therapeutic targets – Page 16 – Communicable Diseases Research

Treatment of COVID 19-Repurposing drugs commonly used in dermatology

피부과에서 일반적으로 사용되는 COVID 19 - 용도 변경 약물의 치료

Review

Published on 2020-09-012022-08-31
Journal: Dermatologic therapy [Category] SARS, 신약개발, 치료제,

Novel therapeutic approaches toward Hantaan virus and its clinical features’ similarity with COVID-19

한탄 바이러스에 대한 새로운 치료법과 코로나19와 임상 양상의 유사성

Editorial

Published on 2020-09-012022-09-11
Journal: Indian journal of pharmacology [Category] 조류인플루엔자, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused China clinical feature Community coronavirus COVID-19 COVID-19 outbreak COVID-19 pathogenesis death diagnostics Drug discovery dry cough Evolution extracorporeal membrane oxygenation feature Fever Genetic glycoprotein Hantaan virus life cycle high fever high mortality rate highlight host cells immune response induce Intensive involved lack life life cycle multiple organ failure N protein nonstructural protein nonstructural proteins novel nucleocapsid protein opposite Organ failure outbreak Pathogenesis Pneumonia positive Replication reported respiratory ribavirin RNA virus Seven severe acute respiratory syndrome Coronavirus Shortness of breath similarity Symptom target host cells therapeutic Therapeutic approach therapeutic target therapeutic targets Therapeutic treatment Treatment treatments Viral viral pathogenesis virulence virus viruses with COVID-19
[DOI] 10.4103/ijp.ijp_1001_20 PMC 바로가기 [Article Type] Editorial

SARS-CoV-2 Treatment Approaches: Numerous Options, No Certainty for a Versatile Virus

Pharmacology

Published on 2020-08-262022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] ACE2 receptor acting administration angiotensin-converting enzyme 2 receptors Antibiotics Antimalarial drugs Antiretrovirals antiviral activity approach certainty Clinical features convalescent plasma coronavirus coronavirus disease corticoids COVID-19 current therapy drug effective Endocytic pathway endocytosis Epitopes host-virus interaction Hydroxychloroquine identify immune immune response immune system disorders immunosuppressive drug Inflammatory cytokines initial interferons kinase inhibitors Mesenchymal stem cells monoclonal antibodies monoclonal antibody neutralization nucleotide analogue Numerous pandemic pathogenic mechanism pathogenic mechanisms promote Remdesivir RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccine Side effect similarity Spread stem cells Still therapeutic option therapeutic targets therapy Treatment Trial triggered Vaccine virus
[DOI] 10.3389/fphar.2020.01224 PMC 바로가기 [Article Type] Pharmacology

A consideration of publication-derived immune-related associations in Coronavirus and related lung damaging diseases

Research

Published on 2020-08-032022-10-30
Journal: Journal of Translational Medicine [Category] COVID-19, MERS,

[키워드] acute respiratory syndrome affecting approach association caused Cluster co-morbidity co-occurrence coronavirus COVID-19 COVID-19 infections COVID-19 pandemic COVID-19 patients cytokine Cytokine storms Cytokines diagnostic disease Diseases facilitate globe H5N1 H5N1 influenza Haematopoietic cells Health help identify immune immune cell type immune cell types immune responses implicated individual Infection infections Influenza lung Manifestations marker modulate Mortality network analysis pandemic Protein rates of infection Research response responsible Result SARS SARS-CoV virus SARS-CoV-2 similarity Symptom Symptoms therapeutic targets understanding virus with COVID-19
[DOI] 10.1186/s12967-020-02472-z PMC 바로가기 [Article Type] Research

The pathophysiology of ‘happy’ hypoxemia in COVID-19

COVID-19에서 '행복한' 저산소혈증의 병태생리학

Review

Published on 2020-07-282022-09-06
Journal: Respiratory Research [Category] Communicable Disease, COVID-19, SARS,

[키워드] alveolar alveolar dead space arterial blood blood sample Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients dead Dead space dead space ventilation Deterioration determinant dissociation curve distress Dyspnea Gas exchange hallmark Healthcare system hemoglobin hyperventilation Hypoxemia intensive care intensive care unit Interaction management Novel coronavirus novel coronavirus disease occur offer oxygen oxygen saturation oxyhemoglobin pandemic partial pressure pathophysiological pathophysiology Patient physician promote respiratory respiratory distress Respiratory failure SARS-CoV-2 Shunt therapeutic targets Ventilation Viral
[DOI] 10.1186/s12931-020-01462-5 PMC 바로가기 [Article Type] Review

Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2

Cellular and Infection Microbiology

Published on 2020-07-272022-10-31
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS,

[키워드] Activation acute respiratory distress analyses Analysis ARDS (Acute Respiratory Distress Syndrome) binding Cluster Complication core gene COVID-19 death E protein E protein Inhibitors envelope protein envelope protein (E) Evidence feature Features functional Health host cells impacts Inflammasome inhibit SARS-CoV-2 motif Mutation neutralizing antibody Novel coronavirus pathogenicity Prevent RBD receptor ACE2 Receptor binding domain reduce reveal S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sequenced show Spike protein Spread syndrome therapeutic target therapeutic targets therapy triggered Vaccine variant viral entry virus viruses
[DOI] 10.3389/fcimb.2020.00405 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Article

Published on 2020-07-222022-10-04
Journal: Cell Systems [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] antiviral immune response approach batch effect Biomarker build Classifier clinical clinical classifiers clinical decision Clinical use Coagulation system Cohort collected complement COVID-19 COVID-19 infection COVID-19 pandemic diagnostic differentially expressed downstream facilitate Factors generate high-throughput proteomics Hospitalized hospitalized COVID-19 patients hypothese identify implementation include Infection Inflammation Longitudinal studies mass spectrometry pandemic per day platform point-of-care Potential biomarker Precision pro-inflammatory factor Protein proteome proteomic proteomics protocol quantification reduce regulated required serum and plasma severity Standardization Support SWATH-MS the SARS-CoV-2 the WHO therapeutic targets upstream WHO with COVID-19
[DOI] 10.1016/j.cels.2020.05.012 PMC 바로가기 [Article Type] Article

COVID-19/SARS-CoV-2 Infection: Lysosomes and Lysosomotropism Implicate New Treatment Strategies and Personal Risks

Review

Published on 2020-07-132022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] Affect Antibiotics Antiviral approach approved active compounds Bacteria benefit Care cathepsin L CCL20 CCL4 Clinical data Combination Compound condition COVID-19 COVID-19 pandemic Cytokine release syndrome Cytokine storm disease drug drugs early administration effective endothelial Health host cells IL-1B IL-6 immunomodulatory therapy Inflammatory lysosomal lysosomal enzyme lysosome lysosomotropic compounds lysosomotropism MERS New pandemic Patient patients with SARS-CoV-2 Prevent promote Prophylaxis provide Remdesivir SARS-CoV-2 SARS-COV-2 infection Strategy Stress supported systemic inflammation therapeutic targets therapy Treatment triggered viral entry viral host cell entry viruses
[DOI] 10.3390/ijms21144953 PMC 바로가기 [Article Type] Review

SARS-CoV-2 Molecular Network Structure

Physiology

Published on 2020-07-102022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?

Article

Published on 2020-06-082023-07-01
Journal: Infection, genetics and evolution : journal of mol [Category] SARS,

[키워드] Biomarkers COVID-19 microRNA SARS-CoV-2 therapeutic targets
[DOI] 10.1016/j.meegid.2020.104417 PMC 바로가기 [Article Type] Article