Inhibition of SARS-CoV-2 pseudovirus invasion by ACE2 protecting and Spike neutralizing peptides: An alternative approach to COVID19 prevention and therapyResearch Paper Published on 2021-07-132022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, SARS, [키워드] ACE2 addition administration antibody antibody resistance Antibody-dependent enhancement approach Cell cells Cocktail therapy Combination COVID-19 COVID19 docking effective hACE2 host cell host cell membrane Impact in vitro assays inhibited inhibition Interaction intranasal Invasion neutralization Neutralizing neutralizing activities peptide peptides potential risk predicted pseudotype pseudovirus S-protein Safe SARS-CoV-2 SARS-CoV-2 pseudovirus spike Spike protein spike-protein therapeutic therapy Toxicity transgenic mice [DOI] 10.7150/ijbs.61476 PMC 바로가기 [Article Type] Research Paper
An intranasal vaccine durably protects against SARS-CoV-2 variants in miceArticle Published on 2021-07-102022-11-01 Journal: Cell Reports [Category] COVID-19, SARS, [키워드] Abstract Administered antibody Antibody neutralization Antibody Response attenuate B.1.1.28 B.1.351 B.1.617.1 Bone marrow chimpanzee adenovirus-vectored vaccine Complete COVID-19 cross-protection cross-protective dose dose response dose-dependent manner Durability Efficacy function IgA IgG Immunity immunization immunogenic induce inhibitory intranasal intranasally long-lived plasma cell Lower respiratory tract mice mucosal immunity neutralized Neutralizing Pathogenesis PROTECT protection Protective provide reported robust SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variant secreting serum serum antibody Spike protein trials vaccination Vaccine vaccine dose variant variants of concern viruses [DOI] 10.1016/j.celrep.2021.109452 PMC 바로가기 [Article Type] Article
Efficacy of “Essential Iodine Drops” against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)중증 급성 호흡기 증후군-코로나 바이러스 2 (SARS-COV-2)에 대한 "필수 요오드 방울"의 효능Research Article Published on 2021-07-092022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료제, [키워드] 1:1 aerosolization aqueous solution ATCC CCID Cell Cell culture complex controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients CPE Cytopathic effect demonstrated Dilution drop effective end-point dilution Essential evaluated fulvic acid in vitro infecting infectious dose intranasal intranasally Iodine pandemic povidone-iodine Prevent quantified reduce reduced reducing reductions in respiratory respiratory droplet Respiratory droplets Result room temperature SARS-CoV-2 SARS-CoV-2 transmission SARS-CoV-2 viral SARS-CoV-2 virus Severe acute respiratory syndrome Spread temperature titre titres Vero Viral Viral load virucidal virus virus stock viruses was reduced was tested [DOI] 10.1371/journal.pone.0254341 PMC 바로가기 [Article Type] Research Article
Intranasal Administration of RBD Nanoparticles Confers Induction of Mucosal and Systemic Immunity against SARS-CoV-2Article Published on 2021-07-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activated addition Administered administration alternative route Antibody Response BAL CD4 CD8 Cell COVID-19 Defense domain evaluated evidenced Host IgA IgA response IgG IgG1 IgG2a immune system Immunity immunization immunized mice immunogen induction intranasal intranasal route intranasal vaccine intranasally Local lung mice mucosa mucosal nano-delivery vaccine nanoparticle Neutralizing antibodies platform primary site PROTECT RBD respiratory tract response robust SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike glycoprotein serum IgG significantly higher stimulated systemic upper respiratory airway vaccination virus [DOI] 10.3390/vaccines9070768 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infects Endothelial Cells In Vivo and In VitroSARS-CoV-2는 생체 내 및 시험관 내 내피 세포를 감염시킵니다Cellular and Infection Microbiology Published on 2021-07-062022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료기술, [키워드] ACE-2 activated Ad5-hACE2 addition Adenovirus Affect animal models aorta ring cardiovascular complication cardiovascular complications cause CD31 CD34 cellular activation characterized Comparative analysis contribute cytokine Cytokine storm demonstrated died dysfunction edema electron microscopic analysis Endothelial cell endothelial cell infection endothelial cells endotheliopathy Ex vivo exposure to expressing focus hACE2 hemorrhage immunostaining in vivo infect infecting Inflammatory inflammatory cascade intranasal KRAS labeling Localization lung Lung pathology lung tissue Lungs marker mice microscopic analysis non-human primate non-human primates other organs pathway Patient Pneumocytes positive Protein RNA RNA sequencing data SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins severe COVID-19 signaling pathway thrombosis upregulated vascular endothelial cell vascular inflammation vascular permeability Viral viral particle Viral particles [DOI] 10.3389/fcimb.2021.701278 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
