Prognostic Impact of Acute Cardiovascular Events in COVID-19 Hospitalized Patients—Results from the CORONA Germany StudyArticle Published on 2021-09-022022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute cardiovascular event arrhythmia Atrial fibrillation Biomarker cardiac troponin Cardiopulmonary cardiovascular cardiovascular disease clinically cohort study conducted coronary syndrome coronavirus coronavirus disease COVID-19 COVID-19 patient defined elevated Elevation Endpoint epidemiological event Germany Hamburg hospital hospitalized COVID-19 patients Impact increased mortality Mortality multicenter myocardial injury myocarditis occurred Occurrence outcome Patient Potassium Shock stroke thrombosis troponin [DOI] 10.3390/jcm10173982 PMC 바로가기 [Article Type] Article
A Systematic Review and a Meta-Analysis Comparing Prophylactic and Therapeutic Low Molecular Weight Heparins for Mortality Reduction in 32,688 COVID-19 PatientsPharmacology Published on 2021-09-022022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 95% CI 95% confidence interval Activation all-cause mortality anticoagulation bleeding coronavirus disease COVID-19 COVID-19 patients dose effective Effectiveness Efficacy Endpoint evaluated hazard heparin heparin treatment heparins higher risk Hospital stay hospitalized COVID-19 patients increased risk LMWH LOS low molecular weight major bleeding Meta-analysis Mortality no difference Observational cohort study Patient patients performed potential therapy Prophylactic prophylactic dose Randomized controlled trial Ratio RCT reduced reducing mortality Registration reported review SARS-CoV2 secondary subgroup analysis systematic review therapeutic dose Thromboembolism Treatment unfractionated heparin was performed weight [DOI] 10.3389/fphar.2021.698008 PMC 바로가기 [Article Type] Pharmacology
The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen MetabolismArticle Published on 2021-09-022022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] affecting alteration amino acid metabolism Analysis carbon Cohort complex coronavirus COVID-19 COVID-19 patient deaths disease severity dysregulation form hospitalized COVID-19 patients include Infection involved Involving lactic acid liver mass spectrometry metabolic pathway metabolism metabolome metabolomic analysis metabolomics Mild moderate nitrogen pandemic pathophysiology progression SARS-CoV-2 SARS-CoV-2 coronavirus serum serum cytokines Serum level Spread systemic effect the disease Variation [DOI] 10.3390/ijms22179548 PMC 바로가기 [Article Type] Article
Cytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 Cohort입원한 페루 COVID-19 코호트에서 더 나쁜 예후와 관련된 사이토카인 프로필Immunology Published on 2021-09-012022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단, [키워드] 95% confidence interval 95%CI activated adaptive analyses Analysis analyzed anti-Spike IgG anti-spike IgG antibodies Anti-spike IgG antibody antibody concentration baseline Biomarker Biomarkers C-reactive protein chemokine chemokines clinical parameter Clinical parameters Cohort Concentration correlated COVID-19 COVID-19 patient creatinine criteria CRP cytokine Cytokines D-dimer D-dimer levels death determine died discharge disease severity e parameters ELISA enrolled evaluated exacerbated expression expression profile fatal COVID-19 form Frequency GM-CSF groups growth factor Growth factors hazard ratio hemoglobin hospital Hospitalization Hospitalized hospitalized COVID-19 patients identify IL-10 IL-12p70 IL-15 IL-5 IL-6 IL-8 IL1RA Immune cell immune cells Inflammation laboratory-confirmed Laboratory-confirmed COVID-19 Logistic regression longitudinal longitudinal analysis longitudinal samples lymphocyte Lymphocytes MCP-1 MIP-1α moderate disease Mortality multivariable analysis Neutrophils obesity outcome outcomes parameter Patient patient information patients with moderate Peripheral blood pro-inflammatory cytokines profile Prognosis proinflammatory Protein Quantitative Result risk factor SARS-CoV-2 IgG SARS-CoV-2 infected patient SARS-CoV-2 infected patients SARS-COV-2 infection sera severe disease severity Significant significant difference significant differences spike IgG Stratification TNFα worse prognosis [DOI] 10.3389/fimmu.2021.700921 PMC 바로가기 [Article Type] Immunology
Timing of corticosteroids impacts mortality in hospitalized COVID-19 patientsObservational Study Published on 2021-09-012022-10-04 Journal: Internal and Emergency Medicine [Category] 임상, [키워드] 95% CI absence Admission Analysis analyzed benefit collected coronavirus Corticosteroid corticosteroid therapy corticosteroid treatment Corticosteroids COVID-19 COVID-19 patients death demographic evaluated first dose group Hospitalization Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient Impact in-hospital mortality initial initiated Invasive mechanical ventilation Laboratory lower risk mechanically ventilated patient Mortality multivariable Oxygen therapy Patient patients receiving oxygen quantified receiving reduced risk Regression analyses requiring supplemental oxygen symptom onset the patient the timing therapy time time interval Timing Treatment variable was related [DOI] 10.1007/s11739-021-02655-6 PMC 바로가기 [Article Type] Observational Study
