Virological and Serological Discordant Profiles in COVID-19 Pneumonia: Two Atypical Clinical CasesImmunology Published on 2020-10-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] acute respiratory syndrome antibodies antibody binding clinical coronavirus coronavirus disease COVID-19 diagnosed discrepancy Hospitalization Immunoglobulin Infection moderate nasopharyngeal swabs Neutralizing Neutralizing antibodies NP observation one patient oxygen saturation Pathogenesis Patient PCR Pneumonia positive profile SARS-CoV-2 SARS-CoV-2 proteins Spike protein Viral RNA WHO [DOI] 10.3389/fimmu.2020.580867 PMC 바로가기 [Article Type] Immunology
Should We Try SARS-CoV-2 Helicase Inhibitors for COVID-19 Therapy?COVID-19 치료를 위해 SARS-CoV-2 헬리카제 억제제를 사용해야 합니까?Article Published on 2020-10-012022-09-11 Journal: Archives of medical research [Category] MERS, SARS, 신약개발, 진단, 치료제, [키워드] article coronavirus COVID-19 drug Helicase highlight inhibitor inhibitors MERS New coronavirus non-structural proteins nsp13 pathogenicity Research SARS-CoV SARS-CoV-2 SARS-CoV-2 proteins therapy Viral viral infection viral infections viral replication [DOI] 10.1016/j.arcmed.2020.05.024 PMC 바로가기 [Article Type] Article
S Protein-Reactive IgG and Memory B Cell Production after Human SARS-CoV-2 Infection Includes Broad Reactivity to the S2 SubunitResearch Article Published on 2020-09-252022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] accompanied acute respiratory syndrome Analysis analyzed anti-N IgG anti-S2 antibody antibody production asked B cell B cell response circulating conserved convalescent coronavirus coronavirus disease correlated strongly COVID-19 cross-reactive disease ENhance frequencies generate healthy donor Human human coronavirus OC43 IgG IgG antibodies IgG level IgG titer immune memory immune protection Immunity individuals Infection MBC memory B cell memory B cells mononuclear cell MOST non-SARS-CoV-2 protein nucleocapsid pandemic PBMCs Peripheral blood Population Postinfection Production Protein provide RBD reactive Receptor binding domain reflect Reinfection S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sera specificity Spike protein Spread subject subjects susceptibility susceptible the RBD the S protein the SARS-CoV-2 virus Virus-specific IgG [DOI] 10.1128/mBio.01991-20 PMC 바로가기 [Article Type] Research Article
Sequence-based prediction of SARS-CoV-2 vaccine targets using a mass spectrometry-based bioinformatics predictor identifies immunogenic T cell epitopes질량 분석 기반 생물정보학 예측자를 사용한 SARS-CoV-2 백신 표적의 서열 기반 예측으로 면역원성 T 세포 에피토프 식별Research Published on 2020-08-132022-08-13 Journal: Genome Medicine [Category] MERS, 유전자 메커니즘, [키워드] allele alleles Antigen applied Asian binding bioinformatics CD4 CD8 Cell-mediated immunity characterized Computational biology Coronaviridae family Coverage COVID-19 COVID-19 pandemic database demonstrated Donor elicit epitope Epitopes European expression expression of SARS-CoV-2 healthy HLA allele HLA binding HLA-I binding prediction HLA-II binding prediction human leukocyte antigen humoral identify immune Immunity immunogenic infected cell leukocyte mass mass spectrometry mononuclear cell mononuclear cells Open reading frame open reading frames ORFs other coronavirus other coronaviruses PBMCs peptide peptides Peripheral blood platform populations positive predict predicted predictor protective immunity protective role Protein protein expression reported Result SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 T cell epitopes SARS-CoV-2 vaccine subset T cell T cell assay T cell epitope T cell epitopes T cell response T cell responses T cells target the Coronaviridae urgency Vaccine Vaccine design Validity Viral viral genome viral genomes [DOI] 10.1186/s13073-020-00767-w PMC 바로가기 [Article Type] Research
COVID-19-Related Coagulopathy—Is Transferrin a Missing Link?Communication Published on 2020-07-302022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] ADAMTS13 age analyzed Anticoagulants binding C1QTNF1 Coagulation Coagulopathy contribute contributing to COVID-19 COVID-19 disease database dataset decrease Disseminated intravascular coagulation expression expression of gene F11 female Gene ontology gene product HGFAC identify increase individual KLKB1 male males mechanism missing procoagulant Protein proteomics regulated risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins SARS-CoV-2-infected cell SERPINA5 severe COVID-19 disease thrombosis Transferrin upregulated [DOI] 10.3390/diagnostics10080539 PMC 바로가기 [Article Type] Communication
