A snapshot of the immunogenicity, efficacy and safety of a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors: a longitudinal cohort studyPD-1/PD-L1 억제제로 치료받은 암 환자를 대상으로 한 BNT162b2 항-SARS-CoV-2 백신 전체 과정의 면역원성, 효능 및 안전성에 대한 스냅샷: 종단적 코호트 연구Article Published on 2021-10-012022-09-11 Journal: ESMO open [Category] MERS, SARS, 바이오마커, 진단, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive administration anti-SARS-CoV-2 blood sample Blood samples BNT162b2 BNT162b2 anti-SARS-CoV-2 vaccine BNT162b2 vaccine Cancer cancer patient Cancer patients CD4 CD4+ CD4+ T follicular response CD8+ T-cell CD8+ T-cell response cell-mediated immune cellular response Complete coronavirus coronavirus disease coronavirus disease-2019 Course COVID-19 case COVID-19 cases demonstrated Efficacy and safety elicit elicited enrolled enzyme enzyme-linked immunospot assay Focusing follicular humoral IFN-γ Immune checkpoint inhibitors immune response inhibitor interferon interferon-γ interquartile range IQR knowledge longitudinal cohort study mandatory median Messenger RNA mononuclear cell naïve naïve subjects Neutralizing antibodies no difference no differences of BNT162b2 participant Patient patients PBMC PD-1/PD-L1 inhibitors Peripheral blood primary endpoint programmed cell death programmed cell death protein proportion Protein reached reported respiratory response SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody second dose severe acute respiratory syndrome Coronavirus significant increase significantly higher significantly increased Specific T-cell response spike-specific T-cell response subject subjects sustained T cells T-cell Response the primary endpoint treated undetectable vaccination vaccination schedule Vaccine [DOI] 10.1016/j.esmoop.2021.100272 PMC 바로가기 [Article Type] Article
In silico drug repurposing in COVID-19: A network-based analysisCovid-19의 Silico Drug Reperhing에서 : 네트워크 기반 분석Article Published on 2021-10-012022-08-31 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, 신약개발, 임상, 치료제, [키워드] addition Analysis analyzed antibodies Anticoagulants approach Blood cells bowel Central nervous system clinical clinical setting clinical trial clinical trials compounds conditions Corticosteroid Corticosteroids corticosteroids) COVID-19 COVID-19 patient COVID-19 patients de novo drug Drug discovery Drug repurposing examined faster healthy subjects heparin identify Inflammatory bowel disease inhibitor mandatory patients with COVID-19 priority public health emergency SARS-CoV-2 pandemic SCN5A septic Septic shock Shock transcriptomic data treat vaccination whole blood cell whole blood cells [DOI] 10.1016/j.biopha.2021.111954 PMC 바로가기 [Article Type] Article
Association of public health interventions and COVID-19 incidence in Vietnam, January to December 20202020년 1월부터 12월까지 베트남의 공중 보건 개입 및 COVID-19 발병 협회Article Published on 2021-10-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] 95% CI border control calculated Clusters Combination Contact tracing Containment containment delay coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 case COVID-19 incidence detect Effect effective Factor Health identify Immigration Intervention introduced Isolation lockdown lockdowns lowest mandatory maximum likelihood estimation measure multivariable Multivariable regression Public Public health intervention Public health interventions quarantine reproductive significant difference significant differences symptom onset the epidemic Transmission Vietnam were used [DOI] 10.1016/j.ijid.2021.07.044 PMC 바로가기 [Article Type] Article
Public health effects of travel-related policies on the COVID-19 pandemic: A mixed-methods systematic review여행 관련 정책이 코로나19 팬데믹에 미치는 공중보건 영향: 복합적 체계적 고찰Review Published on 2021-10-012022-09-11 Journal: The Journal of Infection [Category] SARS, 임상, 치료기술, [키워드] adopted Asymptomatic Awareness Combination Community Compliance Controlled Controlled trial controlled trials country COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic decrease detect disease spread Effect effective Effectiveness Effects eligibility criteria eligible Evidence Factors followed by Government Health independent less majority mandatory measure MOST non-randomized studies outbreak OVID Oxford pandemic Policy positive progression proportion Public public health measures qualitative studies quarantine Randomized controlled trial reduce reducing Region regions response Risk of bias Screening screening tests searched selected sensitivity systematic review transmission rate transmission rates Travel Travel restrictions unlikely used data website while [DOI] 10.1016/j.jinf.2021.07.017 PMC 바로가기 [Article Type] Review
