Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C가와사키병 및 MIS-C 환자에서 정맥 면역글로불린에 대한 면역 반응Article Published on 2021-10-152022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, 진단, [키워드] Academy activated Activation acute respiratory syndrome Apoptosis blockade caspase cell death cellular children circulation clinical feature coronavirus COVID-19 Cytometry disease Effect examined expressing flow cytometry foundation heart IL-1 IL-1β Inflammatory Innate innate immune system Innate immunity Intravenous immunoglobulin Kawasaki disease leukocyte population mechanism of action MIS-C NADPH oxidase neutrophil Neutrophils Patient Peripheral blood PI3K reduced robust SARS-CoV-2 signaling pathway syndrome therapy Treatment [DOI] 10.1172/JCI147076 PMC 바로가기 [Article Type] Article
Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells인간 PSC 유래 심근세포 및 1차 내피 세포에서 항고혈압 약물 치료 및 SARS-CoV-2 감염에 대한 감수성Article Published on 2021-10-122022-09-11 Journal: Stem Cell Reports [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACEi acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter angiotensin angiotensin receptor blocker angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor Antihypertensive drug antihypertensive medication ARB Cell cell type Coronavirus-2 COVID-19 drug treatment endothelial Endothelial cell endothelial cells Enzyme inhibitor heart hPSC-derived cardiomyocytes Immunity interferon involved Lisinopril losartan MAPK medications membrane-bound mitogen mitogen-activated protein kinase modulate multicenter trials Necrosis NF-κB not affect nuclear pathogenicity Pathways Protein protein coding gene protein coding genes protein kinase receptor receptor blocker RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 signaling pathways significant difference significant differences stem cells susceptibility therapy TNF toxic effect toxic effects Transcriptome transcriptome change transcriptome changes Treatment Tumor tumor necrosis tumor necrosis factor [DOI] 10.1016/j.stemcr.2021.08.018 PMC 바로가기 [Article Type] Article
Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2Articles Published on 2021-10-012022-10-30 Journal: The Lancet. Child & adolescent health [Category] COVID-19, MERS, SARS, [키워드] 1:1 age analysed Analysis Anosmia approach artificial Asymptomatic cause Characteristics children children with COVID-19 Cohort college Council COVID COVID-19 Department determine Engineering Epidemiological study fatigue finding foundation funding Gender greater groups headache heart illness illness duration illness onset imaging Innovation intelligence IQR King Limited London median Medical Research Council mild illness Older pandemic participant persistent positive Prevalence prospective cohort study reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test Science short duration Society Spearman Symptom symptom burden symptomatic Symptoms tested value Wellcome Trust were assessed were excluded [DOI] 10.1016/S2352-4642(21)00198-X PMC 바로가기 [Article Type] Articles
Multiparameter diagnostic sensor measurements in heart failure patients presenting with SARS-CoV-2 infectionSARS-CoV-2 감염이 있는 심부전 환자의 다중 매개변수 진단 센서 측정Article Published on 2021-10-012022-09-11 Journal: ESC heart failure [Category] SARS, 치료기술, [키워드] ambulatory Ambulatory monitoring amplitude change changed changes in COVID-19 CRT diagnostic diagnostics Early detection extreme greater heart heart failure heart rate Heart sound heart sounds Hospitalization hospitalizations ICD Implantable device increase in marker occur parameter Patient Pneumonia predict presenting respiratory rate Retrospective analysis SARS-CoV-2 SARS-COV-2 infection shallow breathing shown significant changes in sustained temperature Thoracic trials Ventilation worsening [DOI] 10.1002/ehf2.13500 PMC 바로가기 [Article Type] Article
Use of Hydroxychloroquine, Remdesivir, and Dexamethasone Among Adults Hospitalized With COVID-19 in the United States : A Retrospective Cohort Study미국에서 COVID-19로 입원한 성인의 Hydroxychloroquine, Remdesivir 및 Dexamethasone 사용 : 후향적 코호트 연구Multicenter Study Published on 2021-10-012022-09-11 Journal: Annals of internal medicine [Category] SARS, 치료제, [키워드] adults hospitalized Advancing aging Care case mix center Cohort cohort study Community COVID COVID-19 COVID-19 therapy declining Dexamethasone Glucocorticoids gradually increased health center health system health systems heart Hospitalized hospitals Hydroxychloroquine individuals Inpatient Intraclass correlation coefficient Invasive mechanical ventilation lung mechanically ventilated multicenter Patient peaking pharmacologic treatment Randomised Evaluation recovery Remdesivir retrospective cohort study study period the United State The United States Treatment treatment protocols Trial United States use of hydroxychloroquine Variation with COVID-19 [DOI] 10.7326/M21-0857 PMC 바로가기 [Article Type] Multicenter Study
