577. COVI-VAC™, a Live Attenuated COVID-19 Vaccine, Provides Single Dose Protection Against Heterologous Challenge with SARS-CoV-2 Beta (B.1.351) in the Syrian Golden Hamster ModelPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] affected Against age Amino acid Analysis animal B.1.351 Beta biodistribution board challenge change clinical trials conducted COVID-19 COVID-19 vaccine demonstrated Efficacy employee evaluated figure furin cleavage site hamster Heterologous heterologous challenge Histopathology in vivo Inc include intranasal intranasally key tissue Kushnir less maintain member Model Mutation neutralization neutralizing antibody non-human primate model Phase 1 PhD presenting prevented protection Protective qPCR raise reduced Result Robert SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant sequence serum Seven silent single dose spike-based vaccines Syrian Golden hamsters timepoint Vaccine variant variant of SARS-CoV-2 Viral antigen viral antigens viral evolution viral replication weighed weight weight loss wildtype [DOI] 10.1093/ofid/ofab466.775 PMC 바로가기 [Article Type] Poster Abstracts
Beneficial and harmful outcomes of tocilizumab in severe COVID-19: A systematic review and meta-analysis중증 COVID-19에서 토실리주맙의 이로운 결과와 유해한 결과: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-11-012022-09-11 Journal: Pharmacotherapy [Category] 임상, 진단, [키워드] 95% CI 95% confidence interval addition Administered administration benefit clinical trials coronavirus Corticosteroid Corticosteroids COVID-19 COVID-19 patient database Evidence greater hospitalized patient hospitalized patients ICU in-hospital mortality intensive care unit intensive care units Medline database Meta-analysis Mortality observational studies observational study occurred Odds ratio outcome Patient patients hospitalized patients with COVID-19 prevented provided random-effects model randomized clinical trial RCTs receiving reported retrospective risk SARS-CoV-2 searched Secondary infection secondary infections significantly higher Standard of care symptom onset systematic review TCZ Tocilizumab treated with COVID-19 [DOI] 10.1002/phar.2627 PMC 바로가기 [Article Type] Meta-Analysis
Apoptosis Enhances the Replication of Human Coronavirus OC43Article Published on 2021-11-012022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] accompanied Apoptosis caspase-3 caspase-dependent apoptosis cell cycle arrest cells cleavage contribute coronavirus cyclin D1 Degradation dephosphorylation HCoV-OC43 Human human coronavirus implication induce Infection inhibitor involved mild common cold molecular mechanism OC43 PARP prevented promote reduced Replication Stat1 STAT3 Vero Cell viral replication [DOI] 10.3390/v13112199 PMC 바로가기 [Article Type] Article
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations단일 클론 항체 조합에 의한 SARS-CoV-2 변이체 전반의 저용량 생체 내 보호 및 중화Article Published on 2021-10-292022-09-10 Journal: Nature Immunology [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered angiotensin angiotensin-converting enzyme 2 antibodies antibody Antimicrobial responses clearance Combination combinations complementary coronavirus Coverage cross-neutralizing demonstrated Effect escape mutants F486 function functions identify in vivo low-dose mAb mAb cocktail mAbs mechanism monoclonal antibodies monoclonal antibody monoclonal antibody combination N-terminal domain neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody NTD prevented prevention PROTECT provided RBD Receptor-binding domain recognize residue respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus spike glycoprotein Spike protein target the RBD the receptor-binding domain the spike protein therapeutic These data unique variants variants of concern Viral viral escape viral inactivation viral infection viral neutralization vulnerability [DOI] 10.1038/s41590-021-01068-z PMC 바로가기 [Article Type] Article
Clinical outcomes and cost-effectiveness of COVID-19 vaccination in South AfricaArticle Published on 2021-10-292022-10-04 Journal: Nature Communications [Category] MERS, SARS, 임상, 치료법, [키워드] assumption benefit Care Characteristics clinical Clinical outcome country Coverage COVID-19 vaccination COVID-19 vaccine death distribution Effectiveness Efficacy Efficiency Epidemic Epidemiology evaluate Factors growth Health Health care economics hospitalizations Immunity implementation Infection Model outcome Prevalence prevented provided Providing public health reduced resource SARS-CoV-2 South Africa Supply shortages the vaccine vaccination Vaccine [DOI] 10.1038/s41467-021-26557-5 PMC 바로가기 [Article Type] Article
