Age-Stratified Infection Probabilities Combined With a Quarantine-Modified Model for COVID-19 Needs Assessments: Model Development StudyOriginal Paper Published on 2021-05-312022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, SARS, [키워드] added Adults age age stratification theory China city classic Combined Community compartmental model country COVID-19 COVID-19 infection death death rate death rates develop development disease distribution Effect Epidemic modeling estimate expected fatality groups homogenous incidence include individual Infection infection probability Local Mathematical modelling measure median age Model Mortality much lower objective observation Older pandemic parameter Population predict predicted Probability quarantine Result SEIR social distancing Spread Stratification susceptible-exposed-infectious-removed Testing the disease weakness were used [DOI] 10.2196/19544 PMC 바로가기 [Article Type] Original Paper
Multi-biomarker is an early-stage predictor for progression of Coronavirus disease 2019 (COVID-19) infection다중 바이오마커는 코로나바이러스 질병 2019(COVID-19) 감염의 진행에 대한 초기 단계 예측자입니다Meta-Analysis Published on 2021-05-272022-08-31 Journal: International Journal of Medical Sciences [Category] MERS, 바이오마커, [키워드] accounted Accuracy categories Cell center clinical Combination Community coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection cured death enrolled highest ICU IL-6 Infection intensive care intensive care unit interleukin interleukin-6 Mild disease mild patient mild patients Multi-biomarker natural neutrophil Patient patients hospitalized predict predictors progressed progression Public regression equation risk sensitivity severe disease specificity Spread Stratification Treatment undergo with COVID-19 with mild disease [DOI] 10.7150/ijms.58742 PMC 바로가기 [Article Type] Meta-Analysis
Implementing Personalized Medicine in COVID-19 in Andalusia: An Opportunity to Transform the Healthcare SystemReview Published on 2021-05-262022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] asymptomatic infection Care Clinical course Clinical practice clinical trials COVID-19 COVID-19 infection COVID-19 pandemic Diagnosis disease Epidemiology facilitate genetic variants Health health care systems host genetics Implementing increasingly Infection inter-individual life-threatening likelihood Local management Manifestations measure Medicine National opportunity outbreak pandemic Patient Personalized medicine positive precision medicine profiles Prognosis public health public health measure SARS CoV2 SARS-CoV2 genome Sequencing Stratification Support Surveillance susceptibility System therapeutic strategy therapy transmission pattern Treatment vaccination Variability viral genome [DOI] 10.3390/jpm11060475 PMC 바로가기 [Article Type] Review
Thromboembolic Complications of SARS-CoV-2 and Metabolic Derangements: Suggestions from Clinical Practice Evidence to Causative AgentsReview Published on 2021-05-252022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] ACE2 administration Affect agent angiotensin-converting enzyme 2 binding bleeding Causative cause cell metabolism cellular receptor ChAdOx1 nCoV-19 clinical Clinical severity Comorbidity Complication COVID-19 Cytokines higher risk human host implicated infect Infection Inflammation issue mechanism metabolic metabolism Mild multi organ support oxygen supplementation pathophysiology Patient positive Practice respiratory Respiratory Support RNA SARS-CoV-2 SARS-COV-2 infection ssRNA Stratification suggestion systemic illness systemically the disease thrombosis thrombotic complication Treatment Vaccine viral spike protein widespread β-coronavirus [DOI] 10.3390/metabo11060341 PMC 바로가기 [Article Type] Review
Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance프랑스 SARS-CoV-2 항체 유병률: 전국적인 혈청학적 감시 결과Article Published on 2021-05-212022-09-10 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] 95% CI age anti-SARS-CoV-2 IgG assessment Course COVID-19 COVID-19 epidemic COVID-19 pandemic Critical cumulative cumulative incidence detectable epidemic wave Epidemiology Fatality rate first stage first stages First wave framework France French incidence increase infected individual infected individuals lockdown majority National Neutralising Antibodies neutralising antibody Population prevalence study progression proportion provide public health remained SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections serological surveillance seropositive individual seropositive individuals Sex specimen Stratification susceptible Testing Transmission Viral viral infection Viral transmission [DOI] 10.1038/s41467-021-23233-6 PMC 바로가기 [Article Type] Article
