Leaving no one behind in prison: improving the health of people in prison as a key contributor to meeting the Sustainable Development Goals 2030Analysis Published on 2021-03-262022-10-28 Journal: BMJ Global Health [Category] Coronavirus, SARS, [키워드] Analysis contribute COVID-19 pandemic exclusion Health Health policy health systems International Mental physical public health Recognition sustainable development goal turn [DOI] 10.1136/bmjgh-2020-004252 PMC 바로가기 [Article Type] Analysis
Computational Mutagenesis at the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 Binding Interface: Comparison with Experimental EvidenceSARS-CoV-2 스파이크 단백질/안지오텐신 전환 효소 2 결합 인터페이스에서의 전산 돌연변이 유발: 실험 증거와의 비교Article Published on 2021-03-182022-09-10 Journal: ACS Nano [Category] 변종, [키워드] ACE2 ACE2 residue acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral therapeutics arginine aspartic acid binding caused cellular China computational mutagenesis contribute coronavirus coronavirus disease coronavirus disease-2019 COVID-19 D30E dimension dimensions Effect Emergency use authorization ENhance free energy of binding glutamic acid glycoprotein human host hydrophobic in silico inhibitor interface residue Invasion isoleucine lysine molecular molecular dynamics molecular mechanics/Poisson−Boltzmann surface area (MM/PBSA) mutant Neutralizing antibodies neutralizing antibody pandemic pathogen polar predicted Prevent promote Protein Protein binding receptor binding domain Receptor binding domain Recognition regimen replaced REPLACED BY residue residues respiratory resulting S-protein S-RBD SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 spike protein Serine severe acute respiratory syndrome Coronavirus shape spike spike glycoprotein Spread strength the SARS-CoV-2 therapeutic threonine treat Tryptophan Vaccine variant variants Variation Viral viral spike wild-type yielding [DOI] 10.1021/acsnano.0c10833 PMC 바로가기 [Article Type] Article
Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies다클론성 인간 혈장 항체의 인식에 영향을 미치는 SARS-CoV-2 수용체 결합 도메인의 돌연변이에 대한 포괄적인 매핑Article Published on 2021-03-102022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] Affect affected antibody Antibody binding antibody escape Antibody-mediated immunity Comprehensive convalescent plasma deep mutational scanning domain epitope Epitopes Evolution Evolution of SARS-CoV-2 facilitate heterogeneity Human plasma Immunity impacted impair individual lineages longitudinal samples Mutation mutations neutralization Neutralizing activity occur plasma plasma antibody polyclonal polyclonal immunity RBD Receptor-binding domain receptor-binding motif Recognition reduce reduced SARS-CoV-2 SARS-CoV-2 evolution spike Surveillance the RBD the SARS-CoV-2 virus [DOI] 10.1016/j.chom.2021.02.003 PMC 바로가기 [Article Type] Article
Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification바이러스 진입 및 선천 면역의 생식선 유전 변이가 SARS-CoV-2 감염에 대한 감수성에 영향을 줄 수 있음: 위험 계층화를 위한 다유전자 위험 점수를 향하여Review Published on 2021-03-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 치료기술, [키워드] affected affecting Alter analyzed approach association Autoimmune diseases Bacterial bacterial and viral infections caused Cell Chronic illness clinical consequences clinically complex consequence COVID-19 COVID-19 pandemic detect determinant develop Epidemics Evidence evidence of Factor focus followed by genetic association genetic associations genetic susceptibility Genome genomic genotype-phenotype association studies germline healthcare healthy individual healthy individuals immune influence Innate Innate immunity knowledge Manifestations multitude Novel coronavirus nucleotide older patient older patients polygenic risk score Previous studies previous study Protective provided Recognition risk risk stratification SARS-CoV-2 SARS-COV-2 infection score severe complications Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility susceptibility loci variants variations Viral viral entry viral infections [DOI] 10.3389/fimmu.2021.653489 PMC 바로가기 [Article Type] Review
Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses외피 단일 가닥 RNA 바이러스에 대한 항바이러스제로서의 숙주 방어 RNaseReview Published on 2021-03-042022-09-10 Journal: Virulence [Category] SARS, 치료법, [키워드] agent antiviral activity antiviral drugs apoptosis pathways approved coronavirus coronavirus disease COVID-19 Defense develop drug drug candidate Drug development effective Enveloped single-stranded RNA Viruses evade focus Host host defense immune immune modulation immune regulation include information innate immune system Innate immunity outbreak pandemic Pathogens Pathways Perspective Prevent Recognition reported RNA RNase RNases Safe single-stranded ssRNA Stress treat unique Viral viral genome viral infection viral infections viral pathogens virus virus-host interplay viruses [DOI] 10.1080/21505594.2021.1871823 PMC 바로가기 [Article Type] Review
