T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation Antigen CD3+ CD4 CD4+ CD4− CD8− double-negative T cells CD8 CD8+ CD8+ T cell CD8+ T cells children classical CTL Cytotoxic T cell enrolled epitope Epitopes example Follow-up frequencies helper immunodominant epitopes initial IQR lymphopenia magnitude majority MIS-C Numerous pathogenic Patient peptide peptide pool peptide pools peptides physiological response Protein Proteins Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 spike SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells single subject subject subjects subpopulation T cell T cell receptor T cell receptor Vβ21.3 T cell response T cell responses T cells T helper TCRs virus [DOI] 10.3390/ijms23137219 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopesSARS-CoV-2 Delta 변이체는 주로 클래스 1 및 2 항체 에피토프에 초점을 맞춘 항체 반응을 유도합니다Article Published on 2022-06-292022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition antibodies antibody Antibody binding antibody epitope antibody immunity Antibody Response Antibody responses antigenic Beta Beta variant binding class D614G Delta delta variant Effect elicit elicited epitope Epitopes exposure help Impact induce Infection infections K417N mRNA mRNA vaccine Mutation neutralization Neutralizing antibody response polyclonal polyclonal antibody RBD Receptor-binding domain reduce responses SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 variant SARS-CoV-2 variants specificity the RBD the receptor-binding domain vaccination Vaccinations Vaccine variant virus viruses [DOI] 10.1371/journal.ppat.1010592 PMC 바로가기 [Article Type] Article
Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain백신 유도 생식계열 인코딩 인간 항체의 구조는 SARS-CoV-2 스파이크 N-말단 도메인에서 중화 에피토프를 정의합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity Affinity maturation Alpha antibody Antigen arms race B cell B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Biliverdin bind binding Cell cognate antigen complementarity-determining region complex conserved coronavirus cryo-EM Donor electron microscopy engage epitope evolutionary arms race Genetic germ line HCDR3 heme high-resolution structure Host Human hydrophobic Infection intermolecular interaction intermolecular interactions knowledge mAb maintain metabolite monoclonal monoclonal antibodies monoclonal antibody mRNA vaccination N-terminal domain neutralize Neutralizing NTD pathogen plasmablast plasmablasts provide respiratory responses reveal SARS-CoV-2 SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus shown spike spike glycoprotein Structure the SARS-CoV-2 the vaccine undergo vaccination Vaccine vaccine immunogen variant variants Viral viral strain viral variant Viral variants [DOI] 10.1128/mbio.03580-21 PMC 바로가기 [Article Type] Article
Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spikeSARS-CoV-2 Omicron BA.2 스파이크의 Cryo-EM 구조Article Published on 2022-06-282022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody binding antibodies coronavirus CP: Microbiology cryo-EM Cryoelectron microscopy determine domain ectodomain epitope Epitopes functional fusion peptide hallmark immune immune evasion induce Interaction less Lineage Microbiology Microscopy Mutation neutralize omicron Omicron BA.2 Omicron variant peptide proportion Protein Pseudovirus neutralization assay RBD Receptor binding domain Region remodeling respiratory resulting S proteins SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus Structure structures the RBD underlie variant Variation [DOI] 10.1016/j.celrep.2022.111009 PMC 바로가기 [Article Type] Article
Superimmunity by pan-sarbecovirus nanobodies범사르베코바이러스 나노바디에 의한 초면역Article Published on 2022-06-282022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] activities against SARS-CoV best booster breadth broadly neutralizing nanobody camelid clade conserved correlated CP: Immunology distance domain effective epitope Epitopes Evolution facilitate FIVE flat flexible Immunity immunized immunology Infection inhalable bispecific nanobody PiN-31 mechanism median milliliter nanobody neutralization potency Neutralizing observé omicron pan-sarbecovirus neutralization proteomics RBD RBD surface Receptor binding residues sarbecovirus SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 variants super immunity. the SARS-CoV-2 V(H)H antibody [DOI] 10.1016/j.celrep.2022.111004 PMC 바로가기 [Article Type] Article
