Conformational Reorganization of the SARS Coronavirus Spike Following Receptor Binding: Implications for Membrane FusionResearch Article Published on 2007-10-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] ACE2 ACE2 binding Analysis angiotensin-converting enzyme 2 Cell culture change conformational change Cryo-electron microscopy domain fusion in viral initial Isolation membrane fusion molecular morphology occur produced Protein Proteins provide purified receptor Receptor binding reorganization SARS Coronavirus SARS-CoV shown spike subsequent transmembrane domains viral spike virion [DOI] 10.1371/journal.pone.0001082 PMC 바로가기 [Article Type] Research Article
Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike proteinArticle Published on 2006-04-172022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] affected Anti-viral antiviral activity Asia Atypical cell cytotoxicity Class I viral fusion protein Concentration concentrations coronavirus CoV domain dose-dependent Effect Europe fusion peptide fusion protein glycoprotein heptad repeat hydrophobicity IC50 identify inhibited inhibition inhibitor membrane membrane fusion MHV murine hepatitis virus N-terminus North America peptide Peptide inhibitor Pneumonia provide recent Receptor binding Region regions responsible S2 subunit SARS-CoV severe Severe acute respiratory syndrome-associated coronavirus six-helix bundle tested the S protein viral infectivity viral spike viral spike protein was used white [DOI] 10.1016/j.virusres.2006.03.001 PMC 바로가기 [Article Type] Article