pro-inflammatory cytokine – Page 16 – Communicable Diseases Research

Coronavirus disease-19 and cardiovascular disease: A risk factor or a risk marker?

코로나바이러스감염증-19와 심혈관질환: 위험인자인가, 위험표지자인가?

Review

Published on 2021-05-012022-09-11
Journal: Reviews in Medical Virology [Category] SARS, 바이오마커, 치료제,

Computational Identification of Potential Anti-Inflammatory Natural Compounds Targeting the p38 Mitogen-Activated Protein Kinase (MAPK): Implications for COVID-19-Induced Cytokine Storm

Article

Published on 2021-04-292022-10-28
Journal: Biomolecules [Category] COVID-19, MERS,

[키워드] Activation aggregation Anti-inflammatory anti-inflammatory activity anti-inflammatory compounds Antiviral AUC AutoDock binding energy characteristic China Compound Concentration coronavirus coronavirus disease COVID-19 Critical Cytokine storm elevated elicit exhibit exhibited greater identification identify immunosuppressive in vitro Inflammation inhibitor inhibitors inhibitory kinase kinase inhibitors MAPK mitigate molecular molecular docking Molecular dynamics simulation natural natural products p38 MAPK Patient PDB ID pharmacological Platelet platelet activation Potential predicted pro-inflammatory cytokine pro-inflammatory cytokines profile receptor reported residue ROC screened storm targeting the cytokine storm therapeutic target Toxicity with COVID-19 X-ray
[DOI] 10.3390/biom11050653 PMC 바로가기 [Article Type] Article

Role of Inflammatory Cytokines in COVID-19 Patients: A Review on Molecular Mechanisms, Immune Functions, Immunopathology and Immunomodulatory Drugs to Counter Cytokine Storm

Review

Published on 2021-04-292022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] Activation acute respiratory distress acute respiratory syndrome alveolar cell Anti-inflammatory anti-inflammatory drug antiviral drug B cell candidate cascade caused cells characterized Chronic diseases Complication complications coronavirus Coronavirus disease 2019 counter COVID-19 COVID-19-related complications cytokine Cytokine storm drug drugs dysregulated effective elevated event function Genomics hypercytokinemia Hyperinflammatory IL-1 IL-6 Immune cell Immunity immunological pathways immunomodulatory drug immunomodulatory drugs immunopathology Implications incidence Inflammatory Inflammatory cytokines Inflammatory marker inflammatory monocyte Jak JAK/STAT signaling lung alveolar Macrophage macrophages measure mechanisms molecular mortality rate multiple organ failure pandemic pathway Pathways Pneumonia pro-inflammatory cytokine progression recruit reported review role SARS-CoV-2 secretion severely ill patient severity storm suppressed survival rate syndrome the cytokine storm the disease therapeutic drug Therapies TNF-α Trial viral infection with COVID-19
[DOI] 10.3390/vaccines9050436 PMC 바로가기 [Article Type] Review

Respiratory Impairment Predicts Response to IL-1 and IL-6 Blockade in COVID-19 Patients With Severe Pneumonia and Hyper-Inflammation

호흡기 장애, 중증 폐렴 및 과염증이 있는 COVID-19 환자에서 IL-1 및 IL-6 차단에 대한 반응 예측

Clinical Trial

Published on 2021-04-292022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단,

[키워드] administration Anakinra anti-cytokine therapy anti-cytokine therapy initiation coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 patient Cytokines Efficacy Evidence evidence of Follow-up hyper-inflamed COVID-19 patient hyper-inflamed COVID-19 patients identify IL-1 IL-6 IL-6 blockade IL-6 blocking inhibitor initiated interleukin interleukin (IL)-1 interleukin-1 interleukin-6 median Mortality objective PaO Patient patients treated pro-inflammatory cytokine pro-inflammatory cytokines provided reduced respiratory Respiratory failure respiratory impairment response Restraining maladaptive inflammation Result sarilumab SARS-CoV-2 selective severe coronavirus disease severe hyper-inflamed COVID-19 patients severe respiratory failure significantly higher Standard of care Standard therapy stratified survival survival rate therapeutic therapy Tocilizumab treat treated Treatment treatment failure treatment initiation treatment with biologics window
[DOI] 10.3389/fimmu.2021.675678 PMC 바로가기 [Article Type] Clinical Trial

Cytokine storm modulation in COVID-19: a proposed role for vitamin D and DPP-4 inhibitor combination therapy (VIDPP-4i)

Perspective

Published on 2021-04-282022-10-04
Journal: Immunotherapy [Category] MERS, SARS, 신약개발,

[키워드] Abstract acute respiratory syndrome Anti-inflammatory cardiovascular disease characterized combination therapy coronavirus COVID-19 Cytokine storm diabete diabetes Dipeptidyl peptidase-4 DPP-4 inhibitors Drug repurposing dysregulated immune response Evidence homeostasis immunomodulation immunomodulator immunomodulators immunomodulatory properties immunomodulatory property increasingly inhibitor inhibitors modulate modulation pathophysiology patients with diabete Prevent prevent disease progression pro-inflammatory cytokine pro-inflammatory mediators progression Regulation reported SARS-CoV-2 severe coronavirus disease shown synergistic the cytokine storm Therapeutic approach Treatment Type type 2 diabetes VIDPP-4i virulence Vitamin D
[DOI] 10.2217/imt-2020-0349 PMC 바로가기 [Article Type] Perspective

IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

IFN-γ 및 TNF-α는 심각한 COVID-19 폐 및 조직 염증이 있는 염증성 질환에서 확장된 CXCL10+ CCL2+ 대식세포 표현형을 유도합니다

Research

Published on 2021-04-202022-08-13
Journal: Genome Medicine [Category] MERS, SARS, 유전자 메커니즘,

