Role of ribosomal pathways and comorbidity in COVID-19: Insight from SARS-CoV-2 proteins and host proteins interaction network analysisResearch Article Published on 2024-04-192024-09-05 Journal: Heliyon [Category] update2024, [키워드] Comorbidity COVID-19 Drug repurposing Host interacting genes Ribosomal pathways SARS-CoV-2 proteins [DOI] 10.1016/j.heliyon.2024.e29967 PMC 바로가기 [Article Type] Research Article
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replicationArticle Published on 2022-10-142022-11-16 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis association Calu-3 cell cellular Comorbidity components COVID-19 demonstrated effective eQTL examined EXOSC2 expression form Genome-wide association study higher risk host protein host-virus interactions human RNA identify impede increased expression interact Interaction loci New nonsense mutation polymerase PROTECT Protein protein expression reduced risk loci RNA RNA polymerase Safe SARS-CoV-2 proteins SARS-CoV-2 replication SARS-CoV-2 viral infection the SARS-CoV-2 therapeutic target Treatment valuable resource viability Viral RNA with COVID-19 [DOI] 10.26508/lsa.202201449 PMC 바로가기
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificityArticle Published on 2022-10-032022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] airway analyzed antiviral immunity Breakthrough infection CD4+ T cell CD8+ COVID-19 COVID-19 vaccinee feature highlight Immunity immunological induce Infection nasal nasal mucosa persistence phenotype Primary infection Rapid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 vaccination SARS-CoV-2-infected cell specificity suppress T cell T cell response vaccination vaccinee [DOI] 10.1084/jem.20220780 PMC 바로가기
Native, engineered and de novo designed ligands targeting the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질을 표적으로 하는 네이티브, 엔지니어링 및 드노보 디자인 리간드Review Published on 2022-10-012022-09-12 Journal: Biotechnology advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome affinity Affinity ligands antibody binding Cell concerning Contact coronavirus coronavirus disease de novo de novo design. develop diagnostic diagnostics hACE2 Host human Angiotensin-converting enzyme in vivo infect Interaction lesson Ligand ligands molecular Native natural pandemic Pandemics Patient Prophylactic Protein public health receptor reported responsible S-protein SARS-CoV-2 SARS-CoV-2 proteins Scientific community spike Spike protein the SARS-CoV-2 therapeutic therapy Vaccine virus yielding [DOI] 10.1016/j.biotechadv.2022.107986 PMC 바로가기 [Article Type] Review
Multi-scale mechanism of antiviral drug-alike phytoligands from Ayurveda in managing COVID-19 and associated metabolic comorbidities: insights from network pharmacologyArticle Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral drugs antiviral immunity APCS approach Ayurveda binding affinity cardiovascular complications Comorbidities Comorbidity COVID-19 creating develop Diabetes Mellitus disorders effective highlighting Host hypertension immunomodulators investigated mechanism molecular docking network network pharmacology novel coronavirus disease Protein target public health regulate Regulatory SARS-CoV-2 SARS-CoV-2 proteins synergistic therapy Traditional virus Wuhan, China [DOI] 10.1007/s11030-021-10352-x PMC 바로가기
Complementary Sets of Autoantibodies Induced by SARS-CoV-2, Adenovirus and Bacterial Antigens Cross-React with Human Blood Protein Antigens in COVID-19 CoagulopathiesArticle Published on 2022-09-292022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] Adenovirus antibody antigenic antigenic complementarity antigens autoantibody Autoimmune Autoimmunity Bacteria Bacterial Bacterial infection binding constant Blood bystander bystander infection cardiolipin Clostridia coagulation factor Coagulopathies Coagulopathy Combination COVID-19 cross-reactive develop E. coli Escherichia coli Factor factor IX factor VIII function glycoprotein Human induced infections Interaction investigated involved Klebsiella pneumoniae moderate-to-severe COVID-19 MOST mRNA mRNA vaccine Mycobacterium tuberculosis Patient PF4 Platelet platelet factor 4 polyclonal antibody Protein Proteins recognize Research SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 proteins serum albumin similarity Staphylococcus Streptococcus stroke tested thrombocytopenia thrombosis thrombotic vaccine-induced thrombotic thrombocytopenia virus von Willebrand factor [DOI] 10.3390/ijms231911500 PMC 바로가기