A unique antigen against SARS-CoV-2, Acinetobacter baumannii, and Pseudomonas aeruginosaSARS-CoV-2, Acinetobacter baumannii 및 Pseudomonas aeruginosa에 대한 고유 항원Article Published on 2022-06-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] Acinetobacter antibody Antigen antigenic peptide antimicrobial approved autoimmune responses Characteristics Consensus COVID-19 domain effective vaccine Effective vaccines epitope Epitopes expected FIVE Hospital admissions infections involved linear epitope Neutralizing Nosocomial infections OmpA outbreak P. aeruginosa pathogenicity peptides protective antibodies Protective antibody Pseudomonas aeruginosa raise replaced retained risk SARS-CoV-2 selected selected epitope Selected epitopes sequence Spike protein strain Treatment turn unique variants of SARS-CoV-2 were used [DOI] 10.1038/s41598-022-14877-5 PMC 바로가기 [Article Type] Article
Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss in Spike진화하는 SARS-CoV-2 계통에 걸친 펩티도돔 감시, 스파이크에서 T 세포 에피토프 손실 가능성이 가장 큰 변이체 중 뉴클레오캡시드에서 HLA 결합 보존 밝혀Article Published on 2022-06-232022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] Analysis Antigen B.1.1.529 binding candidate caused CD4+ T cell CD4+ T cells CD8+ comprehensive analysis concern conservation conserved Course COVID-19 disease dominant elicit epitope Epitopes Evidence Genome GISAID heterogeneity HLA immune response immune responses instance interest lineages Loss MOST Mutation N protein N proteins NCBI NIH nucleocapsid omicron pandemic peptide peptides performed Potential predicted Protein protein sequence provided Region remained S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 lineage spike sustained T cells T-cell the N protein the S protein unique vaccination variant variants viral evolution viral variant Viral variants VoC VOCs Volume [DOI] 10.3389/fimmu.2022.918928 PMC 바로가기 [Article Type] Article
Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19모유의 단백질체 분석은 COVID-19에 걸린 산모의 초유에서 영양 및 면역 이점을 나타냅니다Article Published on 2022-06-172022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] adaptive Analysis Antiviral antiviral properties antiviral property benefit Breastfeeding breastmilk casein collected colostrum control group COVID-19 COVID-19 patient COVID-19 patients debate epitope Epitopes Evidence evidence of exhibited glycosylation Health Organization healthy donors Human immune immune-related protein immune-related proteins Immunoglobulin Infant Infection lack mass spectrometry mature milk milk molecular basis mother protective effect Protein proteomics recognizing recommendation risk SARS-CoV-2 significantly higher significantly lower Structure total protein unique upregulated viral entry virus virus transmission whey protein. while with COVID-19 World Health Organization [DOI] 10.3390/nu14122513 PMC 바로가기 [Article Type] Article
ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike ProteinORFeome 파지 디스플레이, SARS-CoV-2 스파이크 단백질의 S2 하위 도메인에 대한 주요 면역원성 에피토프 공개Article Published on 2022-06-172022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Amino acid amino acid sequence anti-SARS-CoV-2 antibodies antibodies antibody Antibody Response Antibody responses applied approved binding binding site blocking cell entry cleave COVID-19 COVID-19 pandemic COVID-19 patients Diseases display Efficacy epitope epitope mapping Epitopes fusion peptide genomic genomic library Host host cell identify immunogenic library Major mechanism monoclonal antibody mutate Mutation neutralization neutralize NGS Open reading frame open reading frames ORFeome ORFs Particle peptide phage phage display RBD RBD region Receptor binding domain representing SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants sequence Serine serine protease serine protease TMPRSS2 spike the cell the RBD the SARS-CoV-2 genome therapeutic therapy TMPRSS2 Vaccine virus variants [DOI] 10.3390/v14061326 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron Variants Reduce Antibody Neutralization and Acquire Usage of Mouse ACE2SARS-CoV-2 오미크론 변이체, 항체 중화 감소 및 마우스 ACE2 사용 획득Article Published on 2022-06-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 orthologues Alpha antibodies antibody Antibody neutralization antigenic antigenic shifts approved Beta binding body weight breadth comprehensive analysis conducted conserved controls convalescent plasma Delta epitope escape followed by Gamma Host host range Infection Infectious virus infectious viruses initial injection intraperitoneal injection Lineage Lung pathology Lungs magnitude majority manifested mouse Mutation neutralization omicron Omicron variant Omicron variants pandemic plasma plasma neutralization. prophylactic treatment raised reduced reduction Regulatory Authorities regulatory authority S309 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection (COVID-19) SARS-CoV-2 patient SARS-CoV-2 patients Spike protein survived the spike protein therapeutic therapeutic antibodies therapy undetectable Usage Vaccine variant variants viruses while wildlife [DOI] 10.3389/fimmu.2022.854952 PMC 바로가기 [Article Type] Article