A novel LC-MS/MS method for determination of the potential antiviral candidate favipiravir for the emergency treatment of SARS-CoV-2 virus in human plasma: Application to a bioequivalence study in Egyptian human volunteers인간 혈장에서 SARS-CoV-2 바이러스의 긴급 치료를 위한 잠재적인 항바이러스 후보 favipiravir의 결정을 위한 새로운 LC-MS/MS 방법: 이집트 인간 지원자의 생물학적 동등성 연구에 적용Article Published on 2021-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] SARS, 치료제, [키워드] acetic acetic acid adopted Antiviral antiviral agent application applied bioanalysis Bioequivalence Bioequivalence study composed Concentration COVID-19 Eclipse electrospray ionization Favipiravir flow rate healthy Human Human plasma isocratic LC–MS/MS Linear regression linearity m/z mass spectrometer methanol pharmacokinetic plasma sample positive protein precipitation pumped pyrazinamide quantification SARS-CoV-2 SARS-CoV-2 virus simple Treatment US-FDA Volunteer volunteers was used [DOI] 10.1016/j.jpba.2021.114057 PMC 바로가기 [Article Type] Article
The Association Between Social Support, COVID-19 Exposure, and Medical Students’ Mental HealthPsychiatry Published on 2021-05-242022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] age Anxiety anxiety symptom anxiety symptoms association China confirmed COVID-19 case coronavirus COVID-19 COVID-19 outbreak demographics Depression depressive depressive symptom Epidemic exposure Factor females Gender Generalized higher risk increased risk Limited Linear regression medical students mental health Mild multivariate Other pandemic poor mental status prevalence rate Psychological public health emergency reported respondent scale Social support student suffered Support virus with COVID-19 [DOI] 10.3389/fpsyt.2021.555893 PMC 바로가기 [Article Type] Psychiatry
Continent-Wide Analysis of COVID 19: Total Cases, Deaths, Tests, Socio-Economic, and Morbidity Factors Associated to the Mortality Rate, and Forecasting Analysis in 2020–2021Article Published on 2021-05-182022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] acute respiratory syndrome age Analysis ARIMA Asia average China clinical feature Continents coronavirus Correlation analysis COVID COVID-19 COVID-19 case death deaths defined diabetes Epidemiology Europe Factor Forecasting GDP highest hospital Infection less Linear regression lowest Mortality mortality rate North America Oceania pandemic predict predicted Rate regression analysis reported risk factor Risk factors SARS-CoV-2 South America statistical Total was performed was recorded were used [DOI] 10.3390/ijerph18105350 PMC 바로가기 [Article Type] Article
Investigation of Knowledge, Attitude and Practice of Personal Protection Among Different Types of Workers Returning to Work Under COVID-19 EpidemicPublic Health Published on 2021-05-172022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Analysis Attitude Attitudes average Chicago conducted convenience sampling coronavirus disease COVID-19 Descriptive statistics employment Factor Gender groups highest IMPROVE Inc. investigation KAP knowledge Linear regression lowest Multiple Multiple linear regression no difference outbreak pandemic participant personal protection Practice practices protection Protective questionnaire reducing risk Safe SPSS stability Type USA was collected was used WeChat work worker [DOI] 10.3389/fpubh.2021.679699 PMC 바로가기 [Article Type] Public Health
Changes in Sitting Time, Screen Exposure and Physical Activity during COVID-19 Lockdown in South American Adults: A Cross-Sectional StudyArticle Published on 2021-05-142022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] activity affected associations change changes Chronic diseases Combination coronavirus COVID-19 cross-sectional demographics effect sizes effort exercise exposure Factors finding Government greater group Health Behavior increase Linear regression lockdown measure moderate multivariable pandemic physical activity Prevalence promote public health question recommendation reduction Screen screen time Sedentary behavior shown Sitting Sociodemographic South spread of COVID-19 time were used [DOI] 10.3390/ijerph18105239 PMC 바로가기 [Article Type] Article
Determinants of IgG antibodies kinetics after severe and critical COVID‐19Research Article Published on 2021-05-122022-10-04 Journal: Journal of medical virology [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome age analyzed BMI body mass index Characteristics Chemiluminescent assay Cohort coronavirus coronavirus disease Corticosteroids covariates COVID‐19 COVID‐19 patient COVID‐19 Critical critically ill patients Demographic factors demographics demonstrated determinant determine Diagnosis elapsed Factor highlight hospital Hospitalized IgG IgG antibody IgG level IgG titer Immunocompromised patient immunodeficiency Immunosuppression IMPROVE investigated Kinetics Linear regression median no significant effect Patient Protein reduced Regression model Research SARS‐CoV‐2 SARS‐CoV‐2 serological serology significantly Specific time Treatment were assessed were measured [DOI] 10.1002/jmv.27059 PMC 바로가기 [Article Type] Research Article
Assessment of physicians’ resilience level during the COVID-19 pandemicArticle Published on 2021-05-122022-10-29 Journal: Translational Psychiatry [Category] COVID-19, SARS, [키워드] Anxiety assessment Care Characteristics COVID-19 COVID-19 pandemic COVID-19 patients decrease Depression detrimental Factor Factors genetics greater hospital IMPROVE Infectious disease intensive care involved IQR Linear regression median Molecular neuroscience multivariable National pandemic participant physician Physicians promote Protective Resilience resilience score RISC scale Support were assessed [DOI] 10.1038/s41398-021-01395-7 PMC 바로가기 [Article Type] Article
Dissociation, Cognitive Reflection and Health Literacy Have a Modest Effect on Belief in Conspiracy Theories about COVID-19Article Published on 2021-05-112022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] belief bullshit receptivity Characteristics cognitive cognitive reflection collected conducted Conspiracy theories COVID-19 cross-sectional descending dissociation Effect eHEALS explained Health health literacy humans less Linear regression literacy Mediation analysis Pandemics predictor Psychological Reflection theory understanding vaccinated against COVID-19 variable [DOI] 10.3390/ijerph18105065 PMC 바로가기 [Article Type] Article
Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 SurvivorsMicrobiology Published on 2021-05-072022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome age Analysis antibody Antigen BMI Characteristics collected coronavirus coronavirus disease correlated correlation COVID-19 diagnosis of COVID-19 Evidence extracorporeal membrane oxygenation Factor Fever first positive IgG Immunity Immunoglobulin indicated Infection Japan Japanese Linear regression male mechanical ventilation median Month MOST multivariable neutralizing antibody Neutralizing antibody titer nucleocapsid protein participant persistence positive quantitative serological test recruited Regression SARS-CoV-2 serum sample significantly Spearman’s correlation Spike protein survivor Survivors sustained tested were assessed were measured [DOI] 10.3389/fmicb.2021.661187 PMC 바로가기 [Article Type] Microbiology
Impact of the COVID-19 Pandemic on the Intensity of Health Services Use in General Practice: A Retrospective Cohort StudySociety Journal Archive Published on 2021-05-072022-10-30 Journal: International Journal of Public Health [Category] COVID-19, [키워드] age blood pressure cardiovascular disease Care chronic conditions chronic disease COVID-19 database decrease diabetes electronic medical record estimates General practice group groups Health Health Service health services use health system hemoglobin hypertension Impact intensity Linear regression P -value Patient patient cohort patients predicted primary care reduced repeated reported risk groups SARS-CoV-2 selected service Switzerland total population Weekly [DOI] 10.3389/ijph.2021.635508 PMC 바로가기 [Article Type] Society Journal Archive