Ethnic and age-specific acute lung injury/acute respiratory distress syndrome risk associated with angiotensin-converting enzyme insertion/deletion polymorphisms, implications for COVID-19: A meta-analysis인종 및 연령별 급성 폐 손상/급성 호흡 곤란 증후군 위험, 안지오텐신 전환 효소 삽입/제거 다형성, COVID-19에 대한 시사점: 메타 분석Meta-Analysis Published on 2021-03-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] 95% CI 95% confidence interval ACE acute lung injury acute respiratory distress syndrome addressed Adults ALI/ARDS allele analyses Analysis angiotensin Angiotensin-converting enzyme ARDS ARDS patient ARDS patients article Asian Asians assessment association associations Bonferroni correction Caucasian Caucasians children CIs Comparisons conducted coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 distress dominant Ethnicity examined genetic model Genotype healthy control healthy controls heterogeneity I/D I/D polymorphism implication include indicated insertion/deletion life lung Lung injury Meta-analysis meta-regression Mortality Odds ratios outcome outlier pandemic Patient patients with COVID-19 polymorphism Polymorphisms Regression reported respiratory distress Respiratory distress syndrome risk robust robustness Significant Statistical power statistically Subgroup analyses subgroup analysis syndrome therapy Topic Treatment was performed [DOI] 10.1016/j.meegid.2020.104682 PMC 바로가기 [Article Type] Meta-Analysis
Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: data from two Italian COVID-19 units페리틴은 폐 침범의 심각성과 관련이 있지만 COVID-19 환자의 더 나쁜 예후와는 관련이 없습니다: 2개의 이탈리아 COVID-19 유닛의 데이터Clinical Trial Published on 2021-03-012022-08-13 Journal: Scientific Reports [Category] SARS, 바이오마커, 임상, 진단, 치료기술, [키워드] 95% CI Abruzzo Admission age and gender Biomarker Care clinical clinical decision Clinical sign Clinical signs complex Computed tomography conducted coronavirus coronavirus 2019 disease Course covariate covariates COVID-19 CT scan death Deceased demonstrated discharged disease disease severity enrolled evaluated feature female ferritin ferritin level ferritin levels help heterogeneous hospital hospitalized patient hospitalized patients identify investigated Italian Italy Logistic regression analysis lung abnormalities lung abnormality lung involvement lymph node enlargement males median age mediastinal lymph node mediastinal lymph node enlargement no differences occurred outcome outcomes pathophysiology Patient patients patients with COVID-19 Prognosis prognosis of patient pulmonary involvement pulmonary lobe pulmonary lobes regression analysis retrospective SARS-CoV-2 SARS-COV-2 infection septal thickening serological severe pulmonary involvement severity Therapeutic approach therapeutic approaches unit worse prognosis [DOI] 10.1038/s41598-021-83831-8 PMC 바로가기 [Article Type] Clinical Trial
Population pharmacokinetics of lopinavir/ritonavir in Covid-19 patients코로나19 환자에서 로피나비르/리토나비르의 집단 약동학Article Published on 2021-03-012022-09-11 Journal: European Journal of Clinical Pharmacology [Category] 치료제, [키워드] 50% effective concentration age Alanine alanine aminotransferase ALT Analysis aspartate Aspartate aminotransferase AST BMI body mass body mass index body weight C reactive protein Concentration concentrations coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 creatinine CRP data set described develop dose effective estimate females Final Gender Height high variability hospitalized patient interval Lopinavir Lopinavir/ritonavir males median mixed-effects modeling parameter Patient patients pharmacokinetic pharmacokinetics PK parameters plasma concentration Population proportion reduce regimen Ritonavir SARS-CoV-2 virus significant effect Steady state tested Vero E6 Vero E6 cell VERO E6 cells was tested [DOI] 10.1007/s00228-020-03020-w PMC 바로가기 [Article Type] Article
Limited role for meteorological factors on the variability in COVID-19 incidence: A retrospective study of 102 Chinese citiesResearch Article Published on 2021-02-242022-10-28 Journal: PLoS Neglected Tropical Diseases [Category] COVID-19, MERS, [키워드] Analysis association changes in Characteristics China Chinese Combination condition covariates COVID-19 COVID-19 incidence COVID-19 pandemic COVID-19 transmission Effect environmental condition environmental factor Epidemic Evidence expected explain explained Factor Factors First wave Generalized healthcare incidence incidence of COVID-19 incidence rate include increase in Intervention Limited linear majority measure null model proportion provide raised reduction resource Retrospective study risk of COVID-19 socio-demographic statistically significant temperature the epidemic Vaccine Variability variables while World Meteorological Organization [DOI] 10.1371/journal.pntd.0009056 PMC 바로가기 [Article Type] Research Article