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoproteinSARS-CoV-2의 전사체 및 프로테옴의 특성화는 스파이크 당단백질에서 푸린 유사 절단 부위의 세포 통과 유도된 프레임 내 결실을 보여줍니다Research Published on 2020-07-282022-08-13 Journal: Genome Medicine [Category] SARS, 유전자 메커니즘, [키워드] 24 nt in-frame deletion analysed Analysis animal challenge model animal challenge models Cell cleavage clinical samples contribute Coronaviruses deleted detection determine Direct RNA sequencing exit expected Frame functional furin furin cleavage site furin site furin-like cleavage site genomic glycoprotein growth Health impacted in-frame deletion infected cells mass spectrometry morbidity morbidity and mortality mutate Novel coronavirus ORF-centric pipeline Pathogenesis peptide peptides phosphopeptide phosphoproteome predicted Protein proteome proteomic Region Research respiratory respiratory pathogen Result reveal S glycoprotein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 protein SARS-CoV-2 proteins significantly spike glycoprotein subgenomic mRNA subgenomic mRNAs subunit tandem Tandem mass spectrometry the SARS-CoV-2 genome Transcription Transcriptome transcriptomic unique Vaccine variant Variation Vero E6 Vero E6 cell VERO E6 cells viable deletion Viral viral genome sequence viral peptide viral peptides viral stock viral stocks viral transcript viral transcriptome viral transcripts virulence virus virus entry virus-infected cells zoonosis [DOI] 10.1186/s13073-020-00763-0 PMC 바로가기 [Article Type] Research
SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responsesArticle Published on 2020-07-142022-10-04 Journal: Nature Communications [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] age antibody Antibody Response Convalescent patients COVID-19 COVID-19 in patient diagnostic effective generate Human immune system IgG IgG and IgM immune system lactate dehydrogenase LDH lymphocyte Microarray N proteins nsp5 Orf9b Patient predicted Protein Protein array analysis Proteins provide respond response S1 protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins SARS-CoV-2 proteome sera the N protein the SARS-CoV-2 therapeutic Vaccination strategies viral infection Viral proteins [DOI] 10.1038/s41467-020-17488-8 PMC 바로가기 [Article Type] Article
Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells대유행 완화제 후보의 삼자 조합: 인간 세포에서 SARS-CoV-2 표적의 게놈 유도 추적으로 정의된 COVID-19 대유행의 표적 완화를 위한 약제의 비타민 D, 케르세틴 및 에스트라디올 매니페스트 특성Article Published on 2020-05-212022-09-10 Journal: Biomedicines [Category] 비임상, [키워드] 2019 coronavirus disease ACE2 activity Affect agent Alter analyses Analysis breath build candidate cell types cellular clinical trial clinical trials Combination condition contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 pandemic deficiency disease drug drugs drugs and medicinal substance repurposing Effect elements enrichment eriodictyol estradiol experiment expression expression profiling facilitate Follow-up function functions furin FURIN expression FURIN gene GATA5 gene expression profile Gene expression profiles gene expression signature Gene Set Enrichment Analyses gene silencing Genomics GSEA HIF1a high mortality HMGA2 HNF4A Human human body human cell human cells human gene human genes hypothetical identify Immediate Immune cell immune cells Immunosuppression Impact infect Infection Inference inhibitor inhibitors of SARS-CoV-2 INSIG1 interfere Intervention intrinsically Luteolin majority male Mitigation mitigation approaches molecular Mortality observation observational study observations Older overexpression pandemic Panel Patient persistence present property Protein Protein target protein targets Proteins quercetin Randomized randomized clinical trial Regulatory reported repressor required RUNX1 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral selective severity SFTPC smoking Spread SUMMIT drug-docking screen target targets Testosterone the SARS-CoV-2 tissues tracing Transgenic mouse Treatment upstream utility Viral Viral protein Viral proteins virus Vitamin D vitamin D deficiency website [DOI] 10.3390/biomedicines8050129 PMC 바로가기 [Article Type] Article
Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunityShort communication Published on 2020-04-092022-10-30 Journal: Journal of Translational Autoimmunity [Category] COVID-19, [키워드] adaptive immune system Antigen Antigen presentation Autoantigens Autoimmunity Bacteria candidate class consequence contribute COVID-19 COVID-19 disease Critical element epitope excluded expected explain exposure failure genes encoding had no homologous homology human protein human proteins Immune Enhancement immune system immunogenic immunological priming Immunopathogenesis in viral indicate Infection injection involved Local lung tissue mapping MERS MERS spike protein MHC Mortality outcomes Pathogenesis pathogenic Pathogenic priming pathway peptide priming Protein provide responsible risk SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Signaling similarity Spike proteins Symptom target Trial vaccination Vaccine Vaccine development Viral protein virus [DOI] 10.1016/j.jtauto.2020.100051 PMC 바로가기 [Article Type] Short communication
Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological StudiesArticle Published on 2020-02-252022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 2019 novel coronavirus 2019-nCoV Analysis B cell B cell epitopes caused China coronavirus coronavirus 2 Coverage COVID-19 COVID-19 outbreak develop effort epitope Genetic help identification immune immunogenic immunological MERS-CoV MHC allele Mutation new virus Novel coronavirus nucleocapsid offer outbreak performed Potential Protein respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 sequence screened similarity Spread structural protein T cell epitope T cell epitopes target Vaccine Vaccine design virus [DOI] 10.3390/v12030254 PMC 바로가기 [Article Type] Article