Usefulness of the HACOR score in predicting success of CPAP in COVID-19-related hypoxemiaObservational Study Published on 2021-10-012022-10-04 Journal: Respiratory medicine [Category] 임상, 진단, [키워드] Accuracy age ARF calculated Care COVID-19 CPAP diagnostic died Endotracheal intubation enrolled evaluate HACOR score Hypoxemia hypoxemic Hypoxemic acute respiratory failure Hypoxemic acute respiratory failure. intubation mandatory Oxygenation PaO Patient patients patients with SARS-CoV-2 Pneumonia presenting Prospective Respiratory failure respiratory rate shown Trial [DOI] 10.1016/j.rmed.2021.106550 PMC 바로가기 [Article Type] Observational Study
“First Do No Harm”. No-Fault Compensation Program for COVID-19 Vaccines as Feasibility and Wisdom of a Policy Instrument to Mitigate Vaccine HesitancyReview Published on 2021-09-302022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] administration adverse event adverse events approved compensation COVID-19 COVID-19 vaccination COVID-19 vaccine Dilution effective Efficacy Europe European European country excluded General population Government healthcare Hesitancy individual Injury instrument introduced Italian Italy law management mandatory no-fault compensation physical Policy Program reported Safe solidarity urgency vaccination Vaccine Vaccine hesitancy [DOI] 10.3390/vaccines9101116 PMC 바로가기 [Article Type] Review
Severe Acute Respiratory Syndrome Coronavirus-2 Infection and Autoimmunity 1 Year Later: The Era of VaccinesImmunology Published on 2021-09-302022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome affected approved ARD patients Autoimmune autoimmune rheumatic disease (ARD) clinical impact coronavirus Coronavirus-2 COVID-19 death Disease prevalence Disease progression domain Effectiveness effort General population group Hospitalization Host immune response immunomodulating agent immunomodulating agents Immunosuppressive agents immunosuppressive therapy include infections management mandatory marker Modification mRNA outcome Patient patients Receptor binding researcher respiratory rheumatic disease risk SARS-CoV-2 the spike protein therapeutic therapy Vaccine vaccine administration Vaccines Viral vector Year [DOI] 10.3389/fimmu.2021.708848 PMC 바로가기 [Article Type] Immunology
Critical Capability Needs for Reduction of Transmission of SARS-CoV-2 IndoorsBioengineering and Biotechnology Published on 2021-09-292022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] applied biosurveillance buildings complex coordination coronavirus COVID-19 COVID-19 transmission effective effort ENhance globe Human Factors indoors Infection Influenza information Intervention knowledge mandatory pain point persistence reduce reduction in Research risk risk reduction and mitigation measures SARS-CoV-2 Summit Transmission transmission of SARS-CoV-2 Transport viral disease viral pathogen [DOI] 10.3389/fbioe.2021.641599 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Surveillance of SARS-CoV-2 transmission in educational institutions, August to December 2020, GermanyOriginal Paper Published on 2021-09-222022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, SARS, [키워드] 1.26 calculated Cluster Contact Contact tracing COVID-19 daycare estimate Germany IMPROVE incidence rate independent index case infectious disease epidemiology Intervention mandatory monitoring pandemic public health quarantine risk SAR SARS SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission School Schools secondary attack rate secondary case Transmission [DOI] 10.1017/S0950268821002077 PMC 바로가기 [Article Type] Original Paper
Impact of wearing personal protective equipment on the performance and decision making of surgeons during the COVID-19 pandemic: An observational cross-sectional studyObservational Study Published on 2021-09-172022-10-05 Journal: Medicine [Category] 임상, [키워드] affected approach confirmed cases coronavirus disease COVID-19 cross-sectional demographic data effort examined HCWs Health care worker hospital Impact IMPROVE infection rate Local mandatory pandemic Pandemics participant participated Personal protective equipment PPE questionnaire reduction in reported Saudi Arabia significantly surgeon [DOI] 10.1097/MD.0000000000027240 PMC 바로가기 [Article Type] Observational Study