A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectivenessResearch Article Published on 2020-12-212022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, SARS, [키워드] acute viral infection Administered antiviral drug Cell Cellular immune response cellular mechanism clearance clinical effectiveness Combination component COVID-19 decrease disease Disease progression dosage drug Effect effective Effectiveness epithelial epithelial cell exhibit faster Hepatitis High dose immune immune response immune-cell Infection infection mechanism Interaction interfere less low dose mechanisms multicellular multiple groups outcome outcomes platform Potential treatment primary viral infection progression promote prophylactically recruitment reduce reduced Remdesivir Replication rate Repository Side effect Simulation spatiotemporal Support susceptibility Therapies therapy tissue tissue damage tissues Treatment viral infection Viral RNA virus virus replication viruses widespread [DOI] 10.1371/journal.pcbi.1008451 PMC 바로가기 [Article Type] Research Article
The Leukotriene Receptor Antagonist Montelukast as a Potential COVID-19 TherapeuticMolecular Biosciences Published on 2020-12-172022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] antagonist anti-inflammatory treatment Antiviral treatment Asthma Brain candidate cardiovascular disease cause Cell Community COVID-19 COVID-19 therapeutics Cytokine storm denominator effective Inflammation involved knowledge leukotriene leukotriene receptor antagonist leukotriene receptor antagonist (LTRA) leukotrienes limit lipid mediator Lung injury Lung pathology mechanism medication Montelukast Pathomechanisms Potential Potential treatment receptor reduce Respiratory disease respiratory virus severe pneumonia target targets therapeutic thrombosis tissue damage Treatment Vascular damage Viral pneumonia virus [DOI] 10.3389/fmolb.2020.610132 PMC 바로가기 [Article Type] Molecular Biosciences
Drug Repurposing for Prevention and Treatment of COVID-19: A Clinical LandscapeReview Article Published on 2020-12-162022-11-01 Journal: Discoveries [Category] COVID-19, [키워드] accelerate accumulate addition affected approval approved candidate caused clinical clinical trial clinically coronavirus COVID-19 COVID-19 patient COVID-19 vaccine distribution drug drug repositioning Effect effective expected FDA help Infection information lack landscape Mutation Novel coronavirus outbreak pandemic pandemic of COVID-19 phases Potential treatment prevention Remdesivir repurposing Research resource respond responsible SARS-CoV-2 suggested Therapeutics therapy treat Treatment USA Vaccine Vaccines viral infection virus [DOI] 10.15190/d.2020.18 PMC 바로가기 [Article Type] Review Article
Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST studyObservational Study Published on 2020-12-012022-10-04 Journal: European journal of internal medicine [Category] 임상, [키워드] addition analyses Analysis analyzed association C-reactive protein Clinical Center COVID-19 COVID-19 patients death death in COVID-19 disease severity elevated finding HCQ HCQ therapy hospitalised COVID-19 patient hospitalized patients Hydroxychloroquine In-hospital death in-hospital mortality Inflammation Inpatient Italian Italy laboratory-confirmed SARS-CoV-2 infection limit lower risk Mortality multicenter multicentre multivariable Patient patients hospitalized Potential treatment primary end-point Probability Randomized controlled trials receiving reduced Regression model retrospective secondary These data Treatment Weighting with COVID-19 [DOI] 10.1016/j.ejim.2020.08.019 PMC 바로가기 [Article Type] Observational Study
Mortality reduction in 46 severe Covid-19 patients treated with hyperimmune plasma. A proof of concept single arm multicenter trial과면역 혈장으로 치료받은 46명의 중증 코비드-19 환자의 사망률 감소. 개념 증명 단일 암 다기관 시험Article Published on 2020-12-012022-09-12 Journal: Haematologica [Category] MERS, SARS, 진단, [키워드] 95%CI Administered antibody ARDS Bilateral changes Chest chest X-ray Cohort conducted convalescent CPAP CRP died disease elevated enrolled expected hospital Hyperimmune plasma Intubated Laboratory LDH male mechanical ventilation monoclonal antibodies Mortality multicenter Multicenter trial Neutralizing null hypothesis occurred outcome paO2/fiO2 Patient patients patients treated plasma Potential treatment radiologic Randomized controlled trial reduction in respiratory secondary Serious Adverse Event severity Statistics Survivors Treatment was obtained weaning [DOI] 10.3324/haematol.2020.261784 PMC 바로가기 [Article Type] Article
