Increased extravascular lung water index (EVLWI) reflects rapid non-cardiogenic oedema and mortality in COVID-19 associated ARDSObservational Study Published on 2021-06-012022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 임상, 치료법, [키워드] acute respiratory distress ARDS cardiac function cohorts comparable control group correlation COVID-19 COVID-19 associated ARDS COVID-19 negative COVID-19 patient develop Disease progression elevated evaluate Horowitz ICU in-hospital mortality Increased intubation lung marker MONITOR Mortality non-COVID-19 ARDS patients oedema parameter Patient patients with ARDS patients with COVID-19 progression prolonged intensive care reflect Respiratory distress syndrome significantly higher subsequent suggested syndrome Thermodilution Treatment vascular permeability ventilated patient viral infection viral persistence [DOI] 10.1038/s41598-021-91043-3 PMC 바로가기 [Article Type] Observational Study
Perspectives on glucocorticoid treatment for COVID-19: a systematic reviewCOVID-19에 대한 글루코코르티코이드 치료에 대한 전망: 체계적인 검토Article Published on 2021-06-012022-09-11 Journal: Pharmacological Reports [Category] SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome ADRS age all the inclusion criteria ARDS changes clinical status clinical trials commercialization coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 COVID-19 patients database described Dexamethasone English geographic location Glucocorticoid treatment Glucocorticoids heterogeneity inclusion criteria infected with SARS-CoV-2 Longitudinal studies longitudinal study Methylprednisolone Mortality nonrandomized clinical trial observational study pandemic Pandemics participant Participants Patient pharmacological treatment radiological Research respiratory distress Respiratory distress syndrome retrospective RT-PCR SARS- CoV-2 SARS-CoV-2 screened selected Sex Spanish syndrome systematic review Treatment Vaccine Viral pneumonia Viremia was done was related [DOI] 10.1007/s43440-021-00225-3 PMC 바로가기 [Article Type] Article
Rifampicin and Letermovir as potential repurposed drug candidate for COVID-19 treatment: insights from an in-silico studyCOVID-19 치료를 위한 잠재적인 용도 변경 약물 후보로서의 Rifampicin 및 Letermovir: in-silico 연구의 통찰력Article Published on 2021-06-012022-09-11 Journal: Pharmacological Reports [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome Analysis approach ARDS binding affinity caused clinical trials Combination Compound COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients COVID-19 treatment Cytokine storm docking study drug drug candidate Drug repurposing examined FDA approved drug FDA approved Drugs free energy Free energy calculations high viral load host immune system hour identify IL-1β IL-6 in vitro in-silico inhibit involved Letermovir Lung function M pro Main protease Mpro medical emergency molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations multiple organ failure outcome protease provide respiratory distress Respiratory distress syndrome rifampicin SARS-CoV-2 SARS-CoV-2 main protease selected subsequent supported surface area syndrome the cytokine storm the SARS-CoV-2 these compounds TNF-α Treatment Viral load Virtual screening was performed [DOI] 10.1007/s43440-021-00228-0 PMC 바로가기 [Article Type] Article
Resuscitative Effect of Centhaquine (Lyfaquin ®) in Hypovolemic Shock Patients: A Randomized, Multicentric, Controlled Trial저혈량성 쇼크 환자에서 Centhaquine(Lyfaquin®)의 소생 효과: 무작위, 다중심, 대조 시험Clinical Trial Published on 2021-06-012022-09-11 Journal: Advances in therapy [Category] SARS, 비임상, 임상, [키워드] 1:1 added adverse event all-cause mortality animal model animal models ARDS base deficit baseline Blood both groups breath Centhaquine Clinical outcome comparable conducted control group Controlled demographics determine diastolic distress Effect effective Efficacy female patient greater Haemoglobin Haemorrhage healthy Hypovolemia hypovolemic Hypovolemic Shock ICU IMPROVE improvement Improvements in both group in both groups increase in Lactate less major surgery male MODS multicentre multiple organ dysfunction multiple organ dysfunction syndrome normal saline observation period organ dysfunction syndrome Patient Randomized respiratory distress Respiratory distress syndrome Resuscitation Resuscitative agent Scoring Shock Standard of care Support syndrome System the patient Tolerability Vasopressor vasopressors ventilator volunteers was recorded [DOI] 10.1007/s12325-021-01760-4 PMC 바로가기 [Article Type] Clinical Trial
Role of extracorporeal membrane oxygenation in critically Ill COVID-19 patients and predictors of mortality중환자 COVID-19 환자 및 사망 예측인자에서 체외막 산소화의 역할Observational Study Published on 2021-06-012022-09-11 Journal: Artificial organs [Category] MERS, SARS, 바이오마커, 임상, [키워드] acute respiratory distress syndrome addition an area AUC COVID-19 COVID-19 patient COVID-19 patients Critical Critical care Critically ill critically ill COVID-19 patients discharged distress ECMO ENhance extra corporeal membrane oxygenation Extracorporeal extracorporeal membrane oxygenation hazard ratio hazard ratios IL-6 Ill in-hospital mortality incidence include independent predictors management membrane Mortality non-survivor NT-pro-BNP NT-proBNP outcome Patient patients treated PCT prediction predictor remained RESP Score respiratory respiratory distress Respiratory distress syndrome retrospective risk factor Risk factors role SARS-CoV-2 selected sensitivity significantly significantly higher single-center study specificity survival Survivors treated Treatment Univariate analysis variable [DOI] 10.1111/aor.13873 PMC 바로가기 [Article Type] Observational Study
