Extracellular – Page 16 – Communicable Diseases Research

Neutrophil Extracellular Traps in SARS-CoV2 Related Pneumonia in ICU Patients: The NETCOV2 Study

Medicine

Published on 2021-02-232022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

LZP is required for hepatic triacylglycerol transportation through maintaining apolipoprotein B stability

LZP는 아포지단백 B의 안정성을 유지하여 간의 트리아실글리세롤 수송에 필요합니다.

Research Article

Published on 2021-02-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence AMFR ApoB Apolipoprotein B assembly Atherosclerosis Author Blood characterized cholesterol components conserved contribute decrease deficiency Degradation disease domain E3 ligase E3 ubiquitin ligase elevated Endoplasmic reticulum enhancement expressed Extracellular Fatty liver fatty liver disease function Golgi apparatus hepatic lipid hepatic steatosis homeostasis Human inhibited knowledge lipid metabolism lipoprotein Lipoproteins liver low-density Low-density lipoprotein low-density lipoproteins Metabolic diseases metabolism mice molecular NAFLD nonalcoholic fatty liver Nonalcoholic Fatty Liver Disease obesity OIT3 organ Particle physiological Prevent Protein receptor receptors Regulation required reveal secreted secretion serum shown significantly stability TG level triacylglycerol Tumor tumor suppressors variety Very Low-Density Lipoproteins VLDL zona pellucida
[DOI] 10.1371/journal.pgen.1009357 PMC 바로가기 [Article Type] Research Article

Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations

코로나19 이후 합병증 및 신경학적 징후의 특성화 및 바이오마커 분석

Article

Published on 2021-02-132022-09-11
Journal: Cells [Category] MERS, 바이오마커, 진단,

[키워드] age All participants amyloid beta analyses antibody characterization co-morbidity collected Comorbidities Complication controls CoV COVID-19 COVID-19 infection cytokine Cytokines demonstrated dysfunction Exosome explain Extracellular had more IL-4 IL6 individual Infection initial Longitudinal studies longitudinal study manifestation marker MONITOR morbidity nCoV neurodegeneration neurogranin Neuroinflammation neurologic neurological neurological problem neurological problems Neurological symptom Neurological symptoms neuronal pandemic participant Participants plasma plasma biomarker Plasma cytokine positive correlation Protein Proteins recovering from COVID-19 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 pandemic Severe infection severity significantly increased systemic effects the SARS-CoV-2 Vesicle volunteers was increased
[DOI] 10.3390/cells10020386 PMC 바로가기 [Article Type] Article

Mechanistic and Therapeutic Implications of Extracellular Vesicles as a Potential Link Between Covid-19 and Cardiovascular Disease Manifestations

Cell and Developmental Biology

Published on 2021-02-112022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] accompanied ACE2 Affect Angiogenesis biogenesis Cardiomyopathy cardiosphere-derived cell cardiovascular cardiovascular disease Cardiovascular function CD9 Cell cell entry cells circulating contribute coronavirus disease COVID–19 disease docking endocytic EVs Exosomes Extracellular extracellular vescicles fibrosis highlight infected cell information manifestation Manifestations mechanisms membrane MSC derived exosomes Particles pathological conditions physiological Potential promote RAS receptor released renin—angiotensin—aldosterone system responsible SARS-CoV-2 secretion secretory pathway Signaling stem cell Therapies transfer uninfected cells Vesicle virus
[DOI] 10.3389/fcell.2021.640723 PMC 바로가기 [Article Type] Cell and Developmental Biology

Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients

Research

Published on 2021-02-082022-11-01
Journal: Critical Care [Category] COVID-19, MERS,

[키워드] Activation anaphylatoxin antibodies Bilirubin block carboxypeptidase Carboxypeptidase B cascade CCK-8 assay Cell cell-free DNA Coagulation Coagulopathy complement component contribute COVID-19 COVID-19 patient COVID-19 patients CPB2 Critically ill patient cytotoxicity Degradation degrade demonstrated Disease progression endothelial enzyme evaluated Ex vivo Extracellular help homolog Immunofluorescent staining immunothrombosis inactive Intervention lactate dehydrogenase myeloperoxidase NET NETs neutrophil Neutrophil extracellular trap pathological role plasma prevalent Prevent proinflammatory mediators recruited Regulation Result risk of death thrombosis thrombotic event total bilirubin Vascular vascular endothelial cell with COVID-19
[DOI] 10.1186/s13054-021-03482-z PMC 바로가기 [Article Type] Research

Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines

Review

Published on 2021-02-022022-10-28
Journal: Pharmaceutics [Category] COVID-19,

Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19

호중구 세포외 트랩의 순환 마커는 COVID-19 환자에서 예후 가치가 있습니다

Article

Published on 2021-02-012022-09-11
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] MERS, 바이오마커,