[키워드] affected anti-cytokine antiviral interferon approach Arthritis association bronchoalveolar lavage samples CCL2 CCL3 CD ileum Cell cell-type identification cellular phenotype cellular phenotypes Combination COVID-19 Crohn’s disease CXCL10 CXCL9 Cytokines defined disease-affected donor disease-affected donors disparate Donor driving Effect elevated environmental factor environmental factors established therapy exhibited FIVE GBP1 Genes healthy healthy control healthy subject healthy subjects help human blood-derived macrophage human blood-derived macrophages identify IFN-beta IFN-beta (IFN-β IFN-gamma IFN-β IFN-γ IL1B Immune cell immune cell state immune cell states immune state Immunomodulatory therapies inflamed CD ileum inflamed RA synovium inflamed tissue inflamed tissues Inflammatory inflammatory disease Inflammatory diseases inflammatory factors inflammatory macrophage phenotype Integrative analysis interferon response interferons Interstitial lung disease lung Lung disease lupus erythematosus Macrophage Macrophage heterogeneity macrophage phenotype macrophage phenotypes macrophage state Macrophage stimulation macrophages Meta-analysis mixed-effects modeling Patient patients with COVID-19 pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines protective effect RA synovium Result rheumatoid arthritis severe COVID-19 severe COVID-19-affected lungs single-cell Single-cell multi-disease tissue integration single-cell profile Single-cell transcriptomics SLE Stat1 stimulated Stimulation Support systemic lupus erythematosus tested These cells tissue tissue inflammation tissues TNF TNF-α transcriptomic profile Treatment UC colon ulcerative colitis understanding
[DOI] 10.1186/s13073-021-00881-3 PMC 바로가기 [Article Type] Research

Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by Dexamethasone

Original Article

Published on 2021-04-162022-10-30
Journal: Inflammation [Category] COVID-19, MERS, SARS,

[키워드] Activation anti-inflammatory activity blocked caused clinical benefit COVID-19 Cytokine storm Cytokines Degradation Dexamethasone DNA binding Effect experiment Human IL-1β IL-6 IL-8 increase in induction Inflammation Inflammatory inhibition investigated involved IκBα MAPK mechanism molecular mononuclear cell NF-_KB NF-κB NF-κB activation NLRP3 inflammasome p65 PBMC PBMCs peripheral Peripheral blood pharmacological target Phosphorylation pro-inflammatory cytokine produced Production recombinant reducing reduction reduction in SARS-CoV-2 SARS-CoV-2 cytokine storm SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike glycoprotein S1 SARS-CoV-2 virus infection significantly increased spike spike glycoprotein stimulated Stimulation TNFα was reduced
[DOI] 10.1007/s10753-021-01464-5 PMC 바로가기 [Article Type] Original Article

Tocilizumab treatment in critically ill patients with COVID-19: A retrospective observational study

코로나19 중증 환자에 대한 토실리주맙 치료: 후향적 관찰 연구

Observational Study

Published on 2021-04-012022-09-12
Journal: International Journal of Infectious Diseases [Category] SARS, 임상, 진단, 치료법,

[키워드] acute respiratory distress syndrome administration attenuate chimeric antigen receptor conducted COVID-19 COVID-19 patients Critically ill Critically ill patient Cytokine release syndrome Cytokine storm death disease severity distress dysregulated immune response group hospital hospital discharge intensive care interleukin-6 receptor Intubated invasive measurement mechanical ventilation not different on mechanical ventilation outcome Patient patients patients treated percentage Pneumonia pro-inflammatory cytokine progressed required Respiratory disease retrospective SARS-CoV2 Secondary infection severe COVID-19 infections subgroup of patient Tocilizumab treat Treatment venous
[DOI] 10.1016/j.ijid.2021.02.057 PMC 바로가기 [Article Type] Observational Study

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

COVID-19 발병의 전염증성 사이토카인: 무엇이 잘못되었습니까?

Review

Published on 2021-04-012022-09-12
Journal: Microbial pathogenesis [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] addition appear cause caused China Clinical outcome contribute coronavirus 2 coronavirus disease country COVID-19 CRS cytokine Cytokine release syndrome Cytokines described effector cell exacerbated extensive lung damage human SARS-CoV-2 IL-17 IL-1β IL-6 IL-8 immune immune response immune system immunological infected with SARS-CoV-2 Infection Inflammation involved knowledge MERS non-immune outbreak Pathogenesis pro-inflammatory cytokine pro-inflammatory cytokines pulmonary inflammation respiratory SARS-CoV-2 Severe case severe COVID-19 patients spread to subject systemic inflammatory response thrombosis TNFα
[DOI] 10.1016/j.micpath.2021.104799 PMC 바로가기 [Article Type] Review

Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19

아미노산 감지 경로: 비만과 코로나19 발병의 주요 체크포인트

Review

Published on 2021-04-012022-09-11
Journal: Obesity Reviews [Category] SARS, 유전자 메커니즘,

[키워드] Activation aggravate Amino acid amino acid sensor GCN2 amino acids antiviral response Comorbidities Comorbidity correlation COVID-19 COVID-19 susceptibility deficiency effective GCN2 Host host cell host cells Hyperactivation IL-1β increase Infection Inflammation inhibiting interleukin interleukin-1 beta intestinal inflammation mammalian mechanism mitigate Mortality mTOR obesity obesogenic opposite overnutrition oxygen Pathogenesis Pathologies pathway pro-inflammatory cytokine Rapamycin reactive oxygen species reactive oxygen specy Replication reprogramming ROS SARS-CoV-2 serum shown suppresse susceptibility translation translational viral infections Viremia while with COVID-19
[DOI] 10.1111/obr.13221 PMC 바로가기 [Article Type] Review