priming – Page 16 – Communicable Diseases Research

Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes

SARS-CoV-2 감염 및 인간의 정량적 표현형에 관여하는 ACE2 및 TMPRSS2 유전자의 유전적 변이체 간의 연관성 부족

Genetics

Published on 2020-06-082022-08-13
Journal: Frontiers in Genetics [Category] 유전자 메커니즘,

Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming

Article

Published on 2020-05-222022-10-30
Journal: Molecules [Category] COVID-19, MERS, SARS,

[키워드] Anthrax toxin bacterial toxin cleavage site cleavage sites comparison Confusion coronavirus Coronaviruses COVID19 Critical cross determine develop effective effort furin Genome highly pathogenic homologue host serine protease human host in vivo inhibitor involved less MERS-CoV Mutation Pandemics pathogenic strain pathogenicity Potential priming processed processing Protease inhibitor Proteases protecting antigen recent Receptor binding domain S-protein S2′ cleavage SARS-CoV2 sequence serine protease serine protease inhibitor spike spike glycoprotein targeting TMPRSS2 Toxicity Viral protein virulence virus
[DOI] 10.3390/molecules25102424 PMC 바로가기 [Article Type] Article

SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells

Resource

Published on 2020-04-142022-10-31
Journal: The EMBO Journal [Category] COVID-19, MERS,

[키워드] COVID‐19

FURIN

ACE affecting ase binding bronchial branche bronchial cell Cell cell type cells Chromatin, Epigenetics, Genomics & Functional Genomics ciliated cofactor Computational biology coronavirus COVID distribution donors epithelial differentiation expressed expression expression level Factor GTP Host Human Cell Atlas identify identity Infection lung tissue Microbiology, Virology & Host Pathogen Interaction nuclei pandemic Pathogenesis pathway priming public health receptor Replication reported resource Respiratory system respiratory tract RHO RNA RNA sequencing secretory cell Single Cell subsegmental tissues TMPRSS 2 virus infection while
[DOI] 10.15252/embj.20105114 PMC 바로가기 [Article Type] Resource

Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity

Short communication

Published on 2020-04-092022-10-30
Journal: Journal of Translational Autoimmunity [Category] COVID-19,

[키워드] adaptive immune system Antigen Antigen presentation Autoantigens Autoimmunity Bacteria candidate class consequence contribute COVID-19 COVID-19 disease Critical element epitope excluded expected explain exposure failure genes encoding had no homologous homology human protein human proteins Immune Enhancement immune system immunogenic immunological priming Immunopathogenesis in viral indicate Infection injection involved Local lung tissue mapping MERS MERS spike protein MHC Mortality outcomes Pathogenesis pathogenic Pathogenic priming pathway peptide priming Protein provide responsible risk SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Signaling similarity Spike proteins Symptom target Trial vaccination Vaccine Vaccine development Viral protein virus
[DOI] 10.1016/j.jtauto.2020.100051 PMC 바로가기 [Article Type] Short communication

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Article

Published on 2020-03-052023-06-14
Journal: Cell [Category] MERS, SARS,

[키워드] ACE2 coronavirus COVID-19 Entry neutralization priming SARS-CoV-2 spike TMPRSS2
[DOI] 10.1016/j.cell.2020.02.052 PMC 바로가기 [Article Type] Article

Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trial

DNA 또는 NYVAC 벡터(HVTN 096)가 있는 외피 단백질을 포함하는 다가 HIV 백신의 안전성 및 면역원성: 1b상, 이중 맹검, 위약 대조 시험

Article

Published on 2019-10-072022-09-06
Journal: The Lancet. HIV [Category] Communicable Disease,