The impact of COVID-19 pandemic on medical students’ mental health and sleep quality in Jordan: a nationwide cross-sectional studyResearch Published on 2021-10-262022-10-29 Journal: Middle East Current Psychiatry [Category] COVID-19, [키워드] Affect ANOVA Anxiety associations Care caused Chi-square COVID-19 COVID-19 pandemic cross-sectional cross-sectional design Depression depressive expected fear Jordan limitation Local medical students Medicine mental health Mild pandemic pandemic of COVID-19 Prevalence prevented Psychological distress Quality questionnaire reported resource Result scale School second wave significantly lower Sleep sleep quality student susceptible Symptom was used were used while [DOI] 10.1186/s43045-021-00150-4 PMC 바로가기 [Article Type] Research
Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient childIRF9 결핍 아동에서 SARS-CoV-2의 단일 클론 항체 매개 중화Case Reports Published on 2021-10-262022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, 진단, [키워드] antibody Antiviral autoantibodies autoantibody Blood blood type Casirivimab caused children clinical manifestation clinical manifestations component Course COVID-19 COVID-19 pneumonia Critical deficiency expression girl high risk IFN IFN-stimulated gene IFN-stimulated genes IFN-α2 IFNs Imdevimab Immunity Infection Influenza influenza pneumonia inherited deficiency inherited primary immunodeficiency interferon interferons IRF9 lack leukocyte leukocytes life-threatening monoclonal antibodies monoclonal antibody nasal neutralization Neutralizing neutralizing monoclonal antibody overcome Patient peaked Pneumonia prevented reported respiratory respiratory tract infection response risk RNA-Seq SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 virus secretion selected Significance transcription factor type I type I and III interferons type I IFNs type I interferon Type III IFN upper respiratory tract upper respiratory tract infection Viremia virus [DOI] 10.1073/pnas.2114390118 PMC 바로가기 [Article Type] Case Reports
Case Report: Cyclophosphamide in COVID-19 – when an absolute contraindication is an absolute necessityCase Report Published on 2021-10-252022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] abnormality Acute kidney injury acute respiratory distress alveolar alveolar haemorrhage Antibiotics antibody antibody panel carried changes in Corticosteroid Course COVID-19 COVID-19 diagnosis Cyclophosphamide cytoplasmic Diagnosis Dyspnoea Fever greater had no immunoglobulins in some initial treatment initiated intravenous kidney Kidney function knowledge Laboratory Laboratory test life-threatening lung other disease p-ANCA parameter Patient Pneumonia positive prevented pulmonary radiological Remdesivir renal retrieved SARS-CoV-2 syndrome the patient treating SARS-CoV-2 infection Treatment Vasculitis [DOI] 10.12688/f1000research.55625.2 PMC 바로가기 [Article Type] Case Report
Can we use the internet to study speech production? Yes we can! Evidence contrasting online versus laboratory naming latencies and errors인터넷을 사용하여 스피치 제작을 연구할 수 있습니까? 그래 우리는 할 수있어! 온라인과 실험실 명명 대기 시간 및 오류를 대조하는 증거Research Article Published on 2021-10-222022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] addition affected Analysis assumed Can carried caused closure cognitive Cognitive psychology collected conducted COVID-19 pandemic Effect effect sizes Evidence experiments feasible Frequency Internet lab Laboratory latency less pandemic participant prevented researcher researchers Sample size significantly tested [DOI] 10.1371/journal.pone.0258908 PMC 바로가기 [Article Type] Research Article
The SARS-CoV-2 main protease M pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cellsArticle Published on 2021-10-212022-10-04 Journal: Nature Neuroscience [Category] Fulltext, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome animal models block blood-brain barrier Brain Capillaries cause cell death Central nervous system infections changes in cleavage cleave cleaving coronavirus Coronavirus disease 2019 COVID-19 death Deletion Endothelial cell Evidence Germany individual induce inhibitor Lubeck M pro membrane mice NEMO Neurological symptoms nuclear Occurrence pathology patients with COVID-19 pharmacological potential mechanism potential therapeutic target prevented protease Protein Regulated cell death representing SARS-CoV-2 SARS-CoV-2 main protease Signaling small vessel Symptoms treat undergo Vascular vessel [DOI] 10.1038/s41593-021-00926-1 PMC 바로가기 [Article Type] Article