Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome
중심소체 생합성, Phenocopies Seckel 증후군의 조절자인 마우스 Cenpj의 교란
Research Article
[키워드] Abnormalities
addition
allele
Apoptosis
Author
Birth
Brain
cause
Cell
cell death
CENPJ
centriole
characteristic
chromosomal abnormalities
chromosomal abnormality
chromosome
chromosomes
clinical feature
Clinical features
clinical manifestations
compared
conserved
contribute
CPAP
damaged
disorder
Disruption
DNA damage
dwarfism
elevated
Embryo
embryonic
embryonic development
exhibited
expresse
expressed
feature
fibroblast
found
Frequency
Gene
genomic
growth
growth failure
hypomorphic
immunohistochemistry
impairment
in addition to
Increased
J gene
lead
majority
mechanism
memory
memory impairment
Mental
mental retardation
mice
microcephaly
mitotic
mono
mouse
Mutation
ocular
phenocopy
proliferation
Protein
reduced
reduction in
regulator
Seckel
Seckel syndrome
Signaling
skeletal
specific mutation
specific mutations
syndrome
wild-type cells
[DOI] 10.1371/journal.pgen.1003022 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1003022 PMC 바로가기 [Article Type] Research Article