A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of COVID-19Commentary Article Published on 2020-12-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] acute response addition adverse impact affected Alter cardiovascular disease cellular Combination COVID-19 COVID-19 pandemic death demonstrated Effect effective Effectiveness Effects Factor Gut Hospitalization immune response immunomodulation individuals Infection inflammatory conditions Isolation measure metabolic condition Microbiome mitigate mitochondrial dysfunction Non-invasive Other Pain pandemic Photobiomodulation Potential Potential treatment potential treatment option prevention risk role Safe shown Spread symptoms of infection therapy those with comorbidities those with comorbidity tissue Treatment virus [DOI] 10.14336/AD.2020.0901 PMC 바로가기 [Article Type] Commentary Article
Anti–coronavirus disease 2019 (COVID‐19) targets and mechanisms of puerarin푸에라린의 항 코로나 바이러스 질병 2019 (COVID-19) 표적 및 메커니즘Original Article Published on 2020-11-262022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] Apoptosis B cell BCl2 binding CASP3 CASP8 caspase caspase 3 caspase 8 Cell COVID‐19 COVID‐19 disease docking effective EGFR epidermal epidermal growth factor FOS growth factor IL2 in silico inflammatory cascades interleukin interleukin 2 MAPK marker mechanism methodology modulation molecular docking molecular markers Necrosis network pharmacology nitric oxide nitric oxide synthase NOS3 oxidative stress p53 pathway Pathways pharmacological potential molecular Potential treatment PPARG PRKCA PRKCB Protein protein kinase protein p53 PTGS2 puerarin receptor RELA suppression target targets TNF TP53 treat Treatment tumour necrosis factor [DOI] 10.1111/jcmm.16117 PMC 바로가기 [Article Type] Original Article
SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?Perspective Published on 2020-11-252022-10-31 Journal: Cell Death Discovery [Category] COVID-19, [키워드] association Basic science Cell cell death clinical feature COVID-19 develop drug candidate Ferroptosis Hypothesis in vitro in vivo inhibitor Intracellular lymphopenia mechanism Microbiology multiple organ involvement New coronavirus new treatment strategy observation organ outbreak Patient patients performed Potential treatment programmed cell death proportion reported SARS-CoV-2 SARS-COV-2 infection serum severe coronavirus disease severe disease Stage the disease therapeutic agent therapeutic strategy Treatment understanding [DOI] 10.1038/s41420-020-00369-w PMC 바로가기 [Article Type] Perspective
Adaptive platform trials using multi-arm, multi-stage protocols: getting fast answers in pandemic settings다단계, 다단계 프로토콜을 사용하는 적응형 플랫폼 시험: 전염병 상황에서 빠른 답변 얻기Opinion Article Published on 2020-11-232022-09-11 Journal: F1000Research [Category] MERS, 임상, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive platform trial approach benefit Clinicians competing conduct conducted control arm coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 determine effective interventions efficient Epidemic FAME faster greater Health Health care Health care system health care systems help identify in-silico In-vitro inefficient Infection Interim analyses interim analysis International Intervention investigated IPD limitation majority MAMS Meta-analysis multi-arm multi-stage not used overcome pandemic Pandemics patients platform Platform trial potential therapeutic agent potential therapeutic agents Potential treatment promise provide Randomised clinical trials recruitment respiratory SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus significantly solution Standard-of-care subsequent therapeutic agents Treatment Trial trials Two-arm Vaccinations well [DOI] 10.12688/f1000research.26253.2 PMC 바로가기 [Article Type] Opinion Article
The role of pharmaceutical nanotechnology in the time of COVID-19 pandemic코로나19 팬데믹 시대에 제약 나노기술의 역할Review Published on 2020-11-202022-09-10 Journal: Future Microbiology [Category] SARS, 비임상, 임상, 치료제, [키워드] Antiviral antiviral activity approach approved breath Clinical use COVID-19 COVID-19 pandemic COVID-19 treatment COVID-19 treatments demonstrated drug drug toxicity drugs effective therapy Efficacy exhibiting IMPROVE in vitro nanostructured delivery systems Nanotechnology Potential treatment potential treatments tested therapeutic action Toxicity Treatment [DOI] 10.2217/fmb-2020-0118 PMC 바로가기 [Article Type] Review