Evaluation of Antibody Response to Heterologous Prime–Boost Vaccination with ChAdOx1 nCoV-19 and BNT162b2: An Observational StudyArticle Published on 2021-12-142022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] BNT162b2 booster dose ChAdOx1 ChAdOx1 nCoV-19 combinations convalescent correlated COVID-19 first dose healthy subject Heterologous highlight homologous IgG immunogenicity magnitude median Messenger RNA mRNA naïve national guideline Neutralizing titer of BNT162b2 positive priming proportion regimen response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein serum IgG significantly higher significantly lower subject tested the antibody response thrombotic event vaccination Vaccine was reduced were assessed [DOI] 10.3390/vaccines9121478 PMC 바로가기 [Article Type] Article
Cardiomyopathy Associated with Anti-SARS-CoV-2 Vaccination: What Do We Know?Review Published on 2021-12-132022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] administration Adults adverse effect age Autoimmune response Characteristics clinically COVID-19 death described develop dose Effect effective effort Epidemiology event Evolution exacerbated General population greater highlighting Hospitalization immune response lack less manifested mechanism Messenger RNA Mild moderate morbidity and mortality myocarditis Pediatric patients Pericarditis Prevent Prognosis Proteins reactogenicity responsible SARS-CoV-2 SARS-CoV-2 pandemic severity Symptom Vaccines [DOI] 10.3390/v13122493 PMC 바로가기 [Article Type] Review
Rational preparation and application of a mRNA delivery system with cytidinyl/cationic lipid시티디닐/양이온 지질을 사용한 mRNA 전달 시스템의 합리적인 준비 및 적용Article Published on 2021-12-102022-09-11 Journal: Journal of controlled release : official journal o [Category] SARS, 치료기술, [키워드] acetamide Adaptive immune response adverse event approved Cationic lipid cell immunity CLD Combination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA vaccine cytoplasm Efficacy and safety electrostatic encapsulate Formulation H-bonding immunized mice induce interactions intramuscular Lipid lipids Lipoplexes Messenger RNA Mild Moderna mRNA mRNA delivery. mRNA vaccines Neutral Neutralizing antibodies neutralizing antibody nucleotide outbreak Pfizer-BioNTech propanoate reported robust shown single nucleotide stimulate therapy [DOI] 10.1016/j.jconrel.2021.10.023 PMC 바로가기 [Article Type] Article
A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virusArticle Published on 2021-12-092022-10-04 Journal: Nature Medicine [Category] 비임상, 임상, 치료제, [키워드] Administered Adverse antibody approved arthralgia Arthritis cause characterized Chikungunya virus clinical trial Concentration conducted detectable disease dose dose-dependent Effect evaluate evaluated Ex vivo expression Fever functional healthy Human IgG IgG level immunocompromised individual Immunoglobulin in vivo Infant Infection Infectious diseases interim analysis intravenous knowledge Messenger RNA Mild moderate monoclonal monoclonal antibody mRNA mRNA-based Neutralizing Neutralizing activity neutralizing antibody offer participant patients phase 1 trial Placebo placebo-controlled plasma concentration predicted Preventive medicine Primary outcome Randomized Rash serum severity single dose therapeutic therapeutic use therapy Tolerability Treatment Trial viral infection [DOI] 10.1038/s41591-021-01573-6 PMC 바로가기 [Article Type] Article
mRNA, a Revolution in BiomedicineReview Published on 2021-12-052022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] addressed biomedicine carried COVID-19 pandemic effective feasibility gene editing Immunotherapy increasingly Intensive knowledge limitations Messenger RNA mRNA overcome Perspective protein replacement therapies regenerative required Research revolution target cell therapeutic therapeutic potential vaccination [DOI] 10.3390/pharmaceutics13122090 PMC 바로가기 [Article Type] Review
Antibody maintenance 3 months after complete messenger RNA COVID-19 vaccination in haemodialysis patients혈액투석 환자에서 메신저 RNA 코로나19 백신 접종 3개월 후 항체 유지Article Published on 2021-12-022022-09-12 Journal: Nephrology, dialysis, transplantation : official p [Category] SARS, 진단, [키워드] Complete COVID-19 vaccination Haemodialysis Messenger RNA Patient [DOI] 10.1093/ndt/gfab272 PMC 바로가기 [Article Type] Article
Association of Disease-Modifying Treatment and Anti-CD20 Infusion Timing With Humoral Response to 2 SARS-CoV-2 Vaccines in Patients With Multiple SclerosisArticle Published on 2021-12-012022-11-15 Journal: JAMA Neurology [Category] 바이오마커, 진단, [키워드] cohort study humoral infusion Messenger RNA Multiple multiple sclerosis Patient response SARS-CoV-2 sclerosis treated Vaccine [DOI] 10.1001/jamaneurol.2021.3609 PMC 바로가기
Vaccination versus infection with SARS-CoV-2: Establishment of a high avidity IgG response versus incomplete avidity maturation백신 접종 대 SARS-CoV-2 감염: 높은 결합력 IgG 반응의 확립 대 불완전한 결합력 성숙Article Published on 2021-12-012022-09-12 Journal: Journal of medical virology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome avidity binding Complete coronavirus coronavirus disease COVID-19 defined domain epitope Epitopes facilitate IgG IgG response Immunity Immunoglobulin Incomplete individual induce Infection infection with SARS-CoV-2 initial maturation Messenger RNA mRNA naïve individual naïve individuals patients Prevent Protective protective immunity RBD Receptor-binding domain recomLine SARS-CoV-2 IgG SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individuals vaccination [DOI] 10.1002/jmv.27270 PMC 바로가기 [Article Type] Article
Serum antibody response in patients with philadelphia-chromosome positive or negative myeloproliferative neoplasms following vaccination with SARS-CoV-2 spike protein messenger RNA (mRNA) vaccinesSARS-CoV-2 스파이크 단백질 메신저 RNA(mRNA) 백신 접종 후 필라델피아 염색체 양성 또는 음성 골수증식성 신생물이 있는 환자의 혈청 항체 반응Article Published on 2021-12-012022-09-12 Journal: Leukemia [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Antibody Response Messenger RNA mRNA myeloproliferative neoplasm Patient positive SARS-CoV-2 spike protein vaccination Vaccine [DOI] 10.1038/s41375-021-01457-1 PMC 바로가기 [Article Type] Article
BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2 Research Published on 2021-11-302022-10-05 Journal: Nature Immunology [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis antibody B cell B cell response BNT162b2 vaccine coronavirus dose drug elicit first dose food induce investigated memory B cell Messenger RNA mutated neutralizing antibody plasmablast Protective Protein recall Receptor binding domain SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 spike second dose single-cell subunit transcriptomics Vaccine vaccine dose variant variants [DOI] 10.1038/s41590-021-01088-9 [Article Type] Research