Leveraging publicly available coronavirus data to identify new therapeutic targets for COVID-19COVID-19에 대한 새로운 치료 목표를 식별하기 위해 공개적으로 사용 가능한 코로나 바이러스 데이터를 활용Research Article Published on 2021-09-292022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Analysis Antiviral Asymptomatic Bioinformatic bioinformatic analysis Brain coronavirus Coronavirus-2 COVID-19 dataset disease disease susceptibility dysfunction Effects Evidence evidence of facilitate Factor Gut heart Host identify immune immune surveillance include individuals Innate immunity interferon liver long-lasting Loss of Smell lung mechanism MERS-CoV outbreak promotion question representing respiratory responsible SARS-CoV-1 SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus subversion Surveillance susceptibility therapeutic target Variability Vascular Viral viral pathogen viral replication [DOI] 10.1371/journal.pone.0257965 PMC 바로가기 [Article Type] Research Article
Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues비만 및 케톤 생성 식단은 쥐의 폐와 심장 조직에서 SARS-CoV-2 진입 단백질 ACE2 및 TMPRSS2와 레닌-안지오텐신 시스템을 뚜렷하게 조절합니다Article Published on 2021-09-252022-09-10 Journal: Nutrients [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 Affect Alter angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-inflammatory effect attenuate components diet elevated enzyme Gene Expression heart hearts IL6 increase individuals Inflammation inflammatory gene inflammatory genes interleukin-6 interleukin-6 receptor ketogenic Ketogenic diet Ketogenic Diets ketones lung lung tissues Lungs MasR mechanism Migration obese obesity obesogenic outcomes protease Protein RAS RAT Renin renin-angiotensin system SARS-CoV-2 SARS-CoV-2 entry Serine serine 2 severity Severity of infection sucrose System tested the SARS-CoV-2 tissues TLR4 TMPRSS2 TMPRSS2 level TMPRSS2 levels TNF-alpha Toll-like receptor toll-like receptor 4 transmembrane transmembrane protease serine 2 Viral viral entry were measured [DOI] 10.3390/nu13103357 PMC 바로가기 [Article Type] Article
The Effects of Physical Inactivity and Exercise at Home in Young Patients with Congenital Heart Disease during the COVID-19 PandemicArticle Published on 2021-09-252022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] BMI carried CHD concerning congenital congenital heart disease COVID-19 COVID-19 mitigation measure COVID-19 pandemic decrease disease Effect effective Effects enrolled exercise Exercise training heart home hospital less lockdown material pandemic parameter Patient performed physical activity physically questionnaire risk RPA significant increase significantly Stress subject Tolerance [DOI] 10.3390/ijerph181910065 PMC 바로가기 [Article Type] Article
Vaccination for Respiratory Infections in Patients with Heart FailureReview Published on 2021-09-222022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Adverse Bronchopulmonary cardiac effect Cardiology cardiovascular disease Cardiovascular events concerning Coverage COVID-19 COVID-19 vaccine Efficacy evaluate evaluated failure French Health heart heart failure Hospitalization implementation IMPROVE Infection Inflammation Inflammatory Influenza influenza infections influenza vaccine knowledge multicenter National Nurses pathophysiology Patient patients pneumococcal pneumococcal infection pneumococcal vaccine protective effect randomized clinical trial recommendation respiratory Respiratory disease respiratory infection respiratory infections review article Society Streptococcus pneumoniae Thrombotic events vaccination vaccination against COVID-19 vaccination coverage Vaccinations Vaccine [DOI] 10.3390/jcm10194311 PMC 바로가기 [Article Type] Review
The Association between Nutritional Status and In-Hospital Mortality of COVID-19 in Critically-Ill Patients in the ICUArticle Published on 2021-09-222022-10-31 Journal: Nutrients [Category] COVID-19, SARS, [키워드] Admission affected age analysed being BMI body mass index cause clinical conducted Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill Critically ill patient death death rate died Factor failure heart higher risk hypertension ICU in-hospital mortality include increase increased mortality intensive care intensive care unit Invasive mechanical ventilation Malnutrition medical record men nonsurvivor nutritional status obese Older parameter Patient PCT Poland Potassium procalcitonin Retrospective study risk risk of death SARS-CoV-2 significantly significantly higher statistically status university [DOI] 10.3390/nu13103302 PMC 바로가기 [Article Type] Article