Transplantation of Hematopoietic Stem Cells in Human Severe Combined Immunodeficiency: Longterm OutcomesArticle Published on 2013-09-262024-09-04 Journal: Immunologic research [Category] 대상포진, [키워드] Bone marrow transplantation chimerism severe combined immunodeficiency survival thymic output [DOI] 10.1007/s12026-010-8191-9 PMC 바로가기 [Article Type] Article
A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors출생 후 멜라닌 세포 계통의 유지와 멜라닌 세포 줄기 세포 전구체의 분화에서 SOX10의 이중 역할Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adult stem cells appear Author cause Cell cell fate cell type Critical differentiation downregulated downstream driving embryogenesis exacerbate examined Express expression Factor growth hair hair follicle haploinsufficiency idea in vivo increased expression leads Lineage maintain maintenance mechanism Melanocyte melanocytes melanogenesis MITF mitigate Mouse models negative regulation observation overexpression pigment portion precursor Premature prevented progenitor raise regulated Regulation Regulatory role Sox10 STEM stem cell stem cells survival sustained target Transcription transcription factor transcription factors [DOI] 10.1371/journal.pgen.1003644 PMC 바로가기 [Article Type] Research Article
Integrative “Omics”-Approach Discovers Dynamic and Regulatory Features of Bacterial Stress Responses통합 "Omics" 접근 방식으로 세균 스트레스 반응의 동적 및 조절 기능 발견Research Article Published on 2013-06-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (transcriptome adaptation adaptive mechanism adaptive mechanisms addition alternative approach assigned Author Bacteria cellular stress responses change choice complex conditions determine different dynamic Effect elevated temperature event events example exhibited expression expression level expression pattern expressome Factor Factors feature found fraction Frequency Gene Genes Genome help in addition to include initiated integration maintain mass spectrometry Microarrays mRNA mRNA level mRNA levels mRNAs Occurrence open reading frames operon organism oxygen phototrophic polar polysome Population post-transcriptional level Protein Proteins proteome provided quantification quorum regulated Regulation Regulatory reported required response RNA-Seq RpoE singlet oxygen Stress stress condition stress conditions stress response stress responses survival transcriptional activation transcriptional level transcriptional regulator transcriptional regulators Transcriptome translation translational was used [DOI] 10.1371/journal.pgen.1003576 PMC 바로가기 [Article Type] Research Article
Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expressionResearch Published on 2013-01-192022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activated addition BCL-2 cause Cell cell cycle progression cells E protein Effect Endoplasmic reticulum epidemic diarrhea ER stress Express expressing expression function growth had no IEC IL-8 intestinal epithelial cell investigated NF-Κb NF-κB nucleus pathogen PEDV previous study Research responsible Result Stress subcellular localization survival the cell up-regulate virus [DOI] 10.1186/1743-422X-10-26 PMC 바로가기 [Article Type] Research
The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegansGATA 전사 인자 egl-27은 꼬마선충의 스트레스 저항성을 촉진하여 노화를 지연시킵니다Research Article Published on 2012-12-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated activated Affect age aging aging process alteration animals Author Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans conserved daf-16 Delay Effect elegan expression Factor Factors found FoxO GATA GATA transcription factor Gene Genes heat stress identify IGF-1 impair IMPROVE increase inhibited insulin Intersection involved limit Longevity molecular mechanism molecular mechanisms mutant overexpression oxidative stress pathway Pathways promote Promoting PROTECT protective response protective responses receptor reduced required resistance response Signaling significantly Stress stress response stress responses suppresse survival target transcription factor wild-type worm worms [DOI] 10.1371/journal.pgen.1003108 PMC 바로가기 [Article Type] Research Article
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophilsResearch Published on 2012-05-292022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] affecting Autoimmune blockade CD4 CD4+ T cells Central nervous system clinical consequence CNS compared complex coronavirus cytokine Demyelination detrimental disease downstream effector molecule Encephalomyelitis expression Factor feedback loops GM-CSF IFN-γ IFN-γ IL-17 independent Infected inflammatory condition inflammatory disease Interaction mechanism memory mice morbidity Mortality murine Neurotropic coronavirus neutrophil neutrophil infiltration Neutrophils not express pathogenic positive PROTECT provided recipient reduced reducing relative contribution rescued response Result survival T cell T cells Th1 Th17 Th17 cell tissue damage Transcription transcriptional regulation transfer upregulation virus was used wild-type [DOI] 10.1186/1742-2094-9-104 PMC 바로가기 [Article Type] Research
Role of Exonic Variation in Chemokine Receptor Genes on AIDS: CCRL2 F167Y Association with Pneumocystis PneumoniaAIDS에 대한 케모카인 수용체 유전자의 외음성 변이의 역할: 폐포자충과의 CCRL2 F167Y 연관성Research Article Published on 2011-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI accelerated addition Affect AIDS Amino acid Analysis association associations Atypical Author CCR2 CCR3 CCR5 CCR8 CCRL2 Cell Chemokine receptor chromosome Cluster cohorts conditions CX3CR1 defined dendritic cell disease Disease progression DNA Effect exonic FIVE functional variant functional variants Gene Genes Genetic genetic association Genetic variation genotyped HIV-1 HIV-1 infection host cells Human immune regulation in addition to indicated Inflammation involved key factor lung majority natural history Non-synonymous outcome Pathogenesis Pneumonia progression role Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs surface protein survival survival analysis tested variant Variation [DOI] 10.1371/journal.pgen.1002328 PMC 바로가기 [Article Type] Research Article
Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus VirulenceResearch Article Published on 2011-06-092022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accelerated accessory gene acquisition Activation Analysis Antiviral antiviral response Apoptosis assay association Author benefit binding caspase catalytic caused Cell cellular RNA clinical disease compared conserved coronavirus CoV cultures Cytopathic effect Defense Degradation Deleterious demonstrated eIF2α ENCODE eukaryotic translation evade Evolution expression Genome growth Host host antiviral response host cell hydrophobic immune response indicated Infected infected cells Infection Innate inoculation Interaction led to mechanism modify modulation molecular mechanism motif mutant mutant virus Newborn observation parental pathology Pathways persistence Phosphorylation promoted Protein protein phosphatase 1 provided pull-down reducing required RNA degradation RNA viruses RNase selective sequence subunit suggested survival TGEV tissue translational transmissible gastroenteritis virus Viral RNA virulence virus virus infection [DOI] 10.1371/journal.ppat.1002090 PMC 바로가기 [Article Type] Research Article
Hepatitis B virus infection: a favorable prognostic factor for intrahepatic cholangiocarcinoma after resectionArticle Published on 2011-03-142023-06-11 Journal: World journal of gastroenterology [Category] B형 간염, [키워드] Hepatitis B virus intrahepatic cholangiocarcinoma Prognosis survival [DOI] 10.3748/wjg.v17.i10.1292 PMC 바로가기
Living with Companion Animals, Physical Activity and Mortality in a U.S. National CohortArticle Published on 2010-06-282023-08-30 Journal: International Journal of Environmental Research an [Category] E형 간염, [키워드] domestic animals Mortality physical activity survival [DOI] 10.3390/ijerph7062452 PMC 바로가기 [Article Type] Article