Evaluation of the Levels of Peripheral CD3 + , CD4 + , and CD8 + T Cells and IgG and IgM Antibodies in COVID-19 Patients at Different Stages of Infection감염 단계에서 COVID-19 환자에서 말초 CD3 +, CD4 + 및 CD8 + T 세포 및 IgG 및 IgM 항체의 수준의 평가Research Article Published on 2022-02-232022-08-31 Journal: Microbiology Spectrum [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect antibody production association Blood CD3 CD4 CD45 CD8 Cell Cell-mediated immunity Cellular immune response cellular immune responses cellular immunity changes in China clinical sample clinical samples collected conducted coronavirus COVID-19 cytometry analysis determine died ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Flow flow cytometry Flow cytometry analysis groups healthy individual help Hospitalized IgG IgG and IgM IgM IgM and IgG immune responses immune system Immunity infected with SARS-CoV-2 Infection Level levels of antibodies levels of antibody lymphopenia main role medication moderate Patient patients patients with moderate peripheral Peripheral blood peripheral blood samples recovered patients reduction in reported respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 treatment SARS-CoV-2-infected patient SARS-CoV-2-infected patients serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 shown significant increase significantly Stage stimulatory Support T cell T cells Vaccine virus was performed were used [DOI] 10.1128/spectrum.00845-21 PMC 바로가기 [Article Type] Research Article
T Cell Response After SARS-CoV-2 Vaccination in Immunocompromised Patients with Inflammatory Bowel Disease염증성 장 질환이 있는 면역 저하 환자에서 SARS-CoV-2 백신 접종 후 T 세포 반응Article Published on 2022-02-232022-09-11 Journal: Journal of Crohn's & colitis [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence age analysed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody titres blood sample Blood samples Cell cellular cellular and humoral immune response Cellular immune response cellular immunity close monitoring comparable Control controls COVID19 Cutoff detect dose of vaccination Efficacy first dose group healthy healthy control healthy controls humoral immune response IBD IFN-γ immune response immune responses Immunity Immunocompromised Immunosuppression immunosuppressive infection with SARS-CoV-2 Inflammatory bowel disease one patient Patient patients PROTECT recruited regimens response SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 vaccination second dose slight increase T cell T cell response Th cells TNF TNF-α Total university vaccination [DOI] 10.1093/ecco-jcc/jjab147 PMC 바로가기 [Article Type] Article
Dominant CD8 + T Cell Nucleocapsid Targeting in SARS-CoV-2 Infection and Broad Spike Targeting From VaccinationSARS-CoV-2 감염에서 우세한 CD8 + T 세포 뉴클레오캡시드 표적화 및 백신 접종으로 인한 광범위한 스파이크 표적화Immunology Published on 2022-02-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] anti-SARS-CoV-2 Anti-spike Antibody Response Antibody responses assays average boost breadth CD8 CD8+ T cells Cellular immune response cellular immunity Coverage COVID-19 COVID-19 symptom COVID-19 vaccine demonstrated density dominant ELISpot assays envelope protein envelope proteins epitope Epitopes evaluated Evaluating flow cytometry greater IFN-γ IFN-γ ELISPOT IL-4 Inclusion magnitude nucleocapsid persistence predicted protective role Receptor binding domain Region regions response responses against SARS-CoV-2 SFC spike spot-forming cell spot-forming cells subset sustained T cell T cell response T cell responses T cells targeting Th1 vaccination Vaccine Viral viral infections while [DOI] 10.3389/fimmu.2022.835830 PMC 바로가기 [Article Type] Immunology
Limited induction of SARS-CoV-2–specific T cell responses in children with multisystem inflammatory syndrome compared with COVID-19COVID-19에 비해 다기관 염증 증후군 아동에서 SARS-CoV-2-특이 T 세포 반응의 제한된 유도Research Article Published on 2022-02-222022-09-10 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 치료법, [키워드] Adaptive immunity B cell responses CD4 CD8 Cellular immune response children contribute convalescent COVID-19 cytokine cytokine production cytokine response demonstrated develop full-length functional healthy controls Inflammatory Limited MIS-C mononuclear cell mononuclear cells nucleocapsid participant Pathogenesis peptides Peripheral blood Peripheral blood mononuclear cells plasma predominant quantified RBD Receptor binding domain responses against SARS-CoV-2 antigen SARS-COV-2 infection serologic Serologic response serologic responses significantly lower Spike receptor binding domain subset Support syndrome T cell T cell response T cell responses T cells Th1 Viral Viral proteins was reduced with COVID-19 [DOI] 10.1172/jci.insight.155145 PMC 바로가기 [Article Type] Research Article
