Perspectives for the use of therapeutic Botulinum toxin as a multifaceted candidate drug to attenuate COVID-19Review article Published on 2020-06-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, [키워드] ACE2 acute respiratory syndrome appear attenuate Botox Botulinum toxin Brain circulation clinical symptom Clinical symptoms coronavirus coronavirus disease Coronavirus-2 cough country COVID-19 death dose Dyspnoea functional global public health humans individuals with COVID-19 induce Infection life-threatening lung Lungs Mild multi-organ dysfunction neurodegeneration Neurological deficit neurological deficits other organ outbreak paralysis Pneumonia Prevent provide pulmonary failure purified Respiratory failure resulting SARS-CoV-2 SARS-COV-2 infection the SARS-CoV-2 therapeutic therapeutic use virus while [DOI] 10.1016/j.medidd.2020.100042 [Article Type] Review article
Investigation of Some Antiviral N -Heterocycles as COVID 19 Drug: Molecular Docking and DFT CalculationsArticle Published on 2020-05-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] 6LU7 Affect Amino acid amodiaquine approved atomic binding affinity binding energy Bioactivity calculation caused comparable computation computational modeling coronavirus COVID 19 COVID-19 Critical DFT calculations docked docking drug drug target drugs effective electrostatic evaluate evaluated functional Health highest Hydrogen bond hydrophobic interaction Hydroxychloroquine inhibitor investigated investigation M pro Medicines molecular molecular docking N-heterocycles Novel coronavirus nucleotide analogue pandemic parameter parameters performed polyprotein predicted protease Protein reactivity receptor Remdesivir residue SARS-CoV-2 SARS-CoV-2 main protease selected significantly Simulation study the binding affinity translated Viral RNA were used [DOI] 10.3390/ijms21113922 PMC 바로가기 [Article Type] Article
Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous systemResearch Article Published on 2020-05-252022-11-01 Journal: Glia [Category] Coronavirus, MERS, [키워드] Activation addition Apolipoprotein e CD4+ T cell CD45+ CD86 Cell Central nervous system CNS colony stimulating factor coronavirus Coronavirus infection Coronavirus replication correlated CSF1R cystatin damaged decreased expression Defense demonstrated Demyelination dendritic cells deplete Depletion disease elevated ENhance expressed expression functional growth factor Host host defense impair implicated increase increase in increased mortality Infection inhibitor Macrophage macrophages MHC class mice microenvironment microglia mouse hepatitis virus murine myeloid cell nerve tissue neurologic neurotropic osteopontin PLX5622 Population Protein receptor remyelination RNA sequencing severity susceptible T cell transcript Treatment viral replication [DOI] 10.1002/glia.23844 PMC 바로가기 [Article Type] Research Article
The Role of Extracellular Vesicles as Allies of HIV, HCV and SARS VirusesReview Published on 2020-05-222022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] Ally biogenesis caused Cell Coronaviruses EVs Exosomes Extracellular Extracellular vesicles functional HCV HIV in viral Infection Intercellular communication knowledge nucleic acid Other pathogen Pathogens pathological conditions physiological plasma membrane Protein released respiratory role SARS virus SARS viruses therapeutic strategy Vesicle viral infection virus viruses [DOI] 10.3390/v12050571 PMC 바로가기 [Article Type] Review
The need for early intervention for psychosis to persist throughout the COVID-19 pandemic and beyondPerspective Piece Published on 2020-05-212022-10-30 Journal: Irish Journal of Psychological Medicine [Category] Coronavirus, MERS, SARS, [키워드] affected consequence COVID-19 pandemic disorders functional incidence Intervention mental health mental health services outcome pandemic Perspective reducing symptomatic Treatment [DOI] 10.1017/ipm.2020.56 PMC 바로가기 [Article Type] Perspective Piece
Forensic psychiatry and Covid-19: accelerating transformation in forensic psychiatryPerspective Piece Published on 2020-05-212022-10-30 Journal: Irish Journal of Psychological Medicine [Category] Coronavirus, MERS, SARS, [키워드] approaches clinically Confusion Epidemic Forensic psychiatry functional greater information management Mental disorder mental health service Mortality National outcome Patient Psychiatric psychiatry reducing required Research response risk Schizophrenia symptomatic [DOI] 10.1017/ipm.2020.58 PMC 바로가기 [Article Type] Perspective Piece
A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final CappingReview Published on 2020-05-202022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] capping complex coronavirus COVID-19 COVID19 determinant Efficiency ENhance Final functional homology host protein infected cell Infectious disease Interaction molecular mounted novel coronavirus SARS-CoV-2 pandemic Proofreading Protein protein structure provide Replication Research RNA RNA polymerase RNA replication SARS-CoV-2 SARS-CoV-2 RNA Scientific community synthesis the disease the SARS-CoV-2 therapeutic interventions View viral genome viruses [DOI] 10.3390/cells9051267 PMC 바로가기 [Article Type] Review
Immunogenicity of a DNA vaccine candidate for COVID-19Article Published on 2020-05-202022-10-04 Journal: Nature Communications [Category] MERS, 치료기술, [키워드] ACE2 receptor antibodies antibody Antigen binding biodistribution build cellular immunity clinical study coronavirus Coronaviruses COVID-19 COVID-19 vaccine dataset disease dissemination DNA vaccine DNA vaccines expression functional generate identify immunization immunogenicity in vitro Infection initial INO-4800 Lungs MERS coronavirus mice neutralize Neutralizing antibody response pandemic Protein robust SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 vaccine spike Support T cell T cell responses the disease the S protein the SARS-CoV-2 translational Vaccine vaccine candidate Viral pneumonia [DOI] 10.1038/s41467-020-16505-0 PMC 바로가기 [Article Type] Article
Cadaveric Simulation of Endoscopic Endonasal Procedures: Analysis of Droplet Splatter Patterns During the COVID-19 PandemicResearch Articles Published on 2020-05-192022-10-29 Journal: Otolaryngology--Head and Neck Surgery [Category] COVID-19, MERS, SARS, [키워드] activating Activation acute respiratory syndrome burr cadaver condition Contamination control condition coronavirus COVID-19 droplet droplets endonasal evaluate Fluorescein functional Laboratory Limited nasal Nasal endoscopy objective occur pattern performed Respiratory droplets Result resulting SARS-CoV-2 setting Simulation sinus surgery skull base surgery specimen Splatter Spread suction surgical thought Viral transmission [DOI] 10.1177/0194599820929274 PMC 바로가기 [Article Type] Research Articles
Are Iranian Sulfur Mustard Gas-Exposed Survivors More Vulnerable to SARS-CoV-2? Some Similarity in Their PathogenesisResponder Tools Published on 2020-05-182022-10-31 Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting enzyme caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection Cytokine storm dysregulation entry receptor functional Health immune system Infectious disease Iran lung Lung injury mustard mustard gas overexpression oxidative stress pathogenesis of SARS-CoV-2 pathologic Pulmonary infection receptor SARS-CoV-2 similarity suggested sulfur survivor susceptibility susceptible veteran [DOI] 10.1017/dmp.2020.156 PMC 바로가기 [Article Type] Responder Tools