Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: A prospective cohort study네덜란드 의료 종사자의 4가지 다른 SARS-CoV-2 백신에 의해 유도된 SARS-CoV-2 변이체에 대한 항체 반응: 전향적 코호트 연구Article Published on 2022-05-172022-09-11 Journal: PLoS Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Adenovirus adenovirus vector-based vaccines adjusted age and sex Alpha Analysis Antibody Response Antibody titers AZD1222 Beta BNT162b2 booster booster vaccination cellular immunity COV2.S Delta Effectiveness Fold change followed by Gamma geometric geometric mean geometric mean titers GMT group groups head Head-to-head comparison Health care Health care worker highest include initial lack limitation linear mixed model Linear regression mRNA mRNA vaccine mRNA vaccines mRNA-1273 Netherlands neutralization neutralize Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers of BNT162b2 omicron Omicron variant performed prospective cohort prospective cohort study recipient recipients recognize reduction in SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants sera serum vaccination Vaccine variant VoC VOCs was performed was reduced wild-type [DOI] 10.1371/journal.pmed.1003991 PMC 바로가기 [Article Type] Article
Anti-nucleocapsid antibodies enhance the production of IL-6 induced by SARS-CoV-2 N protein항-뉴클레오캡시드 항체는 SARS-CoV-2 N 단백질에 의해 유도된 IL-6의 생산을 향상시킵니다Article Published on 2022-05-162022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료법, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody cause of death cell lysate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cultured macrophage cultured macrophages cytokine cytokine production Cytokine storm death disease ENhance IL-6 induce infected cells interleukin lysate macrophages mechanism myeloid cells N protein Patient patients Plasmid promote respiratory respiratory distress SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2-infected cell SARS-CoV-2-infected cells Screening secreted sera severe acute respiratory syndrome Coronavirus syndrome the cell the cells the cytokine storm the disease [DOI] 10.1038/s41598-022-12252-y PMC 바로가기 [Article Type] Article
Humoral Immune Response Diversity to Different COVID-19 Vaccines: Implications for the “Green Pass” Policy다양한 COVID-19 백신에 대한 체액 면역 반응 다양성: "그린 패스" 정책에 대한 시사점Article Published on 2022-05-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACE2 binding activities Ad26 Ad26.COV2.S age Analysis anti-RBD anti-RBD antibody titer antibody Antibody Response Antibody titer appear assumption average binding BNT162b2 booster vaccination ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine ChAdOx1 nCoV-19 vaccines concentrations country COV2.S COVID-19 COVID-19 infection COVID-19 pandemic detect Diversity elicit elicited eligibility epitope evaluated Features green Green Pass Policy heterogeneous humoral humoral immune response immune Immunity implication individual maintain mRNA mRNA-1273 Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody observé Pass peptides Policy Protein Randomly Rapid test rationale RBD RBD-ACE2 reactivity reactogenicity Receptor-binding domain reduce reopening response Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike selected sera serum serum sample significantly spike Spike protein synthetic peptide the receptor-binding domain titer vaccinated individual vaccination Vaccine virus spread [DOI] 10.3389/fimmu.2022.833085 PMC 바로가기 [Article Type] Article
Structural mapping of antibody landscapes to human betacoronavirus spike proteins인간 베타 코로나바이러스 스파이크 단백질에 대한 항체 지형의 구조적 매핑Article Published on 2022-05-062022-09-12 Journal: Science Advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Analysis antibody Antibody Response antigenic complexes convalescent CoVs cross-reactive disease severity epitope epitope mapping General population HKU1 human betacoronavirus human CoV Immunity infections molecular OC43 polyclonal reactivity SARS-CoV-2 SARS-CoV-2-infected individuals seasonal coronavirus sera serum antibodies specificity spike Spike protein β-CoV β-CoVs [DOI] 10.1126/sciadv.abn2911 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 Nucleocapsid, Spike, and Neutralizing Antibodies in Vaccinated Japanese백신을 접종한 일본인에서 SARS-CoV-2 뉴클레오캡시드, 스파이크 및 중화 항체 검출Article Published on 2022-05-052022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody titers coronavirus correlated detection detection system Efficacy Efficiency Elecsy Elecsys evaluate evaluated Fujirebio healthy subject healthy subjects IgG investigated Japanese Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers nucleocapsid patients with COVID-19 respiratory Roche SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 N sensitivity sera serological test severe acute respiratory syndrome Coronavirus specificity spike vaccination were assessed [DOI] 10.3390/v14050965 PMC 바로가기 [Article Type] Article
