ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoVStructural Biology Published on 2020-11-042022-10-31 Journal: Clinical Science (London, England : 1979) [Category] COVID-19, SARS, [키워드] ACE ACE inhibitor ACE2 acute respiratory syndrome Alzheimer’s dementia Analysis angiotensin converting enzyme angiotensin converting enzyme 2 blood pressure body fluid cardiovascular disease cleave coronavirus COVID-19 Cryo-electron microscopy disease fibrosis function functional highlight homologue Immunity Infectious disease insecticides Interaction involved Like Lineage mechanism mechanisms metalloproteases methodology obesity organism pandemic physiological provide RAAS receptor Regulation responsible SARS-CoV SARS-CoV-2 substrate therapy tissues Treatment turn understanding X-ray crystallography [DOI] 10.1042/CS20200899 PMC 바로가기 [Article Type] Structural Biology
Smart polymeric eye gear: A possible preventive measure against ocular transmission of COVID-19스마트 폴리머 아이 기어: COVID-19의 안구 전염에 대한 가능한 예방 조치Article Published on 2020-11-012022-08-31 Journal: Medical Hypotheses [Category] 치료제, [키워드] ACE ACE-2 ACE-2 receptor angiotensin Angiotensin-converting enzyme antiviral activities antiviral activity appear attribute binding binding affinity Complete Concentration congestion conjunctival COVID-19 COVID-19 transmission description Evidence evidence of eye Eye infection Face shield functional healthcare Healthcare workers host cells Hypothesis identify IMPROVE In-vitro leads ocular Ocular surface offer Polymer prophylactic measure prophylactic measures Prophylaxis Protective receptor receptors reported Safe SmaRT suggested susceptibility Transmission virus entry [DOI] 10.1016/j.mehy.2020.110288 PMC 바로가기 [Article Type] Article
Pirfenidone: A novel hypothetical treatment for COVID-19피르페니돈: COVID-19에 대한 새로운 가상 치료제Article Published on 2020-11-012022-08-31 Journal: Medical Hypotheses [Category] 신약개발, 유전자 메커니즘, 치료법, [키워드] ACE acute respiratory distress acute respiratory distress syndrome adverse effects angiotensin angiotensin converting enzyme Angiotensin converting enzyme receptor Apoptosis approved ARDS Cell COVID-19 COVID-19 patients cytokine Cytokine storm decrease distress downregulate expression fibrosis hypothetical idiopathic Idiopathic pulmonary fibrosis Inflammation inhibit Invasion IPF kill majority mechanism mechanism of action Mild mild to moderate mild to moderate disease moderate disease morbidity Mortality multiorgan failure oxidative stress pathophysiology Patient patients with COVID-19 Pirfenidone pneumocyte Pneumocytes PROTECT pulmonary pyridone receptor respiratory distress Respiratory distress syndrome syndrome Treatment treatment for COVID-19 treatment of COVID-19 patients [DOI] 10.1016/j.mehy.2020.110005 PMC 바로가기 [Article Type] Article
Characteristics of patients with diabetes hospitalised for COVID-19 infection-a brief case series reportClinical Trial Published on 2020-11-012022-10-05 Journal: Diabetes research and clinical practice [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval ACE ACE inhibitors age angiotensin receptor blocker ARB ARBs Case series case sery Characteristics characteristics of patient Chronic kidney disease collected Comorbidity COVID-19 COVID-19 infection COVID-19 patient demographics deviation diabete diabetes Diabetes Mellitus diagnosed enzyme feature Gender glycaemic control hospital hospitalised hypertension Infection inhibitors less nasal swabs no significant difference non-steroidal anti-inflammatory drug NSAIDS obese Other outcome Patient patients with diabete pharyngeal polymerase chain Prevalence retrospective reverse transcription risk factor RT-PCR shown significantly more study period virus with COVID-19 [DOI] 10.1016/j.diabres.2020.108460 PMC 바로가기 [Article Type] Clinical Trial
Should ACE2 be given a chance in COVID-19 therapeutics: A semi-systematic review of strategies enhancing ACE2Research article Published on 2020-11-012022-10-05 Journal: European journal of pharmacology [Category] 신약개발, [키워드] absence ACE ACE2 acute respiratory syndrome analysed Ang (1–7) Angiotensin converting enzyme-2 Angiotensin II antiviral therapy bind Cardiopulmonary Corona virus COVID-19 COVID-19 disease COVID-19 pathogenesis death diabetes downregulation downstream drug effective enzyme human cell Loss modulation other organs pathophysiological Pathways progression protective effect protective role Protein pulmonary epithelial cell pulmonary system RAAS receptor SARS-CoV-2 stimulate symptomatic therapeutic Treatment Vaccine virus [DOI] 10.1016/j.ejphar.2020.173545 [Article Type] Research article