Higher SARS-CoV-2 Spike Binding Antibody Levels and Neutralization Capacity 6 Months after Heterologous Vaccination with AZD1222 and BNT162b2Article Published on 2022-02-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anti-spike IgG levels AZD1222 BNT162b2 breakthrough infections Capacity Cellular immune response clinically evaluated comparable COVID-19 Delta delta variant Efficacy group Health care worker heterologous prime-boost Heterologous prime-boost vaccination highest homologous humoral humoral and cellular immune response IFNγ Level magnitude Month neutralizing capacity offered peptide peptides question Receptor binding domain recruited regimen resulting SARS-CoV-2 SARS-CoV-2 vaccine secretion significantly significantly higher spike symptomatic disease the vaccine vaccination Vaccinations Vaccine variant of concern variants of concern viral neutralization wild type Wuhan-Hu-1 [DOI] 10.3390/vaccines10020322 PMC 바로가기 [Article Type] Article
A recombinant SARS-CoV-2 receptor-binding domain expressed in an engineered fungal strain of Thermothelomyces heterothallica induces a functional immune response in miceThermothelomyces heterothallica의 조작된 곰팡이 균주에서 발현된 재조합 SARS-CoV-2 수용체 결합 도메인은 마우스에서 기능적 면역 반응을 유도합니다Article Published on 2022-02-162022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] C1 Cellular immune response core protein COVID COVID-19 pandemic domain effective vaccine Effective vaccines expressed expression functional immune response fungal HBV hepatitis B Hepatitis B virus humoral immune immune responses immunogenicity induce intrinsic knowledge mice Neutralizing antibodies pathogen platform priority Protein RBD RBD domain Receptor-binding domain S protein S1 subunit SARS CoV SARS CoV-2 SARS-CoV-2 Scientific community Support target the S1 subunit Vaccine Viral Viral protein [DOI] 10.1016/j.vaccine.2022.01.007 PMC 바로가기 [Article Type] Article
Self-Assembled Particles Combining SARS-CoV-2 RBD Protein and RBD DNA Vaccine Induce Synergistic Enhancement of the Humoral Response in MiceArticle Published on 2022-02-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] antibody approach Cellular immune response cellular response characterized Combination components coronavirus vaccine COVID-19 DNA DNA vaccine domain effective enhancement filtration gel highest humoral Humoral response IgG immunized increase mice Microscopy Neutralizing activity Particle Particles Protein RBD RBD protein response Safe SARS-CoV-2 SARS-CoV-2 RBD self-assembled particles significantly lower the spike protein vaccination Vaccine virus-neutralizing activity [DOI] 10.3390/ijms23042188 PMC 바로가기 [Article Type] Article
Cellular Responses to Membrane and Nucleocapsid Viral Proteins Are Also Boosted After SARS-CoV-2 Spike mRNA Vaccination in Individuals With Either Past Infection or Cross-ReactivityMicrobiology Published on 2022-02-112022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] asymptomatic infection benefit booster CD8 Cell Cellular immune response cellular response Clinical efficacy COVID-19 cross-reactivity epitope first dose General population highlight individual individuals Infection membrane mRNA mRNA vaccine N proteins nucleocapsid performed priming Protein response SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 spike shown spike spike- T-cell T-cell analysis T-cell Response tested the vaccine Viral variants [DOI] 10.3389/fmicb.2021.812729 PMC 바로가기 [Article Type] Microbiology
Full efficacy and long-term immunogenicity induced by the SARS-CoV-2 vaccine candidate MVA-CoV2-S in miceArticle Published on 2022-02-092022-10-04 Journal: NPJ Vaccines [Category] 변종, [키워드] antibody Antibody Response benefit Breakthrough infection C57BL/6 Cellular immune response correlated COVID-19 domain dose Efficacy expressing human clinical trials humoral immunization immunological Infection K18-hACE2 transgenic mice Live attenuated vaccines Lung pathology Lungs marker memory mice neutralizing antibody parental prevented pro-inflammatory cytokines Protein RBD reduced regimen Reinfection SARS-CoV-2 Support survived the SARS-CoV-2 titers of IgG Treatment two-dose regimen vaccination Vaccine vaccine candidate variants of concern viral infection virus virus replication [DOI] 10.1038/s41541-022-00440-w PMC 바로가기 [Article Type] Article
Immunologic response of mRNA SARS-CoV-2 vaccination in adolescent kidney transplant recipients청소년 신장 이식 환자에서 mRNA SARS-CoV-2 백신 접종의 면역학적 반응Article Published on 2022-02-012022-09-12 Journal: Pediatric Nephrology (Berlin, Germany) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adolescent age anti-S antibody antibody Antibody Response Cellular immune response Corticosteroid COVID-19 COVID-19 infection described dose ENhance evaluated Future General population Immunologic Immunosuppressed Immunosuppression inhibitor IQR kidney transplant kidney transplant recipient lower dose mRNA mRNA vaccine non-responders participant Patient patients pediatric positive positive antibody response Protein regimen reported routine clinical care Safe SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccination SARS-CoV-2 vaccine second dose solid organ transplant SOT SOT patient SOT patients Support the median the vaccine treated vaccination vaccine immunogenicity vaccine response Viremia [DOI] 10.1007/s00467-021-05256-9 PMC 바로가기 [Article Type] Article