In Vitro Evaluation of the Antiviral Activity of Methylene Blue Alone or in Combination against SARS-CoV-2Article Published on 2021-07-062022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activity acute respiratory syndrome antimalarial drug Antiviral antiviral drug blue Cell Chloroquine clinically Combination Concentration coronavirus coronavirus disease COVID-19 Effect effective Hydroxychloroquine identifying in vitro investigated median Methylene Methylene blue Post-infection Remdesivir retrieved RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain Side effect Spread Stage Support treat Treatment Vero E6 cell viral entry viral replication Wuhan, China [DOI] 10.3390/jcm10143007 PMC 바로가기 [Article Type] Article
Development of neutralizing antibody responses against SARS-CoV-2 in COVID-19 patientsCOVID-19 환자에서 SARS-CoV-2에 대한 중화 항체 반응 개발Article Published on 2021-07-012022-09-12 Journal: Journal of medical virology [Category] SARS, 진단, [키워드] acute respiratory syndrome age antibodies antibody Antibody titer blood sample Chilean Comorbidity coronavirus coronavirus disease cough COVID-19 COVID-19 confirmed patient COVID-19 patient COVID-19 patients development diabete diabetic patient Dyspnea evaluate evaluated Evolution Fever had no headache health center hospitalized COVID-19 patients Host immune response hypertension hypertensive IgG IgG antibodies immune response Immunoglobulin implication increase in men myalgia Neutralization assay Neutralizing Neutralizing antibodies Neutralizing antibody response normotensive Novel coronavirus Patient patients performed positive problems robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain severe COVID-19 significant increase significantly study population Symptom symptomatic the disease the epidemic therapeutic agent Vero E6 cell women [DOI] 10.1002/jmv.26939 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Variants in Lebanon: Evolution and Current SituationArticle Published on 2021-06-142022-10-28 Journal: Biology [Category] COVID-19, [키워드] acute respiratory syndrome Affect amino acid substitution analyzed approaches cause cellular receptors clade clades Combination compose confirmed case coronavirus COVID-19 current death encoded protein encoded proteins epidemiological events feature GenBank Genetic Genome Genome sequencing GISAID highlight Interaction Lebanon lineages marker Mutation mutations observation Phylogenetic Phylogenetic relationship Protein reported retrieved SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 strain sequenced Sequencing simple situation Spike protein Spike proteins Spread strain Strains structural protein structural proteins the SARS-CoV-2 virus transmission rates whole genome [DOI] 10.3390/biology10060531 PMC 바로가기 [Article Type] Article
Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans인간의 SARS-COV-2 변이체에 대한 AD26.COV2.S 백신의 면역 원성Clinical Trial Published on 2021-06-092022-08-13 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine antibody antibody titres Antibody-dependent cellular phagocytosis B.1.1.7 B.1.351 B.1.351 variant B1.351 binding antibody CAL.20C CAL.20C variants CD4 CD8 cell activation Cellular immune response cellular phagocytosis Clinical efficacy clinical trial comparable complement COV1001 COVID-19 demonstrated effector memory responses fold functional functions Human humoral Humoral and cellular immune responses immune responses immunogenicity implication Killer cell median natural killer natural killer cell natural killer cell activation responses neutralization Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses non-neutralizing antibody response P.1 P.1 variants preserved pseudovirus neutralizing antibody reduced response SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants symptomatic symptomatic COVID-19 T cell T cell response T cell responses These data titre vaccinated individual vaccination Vaccine Vaccines variants WA1/2020 [DOI] 10.1038/s41586-021-03681-2 PMC 바로가기 [Article Type] Clinical Trial
Designing potential siRNA molecule for the nucleocapsid(N) gene silencing of different SARS-CoV-2 strains of Bangladesh: Computational approach방글라데시의 다양한 SARS-CoV-2 균주의 뉴클레오캡시드(N) 유전자 침묵을 위한 잠재적인 siRNA 분자 설계: 전산적 접근Article Published on 2021-06-012022-09-11 Journal: Computational biology and chemistry [Category] SARS, 치료법, [키워드] approach China Clustal Omega Complete computational method effective effective therapy encapsidation evaluate Extensive gene silencing Human N gene NCBI database Nucleocapsid gene outbreak Replication retrieved RNA SARS-CoV-2 SARS-CoV-2 infected individuals SARS-CoV-2 infections SARS-CoV-2 strain secondary structure sequence sequenced single-stranded siRNA siRNA molecules strain therapeutic Therapeutic approach these viruses treat Treatment viral pathogenesis virus was tested were used [DOI] 10.1016/j.compbiolchem.2021.107486 PMC 바로가기 [Article Type] Article