Pattern Recognition of the COVID-19 Pandemic in the United States: Implications for Disease MitigationArticle Published on 2021-03-032022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Analysis analyzed assigned Cluster coronavirus COVID-19 COVID-19 case COVID-19 cases disease early phase examined Health highest information K-means clustering late phase machine learning mapped mitigate Mitigation New York Novel coronavirus outbreak pandemic pattern PCA principal component analysis Recognition recognize reported seasonal-trend decomposition spatial pattern Spread the disease unique United State were infected [DOI] 10.3390/ijerph18052493 PMC 바로가기 [Article Type] Article
COVID-19 Recognition Using Ensemble-CNNs in Two New Chest X-ray Databases두 개의 새로운 흉부 X선 데이터베이스에서 Ensemble-CNN을 사용한 COVID-19 인식Article Published on 2021-03-032022-09-12 Journal: Sensors (Basel, Switzerland) [Category] 진단, [키워드] Accuracy addition appearance approach carried collected data Community Comparisons computer vision Convolutional neural network COVID-19 COVID-19 infection database datasets deep learning effort Ensemble-CNNs evaluate New outperform protocols Recognition researcher resulting second X-ray X-ray scans [DOI] 10.3390/s21051742 PMC 바로가기 [Article Type] Article
SARS-CoV-2/COVID-19 pandemic: first wave, impact, response and lessons learnt in a fully integrated Regional Blood and Tissue Bank. A narrative reportSARS-CoV-2/COVID-19 전염병: 완전히 통합된 지역 혈액 및 조직 은행에서 첫 번째 물결, 영향, 대응 및 교훈. 내러티브 보고서Article Published on 2021-03-012022-09-11 Journal: Blood transfusion = Trasfusione del sangue [Category] SARS, 치료기술, [키워드] activity adverse effect Ambiguity Bank being Blood BST Care cells changes in clinical trial clinical trials Combination complexity convalescent plasma COVID-19 COVID-19 pandemic Critical described development diagnoses Donor donors effective element First wave flexibility Health health system International management material measure Mesenchymal stromal cells occurred pandemic Participation Patient patients promote Recognition recommendation Regional Research research and development response risk service Stress stromal cells Support tissue Tissue Bank volatility [DOI] 10.2450/2021.0259-20 PMC 바로가기 [Article Type] Article
Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication코로나바이러스 엔도리보뉴클레아제 nsp15에 의한 항바이러스 스트레스 과립 형성 억제로 효율적인 바이러스 복제 보장Research Article Published on 2021-02-262022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, 치료법, [키워드] accumulation Activation affected aggregation Analysis antagonist antagonists Anti-viral Antiviral array cells conserved coronavirus Coronavirus infection Coronaviruses Critical Crosstalk decrease demonstrated Depletion dsRNA eIF2α ENCODE endoribonuclease Evidence Factors function Heat shock Host host antiviral response host cell host response IBV IBV infection IFN response IFN-β immune response immunofluorescence analysis include increase infected cells Infection Infectious Bronchitis Virus inhibiting inhibition innate immune interfere Interference intrinsic IRF3 knowledge mechanism mRNAs NaCl Nsp15 overcome overexpressed Pattern recognition pattern recognition receptor Pattern recognition receptors PEDV Phosphorylation PKR prevalent Prevent Protein protein synthesis provided PRRs Recognition recruitment reducing Replication reported responsible RNA viruses SARS-CoV SARS-CoV-2 scaffold proteins shown Signaling sodium sodium arsenite Stress stress granule stress response suppression TGEV Transcription translation Trigger triggered turn Viral viral dsRNA virus virus replication viruses wild type [DOI] 10.1371/journal.ppat.1008690 PMC 바로가기 [Article Type] Research Article
Subtle Influence of ACE2 Glycan Processing on SARS-CoV-2 RecognitionResearch Article Published on 2021-02-192022-10-29 Journal: Journal of Molecular Biology [Category] COVID-19, MERS, SARS, [키워드] Abstract ACE2 ACE2 variants analyzed angiotensin-converting enzyme 2 binding cellular receptor glycan glycan engineering glycans glycoprotein glycosylated glycosylation human cells Impact influence Interaction LC-MS Modification modifications molecular basis N-linked glycan processing receptor Recognition SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral sensitivity severity sialic acid significantly Spike protein SPR suggested surface plasmon resonance variant viral spike virus was determined [DOI] 10.1016/j.jmb.2020.166762 PMC 바로가기 [Article Type] Research Article