Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBsArticle Published on 2016-01-012023-06-19 Journal: The Brazilian journal of infectious diseases : an [Category] B형 간염, [키워드] Chronic Hepatitis B coexistence of HBsAg and anti-HBs reverse transcriptase S gene [DOI] 10.1016/j.bjid.2015.08.014 PMC 바로가기
Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous SystemResearch Article Published on 2015-11-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] affecting Amino acid amino acid change amino acid residue appear ATCC cDNA Central nervous system characterized cleavage cleavage site clone CNS colds contribute convertase coronavirus degenerative demonstrated dissemination Encephalitis etiologies feature functional functions furin-like cleavage site generate Genes glycoprotein HCoV-OC43 Human human respiratory tract identify Impact in viral Infection involved isolate isolates Laboratory less mechanism molecular Mutation nervous neurodegenerative Neuroinvasive neurologic neurological Neurological diseases neurotropic OC43 pathogenic Pathologies pathology Point mutation predominant proportion Proprotein Protein respiratory respiratory pathogen resulting retained S gene S glycoprotein S protein S1 and S2 sequence significantly spike System the S protein variant viral spike virulence virus virus spread while [DOI] 10.1371/journal.ppat.1005261 PMC 바로가기 [Article Type] Research Article
Emergence of porcine epidemic diarrhea virus in southern GermanyCase Report Published on 2015-07-022022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] affected affecting all age group Analysis Asia Blood Case report caused circulating Clinical sign country current Deletion diarrhea distribution emergence enteric disease Epidemic epidemic diarrhea Europe European Evidence full-length Genome Germany high mortality identity indicate information insertion isolate Mortality no increase nucleotide occurred outbreak over PEDV Phylogenetic analysis Porcine epidemic diarrhea virus producing reached reduction reported RT-qPCR S gene S INDEL PEDV S-gene significantly small intestine Southern Germany strain Strains the United State variant virulence virus watery while [DOI] 10.1186/s12917-015-0454-1 PMC 바로가기 [Article Type] Case Report
Genetic drift of human coronavirus OC43 spike gene during adaptive evolutionArticle Published on 2015-06-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] adaptive Analysis binding binding domain characterized coronavirus CoV CoVs Critical dN/dS dominant Epidemic Evolution FIVE Genetic genetic drift Genotype HCoV-OC43 Health human coronavirus OC43 human population human populations majority mechanism N-terminal domain NTD OC43 persistence phylodynamic Phylogenetic Positive selection prevalent S gene S protein Seven spike gene Substitution sugar the S1 subunit [DOI] 10.1038/srep11451 PMC 바로가기 [Article Type] Article
Identification and pathogenicity of a variant porcine epidemic diarrhea virus field strain with reduced virulenceShort Report Published on 2015-06-122022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] C-terminus cause characterized China Complete contagious disease epidemic diarrhea finding Genome high mortality rate identification indicated Mild Newborn North America pathogenicity pathology PEDV Phylogenetic tree Porcine epidemic diarrhea virus prevalent reduced Reduced virulence S gene spike gene Spread strain variant Vero Cell virulence virus was used [DOI] 10.1186/s12985-015-0314-4 PMC 바로가기 [Article Type] Short Report
Molecular Characterization and Phylogenetic Analysis of Porcine Epidemic Diarrhea Viruses Associated with Outbreaks of Severe Diarrhea in Piglets in Jiangxi, China 2013Research Article Published on 2015-03-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accumulated Amino acid amino acid substitution Analysis analyzed antigenic caused change Characteristics characterization characterized China Chinese Complete contagious death diarrhea Effectiveness epidemic diarrhea epitope Genetic Genetic variation Genome genome sequence hydrophilicity identify identity less Multiple Mutation N gene Neutralizing nucleotide ORF1a/b ORF3 outbreak PEDV proximal ranged S gene strain Strains structural protein unique Vaccine viral disease virus viruses vomiting watery [DOI] 10.1371/journal.pone.0120310 PMC 바로가기 [Article Type] Research Article
Genetic Variability and Phylogeny of Current Chinese Porcine Epidemic Diarrhea Virus Strains Based on Spike , ORF3 , and Membrane GenesResearch Article Published on 2014-01-222022-10-29 Journal: The Scientific World Journal [Category] Coronavirus, MERS, [키워드] amplified Analysis analyzed antigenicity changed Characteristics China Chinese conserved current death demonstrated different epidemic diarrhea Frame Gene Genes homology hydrophobicity Immunity isolate M gene membrane Mutation ORF ORF3 outbreak PEDV S gene sequence sequenced spike Spread strain subgroup suggested the disease the S protein the vaccine variant Variation virulence virulent virus widespread [DOI] 10.1155/2014/208439 PMC 바로가기 [Article Type] Research Article
Detection and Molecular Diversity of Spike Gene of Porcine Epidemic Diarrhea Virus in ChinaArticle Published on 2013-10-222022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] amino acids sequence Analysis caused China Chinese classical detection detection rate Diversity epidemic diarrhea full-length S Gene Genetic variation Hainan heterogeneity high mortality homology indicated insertion morbidity MOST Neonatal nucleotide deletion nucleotide sequence PEDV Phylogenetic analysis positive predominant regions RT-PCR S gene sequenced spike strain variant variants virus [DOI] 10.3390/v5102601 PMC 바로가기 [Article Type] Article
Molecular Characterization and Phylogenetic Analysis of New Variants of the Porcine Epidemic Diarrhea Virus in Gansu, China in 2012Article Published on 2013-08-152022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Analysis antigenicity biological properties characterization China classical compared deletions determine diarrhea distribution Effectiveness epidemic diarrhea evaluated exhibited FIVE found full-length S Gansu glycoprotein high mortality infection rate insertions investigated Korean molecular molecular characterization Mutation New outbreak pathogenicity PEDV Phylogenetic Phylogenetic analysis porcine epidemic diarrhea virus (PEDV) S gene sequenced South spike glycoprotein gene strain Strains Vaccine variant virus [DOI] 10.3390/v5081991 PMC 바로가기 [Article Type] Article
An outbreak of feline infectious peritonitis in a Taiwanese shelter: epidemiologic and molecular evidence for horizontal transmission of a novel type II feline coronavirusResearch Published on 2013-07-172022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] Analysis analyzed cause caused coronavirus death detected determine eight Epidemiology Evidence fatal disease fecal samples Feline infectious peritonitis found histopathological Infected Infection infectious molecular Mutation occur outbreak potential risk Recombination S gene serotype Seven Spread Taiwan tissue homogenate Transmission virus [DOI] 10.1186/1297-9716-44-57 PMC 바로가기 [Article Type] Research