Association of SARS-CoV-2 viral load at admission with in-hospital acute kidney injury: A retrospective cohort study입원 시 SARS-CoV-2 바이러스 부하와 병원 내 급성 신장 손상의 연관성: 후향적 코호트 연구Research Article Published on 2021-02-242022-09-10 Journal: PLoS ONE [Category] MERS, 변종, 유전자 메커니즘, 진단, [키워드] acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus adjusted adjusted hazard ratio adjusted hazard ratios Admission AKI association CIs Cohort Comorbidities competing confidence Confidence intervals confounders coronavirus coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 death defined demographics Electronic health record Electronic health records Healthcare system hospitalized patient hospitalized patients In-hospital increased risk interval KDIGO kidney Kidney injury log mechanism New York City outcome patients hospitalized percentile public health emergency quantified real-time RT-PCR respiratory retrospective cohort study risk SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity scores significantly Viral Viral load with COVID-19 [DOI] 10.1371/journal.pone.0247366 PMC 바로가기 [Article Type] Research Article
Evidence and magnitude of the effects of meteorological changes on SARS-CoV-2 transmissionResearch Article Published on 2021-02-172022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] adjusted Analysis change changes coefficient confirmed case confirmed cases correlation country covariates COVID-19 COVID-19 case COVID-19 pandemic COVID-19 transmission criteria Daily temperature death decrease doubling Effect Fahrenheit greater help Hemisphere Importance increase in influence of temperature Intervention Local log magnitude median morbidity multivariable objective pandemic proceed R 2 reduce reduced reduction Regression required respiratory virus Result resulting robust SARS CoV-2 SARS-CoV-2 transmission selected setting significantly temperature the timing time Transmission Variability was used [DOI] 10.1371/journal.pone.0246167 PMC 바로가기 [Article Type] Research Article
COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factorsCovid-19 Published on 2021-02-152022-10-31 Journal: European Journal of Epidemiology [Category] COVID-19, MERS, SARS, [키워드] association Autoimmune disease black body mass index cardiovascular disease characterisation characteristic Cohort Comorbidities Comorbidity contributed contributing to covariates COVID-19 COVID-19 mortality death diabetes employment enrolment explained Factors healthcare worker hypertension increased risk inhibitor investigated lipids Male sex medications Mortality MOST multivariable Non-COVID-19 oral steroid prospective cohort Regression model regression models reported risk risk factor SARS-CoV-2 selected smoker smoking supplementary material UK biobank white with COVID-19 [DOI] 10.1007/s10654-021-00722-y PMC 바로가기 [Article Type] Covid-19
Impact of Employment, Essential Work, and Risk Factors on Food Access during the COVID-19 Pandemic in New York StateArticle Published on 2021-02-042022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] access Analysis analyzed asked black Chi-square chronic disease Complete contracting the virus covariates COVID-19 COVID-19 pandemic cross-sectional demographic characteristics employment Essential essential worker Essential workers examined Factor food Food access Food security Future Health Hispanic identify Impact impacts Improved Infection logistic regression models major depressive disorder mental health disorders New York pandemic participant persistence Population Qualtrics recruited reduce Research risk Risk factors state took place work [DOI] 10.3390/ijerph18041451 PMC 바로가기 [Article Type] Article
Trajectories of anxiety and depressive symptoms during enforced isolation due to COVID-19 in England: a longitudinal observational studyObservational Study Published on 2021-02-012022-10-05 Journal: The lancet. Psychiatry [Category] Fulltext, MERS, 임상, [키워드] analysed Anxiety average being changed Characteristics children collected country Course covariates COVID-19 COVID-19 outbreak COVID-19 pandemic Covid-19 social study declined decrease Depression depressive symptom Depressive symptoms distress early stage England Follow-up foundation group growth growth trajectory Health highest highlight individual information Innovation introduced Isolation lockdown measure mental health mental health conditions missing values occurred pandemic participant Participants poor mental health proportions reduce reduced remained repeated measure risk risk factor Sociodemographic Symptom trajectory UCL Wellcome Trust [DOI] 10.1016/S2215-0366(20)30482-X PMC 바로가기 [Article Type] Observational Study
Geographic Distribution of Mental Health Problems Among Chinese College Students During the COVID-19 Pandemic: Nationwide, Web-Based Survey StudyOriginal Paper Published on 2021-01-292022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, [키워드] 95% CI adopted analyzed Anxiety anxiety symptom association Binary logistic Chi-square China Chinese college college students conducted covariates COVID-19 COVID-19 outbreak COVID-19 pandemic cross-sectional survey demographics depressive symptom Depressive symptoms develop early stage Generalized Geographic distribution geographic location geographical area history identify Infection information Intervention mental health mental health problem mental health problems objective Odds ratio participant Perceived risk positive Prevalence problem reported Result student survey Symptom the epidemic Travel was used were assessed were used widespread Wuhan [DOI] 10.2196/23126 PMC 바로가기 [Article Type] Original Paper