failure – Page 16 – Communicable Diseases Research

SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil

Research Article

Published on 2021-07-312022-10-28
Journal: BMC Infectious Diseases [Category] COVID-19, SARS,

Prone Positioning Is Safe and May Reduce the Rate of Intubation in Selected COVID-19 Patients Receiving High-Flow Nasal Oxygen Therapy

Article

Published on 2021-07-302022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Antibody responses after first and second Covid-19 vaccination in patients with chronic lymphocytic leukaemia

만성 림프구 백혈병 환자에서 제 1 및 제 2 코비드 -19 백신 접종 후 항체 반응

Clinical Trial

Published on 2021-07-302022-08-09
Journal: Blood Cancer Journal [Category] 임상, 진단,

[키워드] Adaptive immunity Antibody Response Antibody responses Antibody titre antibody titres B-cell blood sample Blood samples BNT162b2 BNT162b2 mRNA vaccine booster vaccines BTK inhibitor BTK inhibitors ChAdOx1 Chronic lymphocytic leukaemia clinical risk CLL COVID-19 vaccines detectable dried blood spot Dried blood spots extended interval failure Filter Paper generate healthy donor healthy donors IgA deficiency Immunosuppression Multivariate analysis offer Patient profile remained SARS-COV-2 infection second vaccination Severe infection spike-specific antibody response Spike-specific antibody responses Support the antibody response the patient titre titres Translational research Treatment utility vaccination Vaccination strategy Vaccine venepuncture
[DOI] 10.1038/s41408-021-00528-x PMC 바로가기 [Article Type] Clinical Trial

The Value of Interleukin-6 among Several Inflammatory Markers as a Predictor of Respiratory Failure in COVID-19 Patients

Article

Published on 2021-07-232022-10-31
Journal: Diagnostics [Category] COVID-19,

Biophysical properties of the isolated spike protein binding helix of human ACE2

인간 ACE2의 분리된 스파이크 단백질 결합 나선의 생물물리학적 특성

Article

Published on 2021-07-202022-09-11
Journal: Biophysical Journal [Category] SARS, 변종, 치료기술,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Alanine angiotensin binding binding affinity Concentration coronavirus F28 Factor failure Fluorescence correlation spectroscopy high affinity human ACE2 human Angiotensin-converting enzyme human cell human cells hydrophobic hydrophobic residue hydrophobic residues interact lack much lower mutant oligomerization peptide promoter receptor Receptor-binding domain reduce reduced severe acute respiratory syndrome Coronavirus solubility Spike protein the receptor-binding domain the spike protein viral spike protein virus virus detection without affecting β-sheet
[DOI] 10.1016/j.bpj.2021.06.017 PMC 바로가기 [Article Type] Article

Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques

아급성 SARS-CoV-2 복제는 시노몰구스 원숭이에 CD8+ T 세포가 없을 때 제어할 수 있습니다.

Research Article

Published on 2021-07-192022-09-10
Journal: PLoS Pathogens [Category] SARS, 진단, 치료기술,

[키워드] absence administration Analysis anti-CD8 antibody Antibody titers Arm Asymptomatic CD8 Cell clinical manifestation clinical manifestations comparable contribute convalescent individuals cynomolgus macaques days post-infection deficiency determinant determinants effectors eight examined failure fatal disease FIVE functional immune in viral Infection inoculated intranasally Kinetics lead Lymph node macaque macaques monoclonal Nasopharyngeal swab nasopharyngeal swabs necropsy Neutralizing antibody titer pharyngeal mucosa Pharyngeal swab plasma Post-infection progression Respiratory failure retropharyngeal lymph node RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 RNA Subacute T cell T cells T-cell dysfunction T-cell Response T-cell responses TCID treated undetectable Viral viral control viral replication Viral RNA
[DOI] 10.1371/journal.ppat.1009668 PMC 바로가기 [Article Type] Research Article

Endemic SARS-CoV-2 Polymorphisms Can Cause a Higher Diagnostic Target Failure Rate than Estimated by Aggregate Global Sequencing Data

고유의 SARS-CoV-2 다형성은 종합적인 글로벌 시퀀싱 데이터로 추정한 것보다 더 높은 진단 대상 실패율을 유발할 수 있습니다.

Article

Published on 2021-07-192022-09-11
Journal: Journal of Clinical Microbiology [Category] SARS, 변종, 치료법,

[키워드] Abstract Can cause Estimated failure Mutation nucleocapsid Nucleocapsid gene PCR Rate SARS-CoV-2 target variant
[DOI] 10.1128/JCM.00913-21 PMC 바로가기 [Article Type] Article

Clofazimine for Treatment of Cryptosporidiosis in Human Immunodeficiency Virus Infected Adults: An Experimental Medicine, Randomized, Double-blind, Placebo-controlled Phase 2a Trial

인간 면역 결핍 바이러스 감염된 성인에서 cryptosporidiosis의 치료를위한 clofazimine : 실험 의학, 무작위, 이중 맹검, 위약 대조 2A 시험

Major Articles and Commentaries

Published on 2021-07-152022-09-06
Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease,

[키워드] abdominal pain according to protocol adverse effect Analysis antiretroviral ARV ARV therapy ATP blueprint CD4 counts CFZ clinical Clofazimine controls cryptosporidiosis cryptosporidium diarrhea diarrheal did not reduce died double-blind drug Efficacy evaluated failure form HIV HIV population Human Human immunodeficiency virus identify Immunocompromised immunodeficiency virus individual Infection limit malaise Medicine outcome over Part participant pathway Patient performed pharmacokinetics phase Placebo placebo group placebo-controlled study Plasma level Plasma levels primary analysis Primary outcomes Randomized randomized, double-blind, placebo-controlled study reduction in Registration Result Screening Stool Support the placebo group therapeutic therapeutic potential therapy treated Treatment Trial trials Viral Viral load with HIV
[DOI] 10.1093/cid/ciaa421 PMC 바로가기 [Article Type] Major Articles and Commentaries

COVID-19: Failure of the DisCoVeRy Clinical Trial, and Now–New Hopes?

Opinion

Published on 2021-07-112022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

High Mobility Group Box 1 and Interleukin 6 at Intensive Care Unit Admission as Biomarkers in Critically Ill COVID-19 Patients

중환자 단위에서 고도리 그룹 박스 1 및 인터루킨 6은 중환자 실에 입원하여 중환자가 아픈 Covid-19 환자에서 바이오 마커로

Articles

Published on 2021-07-032022-09-10
Journal: The American Journal of Tropical Medicine and Hygi [Category] SARS, 바이오마커,

[키워드] “cytokine storm” Accuracy Acute kidney injury Admission age Analysis analyzed assessment Biomarkers Box C-reactive protein Comorbidities Comorbidity comparable coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patients COVID-GRAM Critically ill critically ill COVID-19 patients Cytokine storm D-dimer levels discharge elevated enrolled Exuberant failure Gender group healthy control HMGB1 ICU ICU admission ICU patient IL-6 IL-6 level IL-6 levels IL6 Ill Inflammation intensive care intensive care unit interleukin interleukin 6 interleukin-6 investigated Mobility Mortality neutrophil nonsurvivor PaO Pathogenesis Patient plasma Plasma HMGB1 Plasma levels poor oxygenation predicted prognostic prognostic biomarker Prognostic biomarkers Prognostic markers prospective cohort study risk Septic shock severe coronavirus disease severe COVID-19 SOFA SOFA score suggested Survivors Ventilation with COVID-19
[DOI] 10.4269/ajtmh.21-0165 PMC 바로가기 [Article Type] Articles