Interplay between SARS‐CoV‐2‐derived miRNAs, immune system, vitamin D pathway and respiratory systemSARS-CoV-2 유래 miRNA, 면역계, 비타민 D 경로 및 호흡기계 간의 상호작용Original Article Published on 2021-06-222022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, [키워드] analysed Analysis bioinformatics biological processe biological processes China contributing to coronavirus death develop Disease progression Evidence expression level functional enrichment Functional enrichment analysis Genes Genome help Host identify immune pathway immune pathways immune system intensity involved many cases mature miRNA mature miRNAs mechanism Mild miRNA miRNAs molecular New coronavirus pandemic Pathogenesis pathway Pathways precursor predict predicted recognize regulatory element regulatory region Research respiratory Respiratory system RNAseq RNAseq data SARS‐CoV‐2 SARS‐COV2 target gene Target genes the disease therapeutic target Viral viral miRNAs virus virus genome virus pathogenesis Vitamin D vitamin D pathway [DOI] 10.1111/jcmm.16694 PMC 바로가기 [Article Type] Original Article
microRNA Heterogeneity, Innate-Immune Defense and the Efficacy of SARS-CoV-2 Infection—A CommentaryCommentary Published on 2021-06-182022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] Homo sapien (hsa) activity acute respiratory distress acute respiratory syndrome biochemical cause cellular Coronavirus-2 COVID-19 COVID-19 pandemic disease Efficiency explain family Coronaviridae Genetic Genome genus Betacoronavirus host cell host miRNAs human miRNA immunological implication indicate individual individuals Infection Inflammatory Invasion Messenger RNA messenger RNA (mRNA) microRNA microRNA (miRNA) miRNA miRNAs modulation mRNA mRNA abundance Neurological complications neutralization non-coding RNA nucleotide pathological pathophysiological progression recent Replication Research SARS-CoV-2 SARS-COV-2 infection Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) single-stranded Support susceptible systemic disease tissue Variability viral genome viral infection Viral pneumonia Viral RNA [DOI] 10.3390/ncrna7020037 PMC 바로가기 [Article Type] Commentary
Circulating Extracellular Vesicles Carry Immune Regulatory miRNAs and Regulate Vaccine Efficacy and Local Inflammatory Response After VaccinationImmunology Published on 2021-06-152022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Adverse reaction Biomarker Control coronavirus disease creating cytokine Cytokines Diseases Efficacy EVs expected expression extracellular vesicle IL-12 IL-6 IL-6 expression IL-6-dependent immune response IMPROVE individual individuals Inflammatory Innate immunity Local lymphoid cells mice microRNA miR-21 miRNA miRNAs negative feedback loop predict Prophylaxis reduce reducing regulate required response seasonal flu serum Symptom Th1 type I interferon vaccination vaccination efficacy Vaccinations Vaccine [DOI] 10.3389/fimmu.2021.685344 PMC 바로가기 [Article Type] Immunology
In Silico Identification of miRNA–lncRNA Interactions in Male Reproductive Disorder Associated with COVID-19 InfectionCOVID-19 감염과 관련된 남성 생식 장애에서 miRNA-lncRNA 상호 작용의 Silico 식별Article Published on 2021-06-122022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 ARHGAP26 ARHGAP26-AS1 association Bioinformatics analysis BSN-AS1 CACNA1C CACNA1C-IT3 caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients disorder dysregulated enzyme explain expression facilitate FGF14 FGF14-IT1 Gene Expression global pandemic GRM7 GRM7-AS3 GS1-24F4.2 identification indicate infertility Interaction interactions KRBOX1 KRBOX1-AS1 lncRNA long non-coding RNA male male infertility men microRNA MicroRNAs miR-125a-5p miRNA miRNAs modulator molecular mechanism molecular mechanisms pathway post-transcriptional level Potential biomarker potential biomarkers predicted receptor Regulation reproductive respiratory SARS-CoV-2 Serine severe acute respiratory syndrome Coronavirus susceptible testes Testis tissue-specific expression TMPRSS2 TMPRSS2 expression transmembrane serine protease transmembrane serine protease 2 virus entry with COVID-19 [DOI] 10.3390/cells10061480 PMC 바로가기 [Article Type] Article
Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infectionArticle Published on 2021-06-122023-06-16 Journal: Computers in biology and medicine [Category] MERS, SARS, [키워드] COVID19 Genomic alignment miRNA mRNA network [DOI] 10.1016/j.compbiomed.2021.104570 PMC 바로가기 [Article Type] Article
Glycyrrhizic Acid for COVID-19: Findings of Targeting Pivotal Inflammatory Pathways Triggered by SARS-CoV-2Pharmacology Published on 2021-06-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acid activate acute respiratory syndrome Anti-inflammatory Anti-inflammatory effects Anti-viral Antiviral Bioinformatics analysis Biological functions causative pathogen cellular Characteristics complement conducted coronavirus Coronavirus disease 2019 COVID-19 Cytokine storms enrichment analysis Factor Factors finding glycyrrhizic acid GO analysis growth factor Host ICAM1 identify IFN IL-17 IL-6 immune system indicated inflammatory pathway inflammatory pathways inhibit Interaction interactions mechanism miRNA MMP9 Mutation network analysis network pharmacology novel pathway Pathways predominant public health crisis reactive oxygen specy receptor signaling regulate SARS-CoV-2 SARS-COV-2 infection signaling pathway significantly SOCS3 target targeted therapy targeting targets the cytokine storm therapeutic agent Therapies TLR2 TNF-α triggered Viral protein virus [DOI] 10.3389/fphar.2021.631206 PMC 바로가기 [Article Type] Pharmacology
Gender Specific Differences in Disease Susceptibility: The Role of EpigeneticsReview Published on 2021-06-082022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] adverse effect adverse outcomes Autoimmune disease Autoimmune diseases Cancer cellular comparable complex complex diseases COVID-19 difference Diseases Effects Epidemiological study Epigenetic epigenetics escape genes examined explain female females Gender Gender bias Hypothesis immune response immune responses immune system inactivation increasingly Infection Infectious diseases majority male males mechanism miRNA morbidity neurodegenerative outcome Pathogens reported respond role SARS-COV-2 infection Sex skewed skewed X inactivation Specific susceptibility the SARS-CoV-2 vaccination vaccination outcomes women X chromosome xenobiotics [DOI] 10.3390/biomedicines9060652 PMC 바로가기 [Article Type] Review
Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical IndustryReview Published on 2021-06-082022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] addressed Analysis approach association bioinformatics COVID-19 database Diagnosis dimension disorders Drug discovery drug side effects genetics Genome sequencing genomic sequencing healthcare information Interpretation Major management manuscript Microbiology microRNA miRNA pandemic pharmaceutical pharmacovigilance promoted proteomics public health Research researcher Stratification Systems biology translational Treatment [DOI] 10.3390/ijms22126184 PMC 바로가기 [Article Type] Review
Human MicroRNAs Interacting With SARS-CoV-2 RNA Sequences: Computational Analysis and Experimental Target ValidationGenetics Published on 2021-06-072022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] 501Y.V2 A549 cell acute respiratory syndrome affecting Anti-viral applied B.1.1.7 binding bioinformatics cellular miRNA conserved contributing to coronavirus COVID-19 criteria diagnostic eight experimental evidence expressed expression FIVE host cells host miRNA Human humans Interaction luciferase activity lung microRNA miRNA miRNAs molecular mechanism non-coding RNA pandemic Pathogenesis predicted provide reduction reporter plasmid repress respiratory disorder RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 sequences sequence South Africa spike target therapeutic intervention transfecting transfection United Kingdom validation variant viral sequence viral sequences virus virus infection World Health Organization [DOI] 10.3389/fgene.2021.678994 PMC 바로가기 [Article Type] Genetics
Identifying potential biomarkers in hepatitis B virus infection and its response to the antiviral therapy by integrated bioinformatic analysisOriginal Article Published on 2021-05-262023-06-03 Journal: Journal of Cellular and Molecular Medicine [Category] B형 간염, [키워드] bioinformatic analysis Chronic Hepatitis B Immune cell infiltration lncRNA miRNA Therapeutics [DOI] 10.1111/jcmm.16655 PMC 바로가기 [Article Type] Original Article