Computational Simulation of HIV Protease Inhibitors to the Main Protease (Mpro) of SARS-CoV-2: Implications for COVID-19 Drugs DesignSARS-COV-2의 주요 프로테아제 (MPRO)에 대한 HIV 프로테아제 억제제의 계산 시뮬레이션 : COVID-19 약물 설계에 대한 시사점Article Published on 2021-12-052022-08-31 Journal: Molecules [Category] 신약개발, 치료제, [키워드] amino acids Analysis anti-SARS-CoV-2 antiviral drug applied aromatic ring binding affinities binding affinity catalytic coronavirus disease Coronavirus disease 2019 COVID-19 darunavir docking Donor drug drug target experiment His41 HIV HIV protease inhibitor HIV-1 protease inhibitor homologous hydrogen Hydrogen bond hydrophobic inhibiting inhibitors inhibitory effect Inhibitory effects Interaction key amino acid Lopinavir LPV main protease (Mpro) mechanism mechanism of action molecular molecular dynamics molecular dynamics (MD) simulation MPro nelfinavir nonspecific pharmacophore protease Replication replication of SARS-CoV-2 residue ribavirin RTV SARS-CoV SARS-CoV-2 SARS-CoV-2 Mpro Simulation Treatment treatment of COVID-19 [DOI] 10.3390/molecules26237385 PMC 바로가기 [Article Type] Article
Reactogenicity and Immunogenicity of the Pfizer and AstraZeneca COVID-19 Vaccines화이자 및 아스트라제네카 코로나19 백신의 반응원성과 면역원성Immunology Published on 2021-12-012022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus age antibody AstraZeneca collected Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 vaccine cross-sectional cross-sectional study Effectiveness ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Factor groups Health status Height homologous humoral immune response IgG antibodies immunogenicity injection injection site participant Participants Pfizer proportion Randomly reactogenicity receipt recipient recipients reported respiratory Result SARS-CoV-2 SARS-CoV-2 spike protein Saudi Arabia selected Seropositivity Side effect significantly higher specific IgG antibodies Spike protein spike-specific IgG antibodies Spike-specific IgG antibody Symptom the SARS-CoV-2 total score vaccination Vaccine vaccine dose vaccine doses Vaccines weight women [DOI] 10.3389/fimmu.2021.794642 PMC 바로가기 [Article Type] Immunology
Cellular immunity predominates over humoral immunity after homologous and heterologous mRNA and vector-based COVID-19 vaccine regimens in solid organ transplant recipients고형 장기 이식 환자에서 동종 및 이종 mRNA 및 벡터 기반 COVID-19 백신 요법 후 체액성 면역보다 세포 면역이 우세합니다.Article Published on 2021-12-012022-09-11 Journal: American journal of transplantation : official jou [Category] SARS, 진단, 치료기술, [키워드] Analysis analyzed antibody CD4 CD4 and CD8 T cells CD4 T cells CD8 T cell CD8 T cells Cell Biology cellular immunity clinical research/practice Control correlated COVID-19 vaccine ELISA first vaccination flow cytometry Heterologous heterologous vaccine homologous homologous or heterologous humoral humoral and cellular immunity Humoral immunity identify IgG Immunity immunocompromised individuals immunogenicity IMPROVE Infection infection and infectious agents - viral infectious agent infectious agents Infectious disease mRNA mRNA-vaccine mRNA-vaccines Neutralization assay Neutralizing activity patients plasmablast plasmablasts priming quantified recipient recipients regimen regimens Responder responders SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody SARS-CoV-2-specific IgG SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells second vaccination significantly higher solid organ solid organ transplant Specific specific antibodies T cell T cell biology T cells vaccination Vaccine while [DOI] 10.1111/ajt.16818 PMC 바로가기 [Article Type] Article
A Systematic Review on COVID-19 Vaccine Strategies, Their Effectiveness, and IssuesSystematic Review Published on 2021-11-242022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adverse events clinical trials COVID-19 COVID-19 vaccine COVID-19 vaccines Dexamethasone dose drug Effectiveness Efficacy Emergency use authorization European Medicines Agency events food Google Scholar Heterologous homologous inactivated Inactivated Vaccines issue limitations Medicine morbidity and mortality Mortality mRNA vaccine mRNA vaccines mRNA-based nanoparticle-based vaccines pandemic prime-booster strategy recombinant vaccines reducing reported review rising SARS-CoV-2 selected Seroconversion Side effect Side effects Surveillance systematic review Vaccine vaccine candidate Vaccines variant [DOI] 10.3390/vaccines9121387 PMC 바로가기 [Article Type] Systematic Review
Immunogenicity and reactogenicity of BNT162b2 booster in BBIBP-CorV-vaccinated individuals compared with homologous BNT162b2 vaccination: Results of a pilot prospective cohort study from Lebanon상동 BNT162b2 백신과 비교하여 BBIBP-CorV 백신을 접종한 개인에서 BNT162b2 부스터의 면역원성 및 반응성: 레바논의 파일럿 전향 코호트 연구 결과Article Published on 2021-11-052022-09-11 Journal: Vaccine [Category] SARS, 변종, [키워드] 95%CI Administered anti-Spike IgG BBIBP-CorV BNT162b2 booster booster dose booster vaccination ChAdOx1 ChAdOx1-S Combination conducted country COVID-19 dose Effectiveness elicited General Hospital geometric mean geometric mean titer heterologous immunization homologous Homologous immunization immunization immunogenicity individual Lebanon. mRNA vaccine mRNA vaccines of BNT162b2 overcome Population prospective cohort study reactogenicity Result Safe significantly tested the vaccine vaccination Vaccine variants [DOI] 10.1016/j.vaccine.2021.10.007 PMC 바로가기 [Article Type] Article
Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8 + T cell responses in HLA-A transgenic miceArticle Published on 2021-11-022022-10-04 Journal: Cellular and Molecular Immunology [Category] SARS, 치료제, [키워드] 229E acute respiratory syndrome addition Amino acid Antimicrobial responses Antiviral Asian binding CD8 Cell cell line Combination coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients elicited epitope Epitopes experiment expressing facilitate feasibility functional generate healthy donor HKU1 HLA-A homologous Host immune protection in silico in vivo indicated induce mice nine NL63 OC43 pathology Patient PBMC peptide Peptide vaccines populations predicted prevalent provided RdRp protein Research response robust SARS-CoV SARS-CoV-2 SARS-CoV-2 variants Screening T cell T cell epitope T cell response T cell responses the S protein transgenic mice vaccination Vaccine were used wild-type [DOI] 10.1038/s41423-021-00784-8 PMC 바로가기 [Article Type] Article
Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort studyChAdOx1 nCoV-19 및 BNT162b2를 사용한 동종 및 이종 프라임-부스트 면역의 안전성, 반응성 및 면역원성: 전향적 코호트 연구Observational Study Published on 2021-11-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] MERS, SARS, 변종, 임상, 진단, [키워드] 95% CI Alpha anti-RBD Anti-RBD IgG Anti-S1 AstraZeneca B.1.1.7 B.1.351 Berlin Beta Beta variant beta variants binding BNT162b2 boost booster Cambridge ChAdOx1 ChAdOx1 nCoV-19 Concentration COVID-19 COVID-19 vaccines Cutoff dose education enrolled geometric mean Germany health-care Heterologous heterologous prime-boost highest homologous IFN-γ IgG levels immunisation immunogenicity IMPROVE inhibitory interim analysis IQR Mainz median mitigate neutralisation test participant Pfizer-BioNTech prospective cohort study prospective observational cohort pseudovirus neutralisation assay questionnaire RBD IgG RBD-ACE2 reactivity reactogenicity receiving recipient recipients regimen reported Safety SARS-CoV-2 S1 SARS-CoV-2 virus SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody second vaccination specific antibodies supply shortage Symptom systemic systemic symptoms T-cell vaccination Vaccine variants of concern was measured [DOI] 10.1016/S2213-2600(21)00357-X PMC 바로가기 [Article Type] Observational Study
Safety and cross-variant immunogenicity of a three-dose COVID-19 mRNA vaccine regimen in kidney transplant recipients신장 이식 수혜자에서 3회 접종 COVID-19 mRNA 백신 요법의 안전성 및 교차 변이 면역원성Article Published on 2021-11-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, [키워드] anti-Spike IgG antibody Antigen BNT162b2 BNT162b2 vaccine Cell cells cellular response Cellular responses COVID-19 COVID-19 vaccine cytokine cytokine production delta variant dose doses explained Frequency Heterologous homologous IFN-γ IFN-γ response IFN-γ responses IgG immunogenicity immunosuppressive immunosuppressive therapy increase interferon kidney Kidney function kidney transplant kidney transplant recipient longitudinal study Mild mRNA mRNA vaccine neutralization activity Neutralizing activity neutralizing antibody Nice University Hospital one patient Patient PBMC PBMCs performed raised reaction Reactions recipient recipients regimen remained Safety second dose Seroconversion seronegative significant increase spike-specific IgG tested therapy Tolerability university Vaccine variants variants of concern variants of concern, kidney transplantation. [DOI] 10.1016/j.ebiom.2021.103679 PMC 바로가기 [Article Type] Article
Ezrin Peptide Therapy from HIV to COVID: Inhibition of Inflammation and Amplification of Adaptive Anti-Viral ImmunityHIV에서 COVID로의 Ezrin Peptide Therapy: 염증 억제 및 적응형 항바이러스 면역의 증폭Review Published on 2021-10-282022-09-10 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] accompanied activate adaptive adjuvant adjuvants Administered amino acids Anti-viral immunity antibody antibody titres B cell candidiasis chronic diarrhea Clinical studies clinical study Colon COVID Cytokines derivative diarrhea disappearance disease domain duodenum dysregulation effective ENhance enhancer enhancers Enterocolitis expression ezrin ezrin peptides FIVE gp120 HCV herpes herpes zoster HIV HIV-infected patients homologous HPV Human human respiratory viruses IL-6 immune responses Immunity Inflammation inflammatory complications Inflammatory cytokines Influenza Inhaled inhibition inhibitor inhibitors innate immune response innate immune responses mice Microbiome middle Mild-to-moderate mucosal Mutation normalization opportunistic infection opportunistic Infections outbreak peptide peptides Placebo Prevent produced Protein randomised receptor Registered replicated respiratory respiratory viruses resulting Russia SARS-CoV-2 SARS-COV-2 infection shown stomach synthetic synthetic peptides T cell therapy tissue repair treat Treatment ulceration vaccination Viral viral respiratory virus virus infection viruses Volunteer [DOI] 10.3390/ijms222111688 PMC 바로가기 [Article Type] Review
Forced association of SARS-CoV-2 proteins with the yeast proteome perturb vesicle traffickingResearch Article Published on 2021-10-272022-10-30 Journal: Microbial Cell [Category] COVID-19, [키워드] acute respiratory syndrome affected association complex conserved coronavirus coronavirus disease COVID-19 COVID-19 drug target ectopic Extensive Forced function growth homologous Host identify infect mammalian cells membrane nsp1 overlap pathway Patient performed Protein proteome recruit Research SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins Support synthetic synthetic physical interactions the SARS-CoV-2 Transcription Vesicle vesicle trafficking viral infection Viral protein Viral proteins yeast [DOI] 10.15698/mic2021.12.766 PMC 바로가기 [Article Type] Research Article