Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptorIpomoeassin-F는 SARS-CoV-2 스파이크 단백질과 숙주 세포막 수용체의 시험관 내 생합성을 억제합니다125 Published on 2021-02-152022-09-10 Journal: Journal of Cell Science [Category] MERS, 치료제, [키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents assembly biogenesis biosynthetic block causative agent Cell-free translation component COVID-19 Endoplasmic reticulum envelope enzyme ER membrane ER membrane complex highlight highlighting Host host cell host cell membrane human cell in vitro inhibit inhibitor insertion mechanisms membrane protein Membrane proteins ORF8 protein ORF8 proteins paper pathogenic pathogenicity Pathogens Person plasma membrane Protein Protein target receptor reducing respiratory Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Sec61 Sec61 translocon small molecule Spike protein structural proteins synthesised the SARS-CoV-2 therapeutic translocation Viral Viral particles viral pathogens Viral protein biogenesis viral spike viruses [DOI] 10.1242/jcs.257758 PMC 바로가기 [Article Type] 125
Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell CultureBrilacidin, 세포 배양에서 SARS-CoV-2 억제 입증Article Published on 2021-02-092022-09-10 Journal: Viruses [Category] MERS, 치료기술, 치료제, [키워드] acute respiratory syndrome coronavirus AMPs antimicrobial peptide antimicrobial peptides Antiviral antiviral activity biological properties biological property brilacidin Calu Calu-3 captures causative agent Cell culture cell line Clinical use coronavirus coronavirus 2 coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 disease Critical de novo death defensin demonstrated entry inhibition Evidence host defense human lung Increasing inhibit SARS-CoV-2 inhibition manuscript morbidity and mortality peptides peptidomimetic reduce referred to Remdesivir respiratory SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 small molecule strain synergistic therapeutic intervention therapeutic options These data treat Vero Viral viral entry virus [DOI] 10.3390/v13020271 PMC 바로가기 [Article Type] Article
Drug designing against NSP15 of SARS-COV2 via high throughput computational screening and structural dynamics approach고 처리량 컴퓨터 스크리닝 및 구조 역학 접근을 통한 SARS-COV2의 NSP15에 대한 약물 설계Article Published on 2021-02-052022-09-11 Journal: European journal of pharmacology [Category] SARS, 신약개발, 치료제, [키워드] (lopinavir (ritonavir) addition approach best binding binding affinity butanamide complement Compound computational analysis contribute COVID-19 Critical dataset dihydrofuran-2(3H)-one drug drug candidate effective endonuclease ethyl explicit Favipiravir feature generate High Throughput Screening host immune system identify Interference lead Lopinavir molecular dynamics molecular dynamics simulations Nsp15 oseltamivir outbreak pandemic pharmacophore potential therapeutic target Protein pyrazine Replication Ritonavir rule SARS-CoV2 screened selected selective small molecule therapeutic training set Treatment unique virulence was selected [DOI] 10.1016/j.ejphar.2020.173779 PMC 바로가기 [Article Type] Article
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infectionSARS-CoV-2 감염 억제제로서의 기존 의약품 및 한약의 식별422 Published on 2021-02-022022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 변종, 신약개발, 치료제, [키워드] 3CL addition Amino acid amino acid sequence animal models animals antibody Antiviral antiviral agent approved assays caused cell-based and animal studies Compound Concentration confirmed case COVID-19 death disease drug Drug administration Drug repurposing effective Efficacy enzymatic assay evaluate food Food and Drug Administration global pandemic glycosylated hamster hamsters herbal medicine herbal medicines Human identification in vitro in vivo Infection inhibitors of SARS-CoV-2 mefloquine Mentha molecular Mutation nelfinavir outbreak pandemic Perilla frutescen Perilla frutescens protease Remdesivir reported RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection Screen sequence Significance small molecule Small molecules Spike protein tested the disease Treatment Trimeric spike protein Vaccines variant Viral viral surface virus water [DOI] 10.1073/pnas.2021579118 PMC 바로가기 [Article Type] 422
A fluorescence-based high throughput-screening assay for the SARS-CoV RNA synthesis complexArticle Published on 2021-02-012023-07-11 Journal: Journal of virological methods [Category] SARS, [키워드] coronavirus replication complex Screening small molecule [DOI] 10.1016/j.jviromet.2020.114013 PMC 바로가기