SARS-CoV-2 Seroprevalence Study in Pediatric Patients and Health Care Workers Using Multiplex Antibody ImmunoassaysArticle Published on 2022-09-142022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] Adults affected antibody Antigen Beta children circulating Clinical characteristics Cohort correlation COVID-19 delta variant disease ELISA estimate exacerbated False positive Gamma group HCW Health healthcare healthcare worker Healthcare workers highlight hospitals IgA IgA response IgG IgM indicated Infection isotype lowest Luminex assay Mild nucleocapsid PIMS-TS positive correlation RBD recruited SARS-CoV-2 SARS-CoV-2 proteins sensitivity Seropositivity Seroprevalence significantly lower Spain Spanish specificity study period the receptor-binding domain variants were measured worker [DOI] 10.3390/v14092039 PMC 바로가기
Antibody Course and Memory B-Cell Response in the First Year After Severe Acute Respiratory Syndrome Coronavirus 2 InfectionArticle Published on 2022-09-042022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] acute respiratory syndrome antibodies antibody antibody course antibody half-life B-cell B-cells binding domain Concentration coronavirus coronavirus 2 correlated Course COVID-19 Evidence examined Frequency immune response Immunity indicate Infection Influenza virus MBC memory memory B-cell memory B-cells. Mild moderate question raise required respiratory response robust SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 NP antibody SARS-CoV-2 proteins SARS-CoV-2 RBD SARS-CoV-2 receptor SARS-CoV-2 spike protein subject vaccination virus Year [DOI] 10.1093/infdis/jiac034 PMC 바로가기
Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort스페인 지중해 백인 코호트를 대상으로 한 파일럿 연구에서 HLA-C 대립형질과 COVID-19 심각성 사이의 연관성Article Published on 2022-08-122022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] age allele analyzed antiviral response association Asymptomatic cause Cell cell surface class Clinical characteristics clinical presentation Clinical presentations Cohort Comorbidity contrary COVID-19 COVID-19 severity Critical described determine disease epitope Epitopes expressed Factor fatal disease Gender groups HLA HLA allele HLA alleles HLA class I HLA-A HLA-B HLA-B allele HLA-B alleles HLA-C HLA-C allele HLA-C alleles HLA-C1 Host hyperinflammatory state immune response individual Infection involved KIR gene male management mechanism Mild mild infection no significant difference no significant differences outcomes pandemic peptide peptides pilot study recruited SARS-CoV-2 protein SARS-CoV-2 proteins significant difference significant differences small sample size Spain Spanish T cells β2-microglobulin [DOI] 10.1371/journal.pone.0272867 PMC 바로가기 [Article Type] Article
Longitudinal change in SARS-CoV-2 seroprevalence in 3-to 16-year-old children: The Augsburg Plus study3~16세 어린이의 SARS-CoV-2 혈청 유병률의 종단적 변화: 아우크스부르크 플러스 연구Article Published on 2022-08-112022-09-11 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, [키워드] addition age antibody appear Asymptomatic asymptomatic infection asymptomatic infections baseline Blood Blot capillary blood capillary blood samples Child children Cohort collected Commission COVID-19 case COVID-19 vaccination detect diagnosed ELISA evaluate Filter Paper Follow-up Germany IgG IgG antibodies IgG antibody infected children Infection institution longitudinal measurement median number of infected oropharyngeal swab oropharyngeal swabs parent positive prevalence of COVID-19 Rapid test RBD reported Robert Koch SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 seroprevalence SARS-CoV-2 spike protein School Sensitivity and specificity serological test Serological tests significantly Spike protein Standing study duration study period Swab tested Vaccine venous venous blood [DOI] 10.1371/journal.pone.0272874 PMC 바로가기 [Article Type] Article