Impact and Determinants of High-Sensitivity Cardiac Troponin-T Concentration in Patients With COVID-19 Admitted to Critical Care중환자실에 입원한 COVID-19 환자의 고감도 심장 트로포닌-T 농도의 영향 및 결정 요인Multicenter Study Published on 2021-05-152022-09-11 Journal: The American journal of cardiology [Category] SARS, 바이오마커, [키워드] Admission age APACHE Biomarker cardiac cardiac troponin Cohort cohorts Concentration consecutive patients COVID-19 Critically ill Critically ill patient critically ill patients death determinant died discharge Elevation Factors ICU Impact independent intensive care invasive ventilation Kaplan-Meier survival analysis likelihood limit London management mechanism Mortality myocardial injury on admission Patient patients hospitalized peak performed Pneumonitis Predictive predictor remained reported score severe COVID-19 significantly lower Stratification Stress survival analysis survivor troponin ULN with COVID-19 [DOI] 10.1016/j.amjcard.2021.01.037 PMC 바로가기 [Article Type] Multicenter Study
Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platformArticles Published on 2021-05-082022-10-30 Journal: Lancet (London, England) [Category] COVID-19, Fulltext, MERS, [키워드] adjusted adjusted hazard ratio Admission Admissions affected age black Care categories category cause Characteristics clinical factor Comorbidities conducted COVID-19 COVID-19 pandemic death Deprivation Electronic health record England ethnic group finding FIVE funding geographical region group heterogeneity Hospital admissions hospitalisation household size ICU ICU admission increased risk intensive care likelihood mechanism Medical Research Council Model multifactorial multivariable Cox regression Observational cohort study OpenSAFELY outcome platform Population positive positive test result primary care reducing Registered risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 testing second wave Sex Sociodemographic South Asian Stratification study period tested vaccination white [DOI] 10.1016/S0140-6736(21)00634-6 PMC 바로가기 [Article Type] Articles
Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trialClinical Trial Published on 2021-05-012022-10-05 Journal: Stem cells translational medicine [Category] SARS, 임상, 진단, [키워드] 1:1 24 hour acute respiratory distress AEs analyzed anti-inflammatory effect ARDS Cell cell transplantation cellular cellular therapy clinical trials Control control group COVID-19 cytokine death determine distress double-blind Effect Efficacy Endpoint event group groups high mortality immunomodulatory improved patient survival intention to treat intravenous infusion mesenchymal stem cell Mesenchymal stem cells patient survival Randomized Randomized controlled trial randomized, controlled trial respiratory tract SAEs Safe secondary Serious Adverse Event severity significantly Standard of care stem cell Stratification subject survival syndrome Time to recovery transplantation Treatment treatment group UC-MSC umbilical Umbilical cord was performed was used with COVID-19 [DOI] 10.1002/sctm.20-0472 PMC 바로가기 [Article Type] Clinical Trial
Higher vs Lower Doses of Dexamethasone in Patients with COVID-19 and Severe Hypoxia (COVID STEROID 2) trial: Protocol for a secondary Bayesian analysisCOVID-19 및 중증 저산소증(COVID STEROID 2) 환자에서 덱사메타손의 고용량 및 저용량 시험: 이차 베이지안 분석을 위한 프로토콜Comparative Study Published on 2021-05-012022-09-11 Journal: Acta Anaesthesiologica Scandinavica [Category] SARS, 임상, [키워드] adjusted analysed Analysis Bayesian analysis binary outcome clinically Clinicians conducted coronavirus disease Coronavirus disease 2019 Corticosteroids COVID COVID-19 credibility interval Critically ill Critically ill patient days alive death decrease Dexamethasone Effect help hypoxia hypoxic respiratory failure incidence rate Interpretation intravenously logistic regression model logistic regression models Lower lower dose mean difference Mortality optimal dose outcome patients with COVID-19 Primary outcome Probability protocol randomised Registered researcher Respiratory failure risk secondary outcome Sensitivity analyses sensitivity analysis severe hypoxia statistical steroid Stratification Support the mean Trial variable with COVID-19 [DOI] 10.1111/aas.13793 PMC 바로가기 [Article Type] Comparative Study
Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients입원한 COVID-19 환자의 중증도와 관련된 대사 신호Observational Study Published on 2021-04-302022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 바이오마커, 임상, [키워드] adenine adenine nucleotide Admission assist association Barcelona Biomarker Biomarkers blood pressure ceramide Ceramides change clinical evolution collected correlated COVID-19 COVID-19 patient COVID-19 pneumonia Critical Degradation demographic disease severity enrolled evaluate Evolution Hospitalization hospitalized COVID-19 patients hospitalized patient identifying Inclusion Inflammation Kynurenine metabolic metabolic pathway metabolic pathways metabolism metabolomic metabolomics moderate nicotinamide obesity oxygen oxygen saturation parameter pathophysiology plasma samples Pneumonia radiological reaction reductions reductions in Registered respiratory respiratory rate respiratory severity severity signature significantly single-center study Spain Stratification stratified subsequent Tryptophan Viral viral infection was measured with COVID-19 [DOI] 10.3390/ijms22094794 PMC 바로가기 [Article Type] Observational Study