A novel pseudovirus‐based mouse model of SARS-CoV-2 infection to test COVID-19 interventionsCOVID-19 개입을 테스트하기 위한 SARS-CoV-2 감염의 새로운 슈도바이러스 기반 마우스 모델Research Published on 2021-04-302022-09-10 Journal: Journal of Biomedical Science [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 addition Adenovirus administration angiotensin animal model binding can be used cause characterized co-transfection coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pandemic demonstrated followed by Gag generate hACE2 HIV human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human cell human cells infect Infection Intervention intranasal lentivirus lentiviruses luciferase-expressing mice non-infectious Outbreaks Plasmid Prevent pseudovirus purified Research respiratory Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pseudovirus SARS-CoV-2 spike protein simple Spike protein Spread Strains supplementary material the SARS-CoV-2 transfection variant virulent virus worldwide pandemic [DOI] 10.1186/s12929-021-00729-3 PMC 바로가기 [Article Type] Research
Infectious Clones Produce SARS-CoV-2 That Causes Severe Pulmonary Disease in Infected K18-Human ACE2 Mice감염성 클론은 감염된 K18-인간 ACE2 마우스에서 심각한 폐 질환을 일으키는 SARS-CoV-2를 생성합니다Research Article Published on 2021-04-202022-09-10 Journal: mBio [Category] MERS, SARS, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 benefit Brain brains causative agent cause caused changes in clinical disease clinically clone consolidation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine development Cytokines develop effective facilitate feature Genetic hACE2 human ACE2 immunopathology in viral in vivo Infection infectious clones K18-hACE2 K18-hACE2 mice Laboratory lung Lung infection Lung pathology Lungs mCherry mice morbidity Mortality pandemic Pathogenesis Patient Pneumonia Postinfection Produce produced pulmonary Research respiratory respiratory viruses RG-rescued SARS-CoV-2 virus RG-rescued SARS-CoV-2 viruses SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 research SARS-CoV-2 toolkit SARS-CoV-2-mCherry severe acute respiratory syndrome Coronavirus severe COVID-19 structures toolkit utility Validity valuable resource variety Viral Viral pneumonia viruses weight loss [DOI] 10.1128/mBio.00819-21 PMC 바로가기 [Article Type] Research Article
Human ACE2-Functionalized Gold “Virus-Trap” Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS DetectionArticle Published on 2021-04-132022-10-30 Journal: Nano-Micro Letters [Category] COVID-19, [키워드] “Virus-trap” nanostructure ACE2 can be used capture complex composed coronavirus Coronaviruses COVID-19 COVID-19 pandemic detect detection Detection limit Effects expressed feature gold Human human ACE2 machine-learning nanostructure Real-time monitoring resulting S protein S-protein SARS-CoV-2 SARS-CoV-2 virus SERS Single-virus detection supplementary material virus [DOI] 10.1007/s40820-021-00620-8 PMC 바로가기 [Article Type] Article
Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2편자박쥐 ACE2 orthologs에서 파생된 돌연변이는 SARS-CoV-2의 ACE2-Fc 중화를 향상시킵니다Research Article Published on 2021-04-092022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 ortholog ACE2 orthologs ACE2 proteins ACE2 residue ACE2-Fc acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bat bat ACE2 bats binding binding affinity both viruses Cell cellular receptor Combination Consensus coronavirus described domain ENhance expressing FIVE hACE2 heterogeneity horseshoe bat horseshoe bats Human human ACE2 Hypothesis identify impacted inactive infect Infection Infectious virus Interaction intermediate introduced investigated Mutation neutralization neutralize neutralized Neutralizing ortholog orthologs pangolin pangolins potency Protein pseudovirus pseudoviruses RaTG13 RBD RBDs receptor receptor ACE2 Receptor-binding domain Region regions residue respiratory S-protein SARS-CoV SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 RBD SARS-like coronavirus SARS-like viruses selection pressure severe acute respiratory syndrome Coronavirus soluble ACE2 species susceptibility the binding affinity the RBD the SARS-CoV-2 These data Variability variant Viral viral spike virus wild-type [DOI] 10.1371/journal.ppat.1009501 PMC 바로가기 [Article Type] Research Article
Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions다학제적 접근 방식으로 SARS-CoV-2–ACE2 수용체 상호작용을 차단하는 후보로서 인간 ACE2 또는 SARS-CoV-2 스파이크 단백질에 결합하는 화합물 식별Research Article Published on 2021-03-302022-09-10 Journal: mBio [Category] SARS, 신약개발, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antiviral bind binding block blockade candidate causative agent cause caused cellular receptor Compound compounds coronavirus COVID-19 death demonstrated Diseases Dissociation constant dose-dependent drug Drug development Drug screening dual entry inhibitors enzyme evaluate Evans blue Human human ACE2 identify in vitro Infection Infectious disease inhibitor Interaction interfere Intervention library lifitegrast lumacaftor molecular docking Protein RBD RBD binders RBD-ACE2 receptor Receptor binding domain Registered repurposing respiratory SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sodium spike spike glycoprotein Spike protein SPR surface plasmon surface plasmon resonance targets the RBD the SARS-CoV-2 these compounds VERO-E6 virus was used [DOI] 10.1128/mBio.03681-20 PMC 바로가기 [Article Type] Research Article