Pathogenic lipid-binding antiphospholipid antibodies are associated with severity of COVID-19병원성 지질 결합 항인지질 항체는 COVID-19의 중증도와 관련이 있습니다Article Published on 2021-09-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 진단, 치료기술, 치료제, [키워드] accelerate analyzed antibody antiphospholipid antibodies antiphospholipid antibody association Blood Blood coagulation blood coagulation disorder C-reactive protein catastrophic Cell Clinical course Clinical severity Coagulation coagulation disorder Coagulopathy Cohort complex Concentration coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patient COVID-19 patients Critical D-dimer dependent on described detectable dimer disease severity endothelial endothelial cells endothelial protein C receptor EPCR expand hallmark Hospitalized hospitalized COVID-19 patients IgG induce Infection Inflammation inflammatory effects Inflammatory response Lipid manifestation marker median Microvascular thrombosis monocyte Monocytes Mortality outcome pathogenic Patient poor prognosis producing Protein protein C prothrombotic prothrombotic syndrome receptor respiratory secreting Severe acute respiratory syndrome severity of COVID-19 signaling pathway single center stroke syndrome thrombosis thrombotic Thrombus thrombus formation venous [DOI] 10.1111/jth.15455 PMC 바로가기 [Article Type] Article
Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, IndiaExpedited Published on 2021-09-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] Admission Amphotericin conducted coronavirus coronavirus disease COVID-19 COVID-19 pandemic diabetes Diabetes Mellitus Epidemiology evaluate fungi glucocorticoid hospitalized COVID-19 patients Hypoxemia increased mortality increases in India intensive care isavuconazole Mucormycosis multicenter outcome patients Posaconazole Prevalence respiratory infections Retrospective study SARS SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 study period survival Treatment uncontrolled underlying disease viruses zoonoses [DOI] 10.3201/eid2709.210934 PMC 바로가기 [Article Type] Expedited
SARS-CoV-2: Viral Loads of Exhaled Breath and Oronasopharyngeal Specimens in Hospitalized Patients with COVID-19SARS-CoV-2: COVID-19로 입원한 환자의 호기 및 구강 비인두 표본의 바이러스 부하Article Published on 2021-09-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, 치료기술, [키워드] Airborne transmission Assessing breath Chain Reaction COVID-19 COVID-19 patient Delta examined Exhaled Breath Hospitalization hospitalized COVID-19 patients hospitalized patient hospitalized patients individual infectiousness load no correlation noninvasive Pharyngeal swab polymerase chain polymerase chain reaction positive proof of concept Quantitative Respiratory droplets reverse transcription SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection SARS-CoV-2 viral load significantly higher specimen Swab tested variant Viral load viral loads was determined was performed widespread with COVID-19 [DOI] 10.1016/j.ijid.2021.07.012 PMC 바로가기 [Article Type] Article
Point of care ultrasound (POCUS) in diagnosis of proximal deep vein thrombosis among COVID-19 hospitalized patients with a high rate of low molecular weight heparin prophylaxis저분자량 헤파린 예방치료율이 높은 코로나19 입원환자 근위심부정맥혈전증 진단 시 현장진료초음파(POCUS)Case Reports Published on 2021-08-272022-09-11 Journal: Medicina clínica [Category] SARS, 치료기술, [키워드] anticoagulation Care clinical clinical and laboratory features Complication COVID-19 critical condition Deep vein Deep vein thrombosis detect determine Diagnosis discharged DVT Ecografía Embolia pulmonar English helping heparin Heparina de bajo peso molecular hospitalized COVID-19 patients hospitalized patient ICU intensive care intensive care unit Laboratory features limb LMWH low molecular weight low molecular weight heparin Low-molecular-weight heparin Lower lower limb molecular notable outcome pacientes hospitalizado Patient performed planta Point point-of-care popliteal positive Prescriptions Prevalence Prophylaxis proximal pulmonary Pulmonary embolism receiving screened Screening Sin Spanish suffered thrombosis thrombotic complication Thrombotic complications treat Trombosis venosa profunda Ultrasonography ward was performed were assessed with COVID-19 [DOI] 10.1016/j.medcli.2021.01.012 PMC 바로가기 [Article Type] Case Reports
Asthma and COVID-19: Emphasis on Adequate Asthma ControlReview Article Published on 2021-08-242022-10-31 Journal: Canadian Respiratory Journal [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Adequate Affect ARMS association Asthma asthmatic cause Cell-mediated immunity chronic airway inflammation Clinical course clinician Control coronavirus COVID-19 COVID-19 pandemic Dexamethasone disease Evidence explain glucocorticoid Glucocorticoids hospitalized COVID-19 patients humoral incidence increased risk independent risk factor infections Influenza virus Inhaled inhaled corticosteroid management morbidity and mortality Mortality parainfluenza virus pathogenesis of SARS-CoV-2 Pneumonia promote recent reduce respiratory virus SARS-CoV SARS-COV-2 infection severity significant decrease significantly subject subset susceptibility virus [DOI] 10.1155/2021/9621572 PMC 바로가기 [Article Type] Review Article