damaged described Effect endothelial entry receptor enzyme Express expressed functional Genes hematopoietic Hematopoietic stem cell hematopoietic stem cells human cells hyperactivate indicate induce infect Inflammasome Interaction murine NLRP3 inflammasome progenitor cell protease TMPRSS2 protective effect pyroptosis RAAS raise receptor response SARS-CoV-2 SARS-CoV2 shown spike Spike protein stem cell stem cells the SARS-CoV-2 these cell tissue transmembrane umbilical cord blood viral spike protein virus VSELs [DOI] 10.1007/s12015-020-10010-z PMC 바로가기 [Article Type] Article
The COVID-19 Pandemic: Does Our Early Life Environment, Life Trajectory and Socioeconomic Status Determine Disease Susceptibility and Severity?Review Published on 2020-07-192022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] appear biological sample CD8+ Clinical course clinically collected coronavirus disease COVID-19 COVID-19 severity Critical CTL cytotoxic defined determinant determine disease detection early life adversity effective ELA element Environment Factor form functional Health Health inequalities help Hypothesis identify immune exhaustion immune response immune system immunosenescence Infection Influenza life mechanism outcomes over pandemic Pandemics phenotype Preliminary data pro-inflammatory Psychosocial stress raise recognize required risk SARS-CoV-2 senescent severity of COVID-19 social environment Socioeconomic factor socioeconomic status status T-cell Response T-lymphocyte [DOI] 10.3390/ijms21145094 PMC 바로가기 [Article Type] Review