[키워드] acute respiratory distress acute respiratory distress syndrome association Asymptomatic Blood cells C-reactive protein cell-free DNA characterized circulating Clinical outcome Coagulation convalescent plasma coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 disease COVID-19 disease severity Cytokines declined Disease progression disease severity elevated endothelial damage enrolled evaluate Evidence Extracellular extracellular traps fibrinolysis healthy controls healthy individual healthy individuals histone Hospital admission hyperinflammation immunothrombosis in healthy individual in vivo Infection Inflammation Inflammatory cytokines marker moderate moderate to severe Mortality NET NETs neutrophil Neutrophil elastase Neutrophil extracellular trap Neutrophils pathogenic mechanism pathogenic mechanisms patients with COVID-19 plasma plasma sample plasma samples Post-infection progression respiratory respiratory distress Respiratory distress syndrome Respiratory Support SARS-CoV2 severe disease syndrome target targets therapeutic intervention thrombosis thrombotic thrombotic microangiopathy TRAP value were assessed White blood cells with COVID-19
[DOI] 10.1161/ATVBAHA.120.315267 PMC 바로가기 [Article Type] Article

Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model

마우스 모델에서 SARS-CoV-2 스파이크 단백질에 의해 유도된 사이토카인 시그니처

Immunology

Published on 2021-01-282022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory distress acute respiratory distress syndrome Adenovirus alveolitis angiotensin Angiotensin-converting enzyme ARDS BALB/c mice BALF Bronchoalveolar lavage fluid change Clinical use colony-stimulating factor Combination contribute COVID-19 COVID-19 patient CSS cytokine Cytokine storm Cytokine storm syndrome Cytokines domain drugs effective enzyme Extracellular global health GM-CSF granulocyte granulocyte-macrophage colony-stimulating factor Health Human angiotensin-converting enzyme 2 IL-1α IL-6 IL-6 inhibitor immunostimulant indicated induced Inflammatory cytokines inhibitor inhibitors Injury interleukin interleukin 6 interleukin 6 (IL-6 investigated Jak lead lung Lung injury mAb mAbs magnetic resonance imaging mechanism Model monoclonal antibodies monoclonal antibody mortalities mouse murine model myeloperoxidase Neutralizing neutrophilic Occurrence opens phenotype polyinosinic-polycytidylic acid pro-inflammatory Protein reduced respiratory distress Respiratory distress syndrome resulting Safe SARS-CoV-2 signature spike syndrome the cytokine storm therapeutic TNF-α Tocilizumab Treatment wild-type
[DOI] 10.3389/fimmu.2020.621441 PMC 바로가기 [Article Type] Immunology

A New SARS-CoV-2 Dual-Purpose Serology Test: Highly Accurate Infection Tracing and Neutralizing Antibody Response Detection

새로운 SARS-CoV-2 이중 목적 혈청 검사: 매우 정확한 감염 추적 및 중화 항체 반응 검출

Virology

Published on 2021-01-262022-09-10
Journal: Journal of Clinical Microbiology [Category] SARS, 진단, 치료기술,

[키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin antibodies antibody coronavirus detect detection domain Donor eight ELISA expected Extracellular hACE2 human Angiotensin-converting enzyme individual Interaction less neutralization test neutralization tests Neutralizing Neutralizing antibodies New patients positive purified RBD receptor Receptor binding domain Reinfection respiratory response SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 immunity SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain serology serology test serology tests Spike protein Support Surveillance sVNT tracing vaccinated individual vaccinated individuals Vaccines virus neutralization test
[DOI] 10.1128/JCM.02438-20 PMC 바로가기 [Article Type] Virology

Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence

신호 전달 경로 내 및 사이의 다면발광 및 상위성은 진균 독성의 유전적 구조를 정의합니다

Research Article

Published on 2021-01-252022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Affect amphotericin B Analysis antifungal drug resistance approach Author avirulent body temperature CAMP cascade Cell Cell signaling cellular cellular response Cellular responses characterization Combination complex component contribute cross Cryptococcal disease Cryptococcus cyclic AMP disease drug susceptibility drugs ENCODE epistatic interaction Europe Extracellular fungal Genes Genetic genetic architecture genetic difference genetic differences Genetic variation glycerol growth highlight human body Infection information isolate kinase Lineage locus make up mapping microbial modify molecular nucleotide osmolarity osmotic oxidative oxidative stress oxidative stress resistance pathogen pathogenicity Pathogens pathway phenotypic phenotypic variation physiological response pleiotropic polysaccharide capsule progeny promote protein kinase QTL Quantitative quantitative trait locus regulate regulator sensitivity Signal transduction Signaling signaling pathway strain Strains Stress temperate climates thought Tolerance traits underlie Variation virulence virulent
[DOI] 10.1371/journal.pgen.1009313 PMC 바로가기 [Article Type] Research Article