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes환기된 COVID-19 환자의 심각한 T 세포 과민반응은 장기간의 바이러스 지속성 및 나쁜 결과와 상관관계가 있습니다Article Published on 2021-05-212022-09-12 Journal: Nature Communications [Category] SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] basophils benefit blood sample caused Cell clinical recovery components coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine secretion dendritic cells downstream Effect extrinsic Factor female hospitalized COVID-19 patient hospitalized COVID-19 patients hyperinflammation identify IL-2 Immunosuppressive medication independent independent of male marker monocyte Monocytes neutrophil Neutrophils outcome overcome Patient patients plasma plasmacytoid dendritic cells Pneumonia polyclonal poor prognosis predict prolonged virus persistence reduced Respiratory distress syndrome respond SARS-CoV-2 SARS-CoV2 infection shown T cell T cell activation T cell response Ventilated ventilated patients viral infection viral persistence Whole blood [DOI] 10.1038/s41467-021-23334-2 PMC 바로가기 [Article Type] Article
Point-of-care lung ultrasound in COVID-19 patients: inter- and intra-observer agreement in a prospective observational studyClinical Trial Published on 2021-05-212022-10-04 Journal: Scientific Reports [Category] SARS, 바이오마커, 임상, 치료기술, [키워드] analyzed consolidation coronavirus disease COVID-19 COVID-19 patients disease evaluated highest ICU intensive care investigator lowest lung median moderate pathology patients point-of-care prospective observational study quantification random recorded Respiratory distress syndrome Respiratory signs and symptoms score sequence single-center study subpleural Variability viral infection [DOI] 10.1038/s41598-021-90153-2 PMC 바로가기 [Article Type] Clinical Trial
The Molecular Basis of COVID-19 Pathogenesis, Conventional and Nanomedicine TherapyCOVID-19 병인의 분자적 기초, 기존 및 나노의학 요법Review Published on 2021-05-212022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] accompanied activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus ADP-ribose angiotensin Angiotensin II Apoptosis Basis blocker blockers Cell cell death clinical manifestation clinical manifestations Conventional Coronaviridae family coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 pathogenesis cytokine Cytokine storm develop DNA damage Endothelial dysfunction explained Health Organization highly pathogenic humans infect inhibiting investigated involved iron iron oxides losartan macrodomain mechanism mefenamic acid MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular mechanisms morbidity morbidity and mortality nanomedicine Necrosis non-structural protein outbreak oxidative burst oxidative stress pandemic PARG PARP pathogenic virus Potential potential therapeutic targets protein 3 quantum dots RAS RAS pathway receptor receptor potential Renin renin-angiotensin system respiratory respiratory distress Respiratory distress syndrome respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway Spread syndrome tannins the Coronaviridae therapeutic agent therapeutic agents therapeutic targets thought trehalose TRPM2 Viral virus virus entry Vitamin D3 World Health Organization [DOI] 10.3390/ijms22115438 PMC 바로가기 [Article Type] Review
High Levels of Neutrophil Extracellular Traps Persist in the Lower Respiratory Tract of Critically Ill Patients With Coronavirus Disease 2019코로나바이러스 질병 2019를 앓고 있는 중환자의 하기도에서 높은 수준의 호중구 세포외 트랩이 지속됨Article Published on 2021-05-202022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus Admission alveolar alveolar spaces ARDS baseline Blood chemokine chemokines contribute coronavirus correlated Course COVID-19 Critically ill Critically ill patient critically ill patients Deceased deteriorate disease disease severity Extracellular Ill implicated Inflammatory marker inflammatory markers intensive care intensive care unit admission investigated Level Lower Lower respiratory tract LRT lung tissue marker NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils Pathogenesis patient with COVID-19 peaked plasma plasma samples produced respiratory respiratory distress Respiratory distress syndrome respiratory tract retained RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sputum syndrome the SARS-CoV-2 thrombosis tract with COVID-19 [DOI] 10.1093/infdis/jiab050 PMC 바로가기 [Article Type] Article
Understanding COVID-19: are children the key?COVID-19 이해: 어린이가 핵심입니까?Review Published on 2021-05-192022-09-11 Journal: BMJ Paediatrics Open [Category] SARS, 변종, [키워드] acute COVID-19 acute respiratory distress acute respiratory distress syndrome adaptive immune responses Adults Affect Asymptomatic Cell Cell Biology children combating community transmission COVID-19 COVID-19 infection COVID-19 pandemic Critical current Cytokine storm Epidemiology Evidence Health help hyperinflammation identify Immune escape immune response immune responses in some infected with SARS-CoV-2 Infection infection rate infection rates Inflammatory less Microbiology mild illness Mortality pandemic Pandemics Pathogenesis pathogenesis of SARS-CoV-2 patients phenotype Proinflammatory cytokine Reinfection Research respiratory distress Respiratory distress syndrome risk factor SARS-CoV-2 SARS-COV-2 infection severe disease significant survival advantage situation stability sustained syndrome the cytokine storm Treatment undergo understanding vaccination Variability variants of concern Virology with COVID-19 zoonotic [DOI] 10.1136/bmjpo-2021-001063 PMC 바로가기 [Article Type] Review