Antigenic Cross-Reactivity Between SARS-CoV-2 S1-RBD and Its Receptor ACE2SARS-CoV-2 S1-RBD와 수용체 ACE2 간의 항원 교차 반응성Article Published on 2022-05-042022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome addition amino acid residue Analysis analyzed angiotensin converting enzyme 2 angiotensin-converting enzyme 2 anti-ACE2 antibody antibody Antibody binding antigenic autoantibody bind binding Control coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Critical cross-react cross-reactivity denatured disease severity docking domain enzyme epitope higher affinity human cell increase in indicated mAb measurement mechanism mice molecular molecular mimicry monoclonal antibody overlapping patients with COVID-19 peptide positive correlation protein-protein interaction receptor receptor ACE2 recognize responsible SARS-CoV-2 SARS-COV-2 infection sera Serum level significantly significantly higher the binding affinity the S1 subunit the spike protein transmission electron microscopy virus western blotting [DOI] 10.3389/fimmu.2022.868724 PMC 바로가기 [Article Type] Article
Using sero-epidemiology to monitor disparities in vaccination and infection with SARS-CoV-2 Research Published on 2022-05-042022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Bayesian clinical Coverage cross-sectional determine Elecsy equity FIVE greater hospital Immunity individual Infection infection risk infection with SARS-CoV-2 interval MONITOR Mortality pandemic Probability provide Roche San Francisco SARS-CoV-2 sera Spread tested the epidemic unique vaccination Vaccine while white [DOI] 10.1038/s41467-022-30051-x [Article Type] Research
Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences인도-아프리카 서열을 기반으로 하는 EDIII-NS1 컨센서스 디자인을 암호화하는 새로운 뎅기열 DNA 백신의 면역 프로필 및 반응Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] MERS, 변종, 진단, [키워드] antibody Antibody-dependent enhancement Antigen antigens clinical isolates coding sequence Consensus consensus sequence conserved COVID-19 pandemic Dengue dengue surveillance. dengue virus DENV-2 DNA DNA vaccine domain domain III EDIII domain emerging viruses envelope protein epitope Epitopes expand Genotype highlight IgG1 immune immune response immunogenic Immunoglobulin India Indo-African interferon isolate mice neutralizing antibody non-structural protein NS1 protein passive transfer protein expression response sequence Sequencing sera serotype serotype-specific staining Stand Structural analysis Surveillance T cell T cell responses transfer translation vaccination Vaccine vaccine candidate Vaccine design Viral Viral variants virulent viruses whole genome Whole genome sequencing [DOI] 10.1016/j.ymthe.2022.01.013 PMC 바로가기 [Article Type] Article
In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infectionCOVID-19 혈청에 의해 유도된 체외 NET-osis는 백신 접종을 하지 않은 환자의 심각한 임상 경과 및 돌발성 감염의 면역 조절 장애와 관련이 있습니다.Article Published on 2022-05-042022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] ACE Activation affected age approach Breakthrough infection breakthrough infections CD14 CD16 CD3 CD4 CD4+ CD45 CD45RA CD45RO CD64 CD8 CD8+ Cell cells characterized circulating cytokine circulating cytokines classical Clinical course Clinical features complex Concentration controls COVID-19 COVID-19 infections COVID-19 patient COVID-19 patients COVID-19 sera COVID-19 treatment cytokine Cytokines Cytometry disease disease severity dysregulation effector cells expansion healthy healthy donors healthy subject healthy subjects highlight Hospital admission IFN-γ IL-17A IL-1β IL-6 immune Immune cell immune cells immune dysregulation immune response In-vitro inhibitor Inpatients Major marker memory B-cell Mild Mild disease moderate Monocytes myeloid naïve NET NETosis NETs neutrophil Neutrophil extracellular trap overexpressing Patient patients percentage Peripheral blood pilot study ramipril reduced reduction risk sera severe COVID-19 patient Sex T cell T cells T-cell T-cells Treatment viral clearance [DOI] 10.1038/s41598-022-11157-0 PMC 바로가기 [Article Type] Article
Seroprevalence of SARS-CoV-2 IgG Antibodies and Factors Associated with SARS-CoV-2 IgG Neutralizing Activity among Primary Health Care Workers 6 Months after Vaccination Rollout in France프랑스에서 백신 접종 6개월 후 1차 의료 종사자들 사이에서 SARS-CoV-2 IgG 항체 및 SARS-CoV-2 IgG 중화 활성과 관련된 인자의 혈청유병률Article Published on 2022-05-032022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] 95% CI 95% confidence interval activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antibody association booster dose booster doses capillary blood Care conducted coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 vaccine cross-sectional survey Factor Factors France Health Health care Health care worker health care workers highlight Immunoglobulin Immunoglobulin G immunoglobulin G response Month multivariate N protein Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody nucleocapsid Odds ratio participant presence of antibody primary care Primary Health Care Protein questionnaire regression analysis respiratory S protein S-1 SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 IgG SARS-COV-2 infection sera Seroprevalence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly significantly more tested the N protein the S protein vaccination vaccine dose vaccine doses worker [DOI] 10.3390/v14050957 PMC 바로가기 [Article Type] Article