Molecular docking studies of some selected gallic acid derivatives against five non-structural proteins of novel coronavirusResearch Published on 2021-01-252022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] 3D structure binding energy Cardiomyopathy Chloroquine clinical trial Compound COVID-19 COVID-19 infected patient crystal structure database derivative detrimental Dexamethasone disease docked drug Druglikeness drugs Favipiravir FIVE Gallic acid derivatives health emergency Hydroxychloroquine in silico in vitro study in vivo inhibitor Ivermectin liver lower binding energy molecular molecular docking Molecular docking study molecular interactions MPro New coronavirus non-structural protein non-structural proteins Novel coronavirus Nsp12 nsp13 nsp14 Nsp15 Nsp3 pandemic PDB phosphate Plasma Protein Binding Protein Proteins PubChem Remdesivir reported Result retrieved ribavirin SARS-CoV-2 selected Side effect small molecule small molecule inhibitor Support therapeutic compound Vaccine virus World Health Organization [DOI] 10.1186/s43141-021-00120-7 PMC 바로가기 [Article Type] Research
Development of a Cell-Based Luciferase Complementation Assay for Identification of SARS-CoV-2 3CL pro InhibitorsArticle Published on 2021-01-242022-10-28 Journal: Viruses [Category] COVID-19, [키워드] 3CL pro 3CLpro Antiviral antiviral drug BSL-2 BSL-3 facility Cell cleavage cleavage site Complementation compounds COVID-19 current cytotoxicity development effort exhibited facilitate False positive FIVE HCV HIV identification identify in vitro inhibit SARS-CoV-2 inhibitor inhibitors of SARS-CoV-2 lack lentiviral limitations luciferase luciferase activity other compound performed protease protease inhibitors Proteases reduce replication-competent virus reported reporter SARS-CoV-2 screened small molecule specificity viral replication Z-FA-FMK [DOI] 10.3390/v13020173 PMC 바로가기 [Article Type] Article
PROMISCUOUS 2.0: a resource for drug-repositioningPROMISCOUS 2.0: 약물 재배치용 리소스Article Published on 2021-01-082022-09-11 Journal: Nucleic Acids Research [Category] 신약개발, 치료제, [키워드] approaches approved can be used candidate drug candidate drugs Cheminformatics compounds costly COVID-19 COVID-19 pandemic disease drug drug-target interaction Drug-target interactions effort emerging disease expand identify indication indications information open Patient Potential treatment potential treatments reduce researcher resource Section Side-effect Side-effects significantly similarity small molecule Small molecules time-consuming unique user user experience widespread [DOI] 10.1093/nar/gkaa1061 PMC 바로가기 [Article Type] Article
Adaptation of advanced clinical virology assays from HIV-1 to SARS-CoV-2HIV-1에서 SARS-CoV-2로의 고급 임상 바이러스 분석 적응Review Published on 2021-01-012022-09-11 Journal: Current opinion in HIV and AIDS [Category] 치료기술, [키워드] adaptation analyses antiviral therapeutics applied approaches Blood conserved COVID COVID-19 pandemic disease severity Evidence genetic diversity Genetic variation HIV-1 HIV-1 infection IMPROVE infected individual infected individuals knowledge molecular Neutralizing antibodies nucleic acid outcome pandemic Pathogenesis Phylogenetic analysis plasma Precision Prognosis recent reverse transcriptase reverse transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 sequencing sensitive sequence Sequencing shown small molecule small molecule inhibitor Small molecule inhibitors Stage susceptibility therapy Vaccines Viral viral replication Viral RNA viral RNA quantification [DOI] 10.1097/COH.0000000000000656 PMC 바로가기 [Article Type] Review
Prevalence of COVID infections in a population of rheumatic patients from Lombardy and Marche treated with biological drugs or small molecules: A multicentre retrospective studyResearch article Published on 2021-01-012022-10-05 Journal: Journal of autoimmunity [Category] SARS, 신약개발, [키워드] age Analysis biological drug biologics CFR co-morbidity conditions COVID COVID 19 COVID-19 COVID-19 pandemic determine diagnosed with COVID-19 disease DMARDs drug evaluated fatality Final General population Hydroxychloroquine Immunocompromised Immunosuppressant Immunosuppressive treatment increased risk Infection infection rate infections Italian region Local lombardy management Marche mortality rate multicentre negative swab no difference objective Patient patients from Lombardy question raised receiving registries registry data Result Retrospective study rheumatic disease risk risk factor Seven small molecule Small molecules susceptibility susceptible Symptom telephone contact the disease the patient Tocilizumab treat treated Treatment with COVID-19 [DOI] 10.1016/j.jaut.2020.102545 [Article Type] Research article