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development카텝신 L은 인간과 인간화 마우스에서 SARS-CoV-2 감염에 핵심적인 역할을 하며 신약 개발의 유망한 표적입니다Article Published on 2021-03-272022-08-31 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 신약개발, 치료제, [키워드] amantadine anti-influenza drug cathepsin cathepsin L circulating cleaved COVID-19 CTSL disease course drug Drug screening elevated evidenced expression Human human ACE2 human cell human cells humanized in vitro in vivo Infection Infectious diseases inhibited inhibitor knockdown mice molecular basis overexpression patients with COVID-19 positively correlated prevented pseudovirus infection SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 spike protein severity significantly Spike protein the SARS-CoV-2 transgenic mice turn virus entry [DOI] 10.1038/s41392-021-00558-8 PMC 바로가기 [Article Type] Article
Monoclonal antibodies capable of binding SARS‐CoV‐2 spike protein receptor‐binding motif specifically prevent GM‐CSF inductionConcise Report Published on 2021-03-242022-10-29 Journal: Journal of leukocyte biology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Affect antibody binding blocked boost caused coronavirus COVID‐19 cultures cytokine antibody array disease effort enzyme GM‐CSF GM‐CSF Host human ACE2 infections Inflammatory response inhibit inhibited Interaction Like mAb mAbs Macrophage monoclonal antibody mononuclear cell mononuclear cells motif murine pandemic Peripheral blood Prevent Protective antibody protective mechanism Protein purified RBM SARS‐CoV‐2 SARS‐CoV‐2 spike secretion Spike protein suggested surface plasmon resonance the spike protein Vaccine Vaccines viral entry viral spike [DOI] 10.1002/JLB.3COVCRA0920-628RR PMC 바로가기 [Article Type] Concise Report
Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry비교 분석을 통해 SARS-CoV-2 진입에 필요한 ACE2의 종별 유전적 결정인자가 밝혀졌습니다.Research Article Published on 2021-03-242022-08-13 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 protein ACE2 proteins ACE2 sequence animal model binding can not cell entry cellular receptor Comparative analysis coronavirus Critical facilitate functional Genetic genetic determinant genetic determinants genetic engineering host cell host range Human human ACE2 Interaction koala limit mammalian mouse New World New World monkey receptor receptor function replaced REPLACED BY required residue restored restrict reveal SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike protein sequences shown Spike protein Support the spike protein Thr tissue tropism Viral viral entry viral spike protein [DOI] 10.1371/journal.ppat.1009392 PMC 바로가기 [Article Type] Research Article
Shedding Light on the Inhibitory Mechanisms of SARS-CoV-1/CoV-2 Spike Proteins by ACE2-Designed PeptidesACE2 설계 펩티드에 의한 SARS-CoV-1/CoV-2 스파이크 단백질의 억제 메커니즘에 대한 조명Article Published on 2021-03-222022-09-11 Journal: Journal of Chemical Information and Modeling [Category] MERS, SARS, 신약개발, 치료제, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding binding affinities binding affinity can be used cellular receptor comparable Contact coronavirus COVID-19 COVID-19 pandemic demonstrated domain domains Efficiency enzyme full-length Host host cells human ACE2 Interaction involved kinetic analysis LIGHT mechanism neutralization novel peptide peptides Previous studies previous study protocol responsible route SARS Coronavirus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike sequence shedding shown spike Spike protein Spike proteins surface protein the spike protein thermodynamic virus entry virus infection [DOI] 10.1021/acs.jcim.0c01320 PMC 바로가기 [Article Type] Article
Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and ReplicationObservation Published on 2021-03-162022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome Amino acid angiotensin-converting enzyme 2 animal model caused chimeric Contact coronavirus COVID-19 COVID-19 pathogenesis determinant Epidemics events Evidence examined group Host host range Host receptors human ACE2 humanized identify in vitro infect Infection Interaction Intervention mice molecular murine predicted public health threat rapid response receptor Receptor binding domain receptors residue SARS-CoV-2 SARS-COV-2 infection Virus-host interactions [DOI] 10.1128/mBio.03149-20 PMC 바로가기 [Article Type] Observation