SARS-CoV-2 infection in the mouse olfactory systemArticle Published on 2021-07-062022-10-04 Journal: Cell Discovery [Category] 진단, [키워드] ACE2 Analysis Antiviral cause Cell cell death Cell signalling clinical manifestation Combined COVID-19 COVID-19 patient COVID-19 patients Critical downregulation hACE2 humanized humans Immune cell infiltration impair induce Inflammatory responses intranasal Invasion manifestation mechanism Mechanisms of disease mice olfactory olfactory disorder olfactory dysfunction Olfactory epithelium physiological Predictive proteomic provide Quantitative receptor resulting robust SARS-CoV-2 SARS-COV-2 infection sensory neuron Symptom target cell transcriptomic Trigger viral replication [DOI] 10.1038/s41421-021-00290-1 PMC 바로가기 [Article Type] Article
A Nasal Complication of Nasopharyngeal Swab for Reverse Transcription Polymerase Chain Reaction (RT-PCR) Detection of SARS-CoV-2 mRNAOtolaryngology Published on 2021-07-052022-10-31 Journal: Cureus [Category] COVID-19, [키워드] anatomical cause chain Complication COVID-19 detection deviation diagnostic highest intranasal mRNA nasal nasal cavities Nasopharyngeal swab operator Oropharyngeal reaction RNA RT-PCR SARS-CoV-2 SARS-CoV-2 mRNA sensitivity septal specimen surgical World Health Organization [DOI] 10.7759/cureus.16183 PMC 바로가기 [Article Type] Otolaryngology
Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept studyRandomized Controlled Trial Published on 2021-07-022022-10-27 Journal: BMC Neurology [Category] COVID-19, [키워드] animal model clinical Clinical sign clinically Cognition Combination COVID-19 disease dynamic balance Effect effective effective therapy Effectiveness expected help home improvement incidence individual intranasal measure mitigate Mobility Motor symptoms neurodegenerative neurons New objective Parkinson’s disease Parkinson’s disease participant Participants Photobiomodulation populations PROTECT randomized placebo-controlled trial Randomly RANK RCT recruited reduce Registered registry Result Safe shown Side effect significance level significantly supplementary material sustained Symptom threshold Treatment Treatment effectiveness treatment period was used were assessed [DOI] 10.1186/s12883-021-02248-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept studyRandomized Controlled Trial Published on 2021-07-022022-10-27 Journal: BMC Neurology [Category] Coronavirus, COVID-19, SARS, [키워드] animal model clinical Clinical sign clinically Cognition Combination COVID-19 disease dynamic balance Effect effective effective therapy Effectiveness expected help home improvement incidence individual intranasal measure mitigate Mobility Motor symptoms neurodegenerative neurons New objective Parkinson’s disease Parkinson’s disease participant Participants Photobiomodulation populations PROTECT randomized placebo-controlled trial Randomly RANK RCT recruited reduce Registered registry Result Safe shown Side effect significance level significantly supplementary material sustained Symptom threshold Treatment Treatment effectiveness treatment period was used were assessed [DOI] 10.1186/s12883-021-02248-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept studyPhotobiomodulation을 사용한 파킨슨 병의 임상 징후 개선 : 전향 적 개념 증명 연구Randomized Controlled Trial Published on 2021-07-022022-09-10 Journal: BMC Neurology [Category] 비임상, [키워드] All participants animal model animal models balance best breath clinical Clinical sign Clinical signs clinically Cognition Combination COVID-19 disease dopaminergic neurons dynamic balance Effect effective effective therapy Effectiveness expected help home improvement Improvements incidence individual intranasal measure mitigate Mobility Motor symptoms neurodegenerative neurons New objective Parkinson’s disease Parkinson’s disease participant Participants Photobiomodulation populations PROTECT randomized placebo-controlled trial Randomly RANK RCT recruited reduce Registered registration number registry Result Safe shown Side effect significance level significantly Signs and symptoms supplementary material sustained Symptom threshold Treatment Treatment effectiveness treatment period was used were assessed Wilcoxon Signed Ranks test [DOI] 10.1186/s12883-021-02248-y PMC 바로가기 [Article Type] Randomized Controlled Trial