[키워드] active treatment Administered administration adverse event allergy antibodies antibody Antibody Response Antibody responses antibody-dependent cell-mediated cytotoxicity approach assigned binding binding antibody boost Cell-mediated cytotoxicity Combination component computer-generated Coverage cranial cytotoxicity died DNA dose doses double-blind early administration effective Efficacy enrolled envelope protein epitope finding followed by foundation funding glycoprotein gp120 healthy healthy volunteer healthy volunteers HIV infection HIV vaccine IgG IgG response IgG responses immunogenicity individual Infection Infectious diseases injection Lymphadenopathy marker measure Melinda Gate Melinda Gates motor vehicle Neutralising Antibodies outcome participant Participants Placebo placebo group placebo-controlled placebo-controlled trial Primary outcomes priming product Protein purified random Randomly reactogenicity regimen Registered responses risk Safety screened Serious Adverse Event Serious Adverse Events Switzerland the placebo group the vaccine trauma Treatment treatment group treatment groups Trial trials vaccination vaccination schedule Vaccinations Vaccine vector Volunteer
[DOI] 10.1016/S2352-3018(19)30262-0 PMC 바로가기 [Article Type] Article

Pathogenicity and immunogenicity of attenuated porcine epidemic diarrhea virus PC22A strain in conventional weaned pigs

Research Article

Published on 2019-01-112022-10-28
Journal: BMC veterinary research [Category] Coronavirus, MERS,

[키워드] adjuvant Administered age antibody Antibody Response cause caused Cell culture cells diarrhea Efficacy elicit epidemic diarrhea evaluated fecal genetics greater group IgA IgG inactivated induce inoculated intestinal Live attenuated vaccine mortality rate mucosal immune mucosal immunity multiple dose naïve Neonatal Neutralizing PEDV porcine epidemic diarrhea virus (PEDV) post inoculation pregnant priming regimen response Result resulting RNA Safe serum subunit Subunit vaccine supplementary material tested The United States vaccination Vaccine vaccine candidates Viral RNA Viral RNA shedding virulent virus Weaned pigs
[DOI] 10.1186/s12917-018-1756-x PMC 바로가기 [Article Type] Research Article

Immune Priming and Long-term Persistence of Memory B Cells After Inactivated Poliovirus Vaccine in Macaque Models: Support for at least 2 Doses

불활성화 폴리오바이러스 백신 접종 후 마카크 모델에서 면역 프라이밍 및 기억 B 세포의 장기 지속성: 최소 2회 접종에 대한 지지

Article

Published on 2018-11-152024-08-01
Journal: Clinical infectious diseases : an official publication of the Infectious [Category] 폴리오,

[키워드] B-cells IPV memory Neutralizing antibodies polio priming
[DOI] 10.1093/cid/ciy634 PMC 바로가기

Dynamics of Virus-Specific Memory B Cells and Plasmablasts following Viral Infection of the Central Nervous System

Cellular Response to Infection

Published on 2018-10-172022-10-30
Journal: Journal of Virology [Category] Coronavirus,

[키워드] antibody Antigen presentation Antiviral ASC Autoimmune B cell B cell responses B cells Brain Cell Central nervous system Central nervous system infections CNS contributing to coronavirus Coronavirus infection CRE Cre recombinase Cytidine deaminase Delayed demonstrated draining lymph node draining lymph nodes Dynamics event exhibiting expressing expression Factor functional GC reaction gcs germinal centers Humoral response Infection Intervention lack Local marker memory B cell mice modulate MONITOR murine nervous Neuroimmunology neurotropic Pathologies peaked phenotypic plasmablast Prevalence prevalent priming progeny promoter proportion Reactions recruited recruitment regulate reporter robust subset Support supported sustained System Tamoxifen Treatment viral encephalomyelitis viral infections viral persistence while
[DOI] 10.1128/JVI.00875-18 PMC 바로가기 [Article Type] Cellular Response to Infection

Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia

Research Article

Published on 2018-06-072022-11-01
Journal: JCI Insight [Category] Coronavirus, SARS,

[키워드] absence activate activated activated macrophage Activation acute respiratory syndrome adaptive airway Antigen caused coronavirus CoV Heterologous IFN-I immune Immunity immunology independent infiltration Inflammatory inflammatory monocyte influenza A virus Innate immunity inspired air Local lung Lung infection Lungs monocyte Monocytes morbidity Mortality mucosal mucosal immune murine nasal nasal mucosa NK cell Particle pathogen Pneumonia priming PROTECT protective immunity provide pulmonary lymph nodes reduced SARS-CoV Signaling significantly these cell Type I IFN viral infections Virology virus virus infection virus pneumonia
[DOI] 10.1172/jci.insight.99025 PMC 바로가기 [Article Type] Research Article