Genome-wide analysis of 10664 SARS-CoV-2 genomes to identify virus strains in 73 countries based on single nucleotide polymorphism단일 염기 다형성을 기반으로 73개국의 바이러스 균주를 식별하기 위한 10664 SARS-CoV-2 게놈의 게놈 전체 분석Article Published on 2021-06-012022-09-11 Journal: Virus research [Category] SARS, 변종, 치료법, [키워드] absence addition Analysis applied assessment Care Characteristics Cluster Clustering Clusters code Community Consensus country COVID-19 dataset determine environmental condition Evolution ExoN FIVE function genome-wide analysis Hamming distance Hierarchical hierarchical clustering identify linkage Measures Multiple Multiple sequence alignment mutated Non-synonymous Non-synonymous SNP NSP2 nucleocapsid nucleotide ORF3a performed polymorphism Protein provided Q57H Quantitative reported Research responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain SARS-CoV-2 strains sequence Sequence alignment shown Silhouette single nucleotide Single nucleotide polymorphism SNP SNPs stability structures synonymous SNP T85I tendency Vaccine Vaccine design Validity virus virus strain virus strains Visual website [DOI] 10.1016/j.virusres.2021.198401 PMC 바로가기 [Article Type] Article
Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters시리아 햄스터의 신종 SARS-CoV-2 변이체의 감염력 및 독성 비교Comparative Study Published on 2021-05-252022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] African Analysis antibodies Antiviral B.1.1.28.1 B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants Candidates clinical evidence COVID-19 cytokine Cytokines disease dominant Efficacy emergence Epidemics expression profile expression profiles female finding funding Genes golden hamsters hamster Hamster model hamsters histological Infection Lower respiratory tract New outcome Patient pro-inflammatory cytokine Proinflammatory cytokine proinflammatory cytokines quantified relative infectivity replacing respiratory SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant selected Small molecules South strain Strains Syrian golden hamster tomography transmitted United Kingdom Vaccine-induced immunity variants variants of concern (VOC) virulence virulent [DOI] 10.1016/j.ebiom.2021.103403 PMC 바로가기 [Article Type] Comparative Study
Self-Assembling Nanoparticle Vaccines Displaying the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Responses in Rhesus MonkeysSARS-CoV-2의 수용체 결합 도메인을 표시하는 자가 조립 나노입자 백신은 붉은털 원숭이에서 강력한 보호 면역 반응을 이끌어냅니다Article Published on 2021-05-192022-09-11 Journal: Bioconjugate chemistry [Category] SARS, 비임상, 진단, [키워드] Analysis Antigen benefit breath candidate vaccine caused Cell Clinical trial design COVID-19 pandemic cross-neutralize domain effective effective vaccine Efficiency elicit eukaryotic expression ferritin Focusing Humoral immunity immune response immunization immunization program immunized Infection inhibited isolates Monkey nanoparticle nasal Neutralizing antibodies neutralizing antibody new SARS-CoV-2 observation pathology platform protection test purified RBD respiratory response Rhesus monkey Rhesus monkeys Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 virus significantly specific antigen Spike protein T cell the vaccine Vaccine vaccine candidate vaccine platform virus replication [DOI] 10.1021/acs.bioconjchem.1c00208 PMC 바로가기 [Article Type] Article
Antigenic Evolution on a Global Scale Reveals the Potential Natural Selection of Severe Acute Respiratory Syndrome-Coronavirus 2 by Pre-existing Cross-Reactive T-Cell ImmunityMicrobiology Published on 2021-05-182022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Amino acid antigenic evolution B-cell cellular immunity changed changes in circulating community transmission comprehensive analysis coronavirus cross-reactive docking ENhance Evolution Guidance help homology host cell host immune system Immunity Mutation mutations natural natural selection ORF1ab peptide Potential pre-existing cross-reactive T-cell immunity Protein provided Research respiratory SARS-CoV-2 SARS-CoV-2 isolates SARS-CoV-2 strain scale seasonal human coronavirus Selection selective severe acute respiratory syndrome-coronavirus 2 spike susceptible T-cell epitope Vaccine design virus [DOI] 10.3389/fmicb.2021.599562 PMC 바로가기 [Article Type] Microbiology
IPD 2.0: To derive insights from an evolving SARS-CoV-2 genomeIPD 2.0: 진화하는 SARS-CoV-2 게놈에서 통찰력 도출Software Published on 2021-05-132022-09-10 Journal: BMC Bioinformatics [Category] 변종, [키워드] Accuracy adaptive adoption Analysis automated Brazil breakthrough infections clade database Detector Evolution facilitate generate Genome genome sequence Genome sequences genomic Genomic analysis GISAID help heterogenous identify India involved Lineage measure Mutation Next-generation sequencing novel overlapping Pathogen analysis pipeline Phylogenetic clade analysis principle proof Rapid reported required Result SARS-CoV-2 SARS-CoV-2 genome sequences SARS-CoV-2 genomic data SARS-CoV-2 sequence SARS-CoV-2 sequence data SARS-CoV-2 strain South Africa Spread strain supplementary material Surveillance the SARS-CoV-2 Variability variant variants virus [DOI] 10.1186/s12859-021-04172-x PMC 바로가기 [Article Type] Software