Substitutions in Spike and Nucleocapsid proteins of SARS-CoV-2 circulating in South America남미에서 순환하는 SARS-CoV-2의 스파이크 및 뉴클레오캡시드 단백질의 치환Article Published on 2020-11-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 치료법, [키워드] ACE Algorithm Amino acid Betacoronavirus Brazil circulating collected conserved country COVID-19 diagnostic assay COVID-19 pandemic D614G diagnostic tests Ecuador Epidemic Frequency genetic variability Genome genomes genomic Genomic surveillance genus genus Betacoronavirus high affinity human population Illumina Miseq immunogenic infect information Lower respiratory tract muscle N protein Non-synonymous substitutions nucleocapsid nucleotide nucleotide sequence Oxford pandemic Protein Proteins protocol receptor replaced REPLACED BY reported respiratory responsible SARS-CoV-2 SARS-CoV-2 pandemic sequence sequences Seven South South America spike Spike protein structural protein structural proteins Substitution substitutions Surveillance synonymous substitutions the SARS-CoV-2 the spike protein Therapeutics Vaccines virus [DOI] 10.1016/j.meegid.2020.104557 PMC 바로가기 [Article Type] Article
Good or bad: Application of RAAS inhibitors in COVID-19 patients with cardiovascular comorbiditiesReview article Published on 2020-11-012022-10-05 Journal: Pharmacology & therapeutics [Category] SARS, 유전자 메커니즘, [키워드] ACE ACE inhibitor ACE2 receptor Angiotensin-converting enzyme application ARBs blocker bradykinin cardiovascular comorbidity cardiovascular disease cardiovascular system Care caused clinical study Comorbidity coronavirus coronavirus disease CoV COVID-19 COVID-19 patient COVID-19 patients CVD Good Health host cells hypertension IMPROVE infect infected with SARS-CoV-2 Inflammation inhibitor inhibitors media morbidity and mortality pandemic Patient patients treated Prognosis RAAS RAAS inhibitors receptor Regulation respiratory SARS-CoV-2 significantly increased virus [DOI] 10.1016/j.pharmthera.2020.107628 [Article Type] Review article
Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million peopleSpecial Populations Published on 2020-10-312022-10-31 Journal: Heart (British Cardiac Society) [Category] COVID-19, MERS, SARS, [키워드] 95% CI ACE ACE inhibitor adjusted Admission African angiotensin receptor blocker ARB association black cardiac risk factors and prevention cohort study collected data confounders COVID-19 COVID-19 disease Cox proportional hazard diabetes diagnosed disease drug Effect England enzyme Epidemiology ethnic group finding geographical region group higher risk hypertension ICU ICU care increased risk inhibitor intensive care medication participant Patient primary care Primary outcome prospective cohort study raise receiving receptor reduced risk resulting risk risk of COVID-19 RT-PCR severe COVID-19 disease severity significant interaction significantly significantly increased sociodemographic factors susceptibility variables with COVID-19 [DOI] 10.1136/heartjnl-2020-317393 PMC 바로가기 [Article Type] Special Populations
Renin–Angiotensin System: An Important Player in the Pathogenesis of Acute Respiratory Distress SyndromeReview Published on 2020-10-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 Activation activity acute lung injury addition Appropriate ARDS attenuate cell entry cells changes in characterized COVID-19 Defense distress drug effective enzyme help humoral increased vascular permeability Inflammation Initially Injury lack pathogen’ Pathogenesis Pathogens Prognosis Pulmonary edema pulmonary fibrosis question RAS reducing renin–angiotensin system respiratory SARS-CoV-2 SARS-CoV-2 pandemic soluble ACE2 subject survival syndrome Therapeutic strategies therapeutic strategy tissue repair Treatment tumor necrosis factor-α [DOI] 10.3390/ijms21218038 PMC 바로가기 [Article Type] Review
Anti-inflammatory drugs and the renin-angiotensin-aldosterone system: Current knowledge and potential effects on early SARS-CoV-2 infectionReview Published on 2020-10-082022-10-04 Journal: Virus research [Category] 유전자 메커니즘, [키워드] 2003 SARS ACE ACE2 ACE2 expression acute respiratory syndrome Affect affected aggravate angiotensin-converting enzyme 2 bind cellular coronavirus coronavirus disease Coronaviruses Corticosteroid Corticosteroids COVID-19 current disease drug early infection early phase Effect endothelial Endothelium ENhance enzyme explain expresse expressed facilitate gastrointestinal tract host cell in viral Infection influence Interaction kidneys knowledge lung mechanism MERS-CoV Middle East non-steroidal anti-inflammatory drug NSAID NSAIDS organ organ-specific Paracetamol pathogenicity pathology pathway RAAS RBD recent Receptor binding domain renin-angiotensin system Replication reported S-protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection School Spike protein syndrome thought Vascular viral entry viral infection viral replication viruses [DOI] 10.1016/j.virusres.2020.198190 PMC 바로가기 [Article Type] Review