The potential role of serum angiotensin-converting enzyme in coronavirus disease 2019코로나바이러스 질병 2019에서 혈청 안지오텐신 전환 효소의 잠재적 역할Research Article Published on 2020-11-252022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 바이오마커, [키워드] ACE activity analyzed angiotensin Angiotensin-converting enzyme baseline BMI body mass body mass index clinical condition Clinical data Clinical significance consecutive patient control group controls coronavirus disease Coronavirus disease 2019 COVID-19 demographic Demographic and clinical data hypertension lowest marker no significant difference no significant differences Older Patient patients proportion recruited Remission Result Retrospective study SARS-CoV-2 serum Serum ACE severe group Severe patient severity of COVID-19 subject the disease was measured were recorded [DOI] 10.1186/s12879-020-05619-x PMC 바로가기 [Article Type] Research Article
Treatment of COVID‐19 patients with the anti‐CD6 antibody itolizumabOriginal Article Published on 2020-11-252022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] administration adverse event age antibody Autoimmune disease Biomarker cascade CD6 Clinical data Combination Comorbidities Concentration COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical Cytokine release syndrome death Deterioration discharged events expressed FiO2 glycoprotein hospitals Hyperinflammatory hyperinflammatory state ICU IL‐6 individual itolizumab lethality rate Lower Lung function moderate monoclonal antibody morbidity and mortality Mortality Most patient multiple cytokine National neurological manifestation NLR objective pathway Patient patients Prevent prevented proportion protocol reduce reduced Result SARS‐CoV‐2 SARS‐COV2 Secondary objective severe cases Severe patient severe patients significantly subject T lymphocyte T‐cell activation Th1/Th17 therapy time treated Treatment Ventilation [DOI] 10.1002/cti2.1218 PMC 바로가기 [Article Type] Original Article
Factors associated with acute cardiac injury and their effects on mortality in patients with COVID-19급성 심장 손상과 관련된 요인 및 COVID-19 환자의 사망률에 미치는 영향Article Published on 2020-11-242022-09-10 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] ACI Acute cardiac injury Analysis Biomarkers Brain brain natriuretic peptide C-reactive protein Cardiology Clinical characteristics collected Combination COVID-19 cumulative determine develop disease severity Effect elevated Elevation Factor Gender hs-CRP identify IL-6 in-hospital mortality in-patient incidence independent risk factor independent risk factors interleukin interleukin-6 Kaplan–Meier method Laboratory laboratory-confirmed Laboratory-confirmed COVID-19 Lactate lactate dehydrogenase Logistic regression male Mortality N-terminal NT-proBNP oxygen oxygen saturation Patient patients with COVID-19 peptide proportion radiological Risk factors sensitivity severe cases severe group Severe patient severe patients severity significantly higher significantly increased the disease Tongji Hospital Treatment was used were used Wuhan [DOI] 10.1038/s41598-020-77172-1 PMC 바로가기 [Article Type] Article
Nutritional Support and Clinical Outcome of Severe and Critical Patients With COVID-19 PneumoniaNutrition Published on 2020-11-192022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] 2019-nCoV pneumonia calory Characteristics clinical clinical benefit Clinical outcome collected COVID-19 Critical died effective antiviral treatment enrolled Evidence feasible Laboratory no significant difference Novel coronavirus nutrition nutrition support Patient patients patients with SARS-CoV-2 per day permissive low calorie intake Pneumonia Pragmatic Protein Randomized controlled trial recorded restrict Retrospective study SARS-CoV-2 pneumonia severe and critical patients Severe patient small sample size Spread Support the median Treatment two group viral shedding [DOI] 10.3389/fnut.2020.581679 PMC 바로가기 [Article Type] Nutrition
Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysisResearch Published on 2020-11-162022-11-01 Journal: Critical Care [Category] COVID-19, SARS, [키워드] 95% CI assessment AUC China Clinical practice clinician CNKI Coronavirus disease 2019 COVID-19 Critical case database diagnosed disease severity effective eligible evaluate Evaluating global public health help identify Infection Infectious disease Infrastructure management Meta-analysis Methodological quality mild patients Mortality Neutrophil-to-lymphocyte ratio NLR overall mortality Patient patients patients with COVID-19 performed poor prognosis Predictive Predictive value PROSPERO database QUADAS-2 Quality reduce Registered Registration reported Result screened searched sensitivity Severe case Severe patient specificity systematic review Treatment [DOI] 10.1186/s13054-020-03374-8 PMC 바로가기 [Article Type] Research
Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibilityArticle Published on 2020-11-102022-10-04 Journal: Cell Discovery [Category] 변종, 유전자 메커니즘, 임상, 치료기술, [키워드] accounted Affect allele allele frequency Analysis association Asymptomatic Asymptomatic disease bioinformatics Chinese Chinese patient complex diseases conducted confounding factors COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 severity Critical Critically ill death disease severity DPP7 effort FIVE General population Genetic genetic architecture genetic study genetic variants Genome-wide association studies genomic GOLGA3 group help Host IL-1 ill patient Infection initial Interaction International involved Laboratory limitation locus loss of function manifestation Mechanisms of disease Mild missense variant moderate outbreak outcome Patient patients phenotypic provide Sequencing Severe patient severity Shenzhen signaling pathway significantly stability suggested susceptibility TMPRSS2 protein Variability variant whole-genome sequencing [DOI] 10.1038/s41421-020-00231-4 PMC 바로가기 [Article Type] Article
The role of haematological parameters in patients with COVID-19 and influenza virus infectionCOVID-19 및 인플루엔자 바이러스 감염 환자에서 혈액학적 매개변수의 역할Original Paper Published on 2020-11-052022-09-12 Journal: Epidemiology and Infection [Category] SARS, 진단, [키워드] basophils Biomarker can be used coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cut-off value Delta neutrophil index DNI eosinophil eosinophils evaluated Follow-up group haematological parameter Haemoglobin healthy healthy control healthy controls highest Infection Inflammatory Influenza Influenza virus laboratory data leucocytes Lower lymphocyte Lymphocytes neutrophil Neutrophil-to-lymphocyte ratio Neutrophils NLR Novel coronavirus Patient patients with COVID-19 Platelet platelet-to-lymphocyte ratio Platelets predict red blood cell red blood cells SARS-CoV-2 sensitivity Severe patient severe patients severity severity of COVID-19 specificity the disease Treatment Wuhan, China [DOI] 10.1017/S095026882000271X PMC 바로가기 [Article Type] Original Paper
The study of automatic machine learning base on radiomics of non-focus area in the first chest CT of different clinical types of COVID-19 pneumoniaArticle Published on 2020-11-032022-10-04 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] Accuracy AUC can be used characteristic Chest CT Chest CT image Cohort collected control group COVID-19 evaluate feature greater Infectious diseases laboratory data lung moderate Negative predictive value NPV Outcomes research patients with COVID-19 Pneumonia positive PPV predict Predictive Respiratory tract diseases ROC selected severe group Severe patient statistical analysis the patient TNR TPR true negative were used with COVID-19 [DOI] 10.1038/s41598-020-76141-y PMC 바로가기 [Article Type] Article
Hydroxychloroquine treatment in COVID-19: A descriptive observational analysis of 30 cases from a single center in Wuhan, ChinaObservational Study Published on 2020-11-012022-10-05 Journal: Journal of medical virology [Category] 임상, [키워드] ACE2 Analysis C-reactive protein (CRP Chloroquine clinical evidence Clinical outcome coronavirus disease COVID-19 COVID-19 infected patient CRP level cytokine Cytokine storms defined early delivery elevated evaluate the effect faster HCQ HCQ therapy hospital Hospitalization Hydroxychloroquine IL-6 in vitro activity interleukin-6 laboratory parameter Patient patients treated patients with COVID-19 reduced risk factor SARS-CoV-2 Severe patient single center therapeutic effect Topic treated Treatment Treatment response two groups were assessed while Wuhan, China [DOI] 10.1002/jmv.26193 PMC 바로가기 [Article Type] Observational Study
Correlation between the variables collected at admission and progression to severe cases during hospitalization among patients with COVID-19 in ChongqingObservational Study Published on 2020-11-012022-10-05 Journal: Journal of medical virology [Category] 임상, [키워드] addition Admission alanine aminotransferase Aspartate aminotransferase AUC Blood oxygen saturation C-reactive protein CD3 CD4 count Chongqing collected coronavirus COVID-19 creatinine criteria Critical Critical care D-dimer demographics disease Dyspnea enrolled hospital Hospitalization Inflammation interquartile Laboratory test median Mild mild case moderate PaO Patient patients with COVID-19 Platelet Pneumonia Potassium predict predictors procalcitonin progressed progression pulmonary receiver operating characteristics respiratory rate Severe case Severe patient sodium temperature the patient variable with COVID-19 [DOI] 10.1002/jmv.26082 PMC 바로가기 [Article Type] Observational Study